SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Worm Phenotype (WP): protein interaction variant

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + 5:   Variant [WBPhenotype:0000886] <4>
+ + + + 4:   physiology variant [WBPhenotype:0000519] <7>(489|563) (489|241|65)
+ + + 3:   organism physiology variant [WBPhenotype:0000576] <10>(357|420) (358|193|57)
+ + 2:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(347|410) (350|191|56)
+ 1:   organism metabolism processing variant [WBPhenotype:0000027] <25>(171|182) (176|81|24)
0:   protein interaction variant [WBPhenotype:0001369] <3>(48|48) (48|21|9)
- 1:   protein RNA interaction variant [WBPhenotype:0001371] <2>(0|0) (0|0|0)
- 1:   protein protein interaction variant [WBPhenotype:0001370] <2>(48|48) (48|21|9)
- 1:   protein DNA interaction variant [WBPhenotype:0001372](0|0) (0|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
JAB1/MPN domain0Direct
14-3-3 protein0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
RING/U-box0Direct
Cu,Zn superoxide dismutase-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cysteine proteinases0.00000000000003446Direct
UBC-like0.00000000004533Direct
Chaperone J-domain0.0000000004752Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000002374Direct
Hect, E3 ligase catalytic domain0.000000002374Direct
Acid proteases0.00000000386Direct
B-box zinc-binding domain0.0000001801Direct
Cyclophilin-like0.0000006429Direct
FKBP-like0.0000008811Direct
Activating enzymes of the ubiquitin-like proteins0.000001779Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.000008131Direct
HSP20-like chaperones0.00001561Direct
GroEL equatorial domain-like0.00002868Direct
GroEL-intermediate domain like0.00002868Direct
Tubulin nucleotide-binding domain-like0.00003737Direct
Ubiquitin-like0.00007248Direct
Tubulin C-terminal domain-like0.0001145Direct
Actin-like ATPase domain0.0001842Direct
GroEL apical domain-like0.0002025Direct
Galactose-binding domain-like0.000244Direct
ADC-like0.0002471Direct
WWE domain0.0002471Direct
Cdc48 domain 2-like0.0002471Direct
MIT domain0.0002471Direct
EF-hand0.0003809Direct
HSP40/DnaJ peptide-binding domain0.001063Inherited
Sec1/munc18-like (SM) proteins0.004034Inherited
Seven-hairpin glycosidases0.004034Inherited
UBA-like0.005168Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.005734Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.006987Inherited
Skp1 dimerisation domain-like0.02504Inherited
Cullin homology domain0.04072Inherited
PYP-like sensor domain (PAS domain)0.04072Inherited
WD40 repeat-like0.06105Inherited
Translation proteins SH3-like domain0.062Inherited
Translation proteins0.06867Inherited
Cullin repeat-like0.07818Inherited
"Winged helix" DNA-binding domain0.1141Inherited
RNI-like0.6681Inherited
POZ domain0.983Inherited
F-box domain0.9928Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
PDI-like0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
14-3-3 protein0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cu,Zn superoxide dismutase-like0Direct
RING finger domain, C3HC40Direct
Pepsin-like0.00000000000002859Direct
UBC-related0.0000000000003522Direct
Papain-like0.0000000002581Direct
Chaperone J-domain0.0000000003592Direct
Hect, E3 ligase catalytic domain0.000000007873Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.00000001047Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.00000006885Direct
Extended PAW domain0.00000008678Direct
B-box zinc-binding domain0.000000135Direct
Cyclophilin (peptidylprolyl isomerase)0.0000004849Direct
Ubiquitin-related0.00000135Direct
FKBP immunophilin/proline isomerase0.000002402Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.00000615Direct
Tubulin, GTPase domain0.00002867Direct
Actin/HSP700.00003198Direct
Ubiquitin activating enzymes (UBA)0.00004346Direct
Calmodulin-like0.00005643Direct
HSP200.00007679Direct
Group II chaperonin (CCT, TRIC), ATPase domain0.00007679Direct
Tubulin, C-terminal domain0.00008836Direct
Cdc48 N-terminal domain-like0.0003612Direct
MIT domain0.0003612Direct
Cdc48 domain 2-like0.0003612Direct
WWE domain0.0003612Direct
Group II chaperonin (CCT, TRIC), apical domain0.0004928Direct
Sec1/munc18-like (SM) proteins0.003219Inherited
Class I alpha-1;2-mannosidase, catalytic domain0.003219Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.004656Inherited
Elongation factors0.004697Inherited
Sm motif of small nuclear ribonucleoproteins, SNRNP0.00496Inherited
Proteasome subunits0.008514Inherited
SCF ubiquitin ligase complex WHB domain0.01372Inherited
Cullin repeat0.01372Inherited
RecA protein-like (ATPase-domain)0.01372Inherited
Skp1 dimerisation domain-like0.03472Inherited
Cullin homology domain0.0348Inherited
Clathrin adaptor core protein0.0348Inherited
BTB/POZ domain0.2613Inherited
WD40-repeat0.3671Inherited
F-box domain0.6223Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
Cu,Zn superoxide dismutase-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
14-3-3 protein0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
RING/U-box0Direct
JAB1/MPN domain0Direct
Cysteine proteinases0.00000000000002723Direct
UBC-like0.00000000003609Direct
Chaperone J-domain0.0000000003793Direct
Hect, E3 ligase catalytic domain0.000000001901Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000001901Direct
Acid proteases0.000000003094Direct
B-box zinc-binding domain0.0000001456Direct
Cyclophilin-like0.0000005222Direct
FKBP-like0.0000007165Direct
Activating enzymes of the ubiquitin-like proteins0.000001452Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.000006648Direct
HSP20-like chaperones0.00001279Direct
GroEL equatorial domain-like0.00002356Direct
GroEL-intermediate domain like0.00002356Direct
Tubulin nucleotide-binding domain-like0.00003072Direct
Ubiquitin-like0.00005971Direct
Tubulin C-terminal domain-like0.00009454Direct
Actin-like ATPase domain0.0001522Direct
GroEL apical domain-like0.0001674Direct
Galactose-binding domain-like0.0002019Direct
Cdc48 domain 2-like0.0002045Direct
ADC-like0.0002045Direct
MIT domain0.0002045Direct
WWE domain0.0002045Direct
EF-hand0.000316Direct
HSP40/DnaJ peptide-binding domain0.0008909Direct
Sec1/munc18-like (SM) proteins0.003427Inherited
Seven-hairpin glycosidases0.003427Inherited
UBA-like0.004404Inherited
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.00489Inherited
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.005977Inherited
Skp1 dimerisation domain-like0.02189Inherited
Cullin homology domain0.03598Inherited
PYP-like sensor domain (PAS domain)0.03598Inherited
WD40 repeat-like0.05436Inherited
Translation proteins SH3-like domain0.05524Inherited
Translation proteins0.06136Inherited
Cullin repeat-like0.07018Inherited
"Winged helix" DNA-binding domain0.1034Inherited
RNI-like0.6469Inherited
POZ domain0.9718Inherited
F-box domain0.9822Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001901Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000003861Direct
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.00001485Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.00002356Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.00002356Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.00002356Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.00003072Direct
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.00009253Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.0001522Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.0008909Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.00489Inherited
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.004917Inherited
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.01338Inherited
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.01431Inherited
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.01431Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001901Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000008513Direct
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.000005837Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.00002356Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.00489Inherited
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.01431Inherited


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)