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Zebrafish Anatomy (ZA): anatomical group
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: ZA Hierarchy (zebrafish anatomy from ZFIN zebrafish anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this ZA term (Not in SDZA)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| DUSP-like | 0 | DIRECT |
| Trypsin-like serine proteases | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| F-box domain | 0 | DIRECT |
| HIT-like | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| HD-domain/PDEase-like | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| Regulator of G-protein signaling, RGS | 0 | DIRECT |
| Translation proteins | 0 | DIRECT |
| Caspase-like | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| Phoshotransferase/anion transport protein | 0 | DIRECT |
| Plexin repeat | 0 | DIRECT |
| Kazal-type serine protease inhibitors | 0 | DIRECT |
| DEATH domain | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| Zinc beta-ribbon | 0 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| Tropomyosin | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| Class II aaRS and biotin synthetases | 0 | DIRECT |
| LDL receptor-like module | 0 | DIRECT |
| Rhodanese/Cell cycle control phosphatase | 0 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| L27 domain | 0 | DIRECT |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | DIRECT |
| BRCT domain | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
| Bet v1-like | 0 | DIRECT |
| Calcium ATPase, transmembrane domain M | 0 | DIRECT |
| PLP-dependent transferases | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Translation proteins SH3-like domain | 0 | DIRECT |
| Actin depolymerizing proteins | 0 | DIRECT |
| Ypt/Rab-GAP domain of gyp1p | 0 | DIRECT |
| GST C-terminal domain-like | 0 | DIRECT |
| Ricin B-like lectins | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| TNF receptor-like | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| CoA-dependent acyltransferases | 0 | DIRECT |
| SMAD/FHA domain | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| UBA-like | 0 | DIRECT |
| RCC1/BLIP-II | 0 | DIRECT |
| Galactose-binding domain-like | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| LCCL domain | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| CCCH zinc finger | 0 | DIRECT |
| Soluble quinoprotein glucose dehydrogenase | 0 | DIRECT |
| Kringle-like | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Hemopexin-like domain | 0 | DIRECT |
| Myosin rod fragments | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| ENTH/VHS domain | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| Cupredoxins | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| FAD-linked reductases, C-terminal domain | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| Orange domain-like | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| BPTI-like | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| Calcium ATPase, transduction domain A | 0 | DIRECT |
| SOCS box-like | 0 | DIRECT |
| SH2 domain | 0 | DIRECT |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
| Nucleotidylyl transferase | 0 | DIRECT |
| DPP6 N-terminal domain-like | 0 | DIRECT |
| Cullin repeat-like | 0 | DIRECT |
| CAD & PB1 domains | 0 | DIRECT |
| Actin-like ATPase domain | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| Metallo-dependent hydrolases | 0 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| SNARE-like | 0 | DIRECT |
| SET domain | 0 | DIRECT |
| Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| FAD/NAD(P)-binding domain | 0 | DIRECT |
| CalX-like | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| Alkaline phosphatase-like | 0 | DIRECT |
| alpha/beta-Hydrolases | 0 | DIRECT |
| Leucine zipper domain | 0 | DIRECT |
| STAT | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| GTPase activation domain, GAP | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| Nucleotide cyclase | 0 | DIRECT |
| Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
| POZ domain | 0 | DIRECT |
| Ras GEF | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| SNARE fusion complex | 0 | DIRECT |
| Riboflavin synthase domain-like | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Cyclin-like | 0 | DIRECT |
| HSP20-like chaperones | 0 | DIRECT |
| Immunoglobulin | 0.03948 | INHERITED FROM: medial longitudinal fasciculus || white matter || olfactory bulb glomerulus |
| Homeodomain-like | 0.04913 | INHERITED FROM: endocrine cell || cephalic musculature || endocrine pancreas || preoptic area || forebrain || diencephalon |
| Growth factor receptor domain | 0.0499 | INHERITED FROM: intramembranous bone || blood plasma || posterior lateral line ganglion || lymphatic system || blood vasculature |
| WD40 repeat-like | 0.1107 | INHERITED FROM: photoreceptor outer segment layer || retinal outer nuclear layer |
| Cystine-knot cytokines | 0.1142 | INHERITED FROM: spermatogenic cyst |
| Nuclear receptor ligand-binding domain | 0.1725 | INHERITED FROM: gonad || hypophysis || reproductive system || ovarian follicle stage IV |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.1725 | INHERITED FROM: cardiac ventricle || Kolmer-Agduhr neuron || VeLD |
| EGF/Laminin | 0.2846 | INHERITED FROM: pars superior ear || lateral line ganglion || vasculature || posterior lateral line ganglion || lymphatic system || blood vasculature || lymph vessel |
| PDZ domain-like | 0.3355 | INHERITED FROM: central canal |
| C-type lectin-like | 0.3523 | INHERITED FROM: axial vasculature || lymphatic system || lymph vessel |
| FnI-like domain | 0.3523 | INHERITED FROM: chondral bone || palatoquadrate cartilage || replacement bone || skeletal system || skeletal element || palatoquadrate arch |
| Fibronectin type III | 0.4391 | INHERITED FROM: medial longitudinal fasciculus || glomerular layer || white matter || synencephalon |
| DBL homology domain (DH-domain) | 0.4544 | INHERITED FROM: blood vessel endothelium || blood vessel endothelial cell || vascular endothelium |
| Bromodomain | 0.4845 | INHERITED FROM: blood || hematopoietic system |
| Cysteine proteinases | 0.516 | INHERITED FROM: cartilage element || splanchnocranium || olfactory region || chondrocranium cartilage || ethmoid cartilage || skeletal system || oral region || pharyngeal arch cartilage || ventral mandibular arch || neurocranium || skeletal element || mandibular arch skeleton || pericardium || chondrocranium |
| lambda repressor-like DNA-binding domains | 0.5507 | INHERITED FROM: digestive system duct || diencephalon |
| Snake toxin-like | 0.5507 | INHERITED FROM: axial vasculature |
| Tudor/PWWP/MBT | 0.5876 | INHERITED FROM: primordial germ cell || reproductive system |
| Cytokine | 0.5876 | INHERITED FROM: intramembranous bone || olfactory region || dermatocranium |
| Cadherin-like | 0.6307 | INHERITED FROM: cranial nerve || diencephalic white matter || white matter || cranial nerve II || optic tectum |
| p53-like transcription factors | 0.6332 | INHERITED FROM: primordial vasculature |
| beta-beta-alpha zinc fingers | 0.6462 | INHERITED FROM: ventral thalamus |
| GroEL-intermediate domain like | 0.6667 | INHERITED FROM: myotome || trunk musculature || skeletal muscle || striated muscle cell || muscle cell || musculature system || skeletal muscle cell |
| Protease propeptides/inhibitors | 0.6667 | INHERITED FROM: optic tectum |
| Multidrug efflux transporter AcrB transmembrane domain | 0.6667 | INHERITED FROM: retinal ganglion cell layer || dorsal hyoid arch || skeletal muscle || striated muscle cell || hyosymplectic cartilage || skeletal muscle cell |
| HLH, helix-loop-helix DNA-binding domain | 0.677 | INHERITED FROM: heart primordium || Kolmer-Agduhr neuron |
| Retrovirus zinc finger-like domains | 0.7524 | INHERITED FROM: gill || respiratory system || pharyngeal arch 3-7 |
| ACT-like | 0.7524 | INHERITED FROM: ventral wall of dorsal aorta || axial blood vessel || dorsal aorta || artery |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7524 | INHERITED FROM: ventral wall of dorsal aorta || axial blood vessel || dorsal aorta || artery |
| Cytochrome P450 | 0.7593 | INHERITED FROM: hypophysis |
| BAR/IMD domain-like | 0.7593 | INHERITED FROM: olfactory system |
| HMG-box | 0.7935 | INHERITED FROM: vagal ganglion || statoacoustic (VIII) ganglion || ganglion || dorsal root ganglion |
| Serine protease inhibitors | 0.7998 | INHERITED FROM: otolith organ || otolith || vestibuloauditory system || inner ear |
| IP3 receptor type 1 binding core, domain 2 | 0.7998 | INHERITED FROM: skeletal muscle || striated muscle cell || muscle cell || skeletal muscle cell |
| NAD(P)-binding Rossmann-fold domains | 0.8538 | INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer |
| GroEL equatorial domain-like | 0.8689 | INHERITED FROM: myotome || trunk musculature || skeletal muscle || striated muscle cell || muscle cell || skeletal muscle cell |
| GroEL apical domain-like | 0.8985 | INHERITED FROM: myotome || trunk musculature || skeletal muscle || striated muscle cell || muscle cell || skeletal muscle cell |
| MIR domain | 0.9729 | INHERITED FROM: skeletal muscle cell |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| DUSP-like | 0 | Direct |
| Trypsin-like serine proteases | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| F-box domain | 0 | Direct |
| HIT-like | 0 | Direct |
| ALDH-like | 0 | Direct |
| Integrin domains | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| ADC-like | 0 | Direct |
| Connexin43 | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| HD-domain/PDEase-like | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| Regulator of G-protein signaling, RGS | 0 | Direct |
| Translation proteins | 0 | Direct |
| Caspase-like | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| Phoshotransferase/anion transport protein | 0 | Direct |
| Plexin repeat | 0 | Direct |
| Kazal-type serine protease inhibitors | 0 | Direct |
| DEATH domain | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| Zinc beta-ribbon | 0 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| Tropomyosin | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| Class II aaRS and biotin synthetases | 0 | Direct |
| LDL receptor-like module | 0 | Direct |
| Rhodanese/Cell cycle control phosphatase | 0 | Direct |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| L27 domain | 0 | Direct |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | Direct |
| BRCT domain | 0 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
| Bet v1-like | 0 | Direct |
| Calcium ATPase, transmembrane domain M | 0 | Direct |
| PLP-dependent transferases | 0 | Direct |
| PP2C-like | 0 | Direct |
| GroES-like | 0 | Direct |
| NTF2-like | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Translation proteins SH3-like domain | 0 | Direct |
| Actin depolymerizing proteins | 0 | Direct |
| Ypt/Rab-GAP domain of gyp1p | 0 | Direct |
| GST C-terminal domain-like | 0 | Direct |
| Ricin B-like lectins | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| TNF receptor-like | 0 | Direct |
| Plakin repeat | 0 | Direct |
| CoA-dependent acyltransferases | 0 | Direct |
| SMAD/FHA domain | 0 | Direct |
| Translational machinery components | 0 | Direct |
| UBA-like | 0 | Direct |
| RCC1/BLIP-II | 0 | Direct |
| Galactose-binding domain-like | 0 | Direct |
| CCHHC domain | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| SRF-like | 0 | Direct |
| LCCL domain | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| Ribosomal protein S5 domain 2-like | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| CCCH zinc finger | 0 | Direct |
| Soluble quinoprotein glucose dehydrogenase | 0 | Direct |
| Kringle-like | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Hemopexin-like domain | 0 | Direct |
| Myosin rod fragments | 0 | Direct |
| PGBD-like | 0 | Direct |
| ENTH/VHS domain | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| Cupredoxins | 0 | Direct |
| Sec7 domain | 0 | Direct |
| FAD-linked reductases, C-terminal domain | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| Orange domain-like | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| BPTI-like | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| GLA-domain | 0 | Direct |
| Calcium ATPase, transduction domain A | 0 | Direct |
| SOCS box-like | 0 | Direct |
| SH2 domain | 0 | Direct |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
| Nucleotidylyl transferase | 0 | Direct |
| DPP6 N-terminal domain-like | 0 | Direct |
| Cullin repeat-like | 0 | Direct |
| CAD & PB1 domains | 0 | Direct |
| Actin-like ATPase domain | 0 | Direct |
| Polo-box domain | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| Metallo-dependent hydrolases | 0 | Direct |
| Nicotinic receptor ligand binding domain-like | 0 | Direct |
| Aldolase | 0 | Direct |
| SNARE-like | 0 | Direct |
| SET domain | 0 | Direct |
| Glutathione synthetase ATP-binding domain-like | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| FAD/NAD(P)-binding domain | 0 | Direct |
| CalX-like | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Composite domain of metallo-dependent hydrolases | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| Alkaline phosphatase-like | 0 | Direct |
| alpha/beta-Hydrolases | 0 | Direct |
| Leucine zipper domain | 0 | Direct |
| STAT | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| GTPase activation domain, GAP | 0 | Direct |
| Sema domain | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| Nucleotide cyclase | 0 | Direct |
| Formin homology 2 domain (FH2 domain) | 0 | Direct |
| POZ domain | 0 | Direct |
| Ras GEF | 0 | Direct |
| Notch domain | 0 | Direct |
| SNARE fusion complex | 0 | Direct |
| Riboflavin synthase domain-like | 0 | Direct |
| FAS1 domain | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Cyclin-like | 0 | Direct |
| HSP20-like chaperones | 0 | Direct |
| Immunoglobulin | 0.03948 | Inherited |
| Homeodomain-like | 0.04913 | Inherited |
| Growth factor receptor domain | 0.0499 | Inherited |
| WD40 repeat-like | 0.1107 | Inherited |
| Cystine-knot cytokines | 0.1142 | Inherited |
| Nuclear receptor ligand-binding domain | 0.1725 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.1725 | Inherited |
| EGF/Laminin | 0.2846 | Inherited |
| PDZ domain-like | 0.3355 | Inherited |
| C-type lectin-like | 0.3523 | Inherited |
| FnI-like domain | 0.3523 | Inherited |
| Fibronectin type III | 0.4391 | Inherited |
| DBL homology domain (DH-domain) | 0.4544 | Inherited |
| Bromodomain | 0.4845 | Inherited |
| Cysteine proteinases | 0.516 | Inherited |
| lambda repressor-like DNA-binding domains | 0.5507 | Inherited |
| Snake toxin-like | 0.5507 | Inherited |
| Tudor/PWWP/MBT | 0.5876 | Inherited |
| Cytokine | 0.5876 | Inherited |
| Cadherin-like | 0.6307 | Inherited |
| p53-like transcription factors | 0.6332 | Inherited |
| beta-beta-alpha zinc fingers | 0.6462 | Inherited |
| GroEL-intermediate domain like | 0.6667 | Inherited |
| Protease propeptides/inhibitors | 0.6667 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.6667 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.677 | Inherited |
| Retrovirus zinc finger-like domains | 0.7524 | Inherited |
| ACT-like | 0.7524 | Inherited |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7524 | Inherited |
| Cytochrome P450 | 0.7593 | Inherited |
| BAR/IMD domain-like | 0.7593 | Inherited |
| HMG-box | 0.7935 | Inherited |
| Serine protease inhibitors | 0.7998 | Inherited |
| IP3 receptor type 1 binding core, domain 2 | 0.7998 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 0.8538 | Inherited |
| GroEL equatorial domain-like | 0.8689 | Inherited |
| GroEL apical domain-like | 0.8985 | Inherited |
| MIR domain | 0.9729 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this ZA term (Not in SDZA)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Matrix metalloproteases, catalytic domain | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| EF-hand modules in multidomain proteins | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | DIRECT |
| Elongation factors | 0 | DIRECT |
| UBA domain | 0 | DIRECT |
| Leucine zipper domain | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | DIRECT |
| Arrestin/Vps26-like | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| FAD-linked reductases, N-terminal domain | 0 | DIRECT |
| Platelet-derived growth factor-like | 0 | DIRECT |
| Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | DIRECT |
| Actin/HSP70 | 0 | DIRECT |
| Mammalian PLC | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| F-box domain | 0 | DIRECT |
| Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| Extended AAA-ATPase domain | 0 | DIRECT |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Ephrin receptor ligand binding domain | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Hydantoinase (dihydropyrimidinase) | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| SNARE fusion complex | 0 | DIRECT |
| L domain | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| Laminin G-like module | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| Nitrogenase iron protein-like | 0 | DIRECT |
| Tropomyosin | 0 | DIRECT |
| Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | DIRECT |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0 | DIRECT |
| CalX-beta domain | 0 | DIRECT |
| LDL receptor-like module | 0 | DIRECT |
| MYND zinc finger | 0 | DIRECT |
| BAR domain | 0 | DIRECT |
| p120GAP domain-like | 0 | DIRECT |
| Eukaryotic proteases | 0 | DIRECT |
| L27 domain | 0 | DIRECT |
| Histone lysine methyltransferases | 0 | DIRECT |
| P4 origin-binding domain-like | 0 | DIRECT |
| Ephrin ectodomain | 0 | DIRECT |
| Cytoplasmic domain of inward rectifier potassium channel | 0 | DIRECT |
| Anion transport protein, cytoplasmic domain | 0 | DIRECT |
| V set domains (antibody variable domain-like) | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| 28-residue LRR | 0 | DIRECT |
| Clathrin coat assembly domain | 0 | DIRECT |
| Calmodulin-like | 0 | DIRECT |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
| Calpain large subunit, catalytic domain (domain II) | 0 | DIRECT |
| Adenylyl and guanylyl cyclase catalytic domain | 0 | DIRECT |
| Dual specificity phosphatase-like | 0 | DIRECT |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0 | DIRECT |
| Tudor domain | 0 | DIRECT |
| Plexin repeat | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Paired domain | 0 | DIRECT |
| Penta-EF-hand proteins | 0 | DIRECT |
| Calcium ATPase, transduction domain A | 0 | DIRECT |
| Growth factor receptor domain | 0 | DIRECT |
| POU-specific domain | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| Caspase recruitment domain, CARD | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
| Histone deacetylase, HDAC | 0 | DIRECT |
| Myeloperoxidase-like | 0 | DIRECT |
| Tubulin, GTPase domain | 0 | DIRECT |
| Gelsolin-like | 0 | DIRECT |
| RUNT domain | 0 | DIRECT |
| Noncollagenous (NC1) domain of collagen IV | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| Pyridoxal-dependent decarboxylase | 0 | DIRECT |
| CCCH zinc finger | 0 | DIRECT |
| PAPS sulfotransferase | 0 | DIRECT |
| DEATH domain, DD | 0 | DIRECT |
| Hairy Orange domain | 0 | DIRECT |
| Tubulin, C-terminal domain | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
| STAT | 0 | DIRECT |
| Link domain | 0 | DIRECT |
| Fibronectin type II module | 0 | DIRECT |
| LCCL domain | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| Regulator of chromosome condensation RCC1 | 0 | DIRECT |
| Proprotein convertase P-domain | 0 | DIRECT |
| Reprolysin-like | 0 | DIRECT |
| Nucleotide and nucleoside kinases | 0 | DIRECT |
| Choline/Carnitine O-acyltransferase | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Troponin T | 0 | DIRECT |
| TNF receptor-like | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) | 0 | DIRECT |
| Zf-UBP | 0 | DIRECT |
| Cyclin | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| Chromo domain | 0 | DIRECT |
| PB1 domain | 0 | DIRECT |
| Regulator of G-protein signaling, RGS | 0 | DIRECT |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | DIRECT |
| Dachshund-homology domain | 0 | DIRECT |
| SH2 domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Glycerophosphoryl diester phosphodiesterase | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| Subtilases | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Erythroid transcription factor GATA-1 | 0 | DIRECT |
| VWC domain | 0 | DIRECT |
| Tetramerization domain of potassium channels | 0 | DIRECT |
| DUSP, domain in ubiquitin-specific proteases | 0 | DIRECT |
| Armadillo repeat | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| Meta-cation ATPase, catalytic domain P | 0 | DIRECT |
| Long-chain cytokines | 0 | DIRECT |
| Myotubularin-like phosphatases | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| Prohormone convertase 1 pro-domain | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Caspase catalytic domain | 0 | DIRECT |
| First domain of FERM | 0 | DIRECT |
| BTB/POZ domain | 0 | DIRECT |
| Glutathione S-transferase (GST), C-terminal domain | 0 | DIRECT |
| Ubiquitin-related | 0 | DIRECT |
| STAT DNA-binding domain | 0 | DIRECT |
| BCR-homology GTPase activation domain (BH-domain) | 0 | DIRECT |
| Clathrin adaptor core protein | 0 | DIRECT |
| Cell cycle transcription factor e2f-dp | 0 | DIRECT |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Ras GEF | 0 | DIRECT |
| Pentraxin (pentaxin) | 0 | DIRECT |
| Cdc48 N-terminal domain-like | 0 | DIRECT |
| FHA domain | 0 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
| GABA-aminotransferase-like | 0 | DIRECT |
| MMP N-terminal domain | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0 | DIRECT |
| Myosin rod fragments | 0 | DIRECT |
| Ovomucoid domain III-like | 0 | DIRECT |
| Single strand DNA-binding domain, SSB | 0 | DIRECT |
| Hemopexin-like domain | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
| SWIRM domain | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| Calcium ATPase, transmembrane domain M | 0 | DIRECT |
| WD40-repeat | 0.02457 | INHERITED FROM: photoreceptor outer segment layer || retinal cone cell |
| Homeodomain | 0.02992 | INHERITED FROM: endocrine cell || cephalic musculature || pancreatic A cell || dorsal telencephalon || endocrine pancreas || preoptic area || forebrain || diencephalon |
| EGF-type module | 0.08731 | INHERITED FROM: lateral line ganglion || posterior lateral line ganglion || semicircular canal |
| I set domains | 0.09374 | INHERITED FROM: medial longitudinal fasciculus || white matter || synencephalon |
| Motor proteins | 0.124 | INHERITED FROM: renal corpuscle || photoreceptor outer segment layer || pronephric podocyte |
| Nuclear receptor ligand-binding domain | 0.1529 | INHERITED FROM: gonad || hypophysis || reproductive system || ovarian follicle stage IV |
| Nuclear receptor | 0.1642 | INHERITED FROM: gonad || hypophysis || reproductive system || ovarian follicle stage IV |
| Transforming growth factor (TGF)-beta | 0.189 | INHERITED FROM: floor plate || pineal complex || spermatogenic cyst |
| LIM domain | 0.3288 | INHERITED FROM: cardiac ventricle |
| PDZ domain | 0.3647 | INHERITED FROM: central canal |
| Classic zinc finger, C2H2 | 0.4207 | INHERITED FROM: thalamus || ventral thalamus |
| Fibronectin type III | 0.4207 | INHERITED FROM: medial longitudinal fasciculus || glomerular layer || white matter || synencephalon |
| DBL homology domain (DH-domain) | 0.4309 | INHERITED FROM: blood vessel endothelium || blood vessel endothelial cell || vascular endothelium |
| Myb/SANT domain | 0.4309 | INHERITED FROM: neutrophil || granulocyte |
| Bromodomain | 0.4623 | INHERITED FROM: blood || hematopoietic system |
| Laminin-type module | 0.5275 | INHERITED FROM: slow muscle cell |
| Tetratricopeptide repeat (TPR) | 0.5343 | INHERITED FROM: retinal rod cell |
| Protein kinases, catalytic subunit | 0.5492 | INHERITED FROM: dorsal longitudinal anastomotic vessel |
| Fibroblast growth factors (FGF) | 0.5636 | INHERITED FROM: intramembranous bone || olfactory region || dermatocranium |
| ets domain | 0.5636 | INHERITED FROM: myeloid leukocyte || granulocyte |
| Cadherin | 0.637 | INHERITED FROM: cranial nerve || diencephalic white matter || nerve || white matter || cranial nerve II || optic tectum |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.6578 | INHERITED FROM: cartilage element || splanchnocranium || olfactory region || ethmoid cartilage || pharyngeal arch cartilage || ventral mandibular arch || neurocranium || skeletal element || mandibular arch skeleton || pericardium || cranial cartilage || chondrocranium |
| HLH, helix-loop-helix DNA-binding domain | 0.6665 | INHERITED FROM: heart primordium || Kolmer-Agduhr neuron |
| Retrovirus zinc finger-like domains | 0.7415 | INHERITED FROM: gill || respiratory system || pharyngeal arch 3-7 || pharynx |
| Phenylalanine metabolism regulatory domain | 0.7415 | INHERITED FROM: ventral wall of dorsal aorta || axial blood vessel || dorsal aorta || artery |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7415 | INHERITED FROM: ventral wall of dorsal aorta || axial blood vessel || dorsal aorta || artery |
| Multidrug efflux transporter AcrB transmembrane domain | 0.7415 | INHERITED FROM: suspensorium || retinal ganglion cell layer || dorsal hyoid arch || skeletal muscle || slow muscle cell || hyosymplectic cartilage || pharyngeal arch 2 skeleton || ventral hyoid arch || skeletal muscle cell |
| Cytochrome P450 | 0.7528 | INHERITED FROM: hypophysis |
| T-box | 0.7777 | INHERITED FROM: primordial vasculature || pronephros || heart primordium || atrioventricular canal |
| HMG-box | 0.788 | INHERITED FROM: vagal ganglion || statoacoustic (VIII) ganglion || ganglion || dorsal root ganglion || ceratobranchial 5 bone |
| WW domain | 0.8068 | INHERITED FROM: striated muscle cell |
| MIR domain | 0.9741 | INHERITED FROM: skeletal muscle cell |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Matrix metalloproteases, catalytic domain | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| SRF-like | 0 | Direct |
| EF-hand modules in multidomain proteins | 0 | Direct |
| GLA-domain | 0 | Direct |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | Direct |
| Elongation factors | 0 | Direct |
| UBA domain | 0 | Direct |
| Leucine zipper domain | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | Direct |
| Arrestin/Vps26-like | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| FAD-linked reductases, N-terminal domain | 0 | Direct |
| Platelet-derived growth factor-like | 0 | Direct |
| Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | Direct |
| Actin/HSP70 | 0 | Direct |
| Mammalian PLC | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| F-box domain | 0 | Direct |
| Formin homology 2 domain (FH2 domain) | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| Extended AAA-ATPase domain | 0 | Direct |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Ephrin receptor ligand binding domain | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Hydantoinase (dihydropyrimidinase) | 0 | Direct |
| Sec7 domain | 0 | Direct |
| SNARE fusion complex | 0 | Direct |
| L domain | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| Laminin G-like module | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| Nitrogenase iron protein-like | 0 | Direct |
| Tropomyosin | 0 | Direct |
| Class I glutamine amidotransferases (GAT) | 0 | Direct |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | Direct |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0 | Direct |
| CalX-beta domain | 0 | Direct |
| LDL receptor-like module | 0 | Direct |
| MYND zinc finger | 0 | Direct |
| BAR domain | 0 | Direct |
| p120GAP domain-like | 0 | Direct |
| Eukaryotic proteases | 0 | Direct |
| L27 domain | 0 | Direct |
| Histone lysine methyltransferases | 0 | Direct |
| P4 origin-binding domain-like | 0 | Direct |
| Ephrin ectodomain | 0 | Direct |
| Cytoplasmic domain of inward rectifier potassium channel | 0 | Direct |
| Anion transport protein, cytoplasmic domain | 0 | Direct |
| V set domains (antibody variable domain-like) | 0 | Direct |
| Sema domain | 0 | Direct |
| 28-residue LRR | 0 | Direct |
| Clathrin coat assembly domain | 0 | Direct |
| Calmodulin-like | 0 | Direct |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
| Calpain large subunit, catalytic domain (domain II) | 0 | Direct |
| Adenylyl and guanylyl cyclase catalytic domain | 0 | Direct |
| Dual specificity phosphatase-like | 0 | Direct |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0 | Direct |
| Tudor domain | 0 | Direct |
| Plexin repeat | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Paired domain | 0 | Direct |
| Penta-EF-hand proteins | 0 | Direct |
| Calcium ATPase, transduction domain A | 0 | Direct |
| Growth factor receptor domain | 0 | Direct |
| POU-specific domain | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| Caspase recruitment domain, CARD | 0 | Direct |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
| Histone deacetylase, HDAC | 0 | Direct |
| Myeloperoxidase-like | 0 | Direct |
| Tubulin, GTPase domain | 0 | Direct |
| Gelsolin-like | 0 | Direct |
| RUNT domain | 0 | Direct |
| Noncollagenous (NC1) domain of collagen IV | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| Pyridoxal-dependent decarboxylase | 0 | Direct |
| CCCH zinc finger | 0 | Direct |
| PAPS sulfotransferase | 0 | Direct |
| DEATH domain, DD | 0 | Direct |
| Hairy Orange domain | 0 | Direct |
| Tubulin, C-terminal domain | 0 | Direct |
| CCHHC domain | 0 | Direct |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
| STAT | 0 | Direct |
| Link domain | 0 | Direct |
| Fibronectin type II module | 0 | Direct |
| LCCL domain | 0 | Direct |
| Connexin43 | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| Regulator of chromosome condensation RCC1 | 0 | Direct |
| Proprotein convertase P-domain | 0 | Direct |
| Reprolysin-like | 0 | Direct |
| Nucleotide and nucleoside kinases | 0 | Direct |
| Choline/Carnitine O-acyltransferase | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| Nicotinic receptor ligand binding domain-like | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Troponin T | 0 | Direct |
| TNF receptor-like | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| SMAD domain | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| FAS1 domain | 0 | Direct |
| Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) | 0 | Direct |
| Zf-UBP | 0 | Direct |
| Cyclin | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| Chromo domain | 0 | Direct |
| PB1 domain | 0 | Direct |
| Regulator of G-protein signaling, RGS | 0 | Direct |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | Direct |
| Dachshund-homology domain | 0 | Direct |
| SH2 domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Glycerophosphoryl diester phosphodiesterase | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| Subtilases | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Erythroid transcription factor GATA-1 | 0 | Direct |
| VWC domain | 0 | Direct |
| Tetramerization domain of potassium channels | 0 | Direct |
| DUSP, domain in ubiquitin-specific proteases | 0 | Direct |
| Armadillo repeat | 0 | Direct |
| Plakin repeat | 0 | Direct |
| Meta-cation ATPase, catalytic domain P | 0 | Direct |
| Long-chain cytokines | 0 | Direct |
| Myotubularin-like phosphatases | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| Prohormone convertase 1 pro-domain | 0 | Direct |
| Integrin domains | 0 | Direct |
| Caspase catalytic domain | 0 | Direct |
| First domain of FERM | 0 | Direct |
| BTB/POZ domain | 0 | Direct |
| Glutathione S-transferase (GST), C-terminal domain | 0 | Direct |
| Ubiquitin-related | 0 | Direct |
| STAT DNA-binding domain | 0 | Direct |
| BCR-homology GTPase activation domain (BH-domain) | 0 | Direct |
| Clathrin adaptor core protein | 0 | Direct |
| Cell cycle transcription factor e2f-dp | 0 | Direct |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0 | Direct |
| ALDH-like | 0 | Direct |
| PP2C-like | 0 | Direct |
| Notch domain | 0 | Direct |
| Ras GEF | 0 | Direct |
| Pentraxin (pentaxin) | 0 | Direct |
| Cdc48 N-terminal domain-like | 0 | Direct |
| FHA domain | 0 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
| GABA-aminotransferase-like | 0 | Direct |
| MMP N-terminal domain | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0 | Direct |
| Myosin rod fragments | 0 | Direct |
| Ovomucoid domain III-like | 0 | Direct |
| Single strand DNA-binding domain, SSB | 0 | Direct |
| Hemopexin-like domain | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
| SWIRM domain | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| Calcium ATPase, transmembrane domain M | 0 | Direct |
| WD40-repeat | 0.02457 | Inherited |
| Homeodomain | 0.02992 | Inherited |
| EGF-type module | 0.08731 | Inherited |
| I set domains | 0.09374 | Inherited |
| Motor proteins | 0.124 | Inherited |
| Nuclear receptor ligand-binding domain | 0.1529 | Inherited |
| Nuclear receptor | 0.1642 | Inherited |
| Transforming growth factor (TGF)-beta | 0.189 | Inherited |
| LIM domain | 0.3288 | Inherited |
| PDZ domain | 0.3647 | Inherited |
| Classic zinc finger, C2H2 | 0.4207 | Inherited |
| Fibronectin type III | 0.4207 | Inherited |
| DBL homology domain (DH-domain) | 0.4309 | Inherited |
| Myb/SANT domain | 0.4309 | Inherited |
| Bromodomain | 0.4623 | Inherited |
| Laminin-type module | 0.5275 | Inherited |
| Tetratricopeptide repeat (TPR) | 0.5343 | Inherited |
| Protein kinases, catalytic subunit | 0.5492 | Inherited |
| Fibroblast growth factors (FGF) | 0.5636 | Inherited |
| ets domain | 0.5636 | Inherited |
| Cadherin | 0.637 | Inherited |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.6578 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.6665 | Inherited |
| Retrovirus zinc finger-like domains | 0.7415 | Inherited |
| Phenylalanine metabolism regulatory domain | 0.7415 | Inherited |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7415 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.7415 | Inherited |
| Cytochrome P450 | 0.7528 | Inherited |
| T-box | 0.7777 | Inherited |
| HMG-box | 0.788 | Inherited |
| WW domain | 0.8068 | Inherited |
| MIR domain | 0.9741 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this ZA term (Not in SPZA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| HSP20-like chaperones | 0 | DIRECT |
| LDL receptor-like module | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Nucleotidylyl transferase | 0 | DIRECT |
| Hemopexin-like domain | 0 | DIRECT |
| CoA-dependent acyltransferases | 0 | DIRECT |
| UBA-like | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| Ypt/Rab-GAP domain of gyp1p | 0 | DIRECT |
| TNF receptor-like | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| SMAD/FHA domain | 0 | DIRECT |
| PLP-dependent transferases | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| ENTH/VHS domain | 0 | DIRECT |
| Actin-like ATPase domain | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| Alkaline phosphatase-like | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| Kazal-type serine protease inhibitors | 0 | DIRECT |
| HIT-like | 0 | DIRECT |
| Zinc beta-ribbon | 0 | DIRECT |
| Caspase-like | 0 | DIRECT |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
| BPTI-like | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| Kringle-like | 0 | DIRECT |
| Soluble quinoprotein glucose dehydrogenase | 0 | DIRECT |
| Plexin repeat | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| SET domain | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| CalX-like | 0 | DIRECT |
| Translation proteins SH3-like domain | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| DUSP-like | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| GST C-terminal domain-like | 0 | DIRECT |
| FAD/NAD(P)-binding domain | 0 | DIRECT |
| Leucine zipper domain | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Regulator of G-protein signaling, RGS | 0 | DIRECT |
| DEATH domain | 0 | DIRECT |
| SNARE-like | 0 | DIRECT |
| Tropomyosin | 0 | DIRECT |
| Cyclin-like | 0 | DIRECT |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | DIRECT |
| Orange domain-like | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| L27 domain | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Ras GEF | 0 | DIRECT |
| CCCH zinc finger | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| FAD-linked reductases, C-terminal domain | 0 | DIRECT |
| Nucleotide cyclase | 0 | DIRECT |
| F-box domain | 0 | DIRECT |
| Bet v1-like | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| Ricin B-like lectins | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0 | DIRECT |
| Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
| RCC1/BLIP-II | 0 | DIRECT |
| BRCT domain | 0 | DIRECT |
| Cullin repeat-like | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| SOCS box-like | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
| Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
| DPP6 N-terminal domain-like | 0 | DIRECT |
| HD-domain/PDEase-like | 0 | DIRECT |
| Translation proteins | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| POZ domain | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| alpha/beta-Hydrolases | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| Calcium ATPase, transmembrane domain M | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| SH2 domain | 0 | DIRECT |
| GTPase activation domain, GAP | 0 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | DIRECT |
| Calcium ATPase, transduction domain A | 0 | DIRECT |
| Class II aaRS and biotin synthetases | 0 | DIRECT |
| Myosin rod fragments | 0 | DIRECT |
| Galactose-binding domain-like | 0 | DIRECT |
| CAD & PB1 domains | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Aldolase | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| Metallo-dependent hydrolases | 0 | DIRECT |
| SNARE fusion complex | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Rhodanese/Cell cycle control phosphatase | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Trypsin-like serine proteases | 0 | DIRECT |
| STAT | 0 | DIRECT |
| Phoshotransferase/anion transport protein | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| Cupredoxins | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Riboflavin synthase domain-like | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
| LCCL domain | 0 | DIRECT |
| Actin depolymerizing proteins | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| Immunoglobulin | 0.02906 | INHERITED FROM: glomerular layer || white matter || medial longitudinal fasciculus || olfactory bulb glomerulus || synencephalon |
| Homeodomain-like | 0.03659 | INHERITED FROM: preoptic area || pancreatic A cell || dorsal telencephalon || diencephalon || endocrine cell || forebrain || cephalic musculature || endocrine pancreas |
| Growth factor receptor domain | 0.03724 | INHERITED FROM: intramembranous bone || blood vasculature || blood plasma || lymphatic system || posterior lateral line ganglion |
| WD40 repeat-like | 0.089 | INHERITED FROM: retinal outer nuclear layer || photoreceptor outer segment layer || retinal photoreceptor layer || eye || sensory system |
| Cystine-knot cytokines | 0.09224 | INHERITED FROM: spermatogenic cyst || cranial blood vessel || floor plate || pineal complex |
| Nuclear receptor ligand-binding domain | 0.1454 | INHERITED FROM: reproductive system || gonad || hypophysis || ovarian follicle stage IV |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.1454 | INHERITED FROM: VeLD || ovarian follicle stage IV || cardiac ventricle || Kolmer-Agduhr neuron |
| EGF/Laminin | 0.2523 | INHERITED FROM: lateral line ganglion || blood vasculature || lymph vessel || pars superior ear || lymphatic system || posterior lateral line ganglion || vasculature |
| Ankyrin repeat | 0.3017 | INHERITED FROM: ventricular zone |
| PDZ domain-like | 0.3017 | INHERITED FROM: central canal |
| C-type lectin-like | 0.3179 | INHERITED FROM: lymph vessel || lymphatic system || lymph vasculature || axial vasculature |
| FnI-like domain | 0.3179 | INHERITED FROM: chondral bone || palatoquadrate arch || replacement bone || skeletal system || skeletal element || palatoquadrate cartilage |
| Fibronectin type III | 0.4047 | INHERITED FROM: glomerular layer || white matter || medial longitudinal fasciculus || synencephalon |
| DBL homology domain (DH-domain) | 0.4206 | INHERITED FROM: vascular endothelium || blood vessel endothelial cell || blood vessel endothelium |
| Protein kinase-like (PK-like) | 0.4261 | INHERITED FROM: intersegmental vein |
| Bromodomain | 0.4516 | INHERITED FROM: hematopoietic system || blood |
| Cysteine proteinases | 0.4836 | INHERITED FROM: chondrocranium cartilage || cartilage element || splanchnocranium || neurocranium || ventral mandibular arch || ethmoid cartilage || pharyngeal arch cartilage || skeletal system || oral region || skeletal element || pericardium || olfactory region || chondrocranium || mandibular arch skeleton |
| Snake toxin-like | 0.5193 | INHERITED FROM: axial vasculature |
| lambda repressor-like DNA-binding domains | 0.5193 | INHERITED FROM: digestive system duct || diencephalon |
| Cytokine | 0.5576 | INHERITED FROM: intramembranous bone || skeletal element || olfactory region || dermatocranium || chondrocranium |
| Tudor/PWWP/MBT | 0.5576 | INHERITED FROM: reproductive system || primordial germ cell |
| Cadherin-like | 0.6025 | INHERITED FROM: diencephalic white matter || white matter || nerve || cranial nerve II || optic tectum || cranial nerve |
| p53-like transcription factors | 0.6052 | INHERITED FROM: Rohon-Beard neuron || primordial vasculature |
| beta-beta-alpha zinc fingers | 0.6187 | INHERITED FROM: ventral thalamus |
| Protease propeptides/inhibitors | 0.6393 | INHERITED FROM: optic tectum |
| GroEL-intermediate domain like | 0.6393 | INHERITED FROM: skeletal muscle || musculature system || skeletal muscle cell || muscle cell || myotome || striated muscle cell || trunk musculature |
| Multidrug efflux transporter AcrB transmembrane domain | 0.6393 | INHERITED FROM: skeletal muscle || dorsal hyoid arch || suspensorium || hyosymplectic cartilage || skeletal muscle cell || retinal ganglion cell layer || striated muscle cell |
| HLH, helix-loop-helix DNA-binding domain | 0.6502 | INHERITED FROM: heart primordium || Kolmer-Agduhr neuron |
| Retrovirus zinc finger-like domains | 0.7315 | INHERITED FROM: pharyngeal arch 3-7 || respiratory system || pharynx || gill |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7315 | INHERITED FROM: ventral wall of dorsal aorta || axial blood vessel || artery || dorsal aorta |
| ACT-like | 0.7315 | INHERITED FROM: ventral wall of dorsal aorta || axial blood vessel || artery || dorsal aorta |
| BAR/IMD domain-like | 0.7394 | INHERITED FROM: olfactory system |
| Cytochrome P450 | 0.7394 | INHERITED FROM: hypophysis |
| HMG-box | 0.7765 | INHERITED FROM: ceratobranchial 5 bone || ganglion || statoacoustic (VIII) ganglion || vagal ganglion || dorsal root ganglion |
| Serine protease inhibitors | 0.7831 | INHERITED FROM: otolith organ || vestibuloauditory system || otolith || inner ear |
| IP3 receptor type 1 binding core, domain 2 | 0.7831 | INHERITED FROM: skeletal muscle || skeletal muscle cell || muscle cell || striated muscle cell |
| WW domain | 0.7981 | INHERITED FROM: striated muscle cell |
| NAD(P)-binding Rossmann-fold domains | 0.8413 | INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer |
| GroEL equatorial domain-like | 0.8576 | INHERITED FROM: skeletal muscle || skeletal muscle cell || muscle cell || myotome || striated muscle cell || trunk musculature |
| GroEL apical domain-like | 0.8886 | INHERITED FROM: skeletal muscle || skeletal muscle cell || muscle cell || myotome || striated muscle cell || trunk musculature |
| MIR domain | 0.9721 | INHERITED FROM: skeletal muscle cell |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| HSP20-like chaperones | 0 | Direct |
| LDL receptor-like module | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Nucleotidylyl transferase | 0 | Direct |
| Hemopexin-like domain | 0 | Direct |
| CoA-dependent acyltransferases | 0 | Direct |
| UBA-like | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| Nicotinic receptor ligand binding domain-like | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| Ypt/Rab-GAP domain of gyp1p | 0 | Direct |
| TNF receptor-like | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| SMAD/FHA domain | 0 | Direct |
| PLP-dependent transferases | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| Translational machinery components | 0 | Direct |
| ENTH/VHS domain | 0 | Direct |
| Actin-like ATPase domain | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| Alkaline phosphatase-like | 0 | Direct |
| FAS1 domain | 0 | Direct |
| Kazal-type serine protease inhibitors | 0 | Direct |
| HIT-like | 0 | Direct |
| Zinc beta-ribbon | 0 | Direct |
| Caspase-like | 0 | Direct |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
| BPTI-like | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| Kringle-like | 0 | Direct |
| Soluble quinoprotein glucose dehydrogenase | 0 | Direct |
| Plexin repeat | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| SET domain | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| Formin homology 2 domain (FH2 domain) | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| CalX-like | 0 | Direct |
| Translation proteins SH3-like domain | 0 | Direct |
| CCHHC domain | 0 | Direct |
| DUSP-like | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| GST C-terminal domain-like | 0 | Direct |
| FAD/NAD(P)-binding domain | 0 | Direct |
| Leucine zipper domain | 0 | Direct |
| PP2C-like | 0 | Direct |
| Regulator of G-protein signaling, RGS | 0 | Direct |
| DEATH domain | 0 | Direct |
| SNARE-like | 0 | Direct |
| Tropomyosin | 0 | Direct |
| Cyclin-like | 0 | Direct |
| Metal cation-transporting ATPase, ATP-binding domain N | 0 | Direct |
| Orange domain-like | 0 | Direct |
| Integrin domains | 0 | Direct |
| ADC-like | 0 | Direct |
| L27 domain | 0 | Direct |
| Sema domain | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Ras GEF | 0 | Direct |
| CCCH zinc finger | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| FAD-linked reductases, C-terminal domain | 0 | Direct |
| Nucleotide cyclase | 0 | Direct |
| F-box domain | 0 | Direct |
| Bet v1-like | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| Ricin B-like lectins | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Ribosomal protein S5 domain 2-like | 0 | Direct |
| Composite domain of metallo-dependent hydrolases | 0 | Direct |
| RCC1/BLIP-II | 0 | Direct |
| BRCT domain | 0 | Direct |
| Cullin repeat-like | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| SOCS box-like | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| GLA-domain | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| PGBD-like | 0 | Direct |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
| Glutathione synthetase ATP-binding domain-like | 0 | Direct |
| DPP6 N-terminal domain-like | 0 | Direct |
| HD-domain/PDEase-like | 0 | Direct |
| Translation proteins | 0 | Direct |
| Notch domain | 0 | Direct |
| Polo-box domain | 0 | Direct |
| POZ domain | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| alpha/beta-Hydrolases | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| ALDH-like | 0 | Direct |
| NTF2-like | 0 | Direct |
| Calcium ATPase, transmembrane domain M | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| SH2 domain | 0 | Direct |
| GTPase activation domain, GAP | 0 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | Direct |
| Calcium ATPase, transduction domain A | 0 | Direct |
| Class II aaRS and biotin synthetases | 0 | Direct |
| Myosin rod fragments | 0 | Direct |
| Galactose-binding domain-like | 0 | Direct |
| CAD & PB1 domains | 0 | Direct |
| Plakin repeat | 0 | Direct |
| SRF-like | 0 | Direct |
| Aldolase | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| Calpain large subunit, middle domain (domain III) | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| Metallo-dependent hydrolases | 0 | Direct |
| SNARE fusion complex | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Rhodanese/Cell cycle control phosphatase | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Trypsin-like serine proteases | 0 | Direct |
| STAT | 0 | Direct |
| Phoshotransferase/anion transport protein | 0 | Direct |
| Sec7 domain | 0 | Direct |
| Cupredoxins | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Riboflavin synthase domain-like | 0 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
| LCCL domain | 0 | Direct |
| Actin depolymerizing proteins | 0 | Direct |
| Connexin43 | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| GroES-like | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| Immunoglobulin | 0.02906 | Inherited |
| Homeodomain-like | 0.03659 | Inherited |
| Growth factor receptor domain | 0.03724 | Inherited |
| WD40 repeat-like | 0.089 | Inherited |
| Cystine-knot cytokines | 0.09224 | Inherited |
| Nuclear receptor ligand-binding domain | 0.1454 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.1454 | Inherited |
| EGF/Laminin | 0.2523 | Inherited |
| Ankyrin repeat | 0.3017 | Inherited |
| PDZ domain-like | 0.3017 | Inherited |
| C-type lectin-like | 0.3179 | Inherited |
| FnI-like domain | 0.3179 | Inherited |
| Fibronectin type III | 0.4047 | Inherited |
| DBL homology domain (DH-domain) | 0.4206 | Inherited |
| Protein kinase-like (PK-like) | 0.4261 | Inherited |
| Bromodomain | 0.4516 | Inherited |
| Cysteine proteinases | 0.4836 | Inherited |
| Snake toxin-like | 0.5193 | Inherited |
| lambda repressor-like DNA-binding domains | 0.5193 | Inherited |
| Cytokine | 0.5576 | Inherited |
| Tudor/PWWP/MBT | 0.5576 | Inherited |
| Cadherin-like | 0.6025 | Inherited |
| p53-like transcription factors | 0.6052 | Inherited |
| beta-beta-alpha zinc fingers | 0.6187 | Inherited |
| Protease propeptides/inhibitors | 0.6393 | Inherited |
| GroEL-intermediate domain like | 0.6393 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.6393 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.6502 | Inherited |
| Retrovirus zinc finger-like domains | 0.7315 | Inherited |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7315 | Inherited |
| ACT-like | 0.7315 | Inherited |
| BAR/IMD domain-like | 0.7394 | Inherited |
| Cytochrome P450 | 0.7394 | Inherited |
| HMG-box | 0.7765 | Inherited |
| Serine protease inhibitors | 0.7831 | Inherited |
| IP3 receptor type 1 binding core, domain 2 | 0.7831 | Inherited |
| WW domain | 0.7981 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 0.8413 | Inherited |
| GroEL equatorial domain-like | 0.8576 | Inherited |
| GroEL apical domain-like | 0.8886 | Inherited |
| MIR domain | 0.9721 | Inherited |
(show details)
Supra-domains annotated to this ZA term (Not in SPZA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | DIRECT |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | DIRECT |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | DIRECT |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0 | DIRECT |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | DIRECT |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0 | DIRECT |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | DIRECT |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | DIRECT |
101288,50156
101288 - L27 domain
50156 - PDZ domain-like | 0 | DIRECT |
52058,49265
52058 - L domain-like
49265 - Fibronectin type III | 0 | DIRECT |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | DIRECT |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | DIRECT |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
89837,89837
89837 - Doublecortin (DC)
89837 - Doublecortin (DC) | 0 | DIRECT |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | DIRECT |
81324,81324
81324 - Voltage-gated potassium channels
81324 - Voltage-gated potassium channels | 0 | DIRECT |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0 | DIRECT |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0 | DIRECT |
49785,57184
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
46966,47473
46966 - Spectrin repeat
47473 - EF-hand | 0 | DIRECT |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0 | DIRECT |
103575,81296
103575 - Plexin repeat
81296 - E set domains | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
49562,48350
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | DIRECT |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | DIRECT |
111418,81321
111418 - Hormone receptor domain
81321 - Family A G protein-coupled receptor-like | 0 | DIRECT |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
49854,49785
49854 - Spermadhesin, CUB domain
49785 - Galactose-binding domain-like | 0 | DIRECT |
82199,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers | 0 | DIRECT |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | DIRECT |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | DIRECT |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
57196,49854
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0 | DIRECT |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0 | DIRECT |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | DIRECT |
141072,141072
141072 - CalX-like
141072 - CalX-like | 0 | DIRECT |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0 | DIRECT |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49785,49899
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0 | DIRECT |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | DIRECT |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | DIRECT |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0 | DIRECT |
57184,57603
57184 - Growth factor receptor domain
57603 - FnI-like domain | 0 | DIRECT |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
81296,81296
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | DIRECT |
54001,143791
54001 - Cysteine proteinases
143791 - DUSP-like | 0 | DIRECT |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | DIRECT |
49265,49899
49265 - Fibronectin type III
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
100909,49899
100909 - IP3 receptor type 1 binding core, domain 2
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | DIRECT |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0 | DIRECT |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0 | DIRECT |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0 | DIRECT |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0 | DIRECT |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | DIRECT |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | DIRECT |
90257,57997
90257 - Myosin rod fragments
57997 - Tropomyosin | 0 | DIRECT |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0 | DIRECT |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
48097,56112
48097 - Regulator of G-protein signaling, RGS
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
82109,82109
82109 - MIR domain
82109 - MIR domain | 0 | DIRECT |
49854,57196
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin | 0 | DIRECT |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | DIRECT |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0 | DIRECT |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | DIRECT |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 0 | DIRECT |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | DIRECT |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0 | DIRECT |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0 | DIRECT |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0 | DIRECT |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | DIRECT |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.0319 | INHERITED FROM: white matter || medial longitudinal fasciculus || synencephalon |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.06893 | INHERITED FROM: lateral line ganglion || blood vasculature || lymph vessel || lymphatic system || posterior lateral line ganglion || vasculature |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.1454 | INHERITED FROM: VeLD || heart || cardiac ventricle || Kolmer-Agduhr neuron |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.24 | INHERITED FROM: white matter || medial longitudinal fasciculus || brainstem || brain nucleus || synencephalon |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.4516 | INHERITED FROM: vascular endothelium || blood vessel endothelial cell || blood vessel endothelium |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.4536 | INHERITED FROM: head kidney |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6393 | INHERITED FROM: skeletal muscle || musculature system || skeletal muscle cell || muscle cell || myotome || striated muscle cell || trunk musculature |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.6393 | INHERITED FROM: skeletal muscle || musculature system || skeletal muscle cell || muscle cell || myotome || striated muscle cell || trunk musculature |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.656 | INHERITED FROM: diencephalic white matter || white matter || nerve || cranial nerve II || optic tectum || cranial nerve || retinal ganglion cell layer |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0.6844 | INHERITED FROM: myotome || trunk musculature |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.7102 | INHERITED FROM: renal system || pronephros |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.7263 | INHERITED FROM: thalamus || ventral thalamus |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7315 | INHERITED FROM: ventral wall of dorsal aorta || axial blood vessel || artery || dorsal aorta |
82109,100909
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0.7831 | INHERITED FROM: skeletal muscle || skeletal muscle cell || muscle cell || striated muscle cell |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 0.8576 | INHERITED FROM: retinal outer nuclear layer || eye photoreceptor cell |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | Direct |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | Direct |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | Direct |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0 | Direct |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | Direct |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0 | Direct |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | Direct |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | Direct |
101288,50156
101288 - L27 domain
50156 - PDZ domain-like | 0 | Direct |
52058,49265
52058 - L domain-like
49265 - Fibronectin type III | 0 | Direct |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | Direct |
54001,49758
54001 - Cysteine proteinases
49758 - Calpain large subunit, middle domain (domain III) | 0 | Direct |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
89837,89837
89837 - Doublecortin (DC)
89837 - Doublecortin (DC) | 0 | Direct |
56784,81665
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | Direct |
81324,81324
81324 - Voltage-gated potassium channels
81324 - Voltage-gated potassium channels | 0 | Direct |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0 | Direct |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0 | Direct |
49785,57184
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | Direct |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0 | Direct |
46966,47473
46966 - Spectrin repeat
47473 - EF-hand | 0 | Direct |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0 | Direct |
103575,81296
103575 - Plexin repeat
81296 - E set domains | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
49562,48350
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | Direct |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | Direct |
111418,81321
111418 - Hormone receptor domain
81321 - Family A G protein-coupled receptor-like | 0 | Direct |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
49854,49785
49854 - Spermadhesin, CUB domain
49785 - Galactose-binding domain-like | 0 | Direct |
82199,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers | 0 | Direct |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | Direct |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | Direct |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
57196,49854
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | Direct |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0 | Direct |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0 | Direct |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | Direct |
141072,141072
141072 - CalX-like
141072 - CalX-like | 0 | Direct |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0 | Direct |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
49785,49899
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0 | Direct |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | Direct |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | Direct |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
81660,56784
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like | 0 | Direct |
57184,57603
57184 - Growth factor receptor domain
57603 - FnI-like domain | 0 | Direct |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
81296,81296
81296 - E set domains
81296 - E set domains | 0 | Direct |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | Direct |
54001,143791
54001 - Cysteine proteinases
143791 - DUSP-like | 0 | Direct |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | Direct |
49265,49899
49265 - Fibronectin type III
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
100909,49899
100909 - IP3 receptor type 1 binding core, domain 2
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | Direct |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0 | Direct |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0 | Direct |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0 | Direct |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | Direct |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0 | Direct |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | Direct |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | Direct |
90257,57997
90257 - Myosin rod fragments
57997 - Tropomyosin | 0 | Direct |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0 | Direct |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
48097,56112
48097 - Regulator of G-protein signaling, RGS
56112 - Protein kinase-like (PK-like) | 0 | Direct |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
82109,82109
82109 - MIR domain
82109 - MIR domain | 0 | Direct |
49854,57196
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin | 0 | Direct |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | Direct |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0 | Direct |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | Direct |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 0 | Direct |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | Direct |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | Direct |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | Direct |
49758,47473
49758 - Calpain large subunit, middle domain (domain III)
47473 - EF-hand | 0 | Direct |
56112,47769
56112 - Protein kinase-like (PK-like)
47769 - SAM/Pointed domain | 0 | Direct |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | Direct |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0 | Direct |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | Direct |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.0319 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.06893 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.1454 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.24 | Inherited |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.4516 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.4536 | Inherited |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6393 | Inherited |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.6393 | Inherited |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.656 | Inherited |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0.6844 | Inherited |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.7102 | Inherited |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.7263 | Inherited |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7315 | Inherited |
82109,100909
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0.7831 | Inherited |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 0.8576 | Inherited |
(show details)
Supra-domains annotated to this ZA term (Not in SPZA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
57196,63825,57196
57196 - EGF/Laminin
63825 - YWTD domain
57196 - EGF/Laminin | 0 | DIRECT |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | DIRECT |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | DIRECT |
49854,49785,49785
49854 - Spermadhesin, CUB domain
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
90257,90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0 | DIRECT |
55753,55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | DIRECT |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
82109,100909,49899
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0 | DIRECT |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
49854,57196,49854
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
49785,49785,49899
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
90193,90193,90193
90193 - Notch domain
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
52743,49785,57184
52743 - Subtilisin-like
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0 | DIRECT |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
49899,57196,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0 | DIRECT |
82109,82109,100909
82109 - MIR domain
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
75399,75399,75399
75399 - Plakin repeat
75399 - Plakin repeat
75399 - Plakin repeat | 0 | DIRECT |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | DIRECT |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0 | DIRECT |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
57184,52058,49265
57184 - Growth factor receptor domain
52058 - L domain-like
49265 - Fibronectin type III | 0 | DIRECT |
82199,57667,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0 | DIRECT |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
103575,81296,81296
103575 - Plexin repeat
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
46966,46966,47473
46966 - Spectrin repeat
46966 - Spectrin repeat
47473 - EF-hand | 0 | DIRECT |
57196,90193,90193
57196 - EGF/Laminin
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
52058,49265,49265
52058 - L domain-like
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.06359 | INHERITED FROM: white matter || medial longitudinal fasciculus || synencephalon |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.3179 | INHERITED FROM: white matter || medial longitudinal fasciculus || brainstem || brain nucleus || skeletal muscle cell || synencephalon |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.3932 | INHERITED FROM: cardiac ventricle |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6393 | INHERITED FROM: skeletal muscle || musculature system || skeletal muscle cell || muscle cell || myotome || striated muscle cell || trunk musculature |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.6842 | INHERITED FROM: diencephalic white matter || white matter || nerve || macula || cranial nerve II || optic tectum || cranial nerve || retinal ganglion cell layer |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
57196,63825,57196
57196 - EGF/Laminin
63825 - YWTD domain
57196 - EGF/Laminin | 0 | Direct |
81660,56784,81665
81660 - Metal cation-transporting ATPase, ATP-binding domain N
56784 - HAD-like
81665 - Calcium ATPase, transmembrane domain M | 0 | Direct |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | Direct |
49854,49785,49785
49854 - Spermadhesin, CUB domain
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
90257,90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0 | Direct |
55753,55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | Direct |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
82109,100909,49899
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0 | Direct |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
49854,57196,49854
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | Direct |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
49785,49785,49899
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
90193,90193,90193
90193 - Notch domain
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
52743,49785,57184
52743 - Subtilisin-like
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | Direct |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0 | Direct |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
49899,57196,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0 | Direct |
82109,82109,100909
82109 - MIR domain
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
75399,75399,75399
75399 - Plakin repeat
75399 - Plakin repeat
75399 - Plakin repeat | 0 | Direct |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | Direct |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | Direct |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0 | Direct |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
57184,52058,49265
57184 - Growth factor receptor domain
52058 - L domain-like
49265 - Fibronectin type III | 0 | Direct |
82199,57667,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0 | Direct |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
103575,81296,81296
103575 - Plexin repeat
81296 - E set domains
81296 - E set domains | 0 | Direct |
46966,46966,47473
46966 - Spectrin repeat
46966 - Spectrin repeat
47473 - EF-hand | 0 | Direct |
57196,90193,90193
57196 - EGF/Laminin
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
52058,49265,49265
52058 - L domain-like
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.06359 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.3179 | Inherited |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.3932 | Inherited |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6393 | Inherited |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.6842 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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