Worm Phenotype (WP): locomotion variant

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Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children)	WP term [WP ID] <#Children>	(#SF|#FA)	#Supra-domain (Single|Duplex|Triple)
+ + + 3:	Variant [WBPhenotype:0000886] <4>
+ + 2:	behavior variant [WBPhenotype:0000517] <2>	(133|132)	(135|53|20)
+ 1:	organism behavior variant [WBPhenotype:0000525] <21>	(133|132)	(135|53|20)
0:	locomotion variant [WBPhenotype:0000643] <9>	(74|80)	(74|32|15)
- 1:	locomotor coordination variant [WBPhenotype:0004017] <7>	(19|22)	(19|7|1)
- 1:	activity level variant [WBPhenotype:0000641] <6>	(23|26)	(24|11|5)
- 1:	cell migration variant [WBPhenotype:0000594] <6>	(24|25)	(24|6|1)
- 1:	localized movement variant [WBPhenotype:0001699] <3>	(13|14)	(13|5|1)
- 1:	swimming variant [WBPhenotype:0001700] <3>	(1|1)	(1|0|0)
- 1:	chemotaxis variant [WBPhenotype:0001434] <2>	(20|19)	(20|5|0)
- 1:	forward locomotion variant [WBPhenotype:0002345] <2>	(12|14)	(12|4|0)
- 1:	thermotaxis variant [WBPhenotype:0002513] <1>	(6|6)	(6|1|0)
- 1:	enhanced locomotion defective [WBPhenotype:0001773]	(0|0)	(0|0|0)

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Superfamily

Superfamily domains annotated to this WP term (SDWP level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
WWE domain	0	DIRECT
Clathrin adaptor appendage domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Chaperone J-domain	0	DIRECT
RING/U-box	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Transducin (alpha subunit), insertion domain	0.000000000000001777	DIRECT
Skp1 dimerisation domain-like	0.0000000000008184	DIRECT
Hect, E3 ligase catalytic domain	0.000001917	DIRECT
Tubulin C-terminal domain-like	0.000003253	DIRECT
Tubulin nucleotide-binding domain-like	0.00001207	DIRECT
SNF-like	0.00001207	DIRECT
Nicotinic receptor ligand binding domain-like	0.00004916	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0.00006641	DIRECT
B-box zinc-binding domain	0.00007747	DIRECT
Smc hinge domain	0.0002058	DIRECT
Hedgehog/intein (Hint) domain	0.0002514	DIRECT
Periplasmic binding protein-like I	0.000276	DIRECT
Spectrin repeat	0.00072	DIRECT
Tropomyosin	0.00072	DIRECT
cAMP-binding domain-like	0.001145	INHERITED FROM: path curvature variant || forward point velocity variant || body bend variant || head movement variant || amplitude of sinusoidal movement variant || butanone chemotaxis variant || chemotaxis variant || head bend angle variant || turning frequency variant || frequency of body bend variant || benzaldehyde chemotaxis variant || turning variant || sinusoidal movement variant || positive chemotaxis variant || sodium chloride chemotaxis variant || directionality variant || positive chemotaxis defective || odorant positive chemotaxis defective || roller || benzaldehyde chemotaxis defective || thermotaxis variant || odorant positive chemotaxis variant || backward point velocity variant || odorant negative chemotaxis defective || sodium chloride chemotaxis defective || nose movement variant
Cysteine proteinases	0.001157	INHERITED FROM: neuron migration variant || Q neuroblast lineage migration variant || cell migration variant
UBC-like	0.001339	INHERITED FROM: neuron migration variant || Q neuroblast lineage migration variant || cell migration variant
Insulin-like	0.003427	INHERITED FROM: forward point velocity variant || body bend variant || head movement variant || amplitude of sinusoidal movement variant || tail bend angle variant || pausing variant || tail movement variant || head bend angle variant || localized movement variant || turning frequency variant || locomotor coordination variant || backward locomotion variant || turning variant || sinusoidal movement variant || reversal variant || turning frequency reduced || velocity of movement variant || backward point velocity variant || forward locomotion variant
E2F-DP heterodimerization region	0.004274	INHERITED FROM: locomotor coordination variant || backward locomotion variant || reversal variant || directionality variant
Integrin domains	0.004274	INHERITED FROM: distal tip cell migration variant || cell migration variant
EGF/Laminin	0.007126	INHERITED FROM: octanol chemotaxis defective || negative chemotaxis variant || octanol chemotaxis variant || cell migration variant || odorant negative chemotaxis defective
Cysteine-rich domain	0.008616	INHERITED FROM: positive chemotaxis variant || thermotaxis variant || odorant positive chemotaxis variant
TPR-like	0.01514	INHERITED FROM: positive chemotaxis defective
Immunoglobulin	0.01906	INHERITED FROM: locomotion reduced || cell migration variant || ALM migration variant
Fibronectin type III	0.01957	INHERITED FROM: path curvature increased || forward locomotion decreased || locomotion reduced || reversal variant
Periplasmic binding protein-like II	0.03959	INHERITED FROM: chemotaxis variant || sodium chloride chemotaxis variant || positive chemotaxis defective || aqueous positive chemotaxis variant || thermotaxis variant || aqueous positive chemotaxis defective || sodium chloride chemotaxis defective
Myosin rod fragments	0.04228	INHERITED FROM: sluggish
Glutathione synthetase ATP-binding domain-like	0.04401	INHERITED FROM: chemotaxis variant || osmotic avoidance variant || negative chemotaxis variant
BAR/IMD domain-like	0.06378	INHERITED FROM: anterior neuron migration defective
NAD kinase/diacylglycerol kinase-like	0.06712	INHERITED FROM: thermotaxis variant
UBA-like	0.07112	INHERITED FROM: neuron migration variant || Q neuroblast lineage migration variant
WD40 repeat-like	0.07467	INHERITED FROM: osmotic avoidance variant
PH domain-like	0.1128	INHERITED FROM: body bend variant || forward locomotion decreased || diacetyl chemotaxis variant
NHL repeat	0.1348	INHERITED FROM: Q neuroblast lineage migration variant
Ankyrin repeat	0.2211	INHERITED FROM: body bend variant || head movement variant || tail bend angle variant || chemotaxis variant || tail movement variant || head bend angle variant || localized movement variant || turning frequency variant || octanol chemotaxis defective || backward locomotion variant || turning variant || sinusoidal movement variant || reversal variant || octanol chemotaxis variant || odorant negative chemotaxis defective || nose movement variant || forward locomotion variant
Lamin A/C globular tail domain	0.2266	INHERITED FROM: paralyzed
Intermediate filament protein, coiled coil region	0.2266	INHERITED FROM: paralyzed
Second domain of FERM	0.2266	INHERITED FROM: cell migration variant
Nucleotide cyclase	0.2893	INHERITED FROM: anion positive chemotaxis variant || magnesium chemotaxis defective || bromide chemotaxis defective || chemotaxis variant || AWC odorant chemotaxis defective || cation positive chemotaxis variant || osmotic avoidance variant || positive chemotaxis variant || lithium chemotaxis defective || alkaline pH chemotaxis variant || bromide chemotaxis variant || iodide chemotaxis variant || diacetyl chemotaxis variant || cation positive chemotaxis defective || anion positive chemotaxis defective || iodide chemotaxis defective || AWC odorant chemotaxis variant
HD-domain/PDEase-like	0.2994	INHERITED FROM: thermotaxis variant
PX domain	0.3247	INHERITED FROM: neuron migration variant || anterior neuron migration defective || Q neuroblast lineage migration variant
P-loop containing nucleoside triphosphate hydrolases	0.3419	INHERITED FROM: head movement variant || tail bend angle variant || tail movement variant || head bend angle variant || turning frequency variant || backward locomotion variant || roaming variant
PapD-like	0.358	INHERITED FROM: linker cell migration variant || cell migration variant
Voltage-gated potassium channels	0.3649	INHERITED FROM: forward point velocity variant || body bend variant || head movement variant || tail bend angle variant || head bend angle variant || localized movement variant || turning frequency variant || locomotor coordination variant || backward locomotion variant || positive chemotaxis defective || roller || backward point velocity variant || activity level variant || forward locomotion variant
RCC1/BLIP-II	0.3934	INHERITED FROM: neuron migration variant || Q neuroblast lineage migration variant
Regulator of G-protein signaling, RGS	0.4233	INHERITED FROM: chemotaxis variant || negative chemotaxis variant
Protein kinase-like (PK-like)	0.5214	INHERITED FROM: chemotaxis variant || velocity of movement increased || octanol chemotaxis defective || positive chemotaxis variant || alkaline pH chemotaxis variant
Homeodomain-like	0.5763	INHERITED FROM: forward locomotion decreased || backward locomotion variant || roaming reduced
SMAD MH1 domain	0.6052	INHERITED FROM: body bend variant || head movement variant || amplitude of sinusoidal movement variant || tail bend angle variant || tail movement variant || head bend angle variant || localized movement variant || turning frequency variant || frequency of body bend variant || backward locomotion variant || turning variant || sinusoidal movement variant || reversal variant || directionality variant || velocity of movement variant || backward point velocity variant || nose movement variant || roaming variant
HLH, helix-loop-helix DNA-binding domain	0.6088	INHERITED FROM: aqueous positive chemotaxis defective || lysine chemotaxis defective
PLP-dependent transferases	0.6267	INHERITED FROM: path curvature decreased || forward locomotion increased
LDL receptor-like module	0.6576	INHERITED FROM: paralyzed
Troponin coil-coiled subunits	0.7432	INHERITED FROM: locomotion reduced
SMAD/FHA domain	0.8452	INHERITED FROM: body bend variant || head movement variant || amplitude of sinusoidal movement variant || path curvature increased || tail bend angle variant || forward locomotion decreased || tail movement variant || head bend angle variant || turning frequency variant || frequency of body bend variant || backward locomotion variant || turning variant || sinusoidal movement variant || roaming reduced || reversal variant || directionality variant || velocity of movement variant || backward point velocity variant || nose movement variant || roaming variant
POZ domain	0.9514	INHERITED FROM: neuron migration variant || Q neuroblast lineage migration variant
C2 domain (Calcium/lipid-binding domain, CaLB)	1	INHERITED FROM: nose movement decreased || locomotor coordination variant
Glucocorticoid receptor-like (DNA-binding domain)	1	INHERITED FROM: cell migration failure
alpha/beta-Hydrolases	1	INHERITED FROM: swimming variant

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Family

Family domains annotated to this WP term (SDWP level: Moderately Informative)
Highlighted in gray are those with FDR_all>0.001

SCOP term	FDR (all)	Annotation (direct or inherited)
HSP40/DnaJ peptide-binding domain	0	DIRECT
Myotubularin-like phosphatases	0	DIRECT
Integrin domains	0	DIRECT
Zf-UBP	0	DIRECT
Ubiquitin carboxyl-terminal hydrolase UCH-L	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
Quinoprotein alcohol dehydrogenase-like	0	DIRECT
5' to 3' exonuclease catalytic domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
RhoGDI-like	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
Phoshatidylinositol transfer protein, PITP	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Chaperone J-domain	0	DIRECT
Heat shock protein 90, HSP90, N-terminal domain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
Hsp90 middle domain	0	DIRECT
HSP20	0	DIRECT
WWE domain	0	DIRECT
Laminin-type module	0	DIRECT
Smc hinge domain	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0.00000000000001245	DIRECT
Transducin (alpha subunit), insertion domain	0.00000000000006579	DIRECT
Skp1 dimerisation domain-like	0.000000000001135	DIRECT
Ubiquitin carboxyl-terminal hydrolase, UCH	0.0000000002489	DIRECT
UBC-related	0.00000001634	DIRECT
RING finger domain, C3HC4	0.00000002772	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0.000004785	DIRECT
Hect, E3 ligase catalytic domain	0.000006625	DIRECT
Tubulin, C-terminal domain	0.00001877	DIRECT
SNF-like	0.00001929	DIRECT
Nicotinic receptor ligand binding domain-like	0.00005559	DIRECT
Tubulin, GTPase domain	0.00005863	DIRECT
Rhodopsin-like	0.0001583	DIRECT
B-box zinc-binding domain	0.0003444	DIRECT
Spectrin repeat	0.0006762	DIRECT
Hedgehog C-terminal (Hog) autoprocessing domain	0.0006762	DIRECT
L-arabinose binding protein-like	0.001518	INHERITED FROM: anion positive chemotaxis variant || magnesium chemotaxis defective || bromide chemotaxis defective || chemotaxis variant || cation positive chemotaxis variant || lithium chemotaxis defective || alkaline pH chemotaxis variant || bromide chemotaxis variant || iodide chemotaxis variant || thermotaxis variant || cation positive chemotaxis defective || anion positive chemotaxis defective || iodide chemotaxis defective
cAMP-binding domain	0.001529	INHERITED FROM: path curvature variant || forward point velocity variant || head movement variant || amplitude of sinusoidal movement variant || butanone chemotaxis variant || chemotaxis variant || head bend angle variant || turning frequency variant || frequency of body bend variant || benzaldehyde chemotaxis variant || turning variant || positive chemotaxis variant || sodium chloride chemotaxis variant || directionality variant || positive chemotaxis defective || odorant positive chemotaxis defective || roller || benzaldehyde chemotaxis defective || thermotaxis variant || odorant positive chemotaxis variant || backward point velocity variant || odorant negative chemotaxis defective || sodium chloride chemotaxis defective || nose movement variant
Tropomyosin	0.00187	INHERITED FROM: locomotion reduced || sluggish
Insulin-like	0.002847	INHERITED FROM: forward point velocity variant || body bend variant || head movement variant || amplitude of sinusoidal movement variant || tail bend angle variant || pausing variant || tail movement variant || head bend angle variant || localized movement variant || turning frequency variant || locomotor coordination variant || backward locomotion variant || turning variant || sinusoidal movement variant || reversal variant || turning frequency reduced || velocity of movement variant || backward point velocity variant || forward locomotion variant
Cell cycle transcription factor e2f-dp	0.006572	INHERITED FROM: locomotor coordination variant || backward locomotion variant || reversal variant || directionality variant
Reprolysin-like	0.0067	INHERITED FROM: cell migration variant
Fibronectin type III	0.01702	INHERITED FROM: path curvature increased || forward locomotion decreased || locomotion reduced || cell migration variant
EGF-type module	0.0246	INHERITED FROM: activity level variant
I set domains	0.02513	INHERITED FROM: path curvature increased || forward locomotion decreased || locomotion reduced || posterior cell migration variant || Pausing increased || posterior neuron migration variant || cell migration variant || ALM migration variant
Protein kinase cysteine-rich domain (cys2, phorbol-binding domain)	0.03416	INHERITED FROM: thermotaxis variant || odorant positive chemotaxis variant
Phosphate binding protein-like	0.03466	INHERITED FROM: chemotaxis variant || sodium chloride chemotaxis variant || positive chemotaxis defective || aqueous positive chemotaxis variant || thermotaxis variant || aqueous positive chemotaxis defective || sodium chloride chemotaxis defective
BTB/POZ domain	0.03825	INHERITED FROM: neuron migration variant || Q neuroblast lineage migration variant || cell migration variant
First domain of FERM	0.05574	INHERITED FROM: cell migration variant
G proteins	0.06598	INHERITED FROM: body bend variant || head movement variant || amplitude of sinusoidal movement variant || tail bend angle variant || chemotaxis variant || pausing variant || tail movement variant || head bend angle variant || localized movement variant || turning frequency variant || locomotor coordination variant || backward locomotion variant || roaming increased || velocity of movement variant || activity level variant || nose movement variant || roaming variant || forward locomotion variant
NHL repeat	0.06981	INHERITED FROM: Q neuroblast lineage migration variant || cell migration variant
Myosin rod fragments	0.06981	INHERITED FROM: sluggish
Third domain of FERM	0.1079	INHERITED FROM: cell migration variant
WD40-repeat	0.1284	INHERITED FROM: osmotic avoidance variant
Intermediate filament protein, coiled coil region	0.2082	INHERITED FROM: paralyzed
Second domain of FERM	0.242	INHERITED FROM: cell migration variant
Adenylyl and guanylyl cyclase catalytic domain	0.2732	INHERITED FROM: magnesium chemotaxis defective || bromide chemotaxis defective || chemotaxis variant || AWC odorant chemotaxis defective || cation positive chemotaxis variant || osmotic avoidance variant || positive chemotaxis variant || lithium chemotaxis defective || alkaline pH chemotaxis variant || bromide chemotaxis variant || iodide chemotaxis variant || diacetyl chemotaxis variant || cation positive chemotaxis defective || anion positive chemotaxis defective || iodide chemotaxis defective || AWC odorant chemotaxis variant
PDEase	0.2778	INHERITED FROM: thermotaxis variant
Lamin A/C globular tail domain	0.2778	INHERITED FROM: paralyzed
Pyridoxal-dependent decarboxylase	0.2778	INHERITED FROM: forward point velocity variant || body bend variant || head movement variant || amplitude of sinusoidal movement variant || tail bend angle variant || path curvature decreased || localized movement variant || turning frequency variant || locomotor coordination variant || backward locomotion variant || sinusoidal movement variant || reversal variant || directionality variant || forward point velocity increased || roaming increased || backward point velocity increased || backward point velocity variant || activity level variant || forward locomotion increased || forward locomotion variant
Pleckstrin-homology domain (PH domain)	0.3579	INHERITED FROM: body bend variant || forward locomotion decreased || locomotor coordination variant || AWA odorant chemotaxis variant || diacetyl chemotaxis variant
Protein kinases, catalytic subunit	0.375	INHERITED FROM: chemotaxis variant || velocity of movement increased || octanol chemotaxis defective || positive chemotaxis variant || alkaline pH chemotaxis variant
Voltage-gated potassium channels	0.3925	INHERITED FROM: forward point velocity variant || body bend variant || head movement variant || head bend angle variant || turning frequency variant || locomotor coordination variant || roller || AWA odorant chemotaxis variant || backward point velocity variant || nose movement variant || forward locomotion variant
Regulator of G-protein signaling, RGS	0.4019	INHERITED FROM: chemotaxis variant || negative chemotaxis variant
MSP-like	0.4247	INHERITED FROM: linker cell migration variant || cell migration variant
PX domain	0.4317	INHERITED FROM: neuron migration variant || anterior neuron migration defective || Q neuroblast lineage migration variant
Ankyrin repeat	0.5001	INHERITED FROM: body bend variant || head movement variant || tail bend angle variant || tail movement variant || head bend angle variant || turning frequency variant || octanol chemotaxis defective || backward locomotion variant || turning variant || sinusoidal movement variant || reversal variant || octanol chemotaxis variant || odorant negative chemotaxis defective || nose movement variant || forward locomotion variant
Homeodomain	0.5493	INHERITED FROM: forward locomotion decreased || backward locomotion variant || roaming reduced
SMAD MH1 domain	0.583	INHERITED FROM: body bend variant || head movement variant || amplitude of sinusoidal movement variant || tail bend angle variant || tail movement variant || head bend angle variant || localized movement variant || turning frequency variant || frequency of body bend variant || backward locomotion variant || turning variant || sinusoidal movement variant || reversal variant || directionality variant || velocity of movement variant || backward point velocity variant || nose movement variant || roaming variant
HLH, helix-loop-helix DNA-binding domain	0.5921	INHERITED FROM: aqueous positive chemotaxis defective || lysine chemotaxis defective
Integrin A (or I) domain	0.6087	INHERITED FROM: paralyzed
LDL receptor-like module	0.6372	INHERITED FROM: paralyzed
SMAD domain	0.8087	INHERITED FROM: body bend variant || head movement variant || amplitude of sinusoidal movement variant || tail bend angle variant || tail movement variant || head bend angle variant || localized movement variant || turning frequency variant || frequency of body bend variant || backward locomotion variant || turning variant || sinusoidal movement variant || reversal variant || directionality variant || velocity of movement variant || backward point velocity variant || nose movement variant || roaming variant
PLC-like (P variant)	0.8837	INHERITED FROM: body bend variant || frequency of body bend variant || locomotor coordination variant || positive chemotaxis variant || thermotaxis variant
Acetylcholinesterase-like	0.9753	INHERITED FROM: swimming variant
Synaptotagmin-like (S variant)	1	INHERITED FROM: roller

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Supra-domain (including individual superfamily)

Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001

Supra-domain (Single)	FDR (all)	Annotation (direct or inherited)
Clathrin adaptor appendage domain	0	DIRECT
DnaJ/Hsp40 cysteine-rich domain	0	DIRECT
Subdomain of clathrin and coatomer appendage domain	0	DIRECT
Integrin alpha N-terminal domain	0	DIRECT
Chaperone J-domain	0	DIRECT
5' to 3' exonuclease, C-terminal subdomain	0	DIRECT
HSP40/DnaJ peptide-binding domain	0	DIRECT
Frizzled cysteine-rich domain	0	DIRECT
RING/U-box	0	DIRECT
WWE domain	0	DIRECT
Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
HSP90 C-terminal domain	0	DIRECT
Multidrug efflux transporter AcrB transmembrane domain	0	DIRECT
Transducin (heterotrimeric G protein), gamma chain	0	DIRECT
Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
S-adenosylmethionine synthetase	0	DIRECT
Transducin (alpha subunit), insertion domain	0.000000000000001402	DIRECT
Skp1 dimerisation domain-like	0.0000000000006485	DIRECT
Hect, E3 ligase catalytic domain	0.000001564	DIRECT
Tubulin C-terminal domain-like	0.000002659	DIRECT
SNF-like	0.000009876	DIRECT
Tubulin nucleotide-binding domain-like	0.000009876	DIRECT
Nicotinic receptor ligand binding domain-like	0.00004049	DIRECT
Neurotransmitter-gated ion-channel transmembrane pore	0.00005472	DIRECT
B-box zinc-binding domain	0.00006386	DIRECT
Smc hinge domain	0.0001702	DIRECT
Hedgehog/intein (Hint) domain	0.0002081	DIRECT
Periplasmic binding protein-like I	0.0002286	DIRECT
Spectrin repeat	0.0006016	DIRECT
Tropomyosin	0.0006016	DIRECT
cAMP-binding domain-like	0.0009592	DIRECT
Cysteine proteinases	0.00097	DIRECT
UBC-like	0.001124	INHERITED FROM: neuron migration variant || Q neuroblast lineage migration variant || cell migration variant
Insulin-like	0.002907	INHERITED FROM: backward point velocity variant || sinusoidal movement variant || pausing variant || turning frequency variant || turning frequency reduced || head movement variant || tail movement variant || body bend variant || forward point velocity variant || head bend angle variant || localized movement variant || forward locomotion variant || turning variant || amplitude of sinusoidal movement variant || locomotor coordination variant || backward locomotion variant || velocity of movement variant || tail bend angle variant || reversal variant
E2F-DP heterodimerization region	0.003634	INHERITED FROM: directionality variant || locomotor coordination variant || backward locomotion variant || reversal variant
Integrin domains	0.003634	INHERITED FROM: distal tip cell migration variant || cell migration variant
EGF/Laminin	0.0061	INHERITED FROM: negative chemotaxis variant || odorant negative chemotaxis defective || octanol chemotaxis defective || octanol chemotaxis variant || cell migration variant
Cysteine-rich domain	0.007399	INHERITED FROM: thermotaxis variant || positive chemotaxis variant || odorant positive chemotaxis variant
TPR-like	0.01309	INHERITED FROM: positive chemotaxis defective
Immunoglobulin	0.01656	INHERITED FROM: ALM migration variant || locomotion reduced || cell migration variant || posterior neuron migration variant
Fibronectin type III	0.01702	INHERITED FROM: locomotion reduced || forward locomotion decreased || path curvature increased || reversal variant
Periplasmic binding protein-like II	0.03497	INHERITED FROM: sodium chloride chemotaxis defective || chemotaxis variant || thermotaxis variant || aqueous positive chemotaxis variant || sodium chloride chemotaxis variant || aqueous positive chemotaxis defective || positive chemotaxis defective
Myosin rod fragments	0.03738	INHERITED FROM: sluggish || locomotion reduced
Glutathione synthetase ATP-binding domain-like	0.03894	INHERITED FROM: negative chemotaxis variant || chemotaxis variant || osmotic avoidance variant
BAR/IMD domain-like	0.0569	INHERITED FROM: anterior neuron migration defective
NAD kinase/diacylglycerol kinase-like	0.05997	INHERITED FROM: thermotaxis variant
UBA-like	0.06359	INHERITED FROM: neuron migration variant || Q neuroblast lineage migration variant
WD40 repeat-like	0.06689	INHERITED FROM: osmotic avoidance variant
PH domain-like	0.1021	INHERITED FROM: forward locomotion decreased || body bend variant || diacetyl chemotaxis variant
NHL repeat	0.1229	INHERITED FROM: Q neuroblast lineage migration variant
Ankyrin repeat	0.2045	INHERITED FROM: odorant negative chemotaxis defective || sinusoidal movement variant || octanol chemotaxis defective || turning frequency variant || head movement variant || tail movement variant || octanol chemotaxis variant || body bend variant || head bend angle variant || localized movement variant || forward locomotion variant || turning variant || chemotaxis variant || backward locomotion variant || nose movement variant || tail bend angle variant || reversal variant
Intermediate filament protein, coiled coil region	0.2097	INHERITED FROM: paralyzed
Second domain of FERM	0.2097	INHERITED FROM: cell migration variant
Lamin A/C globular tail domain	0.2097	INHERITED FROM: paralyzed
Nucleotide cyclase	0.2704	INHERITED FROM: cation positive chemotaxis variant || AWC odorant chemotaxis defective || iodide chemotaxis variant || anion positive chemotaxis variant || bromide chemotaxis variant || iodide chemotaxis defective || magnesium chemotaxis defective || AWC odorant chemotaxis variant || cation positive chemotaxis defective || anion positive chemotaxis defective || bromide chemotaxis defective || chemotaxis variant || alkaline pH chemotaxis variant || osmotic avoidance variant || lithium chemotaxis defective || positive chemotaxis variant || diacetyl chemotaxis variant
HD-domain/PDEase-like	0.2801	INHERITED FROM: thermotaxis variant
PX domain	0.305	INHERITED FROM: neuron migration variant || anterior neuron migration defective || Q neuroblast lineage migration variant
P-loop containing nucleoside triphosphate hydrolases	0.3218	INHERITED FROM: roaming variant || turning frequency variant || head movement variant || tail movement variant || head bend angle variant || backward locomotion variant || tail bend angle variant
PapD-like	0.3377	INHERITED FROM: cell migration variant || linker cell migration variant
Voltage-gated potassium channels	0.3444	INHERITED FROM: backward point velocity variant || turning frequency variant || head movement variant || body bend variant || forward point velocity variant || head bend angle variant || localized movement variant || forward locomotion variant || locomotor coordination variant || activity level variant || backward locomotion variant || roller || tail bend angle variant || positive chemotaxis defective
RCC1/BLIP-II	0.3727	INHERITED FROM: neuron migration variant || Q neuroblast lineage migration variant
Regulator of G-protein signaling, RGS	0.4019	INHERITED FROM: negative chemotaxis variant || chemotaxis variant
Protein kinase-like (PK-like)	0.4992	INHERITED FROM: velocity of movement increased || octanol chemotaxis defective || chemotaxis variant || alkaline pH chemotaxis variant || positive chemotaxis variant
Homeodomain-like	0.5539	INHERITED FROM: roaming reduced || forward locomotion decreased || backward locomotion variant
SMAD MH1 domain	0.5829	INHERITED FROM: backward point velocity variant || roaming variant || sinusoidal movement variant || frequency of body bend variant || turning frequency variant || head movement variant || tail movement variant || directionality variant || body bend variant || head bend angle variant || localized movement variant || turning variant || amplitude of sinusoidal movement variant || backward locomotion variant || velocity of movement variant || nose movement variant || tail bend angle variant || reversal variant
HLH, helix-loop-helix DNA-binding domain	0.5867	INHERITED FROM: lysine chemotaxis defective || aqueous positive chemotaxis defective
PLP-dependent transferases	0.6046	INHERITED FROM: forward locomotion increased || forward point velocity increased || roaming increased || backward point velocity increased || path curvature decreased
LDL receptor-like module	0.6362	INHERITED FROM: paralyzed
Troponin coil-coiled subunits	0.7231	INHERITED FROM: locomotion reduced
SMAD/FHA domain	0.8278	INHERITED FROM: backward point velocity variant || roaming reduced || roaming variant || sinusoidal movement variant || forward locomotion decreased || frequency of body bend variant || pausing variant || turning frequency variant || head movement variant || tail movement variant || directionality variant || body bend variant || head bend angle variant || turning variant || path curvature increased || amplitude of sinusoidal movement variant || backward locomotion variant || velocity of movement variant || nose movement variant || tail bend angle variant || reversal variant
POZ domain	0.9381	INHERITED FROM: neuron migration variant || Q neuroblast lineage migration variant
alpha/beta-Hydrolases	1	INHERITED FROM: swimming variant
Glucocorticoid receptor-like (DNA-binding domain)	1	INHERITED FROM: cell migration failure
C2 domain (Calcium/lipid-binding domain, CaLB)	1	INHERITED FROM: nose movement decreased || locomotor coordination variant

Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001

Supra-domain (Duplex) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
81383,50978 81383 - F-box domain 50978 - WD40 repeat-like	0	DIRECT
46785,144074 46785 - "Winged helix" DNA-binding domain 144074 - E2F-DP heterodimerization region	0	DIRECT
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like	0	DIRECT
57850,117839 57850 - RING/U-box 117839 - WWE domain	0	DIRECT
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like)	0	DIRECT
100920,100934 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
49348,55711 49348 - Clathrin adaptor appendage domain 55711 - Subdomain of clathrin and coatomer appendage domain	0	DIRECT
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase	0	DIRECT
49493,49493 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
57938,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
49265,48726 49265 - Fibronectin type III 48726 - Immunoglobulin	0	DIRECT
47895,52540 47895 - Transducin (alpha subunit), insertion domain 52540 - P-loop containing nucleoside triphosphate hydrolases	0.000000000000001402	DIRECT
54695,81382 54695 - POZ domain 81382 - Skp1 dimerisation domain-like	0.0000000000001901	DIRECT
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like	0.000009876	DIRECT
46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat	0.00003596	DIRECT
63712,90112 63712 - Nicotinic receptor ligand binding domain-like 90112 - Neurotransmitter-gated ion-channel transmembrane pore	0.00005472	DIRECT
56112,55073 56112 - Protein kinase-like (PK-like) 55073 - Nucleotide cyclase	0.00009183	DIRECT
57850,57845 57850 - RING/U-box 57845 - B-box zinc-binding domain	0.0001268	DIRECT
57889,57889 57889 - Cysteine-rich domain 57889 - Cysteine-rich domain	0.0007882	DIRECT
47473,47473 47473 - EF-hand 47473 - EF-hand	0.001422	INHERITED FROM: sinusoidal movement variant || body bend variant
48403,48403 48403 - Ankyrin repeat 48403 - Ankyrin repeat	0.006754	INHERITED FROM: backward point velocity variant || path curvature variant || sinusoidal movement variant || locomotion reduced || frequency of body bend variant || pausing variant || turning frequency variant || head movement variant || tail movement variant || directionality variant || body bend variant || forward point velocity variant || head bend angle variant || backing decreased || forward locomotion variant || turning variant || amplitude of sinusoidal movement variant || backward locomotion variant || velocity of movement variant || nose movement variant || tail bend angle variant || reversal variant
50044,55550 50044 - SH3-domain 55550 - SH2 domain	0.009947	INHERITED FROM: cell migration variant
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin	0.04901	INHERITED FROM: backward point velocity variant || locomotion reduced || turning frequency variant || head movement variant || tail movement variant || body bend variant || forward point velocity variant || head bend angle variant || turning variant || path curvature increased || amplitude of sinusoidal movement variant || backward locomotion variant || nose movement variant || tail bend angle variant || reversal variant
47031,50729 47031 - Second domain of FERM 50729 - PH domain-like	0.05554	INHERITED FROM: cell migration variant
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III	0.06359	INHERITED FROM: backward point velocity variant || locomotion reduced || forward locomotion decreased || turning frequency variant || head movement variant || tail movement variant || forward point velocity variant || head bend angle variant || turning variant || amplitude of sinusoidal movement variant || backward locomotion variant || nose movement variant || tail bend angle variant || reversal variant
48452,48452 48452 - TPR-like 48452 - TPR-like	0.1042	INHERITED FROM: positive chemotaxis defective
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.1329	INHERITED FROM: locomotion reduced
50978,50978 50978 - WD40 repeat-like 50978 - WD40 repeat-like	0.2801	INHERITED FROM: negative chemotaxis variant || chemotaxis variant || aqueous positive chemotaxis variant || osmotic avoidance variant || aqueous positive chemotaxis defective || positive chemotaxis variant || positive chemotaxis defective
64593,74853 64593 - Intermediate filament protein, coiled coil region 74853 - Lamin A/C globular tail domain	0.2801	INHERITED FROM: locomotion reduced || paralyzed
57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module	0.5829	INHERITED FROM: paralyzed

Supra-domains annotated to this WP term (Not in SPWP)
Highlighted in gray are those with FDR>0.001

Supra-domain (Triple) in N- to C-terminal order	FDR (all)	Annotation (direct or inherited)
46966,46966,46966 46966 - Spectrin repeat 46966 - Spectrin repeat 46966 - Spectrin repeat	0	DIRECT
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
53067,100920,100934 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain	0	DIRECT
55973,55973,55973 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase 55973 - S-adenosylmethionine synthetase	0	DIRECT
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain	0	DIRECT
48726,49265,48726 48726 - Immunoglobulin 49265 - Fibronectin type III 48726 - Immunoglobulin	0	DIRECT
57938,49493,49493 57938 - DnaJ/Hsp40 cysteine-rich domain 49493 - HSP40/DnaJ peptide-binding domain 49493 - HSP40/DnaJ peptide-binding domain	0	DIRECT
57362,57362,57362 57362 - BPTI-like 57362 - BPTI-like 57362 - BPTI-like	0	DIRECT
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases	0	DIRECT
57196,57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin 57196 - EGF/Laminin	0.000003104	DIRECT
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain)	0.000053	DIRECT
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin	0.01865	INHERITED FROM: backward point velocity variant || locomotion reduced || turning frequency variant || head movement variant || tail movement variant || body bend variant || forward point velocity variant || head bend angle variant || turning variant || amplitude of sinusoidal movement variant || backward locomotion variant || nose movement variant || tail bend angle variant || reversal variant
54236,47031,50729 54236 - Ubiquitin-like 47031 - Second domain of FERM 50729 - PH domain-like	0.1229	INHERITED FROM: cell migration variant
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III	0.1563	INHERITED FROM: locomotion reduced
57424,57424,57424 57424 - LDL receptor-like module 57424 - LDL receptor-like module 57424 - LDL receptor-like module	0.5829	INHERITED FROM: paralyzed