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Worm Phenotype (WP): protein protein interaction variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + 6:   Variant [WBPhenotype:0000886] <4>
+ + + + + 5:   physiology variant [WBPhenotype:0000519] <7>(489|563) (489|241|65)
+ + + + 4:   organism physiology variant [WBPhenotype:0000576] <10>(357|420) (358|193|57)
+ + + 3:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(347|410) (350|191|56)
+ + 2:   organism metabolism processing variant [WBPhenotype:0000027] <25>(171|182) (176|81|24)
+ 1:   protein interaction variant [WBPhenotype:0001369] <3>(48|48) (48|21|9)
0:   protein protein interaction variant [WBPhenotype:0001370] <2>(48|48) (48|21|9)
- 1:   protein aggregation variant [WBPhenotype:0001405] <1>(43|47) (43|19|8)
- 1:   protein complex organization variant [WBPhenotype:0002132] <1>(0|0) (0|0|0)


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Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
UBC-like0Direct
Cysteine proteinases0Direct
JAB1/MPN domain0Direct
14-3-3 protein0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
RING/U-box0Direct
Cu,Zn superoxide dismutase-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Chaperone J-domain4.451e-16Direct
Acid proteases0.0000000000004829Direct
HSP20-like chaperones0.00000000001827Direct
Tubulin nucleotide-binding domain-like0.00000000007281Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000002055Direct
Tubulin C-terminal domain-like0.0000000002805Direct
B-box zinc-binding domain0.0000000009172Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000002159Direct
Hect, E3 ligase catalytic domain0.000000002159Direct
GroEL equatorial domain-like0.000000002159Direct
GroEL-intermediate domain like0.000000002159Direct
Cyclophilin-like0.000000006971Direct
GroEL apical domain-like0.0000000194Direct
Actin-like ATPase domain0.00000003183Direct
Ubiquitin-like0.0000001546Direct
FKBP-like0.0000008117Direct
Activating enzymes of the ubiquitin-like proteins0.000001655Direct
Galactose-binding domain-like0.000001694Direct
WD40 repeat-like0.00002445Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00007475Direct
"Winged helix" DNA-binding domain0.00009793Direct
Sec1/munc18-like (SM) proteins0.0001262Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001396Direct
ADC-like0.0002372Direct
WWE domain0.0002372Direct
Cdc48 domain 2-like0.0002372Direct
MIT domain0.0002372Direct
Seven-hairpin glycosidases0.0003891Direct
Cullin homology domain0.0003891Direct
UBA-like0.0005834Direct
Translation proteins0.0008188Direct
PYP-like sensor domain (PAS domain)0.0009139Direct
HSP40/DnaJ peptide-binding domain0.001021Inherited
Translation proteins SH3-like domain0.001085Inherited
Cullin repeat-like0.001822Inherited
Skp1 dimerisation domain-like0.0239Inherited
RNI-like0.6583Inherited
EF-hand0.9251Inherited
F-box domain0.9879Inherited
POZ domain1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
PDI-like0Direct
UBC-related0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
14-3-3 protein0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cu,Zn superoxide dismutase-like0Direct
RING finger domain, C3HC40Direct
Chaperone J-domain0.00000000000001027Direct
Pepsin-like0.00000000000002425Direct
Papain-like0.0000000000008982Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.00000000002798Direct
Tubulin, GTPase domain0.0000000004544Direct
Actin/HSP700.0000000004736Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000008102Direct
Tubulin, C-terminal domain0.00000000172Direct
Ubiquitin-related0.000000004867Direct
B-box zinc-binding domain0.000000005519Direct
Hect, E3 ligase catalytic domain0.000000007175Direct
Cyclophilin (peptidylprolyl isomerase)0.00000003545Direct
HSP200.00000006341Direct
Group II chaperonin (CCT, TRIC), ATPase domain0.00000006341Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.00000006341Direct
Extended PAW domain0.00000007786Direct
Group II chaperonin (CCT, TRIC), apical domain0.0000005041Direct
FKBP immunophilin/proline isomerase0.000002219Direct
Proteasome subunits0.000007821Direct
Ubiquitin activating enzymes (UBA)0.00004131Direct
Calmodulin-like0.0000497Direct
SCF ubiquitin ligase complex WHB domain0.0002144Direct
Cullin repeat0.0002144Direct
Sec1/munc18-like (SM) proteins0.0002144Direct
RecA protein-like (ATPase-domain)0.0002144Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0002712Direct
Cdc48 N-terminal domain-like0.0003473Direct
MIT domain0.0003473Direct
Cdc48 domain 2-like0.0003473Direct
WWE domain0.0003473Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0.0004439Direct
Cullin homology domain0.0006541Direct
Class I alpha-1;2-mannosidase, catalytic domain0.0006541Direct
Clathrin adaptor core protein0.0006541Direct
Elongation factors0.0008079Direct
WD40-repeat0.02832Inherited
Skp1 dimerisation domain-like0.03326Inherited
F-box domain0.6115Inherited
BTB/POZ domain1Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
UBC-like0Direct
Cu,Zn superoxide dismutase-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cysteine proteinases0Direct
14-3-3 protein0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
RING/U-box0Direct
JAB1/MPN domain0Direct
Chaperone J-domain3.509e-16Direct
Acid proteases0.0000000000003824Direct
HSP20-like chaperones0.00000000001453Direct
Tubulin nucleotide-binding domain-like0.00000000005801Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001639Direct
Tubulin C-terminal domain-like0.0000000002239Direct
B-box zinc-binding domain0.0000000007331Direct
GroEL equatorial domain-like0.000000001727Direct
Hect, E3 ligase catalytic domain0.000000001727Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000001727Direct
GroEL-intermediate domain like0.000000001727Direct
Cyclophilin-like0.000000005592Direct
GroEL apical domain-like0.0000000156Direct
Actin-like ATPase domain0.00000002563Direct
Ubiquitin-like0.0000001249Direct
FKBP-like0.0000006599Direct
Activating enzymes of the ubiquitin-like proteins0.00000135Direct
Galactose-binding domain-like0.000001382Direct
WD40 repeat-like0.00002006Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00006158Direct
"Winged helix" DNA-binding domain0.0000808Direct
Sec1/munc18-like (SM) proteins0.0001043Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001153Direct
Cdc48 domain 2-like0.0001963Direct
ADC-like0.0001963Direct
MIT domain0.0001963Direct
WWE domain0.0001963Direct
Cullin homology domain0.000323Direct
Seven-hairpin glycosidases0.000323Direct
UBA-like0.0004858Direct
Translation proteins0.0006851Direct
PYP-like sensor domain (PAS domain)0.0007654Direct
HSP40/DnaJ peptide-binding domain0.0008556Direct
Translation proteins SH3-like domain0.0009095Direct
Cullin repeat-like0.001534Inherited
Skp1 dimerisation domain-like0.02088Inherited
RNI-like0.637Inherited
EF-hand0.9108Inherited
F-box domain0.977Inherited
POZ domain1Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.00000000005801Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.000000001472Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001727Direct
    54849,52029
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.000000001727Direct
    48592,54849
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 0.000000001727Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000003481Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.000002074Direct
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.00001372Direct
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.00008638Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.0001043Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.0001043Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001153Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.0001708Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.0008556Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.01275Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    48592,54849,52029
  • 48592 - GroEL equatorial domain-like
  • 54849 - GroEL-intermediate domain like
  • 52029 - GroEL apical domain-like
  • 0.000000001727Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001727Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000007754Direct
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.000005434Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.0001043Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001153Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
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