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Worm Phenotype (WP): protein aggregation variant

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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: WP Hierarchy (worm phenotype from Wormbase Release WS226)

Shortest distance to current term (+ for parents, - for children) WP term [WP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ + + + + + + 7:   Variant [WBPhenotype:0000886] <4>
+ + + + + + 6:   physiology variant [WBPhenotype:0000519] <7>(489|563) (489|241|65)
+ + + + + 5:   organism physiology variant [WBPhenotype:0000576] <10>(357|420) (358|193|57)
+ + + + 4:   organism homeostasis metabolism variant [WBPhenotype:0000577] <17>(347|410) (350|191|56)
+ + + 3:   organism metabolism processing variant [WBPhenotype:0000027] <25>(171|182) (176|81|24)
+ + 2:   protein interaction variant [WBPhenotype:0001369] <3>(48|48) (48|21|9)
+ 1:   protein protein interaction variant [WBPhenotype:0001370] <2>(48|48) (48|21|9)
0:   protein aggregation variant [WBPhenotype:0001405] <1>(43|47) (43|19|8)
- 1:   protein aggregation induced behavior variant [WBPhenotype:0002425] <3>(9|9) (9|3|1)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

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SCOP termFDR (all)Annotation (direct or inherited)
UBC-like0Direct
JAB1/MPN domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Chaperone J-domain0Direct
RING/U-box0Direct
Cu,Zn superoxide dismutase-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Acid proteases0.0000000000003384Direct
HSP20-like chaperones0.00000000001289Direct
Tubulin nucleotide-binding domain-like0.0000000000545Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001636Direct
Tubulin C-terminal domain-like0.0000000002106Direct
B-box zinc-binding domain0.0000000006897Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000001759Direct
Hect, E3 ligase catalytic domain0.000000001759Direct
Cyclophilin-like0.000000005369Direct
Actin-like ATPase domain0.00000002261Direct
Ubiquitin-like0.00000009928Direct
FKBP-like0.0000006804Direct
Galactose-binding domain-like0.000001268Direct
Activating enzymes of the ubiquitin-like proteins0.000001417Direct
WD40 repeat-like0.00001543Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00006058Direct
"Winged helix" DNA-binding domain0.00006901Direct
Sec1/munc18-like (SM) proteins0.0001133Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001229Direct
ADC-like0.0002174Direct
WWE domain0.0002174Direct
Cdc48 domain 2-like0.0002174Direct
MIT domain0.0002174Direct
Seven-hairpin glycosidases0.0003502Direct
Cullin homology domain0.0003502Direct
UBA-like0.0004939Direct
EF-hand0.0006513Direct
Translation proteins0.0006956Direct
PYP-like sensor domain (PAS domain)0.0008244Direct
HSP40/DnaJ peptide-binding domain0.0009371Direct
Translation proteins SH3-like domain0.0009635Direct
Cullin repeat-like0.001648Inherited
Skp1 dimerisation domain-like0.02162Inherited
RNI-like0.638Inherited
F-box domain0.9779Inherited
POZ domain1Inherited


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Family

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SCOP termFDR (all)Annotation (direct or inherited)
Ubiquitin carboxyl-terminal hydrolase UCH-L0Direct
PDI-like0Direct
UBC-related0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Cu,Zn superoxide dismutase-like0Direct
RING finger domain, C3HC40Direct
Chaperone J-domain0.000000000000005918Direct
Pepsin-like0.00000000000001618Direct
Papain-like0.0000000000005592Direct
Ubiquitin carboxyl-terminal hydrolase, UCH0.00000000001866Direct
Actin/HSP700.0000000003251Direct
Tubulin, GTPase domain0.0000000003313Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000006312Direct
Tubulin, C-terminal domain0.000000001257Direct
Ubiquitin-related0.000000003306Direct
B-box zinc-binding domain0.000000004048Direct
Hect, E3 ligase catalytic domain0.000000005735Direct
Cyclophilin (peptidylprolyl isomerase)0.00000002666Direct
HSP200.00000005197Direct
Group II chaperonin (CCT, TRIC), ATPase domain0.00000005197Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.00000005197Direct
Extended PAW domain0.00000005992Direct
Group II chaperonin (CCT, TRIC), apical domain0.0000004148Direct
FKBP immunophilin/proline isomerase0.000001831Direct
Proteasome subunits0.000006351Direct
Calmodulin-like0.00003654Direct
Ubiquitin activating enzymes (UBA)0.00003655Direct
SCF ubiquitin ligase complex WHB domain0.0001903Direct
Cullin repeat0.0001903Direct
Sec1/munc18-like (SM) proteins0.0001903Direct
RecA protein-like (ATPase-domain)0.0001903Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0002362Direct
Cdc48 N-terminal domain-like0.0003157Direct
MIT domain0.0003157Direct
Cdc48 domain 2-like0.0003157Direct
WWE domain0.0003157Direct
Sm motif of small nuclear ribonucleoproteins, SNRNP0.00038Direct
Cullin homology domain0.0005827Direct
Class I alpha-1;2-mannosidase, catalytic domain0.0005827Direct
Clathrin adaptor core protein0.0005827Direct
Elongation factors0.000683Direct
WD40-repeat0.02233Inherited
Skp1 dimerisation domain-like0.02987Inherited
BTB/POZ domain0.3588Inherited
F-box domain0.5844Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

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Supra-domain (Single) FDR (all) Annotation (direct or inherited)
UBC-like0Direct
Cu,Zn superoxide dismutase-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Chaperone J-domain0Direct
RING/U-box0Direct
JAB1/MPN domain0Direct
Acid proteases0.0000000000002679Direct
HSP20-like chaperones0.00000000001025Direct
Tubulin nucleotide-binding domain-like0.0000000000434Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0.0000000001305Direct
Tubulin C-terminal domain-like0.000000000168Direct
B-box zinc-binding domain0.000000000551Direct
Hect, E3 ligase catalytic domain0.000000001408Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0.000000001408Direct
Cyclophilin-like0.000000004305Direct
Actin-like ATPase domain0.00000001819Direct
Ubiquitin-like0.00000008008Direct
FKBP-like0.0000005529Direct
Galactose-binding domain-like0.000001033Direct
Activating enzymes of the ubiquitin-like proteins0.000001155Direct
WD40 repeat-like0.00001265Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0.00004991Direct
"Winged helix" DNA-binding domain0.00005685Direct
Sec1/munc18-like (SM) proteins0.00009356Direct
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain0.0001015Direct
Cdc48 domain 2-like0.0001797Direct
ADC-like0.0001797Direct
MIT domain0.0001797Direct
WWE domain0.0001797Direct
Cullin homology domain0.0002904Direct
Seven-hairpin glycosidases0.0002904Direct
UBA-like0.0004105Direct
EF-hand0.0005431Direct
Translation proteins0.0005808Direct
PYP-like sensor domain (PAS domain)0.0006897Direct
HSP40/DnaJ peptide-binding domain0.0007849Direct
Translation proteins SH3-like domain0.0008073Direct
Cullin repeat-like0.001386Inherited
Skp1 dimerisation domain-like0.01885Inherited
RNI-like0.6163Inherited
F-box domain0.9663Inherited
POZ domain0.9955Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    50692,54585
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 0Direct
    54585,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54495,46934
  • 54495 - UBC-like
  • 46934 - UBA-like
  • 0Direct
    54534,54534
  • 54534 - FKBP-like
  • 54534 - FKBP-like
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0.0000000000434Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0.000000001034Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001408Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000002793Direct
    57850,57845
  • 57850 - RING/U-box
  • 57845 - B-box zinc-binding domain
  • 0.000001711Direct
    57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.00001159Direct
    49785,49785
  • 49785 - Galactose-binding domain-like
  • 49785 - Galactose-binding domain-like
  • 0.00007477Direct
    75632,46785
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.00009356Direct
    74788,75632
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 0.00009356Direct
    50447,50465
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001015Direct
    52540,50447
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 0.0001457Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0.0007849Direct
    54695,81382
  • 54695 - POZ domain
  • 81382 - Skp1 dimerisation domain-like
  • 0.01149Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    54585,52540,52540
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50692,54585,52540
  • 50692 - ADC-like
  • 54585 - Cdc48 domain 2-like
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0.000000001408Direct
    52833,52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0.00000006356Direct
    57850,57850,57850
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 57850 - RING/U-box
  • 0.000004662Direct
    74788,75632,46785
  • 74788 - Cullin repeat-like
  • 75632 - Cullin homology domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0.00009356Direct
    52540,50447,50465
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain
  • 0.0001015Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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