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Worm Phenotype (WP): cell homeostasis metabolism variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + 3:   Variant [WBPhenotype:0000886] <4>
+ + 2:   physiology variant [WBPhenotype:0000519] <7>(487|558) (487|240|64)
+ 1:   cell physiology variant [WBPhenotype:0000536] <26>(152|154) (153|66|17)
+ 1:   blast cell physiology variant [WBPhenotype:0000985] <26>(152|154) (153|66|17)
0:   cell homeostasis metabolism variant [WBPhenotype:0000585] <12>(65|61) (65|26|11)
- 1:   cell stress response variant [WBPhenotype:0000142] <12>(28|24) (28|9|3)
- 1:   protein metabolism variant [WBPhenotype:0001644] <10>(28|24) (28|15|8)
- 1:   DNA metabolism variant [WBPhenotype:0000732] <7>(1|0) (1|0|0)
- 1:   RNA metabolism variant [WBPhenotype:0001827] <6>(1|1) (1|1|0)
- 1:   chromosome segregation variant [WBPhenotype:0000773] <6>(11|9) (11|2|0)
- 1:   organelle metabolism variant [WBPhenotype:0001283] <3>(1|2) (1|0|0)
- 1:   autophagy variant [WBPhenotype:0000736] <2>(0|0) (0|0|0)
- 1:   cell acidification variant [WBPhenotype:0001393] <2>(0|0) (0|0|0)
- 1:   chromosome instability [WBPhenotype:0000000] <2>(1|1) (1|0|0)
- 1:   telomere homeostasis variant [WBPhenotype:0001673] <1>(0|0) (0|0|0)
- 1:   endo lysosomal degradation pathway defective [WBPhenotype:0002236](0|0) (0|0|0)
- 1:   integrity of membranous organelles defective early emb [WBPhenotype:0000767](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Restriction endonuclease-like0Direct
RBP11-like subunits of RNA polymerase0Direct
The spindle assembly checkpoint protein mad20Direct
HSP90 C-terminal domain0Direct
Histone-fold0Direct
LEM domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.000005814Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.00001816Direct
Cu,Zn superoxide dismutase-like0.0004241Direct
Integrin domains0.0004241Direct
Cdc48 domain 2-like0.0004241Direct
ADC-like0.0004241Direct
PLC-like phosphodiesterases0.0005161Direct
SET domain0.005521Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.01501Inherited
Smc hinge domain0.01501Inherited
Calpain large subunit, middle domain (domain III)0.01501Inherited
Lipovitellin-phosvitin complex, superhelical domain0.01501Inherited
CCCH zinc finger0.01547Inherited
Protein kinase-like (PK-like)0.01781Inherited
RING/U-box0.02199Inherited
Cyclin-like0.02256Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.0259Inherited
P-loop containing nucleoside triphosphate hydrolases0.03968Inherited
5' to 3' exonuclease, C-terminal subdomain0.06862Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.06862Inherited
F1F0 ATP synthase subunit C0.06862Inherited
Lipocalins0.1073Inherited
PIN domain-like0.1074Inherited
Nucleic acid-binding proteins0.1202Inherited
GroEL equatorial domain-like0.1312Inherited
GroEL-intermediate domain like0.1312Inherited
Transducin (alpha subunit), insertion domain0.1501Inherited
Immunoglobulin0.1587Inherited
Translation proteins0.1673Inherited
Voltage-gated potassium channels0.1791Inherited
cAMP-binding domain-like0.2178Inherited
Clavaminate synthase-like0.2181Inherited
GroEL apical domain-like0.23Inherited
Cysteine-rich domain0.3373Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.345Inherited
Spectrin repeat0.3458Inherited
E set domains0.3548Inherited
Cysteine proteinases0.3673Inherited
EF-hand0.4149Inherited
Saposin0.4213Inherited
PLP-dependent transferases0.4583Inherited
Metallo-dependent phosphatases0.4617Inherited
Quinoprotein alcohol dehydrogenase-like0.4752Inherited
DNA/RNA polymerases0.4752Inherited
FYVE/PHD zinc finger0.4796Inherited
Activating enzymes of the ubiquitin-like proteins0.4933Inherited
"Winged helix" DNA-binding domain0.4979Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.5433Inherited
Nucleotidylyl transferase0.5442Inherited
RNA-binding domain, RBD0.5817Inherited
Sm-like ribonucleoproteins0.5946Inherited
BRCT domain0.6273Inherited
SNARE-like0.7021Inherited
PH domain-like0.8076Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.8623Inherited
Thioredoxin-like0.9086Inherited
Homeodomain-like0.9345Inherited
POZ domain1Inherited
Skp1 dimerisation domain-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
LEM domain0Direct
Nucleosome core histones0Direct
Arginine methyltransferase0Direct
Phoshoinositide 3-kinase (PI3K) helical domain0Direct
Integrin domains0Direct
XPF/Rad1/Mus81 nuclease0Direct
Smc hinge domain0Direct
RNA-polymerase beta0Direct
Heat shock protein 90, HSP90, N-terminal domain0Direct
Mammalian PLC0Direct
Hsp90 middle domain0Direct
HSP90 C-terminal domain0Direct
PLC-like (P variant)0.00000003715Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.00004375Direct
Ubiquitin carboxyl-terminal hydrolase UCH-L0.0006401Direct
Cdc48 N-terminal domain-like0.0006401Direct
Cu,Zn superoxide dismutase-like0.0006401Direct
Cdc48 domain 2-like0.0006401Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0.001183Inherited
Cyclin0.001591Inherited
Fatty acid binding protein-like0.004554Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.01279Inherited
Calpain large subunit, middle domain (domain III)0.01279Inherited
Lipovitellin-phosvitin complex, superhelical domain0.01279Inherited
Calpain large subunit, catalytic domain (domain II)0.01279Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.01279Inherited
PHD domain0.0133Inherited
RING finger domain, C3HC40.02011Inherited
Histone lysine methyltransferases0.02078Inherited
Erythroid transcription factor GATA-10.02792Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.03284Inherited
CCCH zinc finger0.03336Inherited
Elongation factors0.03805Inherited
I set domains0.03805Inherited
Motor proteins0.04727Inherited
Protein kinases, catalytic subunit0.05172Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.06041Inherited
Group II chaperonin (CCT, TRIC), intermediate domain0.06041Inherited
F1F0 ATP synthase subunit C0.06041Inherited
5' to 3' exonuclease, C-terminal subdomain0.06041Inherited
EF-hand modules in multidomain proteins0.06041Inherited
5' to 3' exonuclease catalytic domain0.06041Inherited
Pleckstrin-homology domain (PH domain)0.07823Inherited
FAD/NAD-linked reductases, N-terminal and central domains0.1187Inherited
Tandem AAA-ATPase domain0.1975Inherited
Group II chaperonin (CCT, TRIC), ATPase domain0.2012Inherited
Spectrin repeat0.2012Inherited
Transducin (alpha subunit), insertion domain0.2232Inherited
Glutathione peroxidase-like0.282Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.325Inherited
LIM domain0.325Inherited
Group II chaperonin (CCT, TRIC), apical domain0.3266Inherited
Voltage-gated potassium channels0.3551Inherited
ABC transporter ATPase domain-like0.3635Inherited
Clathrin adaptor core protein0.4726Inherited
Proteasome subunits0.5261Inherited
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.5474Inherited
Glutathione S-transferase (GST), N-terminal domain0.6269Inherited
Canonical RBD0.8399Inherited
BTB/POZ domain1Inherited
Skp1 dimerisation domain-like1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
The spindle assembly checkpoint protein mad20Direct
Histone-fold0Direct
RBP11-like subunits of RNA polymerase0Direct
Restriction endonuclease-like0Direct
HSP90 C-terminal domain0Direct
LEM domain0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0.000004753Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0000149Direct
Cu,Zn superoxide dismutase-like0.0003523Direct
Integrin domains0.0003523Direct
ADC-like0.0003523Direct
Cdc48 domain 2-like0.0003523Direct
PLC-like phosphodiesterases0.0004292Direct
SET domain0.004706Inherited
Lipovitellin-phosvitin complex; beta-sheet shell regions0.01298Inherited
Calpain large subunit, middle domain (domain III)0.01298Inherited
Lipovitellin-phosvitin complex, superhelical domain0.01298Inherited
Smc hinge domain0.01298Inherited
CCCH zinc finger0.01338Inherited
Protein kinase-like (PK-like)0.01546Inherited
RING/U-box0.01918Inherited
Cyclin-like0.01969Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.02266Inherited
P-loop containing nucleoside triphosphate hydrolases0.03506Inherited
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0.06134Inherited
F1F0 ATP synthase subunit C0.06134Inherited
5' to 3' exonuclease, C-terminal subdomain0.06134Inherited
Lipocalins0.09707Inherited
PIN domain-like0.09715Inherited
Nucleic acid-binding proteins0.1091Inherited
GroEL-intermediate domain like0.1194Inherited
GroEL equatorial domain-like0.1194Inherited
Transducin (alpha subunit), insertion domain0.1373Inherited
Immunoglobulin0.1453Inherited
Translation proteins0.1534Inherited
Voltage-gated potassium channels0.1646Inherited
cAMP-binding domain-like0.2013Inherited
Clavaminate synthase-like0.2016Inherited
GroEL apical domain-like0.2129Inherited
Cysteine-rich domain0.3173Inherited
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0.3249Inherited
Spectrin repeat0.3257Inherited
E set domains0.3345Inherited
Cysteine proteinases0.347Inherited
EF-hand0.3936Inherited
Saposin0.3999Inherited
PLP-dependent transferases0.4368Inherited
Metallo-dependent phosphatases0.4401Inherited
DNA/RNA polymerases0.4534Inherited
Quinoprotein alcohol dehydrogenase-like0.4534Inherited
FYVE/PHD zinc finger0.4578Inherited
Activating enzymes of the ubiquitin-like proteins0.4712Inherited
"Winged helix" DNA-binding domain0.4758Inherited
S-adenosyl-L-methionine-dependent methyltransferases0.5213Inherited
Nucleotidylyl transferase0.5223Inherited
RNA-binding domain, RBD0.5592Inherited
Sm-like ribonucleoproteins0.5722Inherited
BRCT domain0.6054Inherited
SNARE-like0.6817Inherited
PH domain-like0.7889Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.8457Inherited
Thioredoxin-like0.8936Inherited
Homeodomain-like0.9207Inherited
Skp1 dimerisation domain-like1Inherited
POZ domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
49562,48371
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 0Direct
    47473,51695
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    50729,47473
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 0Direct
    51695,49562
  • 51695 - PLC-like phosphodiesterases
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    57903,51197
  • 57903 - FYVE/PHD zinc finger
  • 51197 - Clavaminate synthase-like
  • 0Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0000149Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0.0003523Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.0003523Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.00671Inherited
    56968,48431
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 0.01298Inherited
    54001,49758
  • 54001 - Cysteine proteinases
  • 49758 - Calpain large subunit, middle domain (domain III)
  • 0.01298Inherited
    48431,56968
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.01298Inherited
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0.01442Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.01442Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.03814Inherited
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0.06134Inherited
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.1194Inherited
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.1194Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.1373Inherited
    48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.1433Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.2013Inherited
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.3249Inherited
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0.6681Inherited
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50729,47473,51695
  • 50729 - PH domain-like
  • 47473 - EF-hand
  • 51695 - PLC-like phosphodiesterases
  • 0Direct
    49562,48371,56112
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 48371 - ARM repeat
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0000149Direct
    56968,48431,56968
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 48431 - Lipovitellin-phosvitin complex, superhelical domain
  • 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
  • 0.01298Inherited
    48726,48726,49265
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.02838Inherited
    48726,48726,48726
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 48726 - Immunoglobulin
  • 0.06846Inherited
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.1194Inherited
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.3249Inherited
    57716,57716,57716
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 57716 - Glucocorticoid receptor-like (DNA-binding domain)
  • 0.4712Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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