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Worm Phenotype (WP): early embryonic lethal

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Variant [WBPhenotype:0000886] <4>
+ + + + 4:   development variant [WBPhenotype:0000518] <7>(506|577) (506|246|68)
+ + + 3:   organism development variant [WBPhenotype:0000531] <10>(504|576) (504|246|68)
+ + 2:   lethal [WBPhenotype:0000062] <5>(498|574) (498|245|68)
+ + 2:   embryonic development variant [WBPhenotype:0000749] <21>(445|531) (445|231|63)
+ 1:   embryonic lethal [WBPhenotype:0000050] <7>(443|531) (443|230|63)
0:   early embryonic lethal [WBPhenotype:0001100] <30>(61|63) (61|26|4)
- 1:   meiosis defective early emb [WBPhenotype:0001041] <11>(38|34) (38|16|4)
- 1:   meiosis variant [WBPhenotype:0000775] <11>(38|34) (38|16|4)
- 1:   nuclear appearance number defective early emb [WBPhenotype:0001035] <9>(5|7) (5|3|0)
- 1:   nuclear morphology variation early emb [WBPhenotype:0001026] <9>(6|8) (6|4|0)
- 1:   nucleus defective early emb [WBPhenotype:0001138] <9>(5|7) (5|3|0)
- 1:   pronuclear morphology defective early emb [WBPhenotype:0001159] <9>(5|7) (5|3|0)
- 1:   pronuclear nuclear appearance defective early emb [WBPhenotype:0001034] <9>(5|7) (5|3|0)
- 1:   pronucleus centrosomes defective early emb [WBPhenotype:0001151] <9>(5|7) (5|3|0)
- 1:   cytoplasmic appearance defective early emb [WBPhenotype:0000769] <4>(4|5) (4|2|0)
- 1:   cytoplasmic morphology defective early emb [WBPhenotype:0001081] <4>(4|5) (4|2|0)
- 1:   aster defective early emb [WBPhenotype:0001110] <3>(0|0) (0|0|0)
- 1:   cytokinesis defective early emb [WBPhenotype:0001078] <3>(6|8) (6|0|0)
- 1:   cell position defective early emb [WBPhenotype:0001118] <2>(1|0) (1|0|0)
- 1:   egg integrity defective early emb [WBPhenotype:0001178] <2>(2|1) (2|0|0)
- 1:   embryonic morphology defective early emb [WBPhenotype:0001135] <2>(0|0) (0|0|0)
- 1:   other abnormality early emb [WBPhenotype:0001007] <2>(11|6) (11|2|1)
- 1:   polar body defective early emb [WBPhenotype:0001147] <2>(2|2) (2|2|0)
- 1:   pseudocleavage defective early emb [WBPhenotype:0001167] <2>(0|0) (0|0|0)
- 1:   spindle defective early emb [WBPhenotype:0000759] <2>(7|11) (7|5|0)
- 1:   cell cell contacts defective early emb [WBPhenotype:0001117] <1>(2|1) (2|0|0)
- 1:   cell cycle defective early emb [WBPhenotype:0001114] <1>(2|2) (2|0|0)
- 1:   Aba ABp division axis defective early emb [WBPhenotype:0001134](2|1) (2|1|0)
- 1:   asymmetric cell division defective early emb [WBPhenotype:0000748](0|0) (0|0|0)
- 1:   centrosome attachment defective early emb [WBPhenotype:0000771](0|0) (0|0|0)
- 1:   chromosome segregation variant karyomeres early emb [WBPhenotype:0001077](1|1) (1|1|0)
- 1:   cortical dynamics defective early emb [WBPhenotype:0001044](0|0) (0|0|0)
- 1:   egg size defective early emb [WBPhenotype:0000044](0|0) (1|0|0)
- 1:   integrity of membranous organelles defective early emb [WBPhenotype:0000767](0|0) (0|0|0)
- 1:   interphase entry defective early emb [WBPhenotype:0001043](0|0) (0|0|0)
- 1:   one cell arrest early emb [WBPhenotype:0000040](2|4) (2|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
Smc hinge domain0Direct
The spindle assembly checkpoint protein mad20Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Helical domain of Sec23/240Direct
Ribosomal protein L10Direct
Histone-fold0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Zn-finger domain of Sec23/240Direct
LEM domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
Skp1 dimerisation domain-like0.000000000000353Direct
ARM repeat0.000000000000466Direct
Nucleic acid-binding proteins0.000000000003411Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0000000005929Direct
"Winged helix" DNA-binding domain0.000000001512Direct
Class II aaRS and biotin synthetases0.000000001562Direct
GroEL equatorial domain-like0.000000005832Direct
GroEL-intermediate domain like0.000000005832Direct
GroEL apical domain-like0.00000005171Direct
Zn-binding ribosomal proteins0.000000503Direct
WD40 repeat-like0.000001249Direct
Activating enzymes of the ubiquitin-like proteins0.000003514Direct
Translation proteins SH3-like domain0.00001638Direct
S15/NS1 RNA-binding domain0.00004129Direct
Tubulin C-terminal domain-like0.00005467Direct
Sm-like ribonucleoproteins0.00009737Direct
Prefoldin0.00009781Direct
Class II aaRS ABD-related0.00009781Direct
Cyclin-like0.000203Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.0002574Direct
L30e-like0.0002574Direct
TPR-like0.0002622Direct
Tubulin nucleotide-binding domain-like0.0002637Direct
DNA ligase/mRNA capping enzyme, catalytic domain0.0003637Direct
beta-sandwich domain of Sec23/240.0003637Direct
DNA repair protein MutS, domain III0.0003637Direct
Cdc48 domain 2-like0.0003637Direct
ADC-like0.0003637Direct
Nucleotidylyl transferase0.0005157Direct
Cullin homology domain0.0006484Direct
Actin-like ATPase domain0.0007629Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.001092Inherited
Ribosomal proteins S24e, L23 and L15e0.00154Inherited
F1F0 ATP synthase subunit C0.00154Inherited
Translation proteins0.001794Inherited
Ribosomal protein S5 domain 2-like0.002876Inherited
Translational machinery components0.003983Inherited
FKBP-like0.004829Inherited
Calponin-homology domain, CH-domain0.0055Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.02213Inherited
Quinoprotein alcohol dehydrogenase-like0.02403Inherited
SNARE-like0.02499Inherited
POZ domain0.02718Inherited
GTPase activation domain, GAP0.06054Inherited
Invertebrate chitin-binding proteins0.06056Inherited
DNA/RNA polymerases0.0973Inherited
BAR/IMD domain-like0.107Inherited
UBC-like0.1247Inherited
Protein kinase-like (PK-like)0.3318Inherited
Multidrug efflux transporter AcrB transmembrane domain0.5835Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Ribosomal protein L10Direct
LEM domain0Direct
DNA replication initiator (cdc21/cdc54) N-terminal domain0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Nucleosome core histones0Direct
Zn-finger domain of Sec23/240Direct
Helical domain of Sec23/240Direct
a tRNA synthase domain0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Ubiquitin activating enzymes (UBA)0Direct
DNA gyrase/MutL, second domain0Direct
beta-sandwich domain of Sec23/240Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Smc hinge domain0Direct
Anticodon-binding domain of Class II aaRS0Direct
Proteasome subunits0Direct
Trunk domain of Sec23/240Direct
Skp1 dimerisation domain-like0.000000000001136Direct
Extended AAA-ATPase domain0.0000000001636Direct
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain0.000000001314Direct
Group II chaperonin (CCT, TRIC), apical domain0.00000002181Direct
Armadillo repeat0.0000001403Direct
BTB/POZ domain0.00000101Direct
Cyclin0.000004391Direct
RecA protein-like (ATPase-domain)0.00001002Direct
WD40-repeat0.00001255Direct
Actin/HSP700.00002448Direct
Prefoldin0.00006009Direct
Motor proteins0.00006777Direct
L30e/L7ae ribosomal proteins0.0000757Direct
Pumilio repeat0.0001012Direct
Tubulin, C-terminal domain0.0001744Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0.0003044Direct
G proteins0.0004232Direct
DNA gyrase/MutL, N-terminal domain0.0005624Direct
Cdc48 N-terminal domain-like0.0005624Direct
DNA repair protein MutS, domain III0.0005624Direct
RNA editing terminal uridyl transferase 2, RET2, domain 20.0005624Direct
Anticodon-binding domain0.0005624Direct
Cdc48 domain 2-like0.0005624Direct
Tubulin, GTPase domain0.0007057Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0.0009438Direct
Nitrogenase iron protein-like0.002208Inherited
F1F0 ATP synthase subunit C0.002378Inherited
DEP domain0.002378Inherited
Translational machinery components0.002666Inherited
FKBP immunophilin/proline isomerase0.008439Inherited
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.009011Inherited
Cold shock DNA-binding domain-like0.009507Inherited
Clathrin adaptor core protein0.01233Inherited
DNA polymerase I0.01233Inherited
Calponin-homology domain, CH-domain0.01428Inherited
Tetratricopeptide repeat (TPR)0.01502Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.03364Inherited
Elongation factors0.03448Inherited
Tandem AAA-ATPase domain0.04508Inherited
BCR-homology GTPase activation domain (BH-domain)0.07806Inherited
PDZ domain0.1556Inherited
Protein kinases, catalytic subunit0.5029Inherited
UBC-related0.5687Inherited
Multidrug efflux transporter AcrB transmembrane domain0.6286Inherited


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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
The spindle assembly checkpoint protein mad20Direct
Ribosomal protein L10Direct
Histone-fold0Direct
Helical domain of Sec23/240Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Zn-finger domain of Sec23/240Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
P-loop containing nucleoside triphosphate hydrolases0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
LEM domain0Direct
Smc hinge domain0Direct
Skp1 dimerisation domain-like0.0000000000002796Direct
ARM repeat0.0000000000003691Direct
Nucleic acid-binding proteins0.00000000000271Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.0000000004737Direct
"Winged helix" DNA-binding domain0.00000000121Direct
Class II aaRS and biotin synthetases0.000000001251Direct
GroEL-intermediate domain like0.000000004678Direct
GroEL equatorial domain-like0.000000004678Direct
GroEL apical domain-like0.00000004169Direct
Zn-binding ribosomal proteins0.0000004079Direct
WD40 repeat-like0.000001018Direct
Activating enzymes of the ubiquitin-like proteins0.000002872Direct
Translation proteins SH3-like domain0.00001343Direct
S15/NS1 RNA-binding domain0.00003398Direct
Tubulin C-terminal domain-like0.00004505Direct
Sm-like ribonucleoproteins0.00008034Direct
Class II aaRS ABD-related0.00008072Direct
Prefoldin0.00008072Direct
Cyclin-like0.0001679Direct
L30e-like0.0002132Direct
ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase0.0002132Direct
TPR-like0.0002171Direct
Tubulin nucleotide-binding domain-like0.0002184Direct
DNA ligase/mRNA capping enzyme, catalytic domain0.0003017Direct
beta-sandwich domain of Sec23/240.0003017Direct
DNA repair protein MutS, domain III0.0003017Direct
ADC-like0.0003017Direct
Cdc48 domain 2-like0.0003017Direct
Nucleotidylyl transferase0.0004288Direct
Cullin homology domain0.0005408Direct
Actin-like ATPase domain0.000638Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0.000915Direct
F1F0 ATP synthase subunit C0.001294Inherited
Ribosomal proteins S24e, L23 and L15e0.001294Inherited
Translation proteins0.00151Inherited
Ribosomal protein S5 domain 2-like0.002435Inherited
Translational machinery components0.003383Inherited
FKBP-like0.004112Inherited
Calponin-homology domain, CH-domain0.004688Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.01931Inherited
Quinoprotein alcohol dehydrogenase-like0.021Inherited
SNARE-like0.02186Inherited
POZ domain0.0238Inherited
GTPase activation domain, GAP0.05392Inherited
Invertebrate chitin-binding proteins0.05394Inherited
DNA/RNA polymerases0.08777Inherited
BAR/IMD domain-like0.0968Inherited
UBC-like0.1133Inherited
Protein kinase-like (PK-like)0.3119Inherited
Multidrug efflux transporter AcrB transmembrane domain0.561Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.000000000000479Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.000000004678Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.000000004678Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0.00002379Direct
    47954,47954
  • 47954 - Cyclin-like
  • 47954 - Cyclin-like
  • 0.00006447Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.0001362Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.0002184Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0.0003017Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.0003017Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0.0005408Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0.001294Inherited
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0.001294Inherited
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0.003383Inherited
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0.003707Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.01201Inherited
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.01931Inherited
    57196,57196
  • 57196 - EGF/Laminin
  • 57196 - EGF/Laminin
  • 0.04585Inherited
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.05969Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.000000004678Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.01931Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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