SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.

Yeast Phenotype (YP): cellular processes

(show info)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Root: YP Hierarchy (yeast phenotype from Ascomycete phenotype ontology)

Shortest distance to current term (+ for parents, - for children) YP term [YP ID] <#Children> (#SF|#FA) #Supra-domain
(Single|Duplex|Triple)
+ 1:   observable [APO:0000017] <7>
0:   cellular processes [APO:0000066] <6>(218|225) (221|88|20)
- 1:   stress resistance [APO:0000080] <10>(186|199) (188|78|18)
- 1:   chromosome/plasmid maintenance [APO:0000143] <8>(12|10) (12|3|0)
- 1:   intracellular transport [APO:0000073] <6>(6|6) (7|1|1)
- 1:   mitotic cell cycle [APO:0000072] <5>(10|10) (10|2|0)
- 1:   cell death [APO:0000312] <4>(1|2) (1|0|0)
- 1:   prion state [APO:0000274] <3>(2|1) (2|0|0)


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Superfamily

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
Aconitase iron-sulfur domain0Direct
BRCT domain0Direct
post-AAA+ oligomerization domain-like0Direct
Ribonuclease H-like0Direct
Zinc domain conserved in yeast copper-regulated transcription factors0Direct
Zn-binding ribosomal proteins0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
PYP-like sensor domain (PAS domain)0Direct
The spindle assembly checkpoint protein mad20Direct
Cupredoxins0Direct
L30e-like0Direct
Methylglyoxal synthase-like0Direct
PAP/OAS1 substrate-binding domain0Direct
Acid proteases0Direct
GYF domain0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
Phospholipase D/nuclease0Direct
RBP11-like subunits of RNA polymerase0Direct
Tubulin nucleotide-binding domain-like0Direct
F1F0 ATP synthase subunit C0Direct
CCCH zinc finger0Direct
Metallo-dependent hydrolases0Direct
Ribosomal protein L30p/L7e0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
Sec7 domain0Direct
Class II aaRS ABD-related0Direct
PriA/YqbF domain0Direct
LexA/Signal peptidase0Direct
Bromodomain0Direct
LuxS/MPP-like metallohydrolase0Direct
Cytochrome P4500Direct
Thiolase-like0Direct
vWA-like0Direct
KA1-like0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
PreATP-grasp domain0Direct
Sec63 N-terminal domain-like0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Inosine monophosphate dehydrogenase (IMPDH)0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Zn-dependent exopeptidases0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
Alkaline phosphatase-like0Direct
Arginase/deacetylase0Direct
Aldolase0Direct
Clathrin adaptor appendage domain0Direct
Undecaprenyl diphosphate synthase0Direct
DNA-glycosylase0Direct
Chromo domain-like0Direct
Cdc48 domain 2-like0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
SAP domain0Direct
GAT-like domain0Direct
Adenine nucleotide alpha hydrolases-like0Direct
SAICAR synthase-like0Direct
DNA repair protein MutS, domain II0Direct
HIT/MYND zinc finger-like0Direct
Restriction endonuclease-like0Direct
FabD/lysophospholipase-like0Direct
Kelch motif0Direct
DNA/RNA polymerases0Direct
CoA-dependent acyltransferases0Direct
Cytochrome c0Direct
Glutamine synthetase/guanido kinase0Direct
beta-sandwich domain of Sec23/240Direct
Protein prenylyltransferase0Direct
Ribonuclease PH domain 2-like0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Prefoldin0Direct
Radical SAM enzymes0Direct
Alpha-L RNA-binding motif0Direct
Transferrin receptor-like dimerisation domain0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
NTF2-like0Direct
MurD-like peptide ligases, peptide-binding domain0Direct
SNARE-like0Direct
Ribosomal protein L10-like0Direct
Ribosomal protein L140Direct
Aquaporin-like0Direct
Actin depolymerizing proteins0Direct
Single hybrid motif0Direct
C-terminal autoproteolytic domain of nucleoporin nup980Direct
eIF1-like0Direct
Glucocorticoid receptor-like (DNA-binding domain)0Direct
Tubulin C-terminal domain-like0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Chaperone J-domain0Direct
PA domain0Direct
Nucleoporin domain0Direct
Family A G protein-coupled receptor-like0Direct
Ribosomal protein S20Direct
Ras GEF0Direct
Mitochondrial cytochrome c oxidase subunit IV0Direct
GINS helical bundle-like0Direct
PUA domain-like0Direct
DNA repair protein MutS, domain III0Direct
CRAL/TRIO N-terminal domain0Direct
Mss4-like0Direct
DNA-binding domain of Mlu1-box binding protein MBP10Direct
Clavaminate synthase-like0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0Direct
Endosomal sorting complex assembly domain0Direct
Regulator of G-protein signaling, RGS0Direct
POZ domain0Direct
Glycoside hydrolase/deacetylase0Direct
Translational machinery components0Direct
Tricorn protease domain 20Direct
Retrovirus zinc finger-like domains0Direct
Ribosomal protein L220Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Acetyl-CoA synthetase-like0Direct
Metallo-hydrolase/oxidoreductase0Direct
Magnesium transport protein CorA, transmembrane region0Direct
Ligand-binding domain in the NO signalling and Golgi transport0Direct
RmlC-like cupins0Direct
Cap-Gly domain0Direct
Calponin-homology domain, CH-domain0Direct
JAB1/MPN domain0Direct
Supernatant protein factor (SPF), C-terminal domain0Direct
Nucleotide-binding domain0Direct
HSP40/DnaJ peptide-binding domain0Direct
YjgF-like0Direct
Ribosomal protein S80Direct
RNase III domain-like0Direct
Nucleotidylyl transferase0Direct
Glutathione synthetase ATP-binding domain-like0Direct
WW domain0Direct
Fe,Mn superoxide dismutase (SOD), C-terminal domain0Direct
cAMP-binding domain-like0Direct
GST C-terminal domain-like0Direct
VPS9 domain0Direct
GHMP Kinase, C-terminal domain0Direct
Smc hinge domain0Direct
Ribulose-phoshate binding barrel0Direct
CBS-domain pair0Direct
Carbamate kinase-like0Direct
HMG-box0Direct
Ribosomal protein L60Direct
HMA, heavy metal-associated domain0Direct
PP2C-like0Direct
MurD-like peptide ligases, catalytic domain0Direct
Ribosomal protein L11, C-terminal domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
HSP20-like chaperones0Direct
dsRNA-binding domain-like0Direct
DBL homology domain (DH-domain)0Direct
4'-phosphopantetheinyl transferase0Direct
HLH, helix-loop-helix DNA-binding domain0Direct
DNA repair protein MutS, domain I0Direct
HIT-like0Direct
EPT/RTPC-like0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
Trimeric LpxA-like enzymes0Direct
Helical domain of Sec23/240Direct
LeuD/IlvD-like0Direct
R3H domain0Direct
Zn-finger domain of Sec23/240Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
Nop domain0Direct
YVTN repeat-like/Quinoprotein amine dehydrogenase0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
FtsH protease domain-like0Direct
ArfGap/RecO-like zinc finger0Direct
Ferritin-like0Direct
Six-hairpin glycosidases0Direct
alpha/beta knot0Direct
Amidase signature (AS) enzymes0Direct
SET domain0Direct
FAD-linked oxidoreductase0Direct
Cysteine alpha-hairpin motif0Direct
CheY-like0Direct
TK C-terminal domain-like0Direct
L-aspartase-like0Direct
Carbon-nitrogen hydrolase0Direct
PR-1-like0Direct
Fumarate reductase respiratory complex transmembrane subunits0Direct
RNI-like0Direct
HD-domain/PDEase-like0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Ribosomal protein L130Direct
S13-like H2TH domain0Direct
CorA soluble domain-like0Direct
Subtilisin-like0Direct
Seven-hairpin glycosidases0Direct
Rudiment single hybrid motif0Direct
EF-G C-terminal domain-like0Direct
HRDC-like0Direct
post-HMGL domain-like0Direct
Terpenoid synthases0Direct
Activating enzymes of the ubiquitin-like proteins0Direct
Carbohydrate phosphatase0Direct
FMN-binding split barrel0Direct
Eukaryotic type KH-domain (KH-domain type I)0Direct
YAP1 redox domain0Direct
CRAL/TRIO domain0Direct
Ribokinase-like0Direct
Ribosomal L11/L12e N-terminal domain0Direct
HCP-like0Direct
Cation efflux protein transmembrane domain-like0Direct
ThrRS/AlaRS common domain0Direct
Cytidine deaminase-like0Direct
ALDH-like0Direct
Protein kinase-like (PK-like)0.1415Inherited
ARM repeat0.1885Inherited
Nucleic acid-binding proteins0.2362Inherited
"Winged helix" DNA-binding domain0.2955Inherited
Class II aaRS and biotin synthetases0.3265Inherited
Ankyrin repeat0.3641Inherited
Translation proteins SH3-like domain0.4095Inherited
P-loop containing nucleoside triphosphate hydrolases0.5556Inherited
GroEL apical domain-like0.5945Inherited
Histone-fold0.6407Inherited
SH3-domain0.6407Inherited
5' to 3' exonuclease, C-terminal subdomain0.7955Inherited
Cyclophilin-like0.9067Inherited


Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Family

(show details)
SCOP termFDR (all)Annotation (direct or inherited)
PUA domain0Direct
FtsH protease domain-like0Direct
Protein serine/threonine phosphatase0Direct
VPS9 domain0Direct
Aconitase iron-sulfur domain0Direct
La domain0Direct
Class II glutamine amidotransferases0Direct
Anticodon-binding domain0Direct
NagB-like0Direct
FAD/NAD-linked reductases, N-terminal and central domains0Direct
Eps15 homology domain (EH domain)0Direct
Ribosomal protein L130Direct
Cation efflux protein transmembrane domain-like0Direct
eIF1-like0Direct
FAD-linked oxidases, N-terminal domain0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
L-aspartase/fumarase0Direct
CCCH zinc finger0Direct
Trunk domain of Sec23/240Direct
Cap-Gly domain0Direct
Single strand DNA-binding domain, SSB0Direct
Group II chaperonin (CCT, TRIC), intermediate domain0Direct
Histone deacetylase, HDAC0Direct
RNB domain-like0Direct
WW domain0Direct
N-type ATP pyrophosphatases0Direct
NTF2-like0Direct
Glutathione S-transferase (GST), N-terminal domain0Direct
Ribosomal protein L14e0Direct
HSP40/DnaJ peptide-binding domain0Direct
Multidomain cupredoxins0Direct
TRAPP components0Direct
Glucose 6-phosphate dehydrogenase-like0Direct
Ribosomal protein S40Direct
Phoshoinositide 3-kinase (PI3K), catalytic domain0Direct
Class I aldolase0Direct
Isoprenyl diphosphate synthases0Direct
Subtilases0Direct
HLH, helix-loop-helix DNA-binding domain0Direct
FabD-like0Direct
GABA-aminotransferase-like0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Sec7 domain0Direct
Zinc domain conserved in yeast copper-regulated transcription factors0Direct
HMGL-like0Direct
CheY-related0Direct
Ubiquitin-related0Direct
Glutathione S-transferase (GST), C-terminal domain0Direct
Regulator of G-protein signaling, RGS0Direct
DNA repair protein MutS, domain III0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Pumilio repeat0Direct
Pepsin-like0Direct
Tryptophan biosynthesis enzymes0Direct
BC N-terminal domain-like0Direct
YjgF/L-PSP0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
RNA-polymerase beta-prime0Direct
Actin/HSP700Direct
Deoxycytidylate deaminase-like0Direct
Group II chaperonin (CCT, TRIC), apical domain0Direct
Phosphate binding protein-like0Direct
Ribosomal protein L60Direct
Nucleotide and nucleoside kinases0Direct
Cdc48 domain 2-like0Direct
MPP-like0Direct
Clathrin coat assembly domain0Direct
BC C-terminal domain-like0Direct
HMA, heavy metal-associated domain0Direct
ABC transporter transmembrane region0Direct
CorA soluble domain-like0Direct
Glycosyl hydrolases family 160Direct
SWIRM domain0Direct
Acetyl-CoA synthetase-like0Direct
Hexokinase0Direct
PA domain0Direct
Ubiquitin activating enzymes (UBA)0Direct
Ribosomal protein S80Direct
Higher-molecular-weight phosphotyrosine protein phosphatases0Direct
ALDH-like0Direct
Bromodomain0Direct
Ribosomal protein L140Direct
RNA-polymerase beta0Direct
Thiolase-related0Direct
Ribosomal protein S20Direct
Choline/Carnitine O-acyltransferase0Direct
Thiamin biosynthesis kinases0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0Direct
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain0Direct
Folylpolyglutamate synthetase0Direct
C-terminal domain of ribosomal protein L20Direct
Eukaryotic type KH-domain (KH-domain type I)0Direct
Ran-binding domain0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
DBL homology domain (DH-domain)0Direct
SAM (sterile alpha motif) domain0Direct
PHD domain0Direct
Transferrin receptor-like dimerisation domain0Direct
beta-sandwich domain of Sec23/240Direct
PyrH-like0Direct
L30e/L7ae ribosomal proteins0Direct
p120GAP domain-like0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Aquaporin-like0Direct
Retrovirus zinc finger-like domains0Direct
DNA polymerase I0Direct
Class I alpha-1;2-mannosidase, catalytic domain0Direct
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain0Direct
FAD-linked reductases, N-terminal domain0Direct
UBA domain0Direct
Cofilin-like0Direct
XPF/Rad1/Mus81 nuclease0Direct
Helical domain of Sec23/240Direct
C-terminal autoproteolytic domain of nucleoporin nup980Direct
Clathrin adaptor core protein0Direct
Biotinyl/lipoyl-carrier proteins and domains0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
UBC-related0Direct
Myb/SANT domain0Direct
GAPDH-like0Direct
GYF domain0Direct
Ras GEF0Direct
CRAL/TRIO N-terminal domain0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
BCR-homology GTPase activation domain (BH-domain)0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain0Direct
Class I aminoacyl-tRNA synthetases (RS), catalytic domain0Direct
LeuD-like0Direct
BC ATP-binding domain-like0Direct
Ribosomal protein S130Direct
Ribosomal protein L220Direct
Trehalose-6-phosphate synthase, OtsA0Direct
Phosphoribulokinase/pantothenate kinase0Direct
Zn-finger domain of Sec23/240Direct
Inosine monophosphate dehydrogenase (IMPDH)0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
MIF4G domain-like0Direct
HMG-box0Direct
Pyk2-associated protein beta ARF-GAP domain0Direct
Adenosine/AMP deaminase0Direct
Nucleosome core histones0Direct
Ribosomal L11/L12e N-terminal domain0Direct
GHMP Kinase, N-terminal domain0Direct
DNA repair protein MutS, domain I0Direct
Group II chaperonin (CCT, TRIC), ATPase domain0Direct
DNA gyrase/MutL, N-terminal domain0Direct
CBS-domain pair0Direct
Ribokinase-like0Direct
Cyclin0Direct
Gastric lipase0Direct
PR-1-like0Direct
Ribosomal protein L18 and S110Direct
Dual specificity phosphatase-like0Direct
Amidase signature (AS) enzymes0Direct
DJ-1/PfpI0Direct
EF-G/eEF-2 domains III and V0Direct
Pseudouridine synthase I TruA0Direct
Chaperone J-domain0Direct
YAP1 redox domain0Direct
DNA ligase/mRNA capping enzyme postcatalytic domain0Direct
Bacteriorhodopsin-like0Direct
Tetratricopeptide repeat (TPR)0Direct
HAT/Suf repeat0Direct
Lysophospholipase0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain0Direct
Ribosomal protein L30p/L7e0Direct
Magnesium transport protein CorA, transmembrane region0Direct
Phosphoribosylpyrophosphate synthetase-like0Direct
RuBisCo LSMT catalytic domain0Direct
Forkhead DNA-binding domain0Direct
DNA-binding domain of Mlu1-box binding protein MBP10Direct
Bacterial dinuclear zinc exopeptidases0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
Calponin-homology domain, CH-domain0Direct
6-phosphogluconate dehydrogenase-like, N-terminal domain0Direct
Inositol monophosphatase/fructose-1,6-bisphosphatase-like0Direct
RecA protein-like (ATPase-domain)0Direct
Undecaprenyl diphosphate synthase0Direct
DNA polymerase III clamp loader subunits, C-terminal domain0Direct
Histidine acid phosphatase0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
PP2C-like0Direct
Ribosomal protein L11, C-terminal domain0Direct
Ferredoxin reductase FAD-binding domain-like0Direct
PDI-like0Direct
HCP-like0Direct
ENTH domain0Direct
Prefoldin0Direct
Anticodon-binding domain of Class II aaRS0Direct
Proteasome subunits0Direct
Sir2 family of transcriptional regulators0Direct
Smc hinge domain0Direct
Serine carboxypeptidase-like0Direct
Protein prenyltransferases0Direct
VHS domain0Direct
Erythroid transcription factor GATA-10Direct
DNA gyrase/MutL, second domain0Direct
CRAL/TRIO domain0Direct
Cytochrome P4500Direct
Vacuolar sorting protein domain0Direct
DnaQ-like 3'-5' exonuclease0Direct
Reductases0Direct
F1F0 ATP synthase subunit C0Direct
Translational machinery components0Direct
SAP domain0Direct
Armadillo repeat0Direct
FHA domain0Direct
RING finger domain, C3HC40Direct
Tandem AAA-ATPase domain0.04864Inherited
Protein kinases, catalytic subunit0.16Inherited
Cold shock DNA-binding domain-like0.3394Inherited
Ankyrin repeat0.3606Inherited
Glutathione peroxidase-like0.6091Inherited
SH3-domain0.639Inherited
Thioltransferase0.683Inherited
FYVE, a phosphatidylinositol-3-phosphate binding domain0.7823Inherited
5' to 3' exonuclease, C-terminal subdomain0.7823Inherited
5' to 3' exonuclease catalytic domain0.7823Inherited
Inositol polyphosphate 5-phosphatase (IPP5)0.8217Inherited
G proteins0.8866Inherited
Cyclophilin (peptidylprolyl isomerase)0.9337Inherited
Ubiquitin carboxyl-terminal hydrolase, UCH0.9392Inherited


Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
Plot tree as:   Download Newick format tree:
(show help)

Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]

Supra-domain (including individual superfamily)

(show details)
Supra-domain (Single) FDR (all) Annotation (direct or inherited)
MurD-like peptide ligases, peptide-binding domain0Direct
Cation efflux protein transmembrane domain-like0Direct
HSP40/DnaJ peptide-binding domain0Direct
HMA, heavy metal-associated domain0Direct
Rudiment single hybrid motif0Direct
Tricorn protease domain 20Direct
Regulator of G-protein signaling, RGS0Direct
MurD-like peptide ligases, catalytic domain0Direct
N-terminal nucleophile aminohydrolases (Ntn hydrolases)0Direct
C-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
CRAL/TRIO N-terminal domain0Direct
Ribosomal protein S20Direct
WW domain0Direct
VPS9 domain0Direct
RmlC-like cupins0Direct
PYP-like sensor domain (PAS domain)0Direct
Ligand-binding domain in the NO signalling and Golgi transport0Direct
Smc hinge domain0Direct
Ribulose-phoshate binding barrel0Direct
Zn-finger domain of Sec23/240Direct
Zn-dependent exopeptidases0Direct
Cytochrome P4500Direct
DNA-binding domain of Mlu1-box binding protein MBP10Direct
Cdc48 domain 2-like0Direct
Carbon-nitrogen hydrolase0Direct
Ribonuclease PH domain 2-like0Direct
EF-G C-terminal domain-like0Direct
HSP20-like chaperones0Direct
Ras GEF0Direct
DBL homology domain (DH-domain)0Direct
Protein prenylyltransferase0Direct
The spindle assembly checkpoint protein mad20Direct
Arginase/deacetylase0Direct
Ribosomal protein L60Direct
cAMP-binding domain-like0Direct
PUA domain-like0Direct
Ribokinase-like0Direct
Terpenoid cyclases/Protein prenyltransferases0Direct
Ferritin-like0Direct
Nucleotide-binding domain0Direct
Sec7 domain0Direct
CCCH zinc finger0Direct
Tryptophan synthase beta subunit-like PLP-dependent enzymes0Direct
eIF1-like0Direct
Nop domain0Direct
PA domain0Direct
Carbamate kinase-like0Direct
DNA-glycosylase0Direct
Ribosomal protein L220Direct
Subtilisin-like0Direct
Acetyl-CoA synthetase-like0Direct
Cysteine alpha-hairpin motif0Direct
Family A G protein-coupled receptor-like0Direct
Clavaminate synthase-like0Direct
LexA/Signal peptidase0Direct
Transferrin receptor-like dimerisation domain0Direct
FtsH protease domain-like0Direct
Trimeric LpxA-like enzymes0Direct
vWA-like0Direct
DNA repair protein MutS, domain II0Direct
NTF2-like0Direct
Radical SAM enzymes0Direct
Heat shock protein 70kD (HSP70), C-terminal subdomain0Direct
Bromodomain0Direct
Endosomal sorting complex assembly domain0Direct
DNA repair protein MutS, domain I0Direct
HIT/MYND zinc finger-like0Direct
Alpha-L RNA-binding motif0Direct
SAP domain0Direct
Aldolase0Direct
beta-sandwich domain of Sec23/240Direct
FAD-linked oxidoreductase0Direct
beta and beta-prime subunits of DNA dependent RNA-polymerase0Direct
SNARE-like0Direct
CorA soluble domain-like0Direct
Metallo-hydrolase/oxidoreductase0Direct
ValRS/IleRS/LeuRS editing domain0Direct
Ribosomal protein S80Direct
Aconitase iron-sulfur domain0Direct
DNA repair protein MutS, domain III0Direct
KA1-like0Direct
Ribosomal L11/L12e N-terminal domain0Direct
Calponin-homology domain, CH-domain0Direct
Aquaporin-like0Direct
HRDC-like0Direct
Class II aaRS ABD-related0Direct
Supernatant protein factor (SPF), C-terminal domain0Direct
GAT-like domain0Direct
PriA/YqbF domain0Direct
GST C-terminal domain-like0Direct
GHMP Kinase, C-terminal domain0Direct
PreATP-grasp domain0Direct
Six-hairpin glycosidases0Direct
SAICAR synthase-like0Direct
Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain0Direct
Restriction endonuclease-like0Direct
DNA ligase/mRNA capping enzyme, catalytic domain0Direct
YjgF-like0Direct
Undecaprenyl diphosphate synthase0Direct
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain0Direct
4'-phosphopantetheinyl transferase0Direct
ThrRS/AlaRS common domain0Direct
EPT/RTPC-like0Direct
Fumarate reductase respiratory complex transmembrane subunits0Direct
Zn-binding ribosomal proteins0Direct
Methylglyoxal synthase-like0Direct
Seven-hairpin glycosidases0Direct
Glucocorticoid receptor-like (DNA-binding domain)0Direct
CRAL/TRIO domain0Direct
LuxS/MPP-like metallohydrolase0Direct
Alkaline phosphatase-like0Direct
Mss4-like0Direct
RNase III domain-like0Direct
PAP/OAS1 substrate-binding domain0Direct
ALDH-like0Direct
Zinc domain conserved in yeast copper-regulated transcription factors0Direct
Sec63 N-terminal domain-like0Direct
HD-domain/PDEase-like0Direct
alpha/beta knot0Direct
post-AAA+ oligomerization domain-like0Direct
Activating enzymes of the ubiquitin-like proteins0Direct
Single hybrid motif0Direct
JAB1/MPN domain0Direct
Carbohydrate phosphatase0Direct
Chaperone J-domain0Direct
Glutamine synthetase/guanido kinase0Direct
Nucleoporin domain0Direct
FAD/NAD-linked reductases, dimerisation (C-terminal) domain0Direct
Chromo domain-like0Direct
Phosphoenolpyruvate/pyruvate domain0Direct
Eukaryotic type KH-domain (KH-domain type I)0Direct
Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor0Direct
Actin depolymerizing proteins0Direct
Ribosomal protein L11, C-terminal domain0Direct
S13-like H2TH domain0Direct
PR-1-like0Direct
SET domain0Direct
Translational machinery components0Direct
PP2C-like0Direct
post-HMGL domain-like0Direct
TK C-terminal domain-like0Direct
R3H domain0Direct
CheY-like0Direct
Ribosomal protein L140Direct
Cytochrome c0Direct
Helical domain of Sec23/240Direct
DNA/RNA polymerases0Direct
DnaJ/Hsp40 cysteine-rich domain0Direct
POZ domain0Direct
Metallo-dependent hydrolases0Direct
Clathrin adaptor appendage domain0Direct
BRCT domain0Direct
Ribonuclease H-like0Direct
Phospholipase D/nuclease0Direct
Amidase signature (AS) enzymes0Direct
FMN-binding split barrel0Direct
Magnesium transport protein CorA, transmembrane region0Direct
Terpenoid synthases0Direct
CBS-domain pair0Direct
L-aspartase-like0Direct
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases0Direct
Mitochondrial cytochrome c oxidase subunit IV0Direct
Cytidine deaminase-like0Direct
Ribosomal protein L130Direct
Tubulin C-terminal domain-like0Direct
Fe,Mn superoxide dismutase (SOD), C-terminal domain0Direct
YAP1 redox domain0Direct
Adenine nucleotide alpha hydrolases-like0Direct
Ribosomal protein L30p/L7e0Direct
N-terminal domain of alpha and beta subunits of F1 ATP synthase0Direct
GYF domain0Direct
FabD/lysophospholipase-like0Direct
Tubulin nucleotide-binding domain-like0Direct
F1F0 ATP synthase subunit C0Direct
HMG-box0Direct
Prefoldin0Direct
Acid proteases0Direct
Cap-Gly domain0Direct
Cupredoxins0Direct
RBP11-like subunits of RNA polymerase0Direct
C-terminal, gelsolin-like domain of Sec23/240Direct
Glutathione synthetase ATP-binding domain-like0Direct
Thiolase-like0Direct
tRNA-intron endonuclease catalytic domain-like0Direct
Inosine monophosphate dehydrogenase (IMPDH)0Direct
ArfGap/RecO-like zinc finger0Direct
YVTN repeat-like/Quinoprotein amine dehydrogenase0Direct
LeuD/IlvD-like0Direct
RNI-like0Direct
HIT-like0Direct
Ribosomal protein L10-like0Direct
CoA-dependent acyltransferases0Direct
HLH, helix-loop-helix DNA-binding domain0Direct
L30e-like0Direct
HCP-like0Direct
Ypt/Rab-GAP domain of gyp1p0Direct
C-terminal autoproteolytic domain of nucleoporin nup980Direct
Glycoside hydrolase/deacetylase0Direct
Kelch motif0Direct
Homo-oligomeric flavin-containing Cys decarboxylases, HFCD0Direct
Nucleotidylyl transferase0Direct
Retrovirus zinc finger-like domains0Direct
Heat shock protein 70kD (HSP70), peptide-binding domain0Direct
dsRNA-binding domain-like0Direct
GINS helical bundle-like0Direct
Protein kinase-like (PK-like)0.1295Inherited
ARM repeat0.1749Inherited
Nucleic acid-binding proteins0.2215Inherited
"Winged helix" DNA-binding domain0.2797Inherited
Class II aaRS and biotin synthetases0.3106Inherited
Ankyrin repeat0.3472Inherited
Translation proteins SH3-like domain0.3917Inherited
ENTH/VHS domain0.4364Inherited
P-loop containing nucleoside triphosphate hydrolases0.5395Inherited
C2 domain (Calcium/lipid-binding domain, CaLB)0.5477Inherited
GroEL apical domain-like0.5792Inherited
Histone-fold0.6262Inherited
SH3-domain0.6262Inherited
Nucleotidyltransferase0.7505Inherited
5' to 3' exonuclease, C-terminal subdomain0.7869Inherited
Cyclophilin-like0.8993Inherited

(show details)
Supra-domain (Duplex) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
54747,46906
  • 54747 - Ribosomal L11/L12e N-terminal domain
  • 46906 - Ribosomal protein L11, C-terminal domain
  • 0Direct
    57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    56091,50249
  • 56091 - DNA ligase/mRNA capping enzyme, catalytic domain
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    51905,56425
  • 51905 - FAD/NAD(P)-binding domain
  • 56425 - Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
  • 0Direct
    51735,55347
  • 51735 - NAD(P)-binding Rossmann-fold domains
  • 55347 - Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
  • 0Direct
    48371,52540
  • 48371 - ARM repeat
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    54631,51412
  • 54631 - CBS-domain pair
  • 51412 - Inosine monophosphate dehydrogenase (IMPDH)
  • 0Direct
    54211,55666
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55666 - Ribonuclease PH domain 2-like
  • 0Direct
    52440,56059
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 0Direct
    46785,46785
  • 46785 - "Winged helix" DNA-binding domain
  • 46785 - "Winged helix" DNA-binding domain
  • 0Direct
    48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    53067,53067
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 0Direct
    50044,50044
  • 50044 - SH3-domain
  • 50044 - SH3-domain
  • 0Direct
    90229,90229
  • 90229 - CCCH zinc finger
  • 90229 - CCCH zinc finger
  • 0Direct
    54211,54980
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    54236,57829
  • 54236 - Ubiquitin-like
  • 57829 - Zn-binding ribosomal proteins
  • 0Direct
    50447,54980
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    56059,51246
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    103657,50729
  • 103657 - BAR/IMD domain-like
  • 50729 - PH domain-like
  • 0Direct
    52518,52922
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52922 - TK C-terminal domain-like
  • 0Direct
    54980,54211
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    52374,47323
  • 52374 - Nucleotidylyl transferase
  • 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
  • 0Direct
    53067,100920
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    52518,52518
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 52518 - Thiamin diphosphate-binding fold (THDP-binding)
  • 0Direct
    81995,82919
  • 81995 - beta-sandwich domain of Sec23/24
  • 82919 - Zn-finger domain of Sec23/24
  • 0Direct
    46689,46689
  • 46689 - Homeodomain-like
  • 46689 - Homeodomain-like
  • 0Direct
    49493,49493
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    52025,53187
  • 52025 - PA domain
  • 53187 - Zn-dependent exopeptidases
  • 0Direct
    50677,52374
  • 50677 - ValRS/IleRS/LeuRS editing domain
  • 52374 - Nucleotidylyl transferase
  • 0Direct
    52058,52058
  • 52058 - L domain-like
  • 52058 - L domain-like
  • 0Direct
    49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    54211,55060
  • 54211 - Ribosomal protein S5 domain 2-like
  • 55060 - GHMP Kinase, C-terminal domain
  • 0Direct
    100920,100934
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    54631,54631
  • 54631 - CBS-domain pair
  • 54631 - CBS-domain pair
  • 0Direct
    51905,51905
  • 51905 - FAD/NAD(P)-binding domain
  • 51905 - FAD/NAD(P)-binding domain
  • 0Direct
    52490,55307
  • 52490 - Tubulin nucleotide-binding domain-like
  • 55307 - Tubulin C-terminal domain-like
  • 0Direct
    57938,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    56024,56024
  • 56024 - Phospholipase D/nuclease
  • 56024 - Phospholipase D/nuclease
  • 0Direct
    63380,52343
  • 63380 - Riboflavin synthase domain-like
  • 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain
  • 0Direct
    54897,52743
  • 54897 - Protease propeptides/inhibitors
  • 52743 - Subtilisin-like
  • 0Direct
    56235,52402
  • 56235 - N-terminal nucleophile aminohydrolases (Ntn hydrolases)
  • 52402 - Adenine nucleotide alpha hydrolases-like
  • 0Direct
    46938,52087
  • 46938 - CRAL/TRIO N-terminal domain
  • 52087 - CRAL/TRIO domain
  • 0Direct
    53623,53244
  • 53623 - MurD-like peptide ligases, catalytic domain
  • 53244 - MurD-like peptide ligases, peptide-binding domain
  • 0Direct
    143865,144083
  • 143865 - CorA soluble domain-like
  • 144083 - Magnesium transport protein CorA, transmembrane region
  • 0Direct
    52540,48019
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 48019 - post-AAA+ oligomerization domain-like
  • 0Direct
    49879,56112
  • 49879 - SMAD/FHA domain
  • 56112 - Protein kinase-like (PK-like)
  • 0Direct
    52540,47917
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    55681,52954
  • 55681 - Class II aaRS and biotin synthetases
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    82919,53300
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    -9,52954
  • -9 - PDB
  • 52954 - Class II aaRS ABD-related
  • 0Direct
    52777,52777
  • 52777 - CoA-dependent acyltransferases
  • 52777 - CoA-dependent acyltransferases
  • 0Direct
    52540,53254
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 53254 - Phosphoglycerate mutase-like
  • 0Direct
    53613,48613
  • 53613 - Ribokinase-like
  • 48613 - Heme oxygenase-like
  • 0Direct
    54791,54791
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 54791 - Eukaryotic type KH-domain (KH-domain type I)
  • 0Direct
    81811,82754
  • 81811 - Helical domain of Sec23/24
  • 82754 - C-terminal, gelsolin-like domain of Sec23/24
  • 0Direct
    81333,81333
  • 81333 - F1F0 ATP synthase subunit C
  • 81333 - F1F0 ATP synthase subunit C
  • 0Direct
    50249,50104
  • 50249 - Nucleic acid-binding proteins
  • 50104 - Translation proteins SH3-like domain
  • 0Direct
    57850,52540
  • 57850 - RING/U-box
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    51905,55424
  • 51905 - FAD/NAD(P)-binding domain
  • 55424 - FAD/NAD-linked reductases, dimerisation (C-terminal) domain
  • 0Direct
    49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct
    50978,50978
  • 50978 - WD40 repeat-like
  • 50978 - WD40 repeat-like
  • 0Direct
    53187,47672
  • 53187 - Zn-dependent exopeptidases
  • 47672 - Transferrin receptor-like dimerisation domain
  • 0Direct
    48371,-7
  • 48371 - ARM repeat
  • -7 - CATH
  • 0Direct
    51569,89000
  • 51569 - Aldolase
  • 89000 - post-HMGL domain-like
  • 0Direct
    46565,57938
  • 46565 - Chaperone J-domain
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 0Direct
    56053,56053
  • 56053 - Ribosomal protein L6
  • 56053 - Ribosomal protein L6
  • 0Direct
    48464,89009
  • 48464 - ENTH/VHS domain
  • 89009 - GAT-like domain
  • 0Direct
    50249,55681
  • 50249 - Nucleic acid-binding proteins
  • 55681 - Class II aaRS and biotin synthetases
  • 0Direct
    -9,-9
  • -9 - PDB
  • -9 - PDB
  • 0Direct
    63411,63411
  • 63411 - LuxS/MPP-like metallohydrolase
  • 63411 - LuxS/MPP-like metallohydrolase
  • 0Direct
    53732,52016
  • 53732 - Aconitase iron-sulfur domain
  • 52016 - LeuD/IlvD-like
  • 0Direct
    48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    50615,52540
  • 50615 - N-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53756,56784
  • 53756 - UDP-Glycosyltransferase/glycogen phosphorylase
  • 56784 - HAD-like
  • 0Direct
    -7,52540
  • -7 - CATH
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    53901,53901
  • 53901 - Thiolase-like
  • 53901 - Thiolase-like
  • 0Direct
    81301,81631
  • 81301 - Nucleotidyltransferase
  • 81631 - PAP/OAS1 substrate-binding domain
  • 0Direct
    52833,47616
  • 52833 - Thioredoxin-like
  • 47616 - GST C-terminal domain-like
  • 0Direct
    48334,52540
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52833,52833
  • 52833 - Thioredoxin-like
  • 52833 - Thioredoxin-like
  • 0Direct
    50249,50249
  • 50249 - Nucleic acid-binding proteins
  • 50249 - Nucleic acid-binding proteins
  • 0Direct
    52540,140990
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 140990 - FtsH protease domain-like
  • 0Direct
    53150,48334
  • 53150 - DNA repair protein MutS, domain II
  • 48334 - DNA repair protein MutS, domain III
  • 0Direct
    55874,54211
  • 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    52540,90123
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    47923,47923
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 47923 - Ypt/Rab-GAP domain of gyp1p
  • 0Direct
    53098,56672
  • 53098 - Ribonuclease H-like
  • 56672 - DNA/RNA polymerases
  • 0Direct
    52540,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0.2545Inherited

    (show details)
    Supra-domain (Triple) in N- to C-terminal order FDR (all) Annotation (direct or inherited)
    53067,100920,100934
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 100934 - Heat shock protein 70kD (HSP70), C-terminal subdomain
  • 0Direct
    48371,52540,52540
  • 48371 - ARM repeat
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    52540,90123,52540
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50447,54980,54211
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 0Direct
    49562,49562,49562
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
  • 0Direct
    52440,56059,51246
  • 52440 - PreATP-grasp domain
  • 56059 - Glutathione synthetase ATP-binding domain-like
  • 51246 - Rudiment single hybrid motif
  • 0Direct
    90123,52540,90123
  • 90123 - ABC transporter transmembrane region
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 90123 - ABC transporter transmembrane region
  • 0Direct
    57756,57756,57756
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 57756 - Retrovirus zinc finger-like domains
  • 0Direct
    54980,54211,54980
  • 54980 - EF-G C-terminal domain-like
  • 54211 - Ribosomal protein S5 domain 2-like
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    52025,53187,47672
  • 52025 - PA domain
  • 53187 - Zn-dependent exopeptidases
  • 47672 - Transferrin receptor-like dimerisation domain
  • 0Direct
    57938,49493,49493
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    46565,57938,49493
  • 46565 - Chaperone J-domain
  • 57938 - DnaJ/Hsp40 cysteine-rich domain
  • 49493 - HSP40/DnaJ peptide-binding domain
  • 0Direct
    48371,48371,48371
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 48371 - ARM repeat
  • 0Direct
    81995,82919,53300
  • 81995 - beta-sandwich domain of Sec23/24
  • 82919 - Zn-finger domain of Sec23/24
  • 53300 - vWA-like
  • 0Direct
    52540,50447,54980
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 50447 - Translation proteins
  • 54980 - EF-G C-terminal domain-like
  • 0Direct
    53150,48334,52540
  • 53150 - DNA repair protein MutS, domain II
  • 48334 - DNA repair protein MutS, domain III
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 0Direct
    50615,52540,47917
  • 50615 - N-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 52540 - P-loop containing nucleoside triphosphate hydrolases
  • 47917 - C-terminal domain of alpha and beta subunits of F1 ATP synthase
  • 0Direct
    48452,48452,48452
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 48452 - TPR-like
  • 0Direct
    53067,53067,100920
  • 53067 - Actin-like ATPase domain
  • 53067 - Actin-like ATPase domain
  • 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain
  • 0Direct
    49503,49503,49503
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 49503 - Cupredoxins
  • 0Direct


    Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
    Plot tree as:   Download Newick format tree:
    (show help)