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Worm Phenotype (WP): drug response variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   Variant [WBPhenotype:0000886] <4>
+ + + + + 5:   physiology variant [WBPhenotype:0000519] <7>(487|558) (487|240|64)
+ + + + 4:   organism physiology variant [WBPhenotype:0000576] <10>(355|415) (355|191|56)
+ + + 3:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(346|406) (348|189|55)
+ + 2:   organism environmental stimulus response variant [WBPhenotype:0000738] <16>(115|103) (118|51|16)
+ 1:   chemical response variant [WBPhenotype:0000523] <11>(65|58) (66|25|6)
0:   drug response variant [WBPhenotype:0000631] <27>(41|37) (42|16|2)
- 1:   drug resistant [WBPhenotype:0000011] <21>(16|17) (18|6|1)
- 1:   drug hypersensitive [WBPhenotype:0000010] <18>(8|11) (9|5|1)
- 1:   egg laying response to drug variant [WBPhenotype:0001101] <6>(2|4) (3|0|0)
- 1:   serotonin response variant [WBPhenotype:0001232] <5>(2|4) (4|0|0)
- 1:   muscimol response variant [WBPhenotype:0002047] <4>(0|0) (0|0|0)
- 1:   acetylcholinesterase inhibitor response variant [WBPhenotype:0001290] <3>(13|14) (14|5|0)
- 1:   abamectin repsonse variant [WBPhenotype:0002049] <2>(0|0) (0|0|0)
- 1:   anesthetic response variant [WBPhenotype:0000627] <2>(2|1) (2|0|0)
- 1:   calcium channel modulator response variant [WBPhenotype:0000558] <2>(0|0) (0|0|0)
- 1:   drug adaptation variant [WBPhenotype:0000555] <2>(1|1) (1|0|0)
- 1:   levamisole response variant [WBPhenotype:0000845] <2>(2|2) (2|1|0)
- 1:   nicotine response variant [WBPhenotype:0001573] <2>(10|9) (10|4|1)
- 1:   pore forming toxin response variant [WBPhenotype:0002058] <2>(1|1) (1|0|0)
- 1:   tunicamycin response variant [WBPhenotype:0000359] <2>(0|0) (0|0|0)
- 1:   DMPP response variant [WBPhenotype:0000681] <1>(2|2) (2|1|0)
- 1:   adrenergic receptor antagonist response variant [WBPhenotype:0001337] <1>(2|1) (2|0|0)
- 1:   anticonvulsant response variant [WBPhenotype:0001614] <1>(0|0) (0|0|0)
- 1:   hydroxyurea response variant [WBPhenotype:0001878] <1>(2|1) (2|0|0)
- 1:   inhibitor of serotonin uptake variant [WBPhenotype:0001598] <1>(2|1) (2|0|0)
- 1:   ivermectin response variant [WBPhenotype:0001856] <1>(1|1) (1|2|0)
- 1:   benomyl response variant [WBPhenotype:0001854](0|0) (0|0|0)
- 1:   drug induced life span variant [WBPhenotype:0001871](0|0) (0|0|0)
- 1:   drug induced locomotion variant [WBPhenotype:0001872](0|0) (0|0|0)
- 1:   drug susceptible [WBPhenotype:0002109](0|0) (0|0|0)
- 1:   drug withdrawal response variant [WBPhenotype:0001842](0|1) (0|0|0)
- 1:   ligand gated channel activity variant [WBPhenotype:0001783](0|0) (0|0|0)
- 1:   xenotoxicity suppressor [WBPhenotype:0002384](0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Nicotinic receptor ligand binding domain-like0.0000005954Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000008636Direct
Spectrin repeat0.0001517Direct
Troponin coil-coiled subunits0.0002822Direct
Quinoprotein alcohol dehydrogenase-like0.0007036Direct
PDZ domain-like0.001417Inherited
DBL homology domain (DH-domain)0.003321Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.00409Inherited
SAM/Pointed domain0.00515Inherited
ENTH/VHS domain0.005794Inherited
Immunoglobulin0.006241Inherited
t-snare proteins0.00647Inherited
PRTase-like0.00647Inherited
TPR-like0.03043Inherited
SNARE-like0.03299Inherited
Leucine zipper domain0.03918Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.04016Inherited
SH3-domain0.05903Inherited
Cystine-knot cytokines0.07309Inherited
SMAD/FHA domain0.07942Inherited
Tubulin C-terminal domain-like0.1601Inherited
Tubulin nucleotide-binding domain-like0.1601Inherited
PH domain-like0.203Inherited
Calcium ATPase, transmembrane domain M0.2438Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.2438Inherited
Calcium ATPase, transduction domain A0.2438Inherited
ABC transporter transmembrane region0.2438Inherited
Myosin rod fragments0.3157Inherited
Bromodomain0.3157Inherited
Protein kinase-like (PK-like)0.3593Inherited
HAD-like0.3661Inherited
Cysteine-rich domain0.3661Inherited
Voltage-gated potassium channels0.5067Inherited
cAMP-binding domain-like0.7279Inherited
P-loop containing nucleoside triphosphate hydrolases0.7792Inherited
beta-beta-alpha zinc fingers0.8582Inherited
Nucleic acid-binding proteins0.8836Inherited
Homeodomain-like0.9886Inherited
"Winged helix" DNA-binding domain1Inherited
Transducin (alpha subunit), insertion domain1Inherited
Family A G protein-coupled receptor-like1Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

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SCOP termFDR (all)Annotation (direct or inherited)
Quinoprotein alcohol dehydrogenase-like0Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000005099Direct
Nicotinic receptor ligand binding domain-like0.0000005099Direct
Calcium ATPase, transmembrane domain M0.0001722Direct
Spectrin repeat0.0001722Direct
Synaptotagmin-like (S variant)0.0005328Direct
Transforming growth factor (TGF)-beta0.000635Direct
PDZ domain0.0006827Direct
Pyridoxal-dependent decarboxylase0.001098Inherited
Clathrin coat assembly domain0.003558Inherited
Phosphoribosyltransferases (PRTases)0.003558Inherited
DBL homology domain (DH-domain)0.006978Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.007536Inherited
t-snare proteins0.01041Inherited
WD40-repeat0.0261Inherited
I set domains0.04547Inherited
SH3-domain0.04773Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.06441Inherited
ABC transporter transmembrane region0.06607Inherited
Leucine zipper domain0.06771Inherited
Meta-cation ATPase, catalytic domain P0.09543Inherited
Tubulin, C-terminal domain0.1381Inherited
Tubulin, GTPase domain0.1381Inherited
Rhodopsin-like0.1635Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.2148Inherited
Calcium ATPase, transduction domain A0.2148Inherited
Pleckstrin-homology domain (PH domain)0.245Inherited
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)0.2816Inherited
DNA replication initiator (cdc21/cdc54) N-terminal domain0.2846Inherited
Bromodomain0.2846Inherited
Protein kinases, catalytic subunit0.3228Inherited
ABC transporter ATPase domain-like0.3312Inherited
Voltage-gated potassium channels0.3647Inherited
PLC-like (P variant)0.5899Inherited
cAMP-binding domain0.6944Inherited
G proteins0.9795Inherited
Transducin (alpha subunit), insertion domain1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Nicotinic receptor ligand binding domain-like0.0000004832Direct
Neurotransmitter-gated ion-channel transmembrane pore0.0000007023Direct
Spectrin repeat0.0001254Direct
Troponin coil-coiled subunits0.0002339Direct
Quinoprotein alcohol dehydrogenase-like0.0005878Direct
PDZ domain-like0.001191Inherited
DBL homology domain (DH-domain)0.002816Inherited
Tryptophan synthase beta subunit-like PLP-dependent enzymes0.003475Inherited
SAM/Pointed domain0.004388Inherited
ENTH/VHS domain0.004943Inherited
Immunoglobulin0.005331Inherited
t-snare proteins0.005529Inherited
PRTase-like0.005529Inherited
TPR-like0.02672Inherited
SNARE-like0.02902Inherited
Leucine zipper domain0.03461Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.0355Inherited
SH3-domain0.05254Inherited
Cystine-knot cytokines0.06545Inherited
SMAD/FHA domain0.07129Inherited
Tubulin C-terminal domain-like0.1466Inherited
Tubulin nucleotide-binding domain-like0.1466Inherited
PH domain-like0.1871Inherited
WW domain0.2089Inherited
Calcium ATPase, transduction domain A0.2262Inherited
Calcium ATPase, transmembrane domain M0.2262Inherited
Metal cation-transporting ATPase, ATP-binding domain N0.2262Inherited
ABC transporter transmembrane region0.2262Inherited
Bromodomain0.2961Inherited
Myosin rod fragments0.2961Inherited
Protein kinase-like (PK-like)0.339Inherited
HAD-like0.3458Inherited
Cysteine-rich domain0.3458Inherited
Voltage-gated potassium channels0.4848Inherited
cAMP-binding domain-like0.7076Inherited
P-loop containing nucleoside triphosphate hydrolases0.7597Inherited
beta-beta-alpha zinc fingers0.8413Inherited
Nucleic acid-binding proteins0.8677Inherited
Homeodomain-like0.9778Inherited
"Winged helix" DNA-binding domain0.9921Inherited
Transducin (alpha subunit), insertion domain1Inherited
Family A G protein-coupled receptor-like1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
63712,90112
  • 63712 - Nicotinic receptor ligand binding domain-like
  • 90112 - Neurotransmitter-gated ion-channel transmembrane pore
  • 0.0000007023Direct
    49265,48726
  • 49265 - Fibronectin type III
  • 48726 - Immunoglobulin
  • 0.00007235Direct
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0.00009636Direct
    46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.00009636Direct
    57889,57889
  • 57889 - Cysteine-rich domain
  • 57889 - Cysteine-rich domain
  • 0.0004809Direct
    47473,47473
  • 47473 - EF-hand
  • 47473 - EF-hand
  • 0.00233Inherited
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0.003475Inherited
    48065,50729
  • 48065 - DBL homology domain (DH-domain)
  • 50729 - PH domain-like
  • 0.003475Inherited
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0.003475Inherited
    56784,81665
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.07129Inherited
    48726,49265
  • 48726 - Immunoglobulin
  • 49265 - Fibronectin type III
  • 0.1022Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.129Inherited
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.1466Inherited
    90123,52540
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2262Inherited
    81660,56784
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 0.2262Inherited
    47895,52540
  • 47895 - Transducin (alpha subunit), insertion domain
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 1Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    46966,46966,46966
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 46966 - Spectrin repeat
  • 0.0008759Direct
    81660,56784,81665
  • 81660 - Metal cation-transporting ATPase, ATP-binding domain N
  • 56784 - HAD-like
  • 81665 - Calcium ATPase, transmembrane domain M
  • 0.07129Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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