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Zebrafish Anatomy (ZA): anatomical group
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: ZA Hierarchy (zebrafish anatomy from ZFIN zebrafish anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Superfamily domains annotated to this ZA term (Not in SDZA)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Plexin repeat | 0 | DIRECT |
| LDL receptor-like module | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| Caspase-like | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| CalX-like | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Cyclin-like | 0 | DIRECT |
| Nucleotidylyl transferase | 0 | DIRECT |
| Nuclear receptor ligand-binding domain | 0 | DIRECT |
| Metallo-dependent hydrolases | 0 | DIRECT |
| Hemopexin-like domain | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| BPTI-like | 0 | DIRECT |
| CoA-dependent acyltransferases | 0 | DIRECT |
| Rhodanese/Cell cycle control phosphatase | 0 | DIRECT |
| G protein-binding domain | 0 | DIRECT |
| POZ domain | 0 | DIRECT |
| SH2 domain | 0 | DIRECT |
| Ras GEF | 0 | DIRECT |
| UBA-like | 0 | DIRECT |
| DPP6 N-terminal domain-like | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| HSP20-like chaperones | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Trypsin-like serine proteases | 0 | DIRECT |
| Regulator of G-protein signaling, RGS | 0 | DIRECT |
| alpha/beta-Hydrolases | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| Myosin rod fragments | 0 | DIRECT |
| SNARE-like | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| Tudor/PWWP/MBT | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| CCCH zinc finger | 0 | DIRECT |
| TNF receptor-like | 0 | DIRECT |
| Translation proteins SH3-like domain | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
| Kazal-type serine protease inhibitors | 0 | DIRECT |
| HD-domain/PDEase-like | 0 | DIRECT |
| SMAD/FHA domain | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| Class II aaRS and biotin synthetases | 0 | DIRECT |
| Actin-like ATPase domain | 0 | DIRECT |
| DUSP-like | 0 | DIRECT |
| Nucleotide cyclase | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| STAT | 0 | DIRECT |
| SOCS box-like | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| PLP-dependent transferases | 0 | DIRECT |
| GST C-terminal domain-like | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| Growth factor receptor domain | 0 | DIRECT |
| Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| FAD-linked reductases, C-terminal domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| DEATH domain | 0 | DIRECT |
| Actin depolymerizing proteins | 0 | DIRECT |
| Kringle-like | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| BRCT domain | 0 | DIRECT |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
| ENTH/VHS domain | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| GTPase activation domain, GAP | 0 | DIRECT |
| RCC1/BLIP-II | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
| CAD & PB1 domains | 0 | DIRECT |
| Bromodomain | 0 | DIRECT |
| LCCL domain | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Translation proteins | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| Riboflavin synthase domain-like | 0 | DIRECT |
| FAD/NAD(P)-binding domain | 0 | DIRECT |
| Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
| Bet v1-like | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| Phoshotransferase/anion transport protein | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Leucine zipper domain | 0 | DIRECT |
| Galactose-binding domain-like | 0 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| SET domain | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| Zinc beta-ribbon | 0 | DIRECT |
| Alkaline phosphatase-like | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| Orange domain-like | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| F-box domain | 0 | DIRECT |
| HIT/MYND zinc finger-like | 0 | DIRECT |
| Cupredoxins | 0 | DIRECT |
| Soluble quinoprotein glucose dehydrogenase | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| SNARE fusion complex | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Tropomyosin | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| HIT-like | 0 | DIRECT |
| Immunoglobulin | 0.04401 | INHERITED FROM: olfactory bulb glomerulus || medial longitudinal fasciculus || white matter |
| Homeodomain-like | 0.05438 | INHERITED FROM: endocrine pancreas || forebrain || cephalic musculature || endocrine cell || diencephalon || preoptic area |
| EGF/Laminin | 0.06674 | INHERITED FROM: posterior lateral line ganglion || vasculature || lymph vessel || pars superior ear || lymphatic system || lateral line ganglion |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.07506 | INHERITED FROM: Kolmer-Agduhr neuron || cardiac ventricle || VeLD |
| Cystine-knot cytokines | 0.1237 | INHERITED FROM: spermatogenic cyst || cranial blood vessel |
| WD40 repeat-like | 0.1243 | INHERITED FROM: photoreceptor outer segment layer |
| C-type lectin-like | 0.3788 | INHERITED FROM: axial vasculature || lymph vessel || lymphatic system |
| FnI-like domain | 0.3788 | INHERITED FROM: palatoquadrate cartilage || skeletal system || palatoquadrate arch || chondral bone || skeletal element || replacement bone |
| Protein kinase-like (PK-like) | 0.4281 | INHERITED FROM: intersegmental vein |
| DBL homology domain (DH-domain) | 0.458 | INHERITED FROM: blood vessel endothelial cell || vascular endothelium || blood vessel endothelium |
| Fibronectin type III | 0.4593 | INHERITED FROM: medial longitudinal fasciculus || white matter || glomerular layer || synencephalon |
| Snake toxin-like | 0.5539 | INHERITED FROM: axial vasculature |
| Cysteine proteinases | 0.5545 | INHERITED FROM: neurocranium || ethmoid cartilage || chondrocranium cartilage || splanchnocranium || mandibular arch skeleton || oral region || pharyngeal arch cartilage || pericardium || cranial cartilage || olfactory region || skeletal element || cartilage element || chondrocranium || ventral mandibular arch |
| Cytokine | 0.5886 | INHERITED FROM: dermatocranium || intramembranous bone || olfactory region |
| lambda repressor-like DNA-binding domains | 0.5886 | INHERITED FROM: diencephalon || digestive system duct |
| PDZ domain-like | 0.5962 | INHERITED FROM: central canal |
| Cadherin-like | 0.6327 | INHERITED FROM: diencephalic white matter || optic tectum || cranial nerve II || cranial nerve || white matter |
| p53-like transcription factors | 0.6352 | INHERITED FROM: primordial vasculature |
| Protease propeptides/inhibitors | 0.6662 | INHERITED FROM: optic tectum |
| beta-beta-alpha zinc fingers | 0.6662 | INHERITED FROM: ventral thalamus |
| Multidrug efflux transporter AcrB transmembrane domain | 0.6662 | INHERITED FROM: hyosymplectic cartilage || skeletal muscle cell || dorsal hyoid arch || retinal ganglion cell layer || striated muscle cell || skeletal muscle |
| GroEL-intermediate domain like | 0.6662 | INHERITED FROM: myotome || muscle cell || skeletal muscle cell || musculature system || striated muscle cell || skeletal muscle || trunk musculature |
| HLH, helix-loop-helix DNA-binding domain | 0.68 | INHERITED FROM: heart primordium || Kolmer-Agduhr neuron |
| NAD(P)-binding Rossmann-fold domains | 0.682 | INHERITED FROM: retinal outer plexiform layer || retinal inner plexiform layer |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7521 | INHERITED FROM: ventral wall of dorsal aorta || axial blood vessel || dorsal aorta |
| ACT-like | 0.7521 | INHERITED FROM: ventral wall of dorsal aorta || axial blood vessel || dorsal aorta |
| Retrovirus zinc finger-like domains | 0.7521 | INHERITED FROM: pharyngeal arch 3-7 |
| Cytochrome P450 | 0.7864 | INHERITED FROM: hypophysis |
| HMG-box | 0.7944 | INHERITED FROM: ganglion || dorsal root ganglion || statoacoustic (VIII) ganglion || ceratobranchial 5 bone || vagal ganglion |
| IP3 receptor type 1 binding core, domain 2 | 0.7979 | INHERITED FROM: muscle cell || skeletal muscle cell || striated muscle cell || skeletal muscle |
| Serine protease inhibitors | 0.7979 | INHERITED FROM: otolith organ || inner ear || vestibuloauditory system || otolith |
| GroEL equatorial domain-like | 0.8724 | INHERITED FROM: myotome || muscle cell || skeletal muscle cell || striated muscle cell || skeletal muscle || trunk musculature |
| GroEL apical domain-like | 0.8989 | INHERITED FROM: myotome || muscle cell || skeletal muscle cell || striated muscle cell || skeletal muscle || trunk musculature |
| MIR domain | 0.9748 | INHERITED FROM: skeletal muscle cell |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Plexin repeat | 0 | Direct |
| LDL receptor-like module | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| Caspase-like | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| CalX-like | 0 | Direct |
| ALDH-like | 0 | Direct |
| Cyclin-like | 0 | Direct |
| Nucleotidylyl transferase | 0 | Direct |
| Nuclear receptor ligand-binding domain | 0 | Direct |
| Metallo-dependent hydrolases | 0 | Direct |
| Hemopexin-like domain | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| BPTI-like | 0 | Direct |
| CoA-dependent acyltransferases | 0 | Direct |
| Rhodanese/Cell cycle control phosphatase | 0 | Direct |
| G protein-binding domain | 0 | Direct |
| POZ domain | 0 | Direct |
| SH2 domain | 0 | Direct |
| Ras GEF | 0 | Direct |
| UBA-like | 0 | Direct |
| DPP6 N-terminal domain-like | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| HSP20-like chaperones | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Trypsin-like serine proteases | 0 | Direct |
| Regulator of G-protein signaling, RGS | 0 | Direct |
| alpha/beta-Hydrolases | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| Myosin rod fragments | 0 | Direct |
| SNARE-like | 0 | Direct |
| Sec7 domain | 0 | Direct |
| Tudor/PWWP/MBT | 0 | Direct |
| ADC-like | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| CCCH zinc finger | 0 | Direct |
| TNF receptor-like | 0 | Direct |
| Translation proteins SH3-like domain | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Composite domain of metallo-dependent hydrolases | 0 | Direct |
| Kazal-type serine protease inhibitors | 0 | Direct |
| HD-domain/PDEase-like | 0 | Direct |
| SMAD/FHA domain | 0 | Direct |
| FAS1 domain | 0 | Direct |
| Class II aaRS and biotin synthetases | 0 | Direct |
| Actin-like ATPase domain | 0 | Direct |
| DUSP-like | 0 | Direct |
| Nucleotide cyclase | 0 | Direct |
| GLA-domain | 0 | Direct |
| STAT | 0 | Direct |
| SOCS box-like | 0 | Direct |
| PGBD-like | 0 | Direct |
| PLP-dependent transferases | 0 | Direct |
| GST C-terminal domain-like | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| Growth factor receptor domain | 0 | Direct |
| Formin homology 2 domain (FH2 domain) | 0 | Direct |
| Connexin43 | 0 | Direct |
| FAD-linked reductases, C-terminal domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Integrin domains | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| GroES-like | 0 | Direct |
| DEATH domain | 0 | Direct |
| Actin depolymerizing proteins | 0 | Direct |
| Kringle-like | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| Notch domain | 0 | Direct |
| Ribosomal protein S5 domain 2-like | 0 | Direct |
| NTF2-like | 0 | Direct |
| BRCT domain | 0 | Direct |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
| ENTH/VHS domain | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| GTPase activation domain, GAP | 0 | Direct |
| RCC1/BLIP-II | 0 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
| CAD & PB1 domains | 0 | Direct |
| Bromodomain | 0 | Direct |
| LCCL domain | 0 | Direct |
| Translational machinery components | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Translation proteins | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| Riboflavin synthase domain-like | 0 | Direct |
| FAD/NAD(P)-binding domain | 0 | Direct |
| Glutathione synthetase ATP-binding domain-like | 0 | Direct |
| Bet v1-like | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| Phoshotransferase/anion transport protein | 0 | Direct |
| CCHHC domain | 0 | Direct |
| PP2C-like | 0 | Direct |
| Leucine zipper domain | 0 | Direct |
| Galactose-binding domain-like | 0 | Direct |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| SET domain | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| Zinc beta-ribbon | 0 | Direct |
| Alkaline phosphatase-like | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| SRF-like | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Polo-box domain | 0 | Direct |
| Nicotinic receptor ligand binding domain-like | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| Orange domain-like | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| Sema domain | 0 | Direct |
| F-box domain | 0 | Direct |
| HIT/MYND zinc finger-like | 0 | Direct |
| Cupredoxins | 0 | Direct |
| Soluble quinoprotein glucose dehydrogenase | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| SNARE fusion complex | 0 | Direct |
| Plakin repeat | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Tropomyosin | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| HIT-like | 0 | Direct |
| Immunoglobulin | 0.04401 | Inherited |
| Homeodomain-like | 0.05438 | Inherited |
| EGF/Laminin | 0.06674 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.07506 | Inherited |
| Cystine-knot cytokines | 0.1237 | Inherited |
| WD40 repeat-like | 0.1243 | Inherited |
| C-type lectin-like | 0.3788 | Inherited |
| FnI-like domain | 0.3788 | Inherited |
| Protein kinase-like (PK-like) | 0.4281 | Inherited |
| DBL homology domain (DH-domain) | 0.458 | Inherited |
| Fibronectin type III | 0.4593 | Inherited |
| Snake toxin-like | 0.5539 | Inherited |
| Cysteine proteinases | 0.5545 | Inherited |
| Cytokine | 0.5886 | Inherited |
| lambda repressor-like DNA-binding domains | 0.5886 | Inherited |
| PDZ domain-like | 0.5962 | Inherited |
| Cadherin-like | 0.6327 | Inherited |
| p53-like transcription factors | 0.6352 | Inherited |
| Protease propeptides/inhibitors | 0.6662 | Inherited |
| beta-beta-alpha zinc fingers | 0.6662 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.6662 | Inherited |
| GroEL-intermediate domain like | 0.6662 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.68 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 0.682 | Inherited |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7521 | Inherited |
| ACT-like | 0.7521 | Inherited |
| Retrovirus zinc finger-like domains | 0.7521 | Inherited |
| Cytochrome P450 | 0.7864 | Inherited |
| HMG-box | 0.7944 | Inherited |
| IP3 receptor type 1 binding core, domain 2 | 0.7979 | Inherited |
| Serine protease inhibitors | 0.7979 | Inherited |
| GroEL equatorial domain-like | 0.8724 | Inherited |
| GroEL apical domain-like | 0.8989 | Inherited |
| MIR domain | 0.9748 | Inherited |
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this ZA term (Not in SDZA)
Highlighted in gray are those with FDR_all>0.001
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0 | DIRECT |
| STAT DNA-binding domain | 0 | DIRECT |
| Calcium ATPase, transmembrane domain M | 0 | DIRECT |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0 | DIRECT |
| Erythroid transcription factor GATA-1 | 0 | DIRECT |
| STAT | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Platelet-derived growth factor-like | 0 | DIRECT |
| Cdc48 N-terminal domain-like | 0 | DIRECT |
| Link domain | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| p120GAP domain-like | 0 | DIRECT |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0 | DIRECT |
| Ephrin ectodomain | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| FAD-linked reductases, N-terminal domain | 0 | DIRECT |
| Choline/Carnitine O-acyltransferase | 0 | DIRECT |
| VWC domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | DIRECT |
| Pentraxin (pentaxin) | 0 | DIRECT |
| EGF-type module | 0 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | DIRECT |
| PB1 domain | 0 | DIRECT |
| Dual specificity phosphatase-like | 0 | DIRECT |
| Caspase recruitment domain, CARD | 0 | DIRECT |
| Regulator of G-protein signaling, RGS | 0 | DIRECT |
| Nuclear receptor | 0 | DIRECT |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | DIRECT |
| Proprotein convertase P-domain | 0 | DIRECT |
| F-box domain | 0 | DIRECT |
| Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
| Laminin G-like module | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| Troponin T | 0 | DIRECT |
| Reprolysin-like | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
| Histone deacetylase, HDAC | 0 | DIRECT |
| Bromodomain | 0 | DIRECT |
| Leucine zipper domain | 0 | DIRECT |
| Growth factor receptor domain | 0 | DIRECT |
| Myeloperoxidase-like | 0 | DIRECT |
| Eukaryotic proteases | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| GABA-aminotransferase-like | 0 | DIRECT |
| Paired domain | 0 | DIRECT |
| PAPS sulfotransferase | 0 | DIRECT |
| Clathrin coat assembly domain | 0 | DIRECT |
| Hairy Orange domain | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| BTB/POZ domain | 0 | DIRECT |
| RUNT domain | 0 | DIRECT |
| MYND zinc finger | 0 | DIRECT |
| Pyridoxal-dependent decarboxylase | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| Caspase catalytic domain | 0 | DIRECT |
| Gelsolin-like | 0 | DIRECT |
| Chromo domain | 0 | DIRECT |
| Myosin rod fragments | 0 | DIRECT |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0 | DIRECT |
| CalX-beta domain | 0 | DIRECT |
| TNF receptor-like | 0 | DIRECT |
| CCCH zinc finger | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | DIRECT |
| Fibronectin type II module | 0 | DIRECT |
| Calmodulin-like | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Myotubularin-like phosphatases | 0 | DIRECT |
| SMAD domain | 0 | DIRECT |
| LDL receptor-like module | 0 | DIRECT |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | DIRECT |
| Adenylyl and guanylyl cyclase catalytic domain | 0 | DIRECT |
| Glutathione S-transferase (GST), C-terminal domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | DIRECT |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0 | DIRECT |
| Extracellular domain of cell surface receptors | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | DIRECT |
| Ovomucoid domain III-like | 0 | DIRECT |
| Clathrin adaptor core protein | 0 | DIRECT |
| C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
| Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | DIRECT |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) | 0 | DIRECT |
| Mammalian PLC | 0 | DIRECT |
| FHA domain | 0 | DIRECT |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0 | DIRECT |
| Subtilases | 0 | DIRECT |
| Noncollagenous (NC1) domain of collagen IV | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
| SWIRM domain | 0 | DIRECT |
| Class I glutamine amidotransferases (GAT) | 0 | DIRECT |
| Regulator of chromosome condensation RCC1 | 0 | DIRECT |
| Hsp90 middle domain | 0 | DIRECT |
| Dachshund-homology domain | 0 | DIRECT |
| First domain of FERM | 0 | DIRECT |
| Arrestin/Vps26-like | 0 | DIRECT |
| Prohormone convertase 1 pro-domain | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Second domain of FERM | 0 | DIRECT |
| Matrix metalloproteases, catalytic domain | 0 | DIRECT |
| Tudor domain | 0 | DIRECT |
| Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| Tropomyosin | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| Ubiquitin-related | 0 | DIRECT |
| Hemopexin-like domain | 0 | DIRECT |
| Nucleotide and nucleoside kinases | 0 | DIRECT |
| MMP N-terminal domain | 0 | DIRECT |
| SH2 domain | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| Elongation factors | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Extended AAA-ATPase domain | 0 | DIRECT |
| EF-hand modules in multidomain proteins | 0 | DIRECT |
| Nitrogenase iron protein-like | 0 | DIRECT |
| Zf-UBP | 0 | DIRECT |
| UBA domain | 0 | DIRECT |
| PWWP domain | 0 | DIRECT |
| Cell cycle control phosphatase, catalytic domain | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| BAR domain | 0 | DIRECT |
| Plexin repeat | 0 | DIRECT |
| DUSP, domain in ubiquitin-specific proteases | 0 | DIRECT |
| Cytoplasmic domain of inward rectifier potassium channel | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| POU-specific domain | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| BCR-homology GTPase activation domain (BH-domain) | 0 | DIRECT |
| Histone lysine methyltransferases | 0 | DIRECT |
| Cyclin | 0 | DIRECT |
| Actin/HSP70 | 0 | DIRECT |
| P4 origin-binding domain-like | 0 | DIRECT |
| Anion transport protein, cytoplasmic domain | 0 | DIRECT |
| V set domains (antibody variable domain-like) | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Hydantoinase (dihydropyrimidinase) | 0 | DIRECT |
| Tetramerization domain of potassium channels | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Cell cycle transcription factor e2f-dp | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| Tubulin, GTPase domain | 0 | DIRECT |
| L domain | 0 | DIRECT |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
| Tubulin, C-terminal domain | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| DEATH domain, DD | 0 | DIRECT |
| LCCL domain | 0 | DIRECT |
| Armadillo repeat | 0 | DIRECT |
| SNARE fusion complex | 0 | DIRECT |
| Glycerophosphoryl diester phosphodiesterase | 0 | DIRECT |
| Ras GEF | 0 | DIRECT |
| Nuclear receptor ligand-binding domain | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| WD40-repeat | 0.02725 | INHERITED FROM: retinal cone cell || photoreceptor outer segment layer |
| Homeodomain | 0.03317 | INHERITED FROM: endocrine pancreas || dorsal telencephalon || forebrain || cephalic musculature || endocrine cell || diencephalon || pancreatic A cell || preoptic area |
| I set domains | 0.09475 | INHERITED FROM: medial longitudinal fasciculus || white matter || synencephalon |
| Motor proteins | 0.1249 | INHERITED FROM: renal corpuscle || pronephric podocyte || photoreceptor outer segment layer |
| Transforming growth factor (TGF)-beta | 0.2047 | INHERITED FROM: spermatogenic cyst || floor plate || pineal complex |
| LIM domain | 0.3311 | INHERITED FROM: cardiac ventricle |
| Ankyrin repeat | 0.35 | INHERITED FROM: ventricular zone |
| Classic zinc finger, C2H2 | 0.4275 | INHERITED FROM: thalamus || ventral thalamus |
| DBL homology domain (DH-domain) | 0.4346 | INHERITED FROM: blood vessel endothelial cell || vascular endothelium || blood vessel endothelium |
| Myb/SANT domain | 0.4346 | INHERITED FROM: neutrophil || granulocyte |
| Fibronectin type III | 0.4422 | INHERITED FROM: medial longitudinal fasciculus || white matter || glomerular layer || synencephalon |
| Tandem AAA-ATPase domain | 0.5147 | INHERITED FROM: brain || visual system |
| Laminin-type module | 0.5295 | INHERITED FROM: slow muscle cell |
| Kelch motif | 0.5295 | INHERITED FROM: skeletal muscle |
| Tetratricopeptide repeat (TPR) | 0.5646 | INHERITED FROM: pronephros || retinal rod cell |
| Fibroblast growth factors (FGF) | 0.5667 | INHERITED FROM: dermatocranium || intramembranous bone || olfactory region |
| ets domain | 0.5667 | INHERITED FROM: myeloid leukocyte || granulocyte |
| PDZ domain | 0.6405 | INHERITED FROM: central canal |
| Cadherin | 0.6405 | INHERITED FROM: diencephalic white matter || optic tectum || cranial nerve II || cranial nerve || white matter || nerve |
| YWTD domain | 0.6456 | INHERITED FROM: post-vent vasculature |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.6607 | INHERITED FROM: neurocranium || ethmoid cartilage || splanchnocranium || mandibular arch skeleton || pharyngeal arch cartilage || pericardium || cranial cartilage || olfactory region || skeletal element || cartilage element || chondrocranium || ventral mandibular arch |
| HLH, helix-loop-helix DNA-binding domain | 0.6714 | INHERITED FROM: heart primordium || Kolmer-Agduhr neuron |
| Phenylalanine metabolism regulatory domain | 0.7415 | INHERITED FROM: ventral wall of dorsal aorta || axial blood vessel || artery || dorsal aorta |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7415 | INHERITED FROM: ventral wall of dorsal aorta || axial blood vessel || artery || dorsal aorta |
| Retrovirus zinc finger-like domains | 0.7415 | INHERITED FROM: gill || pharynx || respiratory system || pharyngeal arch 3-7 |
| Multidrug efflux transporter AcrB transmembrane domain | 0.7415 | INHERITED FROM: pharyngeal arch 2 skeleton || hyosymplectic cartilage || skeletal muscle cell || slow muscle cell || dorsal hyoid arch || retinal ganglion cell layer || suspensorium || skeletal muscle || ventral hyoid arch |
| Cytochrome P450 | 0.7814 | INHERITED FROM: hypophysis |
| T-box | 0.7814 | INHERITED FROM: heart primordium || pronephros || primordial vasculature || atrioventricular canal |
| HMG-box | 0.7914 | INHERITED FROM: ganglion || dorsal root ganglion || statoacoustic (VIII) ganglion || ceratobranchial 5 bone || vagal ganglion |
| WW domain | 0.8092 | INHERITED FROM: striated muscle cell |
| MIR domain | 0.9752 | INHERITED FROM: skeletal muscle cell |
| SCOP term | FDR (all) | Annotation (direct or inherited) |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| Small Kunitz-type inhibitors & BPTI-like toxins | 0 | Direct |
| STAT DNA-binding domain | 0 | Direct |
| Calcium ATPase, transmembrane domain M | 0 | Direct |
| Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0 | Direct |
| Erythroid transcription factor GATA-1 | 0 | Direct |
| STAT | 0 | Direct |
| ALDH-like | 0 | Direct |
| Platelet-derived growth factor-like | 0 | Direct |
| Cdc48 N-terminal domain-like | 0 | Direct |
| Link domain | 0 | Direct |
| BRK domain-like | 0 | Direct |
| p120GAP domain-like | 0 | Direct |
| FYVE, a phosphatidylinositol-3-phosphate binding domain | 0 | Direct |
| Ephrin ectodomain | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| FAD-linked reductases, N-terminal domain | 0 | Direct |
| Choline/Carnitine O-acyltransferase | 0 | Direct |
| VWC domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), intermediate domain | 0 | Direct |
| Pentraxin (pentaxin) | 0 | Direct |
| EGF-type module | 0 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | Direct |
| PB1 domain | 0 | Direct |
| Dual specificity phosphatase-like | 0 | Direct |
| Caspase recruitment domain, CARD | 0 | Direct |
| Regulator of G-protein signaling, RGS | 0 | Direct |
| Nuclear receptor | 0 | Direct |
| NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | Direct |
| Proprotein convertase P-domain | 0 | Direct |
| F-box domain | 0 | Direct |
| Formin homology 2 domain (FH2 domain) | 0 | Direct |
| Laminin G-like module | 0 | Direct |
| Integrin domains | 0 | Direct |
| FAS1 domain | 0 | Direct |
| Troponin T | 0 | Direct |
| Reprolysin-like | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
| Histone deacetylase, HDAC | 0 | Direct |
| Bromodomain | 0 | Direct |
| Leucine zipper domain | 0 | Direct |
| Growth factor receptor domain | 0 | Direct |
| Myeloperoxidase-like | 0 | Direct |
| Eukaryotic proteases | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Plakin repeat | 0 | Direct |
| GABA-aminotransferase-like | 0 | Direct |
| Paired domain | 0 | Direct |
| PAPS sulfotransferase | 0 | Direct |
| Clathrin coat assembly domain | 0 | Direct |
| Hairy Orange domain | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| BTB/POZ domain | 0 | Direct |
| RUNT domain | 0 | Direct |
| MYND zinc finger | 0 | Direct |
| Pyridoxal-dependent decarboxylase | 0 | Direct |
| Connexin43 | 0 | Direct |
| GLA-domain | 0 | Direct |
| Caspase catalytic domain | 0 | Direct |
| Gelsolin-like | 0 | Direct |
| Chromo domain | 0 | Direct |
| Myosin rod fragments | 0 | Direct |
| Biotinyl/lipoyl-carrier proteins and domains | 0 | Direct |
| Nicotinic receptor ligand binding domain-like | 0 | Direct |
| CalX-beta domain | 0 | Direct |
| TNF receptor-like | 0 | Direct |
| CCCH zinc finger | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| Group II chaperonin (CCT, TRIC), apical domain | 0 | Direct |
| Fibronectin type II module | 0 | Direct |
| Calmodulin-like | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Myotubularin-like phosphatases | 0 | Direct |
| SMAD domain | 0 | Direct |
| LDL receptor-like module | 0 | Direct |
| Heat shock protein 90, HSP90, N-terminal domain | 0 | Direct |
| Adenylyl and guanylyl cyclase catalytic domain | 0 | Direct |
| Glutathione S-transferase (GST), C-terminal domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Formate/glycerate dehydrogenases, NAD-domain | 0 | Direct |
| Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0 | Direct |
| Extracellular domain of cell surface receptors | 0 | Direct |
| SRF-like | 0 | Direct |
| Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | Direct |
| Ovomucoid domain III-like | 0 | Direct |
| Clathrin adaptor core protein | 0 | Direct |
| C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
| Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | Direct |
| Group II chaperonin (CCT, TRIC), ATPase domain | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| Discoidin domain (FA58C, coagulation factor 5/8 C-terminal domain) | 0 | Direct |
| Mammalian PLC | 0 | Direct |
| FHA domain | 0 | Direct |
| Enabled/VASP homology 1 domain (EVH1 domain) | 0 | Direct |
| Subtilases | 0 | Direct |
| Noncollagenous (NC1) domain of collagen IV | 0 | Direct |
| Notch domain | 0 | Direct |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
| SWIRM domain | 0 | Direct |
| Class I glutamine amidotransferases (GAT) | 0 | Direct |
| Regulator of chromosome condensation RCC1 | 0 | Direct |
| Hsp90 middle domain | 0 | Direct |
| Dachshund-homology domain | 0 | Direct |
| First domain of FERM | 0 | Direct |
| Arrestin/Vps26-like | 0 | Direct |
| Prohormone convertase 1 pro-domain | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Second domain of FERM | 0 | Direct |
| Matrix metalloproteases, catalytic domain | 0 | Direct |
| Tudor domain | 0 | Direct |
| Anticodon-binding domain of Class II aaRS | 0 | Direct |
| Sec7 domain | 0 | Direct |
| Tropomyosin | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| Ubiquitin-related | 0 | Direct |
| Hemopexin-like domain | 0 | Direct |
| Nucleotide and nucleoside kinases | 0 | Direct |
| MMP N-terminal domain | 0 | Direct |
| SH2 domain | 0 | Direct |
| CCHHC domain | 0 | Direct |
| Elongation factors | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Extended AAA-ATPase domain | 0 | Direct |
| EF-hand modules in multidomain proteins | 0 | Direct |
| Nitrogenase iron protein-like | 0 | Direct |
| Zf-UBP | 0 | Direct |
| UBA domain | 0 | Direct |
| PWWP domain | 0 | Direct |
| Cell cycle control phosphatase, catalytic domain | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| BAR domain | 0 | Direct |
| Plexin repeat | 0 | Direct |
| DUSP, domain in ubiquitin-specific proteases | 0 | Direct |
| Cytoplasmic domain of inward rectifier potassium channel | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| POU-specific domain | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| BCR-homology GTPase activation domain (BH-domain) | 0 | Direct |
| Histone lysine methyltransferases | 0 | Direct |
| Cyclin | 0 | Direct |
| Actin/HSP70 | 0 | Direct |
| P4 origin-binding domain-like | 0 | Direct |
| Anion transport protein, cytoplasmic domain | 0 | Direct |
| V set domains (antibody variable domain-like) | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Hydantoinase (dihydropyrimidinase) | 0 | Direct |
| Tetramerization domain of potassium channels | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Cell cycle transcription factor e2f-dp | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| Tubulin, GTPase domain | 0 | Direct |
| L domain | 0 | Direct |
| Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
| Tubulin, C-terminal domain | 0 | Direct |
| Sema domain | 0 | Direct |
| DEATH domain, DD | 0 | Direct |
| LCCL domain | 0 | Direct |
| Armadillo repeat | 0 | Direct |
| SNARE fusion complex | 0 | Direct |
| Glycerophosphoryl diester phosphodiesterase | 0 | Direct |
| Ras GEF | 0 | Direct |
| Nuclear receptor ligand-binding domain | 0 | Direct |
| PP2C-like | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| WD40-repeat | 0.02725 | Inherited |
| Homeodomain | 0.03317 | Inherited |
| I set domains | 0.09475 | Inherited |
| Motor proteins | 0.1249 | Inherited |
| Transforming growth factor (TGF)-beta | 0.2047 | Inherited |
| LIM domain | 0.3311 | Inherited |
| Ankyrin repeat | 0.35 | Inherited |
| Classic zinc finger, C2H2 | 0.4275 | Inherited |
| DBL homology domain (DH-domain) | 0.4346 | Inherited |
| Myb/SANT domain | 0.4346 | Inherited |
| Fibronectin type III | 0.4422 | Inherited |
| Tandem AAA-ATPase domain | 0.5147 | Inherited |
| Laminin-type module | 0.5295 | Inherited |
| Kelch motif | 0.5295 | Inherited |
| Tetratricopeptide repeat (TPR) | 0.5646 | Inherited |
| Fibroblast growth factors (FGF) | 0.5667 | Inherited |
| ets domain | 0.5667 | Inherited |
| PDZ domain | 0.6405 | Inherited |
| Cadherin | 0.6405 | Inherited |
| YWTD domain | 0.6456 | Inherited |
| Ubiquitin carboxyl-terminal hydrolase, UCH | 0.6607 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.6714 | Inherited |
| Phenylalanine metabolism regulatory domain | 0.7415 | Inherited |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7415 | Inherited |
| Retrovirus zinc finger-like domains | 0.7415 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.7415 | Inherited |
| Cytochrome P450 | 0.7814 | Inherited |
| T-box | 0.7814 | Inherited |
| HMG-box | 0.7914 | Inherited |
| WW domain | 0.8092 | Inherited |
| MIR domain | 0.9752 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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A presence/absence matrix is generated using protein domain
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Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this ZA term (Not in SPZA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| G protein-binding domain | 0 | DIRECT |
| Bet v1-like | 0 | DIRECT |
| LDL receptor-like module | 0 | DIRECT |
| LCCL domain | 0 | DIRECT |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | DIRECT |
| FAS1 domain | 0 | DIRECT |
| Transcription factor STAT-4 N-domain | 0 | DIRECT |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
| Tricorn protease domain 2 | 0 | DIRECT |
| SAICAR synthase-like | 0 | DIRECT |
| alpha/beta-Hydrolases | 0 | DIRECT |
| Arginase/deacetylase | 0 | DIRECT |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | DIRECT |
| PGBD-like | 0 | DIRECT |
| BRCT domain | 0 | DIRECT |
| FAD-linked reductases, C-terminal domain | 0 | DIRECT |
| Translation proteins SH3-like domain | 0 | DIRECT |
| Bromodomain | 0 | DIRECT |
| GST C-terminal domain-like | 0 | DIRECT |
| SMAD MH1 domain | 0 | DIRECT |
| Hormone receptor domain | 0 | DIRECT |
| HSP90 C-terminal domain | 0 | DIRECT |
| Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
| Trypsin-like serine proteases | 0 | DIRECT |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | DIRECT |
| Class II aaRS and biotin synthetases | 0 | DIRECT |
| TNF receptor-like | 0 | DIRECT |
| Doublecortin (DC) | 0 | DIRECT |
| BPTI-like | 0 | DIRECT |
| GroES-like | 0 | DIRECT |
| Soluble quinoprotein glucose dehydrogenase | 0 | DIRECT |
| Leucine zipper domain | 0 | DIRECT |
| Integrin alpha N-terminal domain | 0 | DIRECT |
| Translation proteins | 0 | DIRECT |
| Ribosomal protein S5 domain 2-like | 0 | DIRECT |
| Riboflavin synthase domain-like | 0 | DIRECT |
| Tudor/PWWP/MBT | 0 | DIRECT |
| Regulator of G-protein signaling, RGS | 0 | DIRECT |
| CCHHC domain | 0 | DIRECT |
| Tubulin nucleotide-binding domain-like | 0 | DIRECT |
| RCC1/BLIP-II | 0 | DIRECT |
| Nicotinic receptor ligand binding domain-like | 0 | DIRECT |
| Tubulin C-terminal domain-like | 0 | DIRECT |
| Plexin repeat | 0 | DIRECT |
| Moesin tail domain | 0 | DIRECT |
| Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
| HIT-like | 0 | DIRECT |
| Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
| Caspase-like | 0 | DIRECT |
| Kazal-type serine protease inhibitors | 0 | DIRECT |
| Sema domain | 0 | DIRECT |
| Nucleotide cyclase | 0 | DIRECT |
| Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
| Actin-like ATPase domain | 0 | DIRECT |
| PLC-like phosphodiesterases | 0 | DIRECT |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
| Mitochondrial carrier | 0 | DIRECT |
| Subtilisin-like | 0 | DIRECT |
| ENTH/VHS domain | 0 | DIRECT |
| DPP6 N-terminal domain-like | 0 | DIRECT |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
| Sec7 domain | 0 | DIRECT |
| SNARE-like | 0 | DIRECT |
| Glutathione synthetase ATP-binding domain-like | 0 | DIRECT |
| Translational machinery components | 0 | DIRECT |
| Hemopexin-like domain | 0 | DIRECT |
| CAD & PB1 domains | 0 | DIRECT |
| Tropomyosin | 0 | DIRECT |
| Troponin coil-coiled subunits | 0 | DIRECT |
| HSP20-like chaperones | 0 | DIRECT |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
| SNARE fusion complex | 0 | DIRECT |
| NTF2-like | 0 | DIRECT |
| HD-domain/PDEase-like | 0 | DIRECT |
| Class I glutamine amidotransferase-like | 0 | DIRECT |
| BRK domain-like | 0 | DIRECT |
| Putative DNA-binding domain | 0 | DIRECT |
| Connexin43 | 0 | DIRECT |
| Cyclin-like | 0 | DIRECT |
| Aquaporin-like | 0 | DIRECT |
| Nucleotidylyl transferase | 0 | DIRECT |
| Notch domain | 0 | DIRECT |
| PP2C-like | 0 | DIRECT |
| SET domain | 0 | DIRECT |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
| Cap-Gly domain | 0 | DIRECT |
| UBA-like | 0 | DIRECT |
| JAB1/MPN domain | 0 | DIRECT |
| Clathrin adaptor appendage domain | 0 | DIRECT |
| SWIB/MDM2 domain | 0 | DIRECT |
| Cupredoxins | 0 | DIRECT |
| DUSP-like | 0 | DIRECT |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
| Zinc beta-ribbon | 0 | DIRECT |
| Integrin domains | 0 | DIRECT |
| Plakin repeat | 0 | DIRECT |
| Growth factor receptor domain | 0 | DIRECT |
| Nuclear receptor ligand-binding domain | 0 | DIRECT |
| Chaperone J-domain | 0 | DIRECT |
| Alkaline phosphatase-like | 0 | DIRECT |
| Actin depolymerizing proteins | 0 | DIRECT |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
| Polo-box domain | 0 | DIRECT |
| SMAD/FHA domain | 0 | DIRECT |
| SRF-like | 0 | DIRECT |
| ALDH-like | 0 | DIRECT |
| Single hybrid motif | 0 | DIRECT |
| GTPase activation domain, GAP | 0 | DIRECT |
| HIT/MYND zinc finger-like | 0 | DIRECT |
| TSP-1 type 1 repeat | 0 | DIRECT |
| Phoshotransferase/anion transport protein | 0 | DIRECT |
| Orange domain-like | 0 | DIRECT |
| CoA-dependent acyltransferases | 0 | DIRECT |
| Rhodanese/Cell cycle control phosphatase | 0 | DIRECT |
| Ras GEF | 0 | DIRECT |
| DEATH domain | 0 | DIRECT |
| Myosin rod fragments | 0 | DIRECT |
| Metallo-dependent hydrolases | 0 | DIRECT |
| POZ domain | 0 | DIRECT |
| Carbonic anhydrase | 0 | DIRECT |
| GLA-domain | 0 | DIRECT |
| F-box domain | 0 | DIRECT |
| Class II aaRS ABD-related | 0 | DIRECT |
| Kringle-like | 0 | DIRECT |
| STAT | 0 | DIRECT |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | DIRECT |
| FAD/NAD(P)-binding domain | 0 | DIRECT |
| CCCH zinc finger | 0 | DIRECT |
| PLP-dependent transferases | 0 | DIRECT |
| SH2 domain | 0 | DIRECT |
| CalX-like | 0 | DIRECT |
| Heme-dependent peroxidases | 0 | DIRECT |
| ADC-like | 0 | DIRECT |
| Cdc48 domain 2-like | 0 | DIRECT |
| Galactose-binding domain-like | 0 | DIRECT |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
| SOCS box-like | 0 | DIRECT |
| Immunoglobulin | 0.03223 | INHERITED FROM: olfactory bulb glomerulus || glomerular layer || white matter || medial longitudinal fasciculus |
| Homeodomain-like | 0.04067 | INHERITED FROM: suspensorium || preoptic area || cephalic musculature || diencephalon || endocrine pancreas || endocrine cell || forebrain || dorsal telencephalon |
| EGF/Laminin | 0.05085 | INHERITED FROM: pars superior ear || lymph vessel || vasculature || lymphatic system || lateral line ganglion || blood vasculature || posterior lateral line ganglion |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.05791 | INHERITED FROM: VeLD || Kolmer-Agduhr neuron || cardiac ventricle |
| Cystine-knot cytokines | 0.1008 | INHERITED FROM: floor plate || pineal complex || cranial blood vessel || reproductive system || spermatogenic cyst |
| WD40 repeat-like | 0.1015 | INHERITED FROM: photoreceptor outer segment layer |
| Ankyrin repeat | 0.3398 | INHERITED FROM: ventricular zone |
| FnI-like domain | 0.3442 | INHERITED FROM: vertebral column || replacement bone || suspensorium || palatoquadrate arch || chondral bone || skeletal element || palatoquadrate cartilage || skeletal system |
| C-type lectin-like | 0.3442 | INHERITED FROM: lymph vessel || lymphatic system || axial vasculature || lymph vasculature |
| Nucleotide-diphospho-sugar transferases | 0.369 | INHERITED FROM: skeletal element |
| Protein kinase-like (PK-like) | 0.3935 | INHERITED FROM: intersegmental vein |
| DBL homology domain (DH-domain) | 0.4242 | INHERITED FROM: blood vessel endothelium || blood vessel endothelial cell || vascular endothelium |
| Fibronectin type III | 0.4252 | INHERITED FROM: glomerular layer || white matter || synencephalon || medial longitudinal fasciculus |
| Snake toxin-like | 0.5234 | INHERITED FROM: axial vasculature |
| Kelch motif | 0.5234 | INHERITED FROM: skeletal muscle |
| Cysteine proteinases | 0.5242 | INHERITED FROM: pericardium || olfactory region || cartilage element || ethmoid cartilage || neurocranium || chondrocranium cartilage || splanchnocranium || cranial cartilage || oral region || pharyngeal arch cartilage || ventral mandibular arch || skeletal element || pericardial region || mandibular arch skeleton || skeletal system || chondrocranium |
| lambda repressor-like DNA-binding domains | 0.5601 | INHERITED FROM: diencephalon || forebrain || digestive system duct |
| Cytokine | 0.5601 | INHERITED FROM: olfactory region || dermatocranium || skeletal element || intramembranous bone || chondrocranium |
| PDZ domain-like | 0.5682 | INHERITED FROM: central canal |
| Cadherin-like | 0.6062 | INHERITED FROM: white matter || cranial nerve || diencephalic white matter || cranial nerve II || optic tectum || nerve |
| p53-like transcription factors | 0.6092 | INHERITED FROM: primordial vasculature |
| Protease propeptides/inhibitors | 0.6401 | INHERITED FROM: optic tectum |
| GroEL-intermediate domain like | 0.6401 | INHERITED FROM: striated muscle cell || myotome || trunk musculature || skeletal muscle cell || liver and biliary system || liver || muscle cell || skeletal muscle || musculature system |
| beta-beta-alpha zinc fingers | 0.6401 | INHERITED FROM: ventral thalamus |
| Multidrug efflux transporter AcrB transmembrane domain | 0.6401 | INHERITED FROM: striated muscle cell || suspensorium || skeletal muscle cell || skeletal muscle || retinal ganglion cell layer || hyosymplectic cartilage || dorsal hyoid arch |
| HLH, helix-loop-helix DNA-binding domain | 0.6554 | INHERITED FROM: Kolmer-Agduhr neuron || heart primordium |
| NAD(P)-binding Rossmann-fold domains | 0.6578 | INHERITED FROM: retinal inner plexiform layer || retinal outer plexiform layer |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7328 | INHERITED FROM: axial blood vessel || ventral wall of dorsal aorta || artery || dorsal aorta |
| Retrovirus zinc finger-like domains | 0.7328 | INHERITED FROM: respiratory system || gill || pharynx || pharyngeal arch 3-7 |
| ACT-like | 0.7328 | INHERITED FROM: axial blood vessel || ventral wall of dorsal aorta || artery || dorsal aorta |
| Cytochrome P450 | 0.7709 | INHERITED FROM: hypophysis |
| HMG-box | 0.7795 | INHERITED FROM: ganglion || statoacoustic (VIII) ganglion || dorsal root ganglion || ceratobranchial 5 bone || vagal ganglion |
| IP3 receptor type 1 binding core, domain 2 | 0.7829 | INHERITED FROM: striated muscle cell || skeletal muscle cell || muscle cell || skeletal muscle |
| Serine protease inhibitors | 0.7829 | INHERITED FROM: inner ear || otolith || otolith organ || vestibuloauditory system |
| WW domain | 0.7997 | INHERITED FROM: striated muscle cell |
| GroEL equatorial domain-like | 0.8609 | INHERITED FROM: striated muscle cell || myotome || trunk musculature || skeletal muscle cell || muscle cell || skeletal muscle |
| GroEL apical domain-like | 0.8899 | INHERITED FROM: striated muscle cell || myotome || trunk musculature || skeletal muscle cell || muscle cell || skeletal muscle |
| MIR domain | 0.9738 | INHERITED FROM: skeletal muscle cell |
| Supra-domain (Single) |
FDR (all) |
Annotation (direct or inherited) |
| G protein-binding domain | 0 | Direct |
| Bet v1-like | 0 | Direct |
| LDL receptor-like module | 0 | Direct |
| LCCL domain | 0 | Direct |
| ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase | 0 | Direct |
| FAS1 domain | 0 | Direct |
| Transcription factor STAT-4 N-domain | 0 | Direct |
| Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
| Tricorn protease domain 2 | 0 | Direct |
| SAICAR synthase-like | 0 | Direct |
| alpha/beta-Hydrolases | 0 | Direct |
| Arginase/deacetylase | 0 | Direct |
| Neurotransmitter-gated ion-channel transmembrane pore | 0 | Direct |
| PGBD-like | 0 | Direct |
| BRCT domain | 0 | Direct |
| FAD-linked reductases, C-terminal domain | 0 | Direct |
| Translation proteins SH3-like domain | 0 | Direct |
| Bromodomain | 0 | Direct |
| GST C-terminal domain-like | 0 | Direct |
| SMAD MH1 domain | 0 | Direct |
| Hormone receptor domain | 0 | Direct |
| HSP90 C-terminal domain | 0 | Direct |
| Composite domain of metallo-dependent hydrolases | 0 | Direct |
| Trypsin-like serine proteases | 0 | Direct |
| C-terminal, gelsolin-like domain of Sec23/24 | 0 | Direct |
| Class II aaRS and biotin synthetases | 0 | Direct |
| TNF receptor-like | 0 | Direct |
| Doublecortin (DC) | 0 | Direct |
| BPTI-like | 0 | Direct |
| GroES-like | 0 | Direct |
| Soluble quinoprotein glucose dehydrogenase | 0 | Direct |
| Leucine zipper domain | 0 | Direct |
| Integrin alpha N-terminal domain | 0 | Direct |
| Translation proteins | 0 | Direct |
| Ribosomal protein S5 domain 2-like | 0 | Direct |
| Riboflavin synthase domain-like | 0 | Direct |
| Tudor/PWWP/MBT | 0 | Direct |
| Regulator of G-protein signaling, RGS | 0 | Direct |
| CCHHC domain | 0 | Direct |
| Tubulin nucleotide-binding domain-like | 0 | Direct |
| RCC1/BLIP-II | 0 | Direct |
| Nicotinic receptor ligand binding domain-like | 0 | Direct |
| Tubulin C-terminal domain-like | 0 | Direct |
| Plexin repeat | 0 | Direct |
| Moesin tail domain | 0 | Direct |
| Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
| HIT-like | 0 | Direct |
| Nuclear receptor coactivator interlocking domain | 0 | Direct |
| Caspase-like | 0 | Direct |
| Kazal-type serine protease inhibitors | 0 | Direct |
| Sema domain | 0 | Direct |
| Nucleotide cyclase | 0 | Direct |
| Formin homology 2 domain (FH2 domain) | 0 | Direct |
| Actin-like ATPase domain | 0 | Direct |
| PLC-like phosphodiesterases | 0 | Direct |
| EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
| Mitochondrial carrier | 0 | Direct |
| Subtilisin-like | 0 | Direct |
| ENTH/VHS domain | 0 | Direct |
| DPP6 N-terminal domain-like | 0 | Direct |
| Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
| Sec7 domain | 0 | Direct |
| SNARE-like | 0 | Direct |
| Glutathione synthetase ATP-binding domain-like | 0 | Direct |
| Translational machinery components | 0 | Direct |
| Hemopexin-like domain | 0 | Direct |
| CAD & PB1 domains | 0 | Direct |
| Tropomyosin | 0 | Direct |
| Troponin coil-coiled subunits | 0 | Direct |
| HSP20-like chaperones | 0 | Direct |
| Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
| SNARE fusion complex | 0 | Direct |
| NTF2-like | 0 | Direct |
| HD-domain/PDEase-like | 0 | Direct |
| Class I glutamine amidotransferase-like | 0 | Direct |
| BRK domain-like | 0 | Direct |
| Putative DNA-binding domain | 0 | Direct |
| Connexin43 | 0 | Direct |
| Cyclin-like | 0 | Direct |
| Aquaporin-like | 0 | Direct |
| Nucleotidylyl transferase | 0 | Direct |
| Notch domain | 0 | Direct |
| PP2C-like | 0 | Direct |
| SET domain | 0 | Direct |
| Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
| Cap-Gly domain | 0 | Direct |
| UBA-like | 0 | Direct |
| JAB1/MPN domain | 0 | Direct |
| Clathrin adaptor appendage domain | 0 | Direct |
| SWIB/MDM2 domain | 0 | Direct |
| Cupredoxins | 0 | Direct |
| DUSP-like | 0 | Direct |
| Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
| Zinc beta-ribbon | 0 | Direct |
| Integrin domains | 0 | Direct |
| Plakin repeat | 0 | Direct |
| Growth factor receptor domain | 0 | Direct |
| Nuclear receptor ligand-binding domain | 0 | Direct |
| Chaperone J-domain | 0 | Direct |
| Alkaline phosphatase-like | 0 | Direct |
| Actin depolymerizing proteins | 0 | Direct |
| Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
| Polo-box domain | 0 | Direct |
| SMAD/FHA domain | 0 | Direct |
| SRF-like | 0 | Direct |
| ALDH-like | 0 | Direct |
| Single hybrid motif | 0 | Direct |
| GTPase activation domain, GAP | 0 | Direct |
| HIT/MYND zinc finger-like | 0 | Direct |
| TSP-1 type 1 repeat | 0 | Direct |
| Phoshotransferase/anion transport protein | 0 | Direct |
| Orange domain-like | 0 | Direct |
| CoA-dependent acyltransferases | 0 | Direct |
| Rhodanese/Cell cycle control phosphatase | 0 | Direct |
| Ras GEF | 0 | Direct |
| DEATH domain | 0 | Direct |
| Myosin rod fragments | 0 | Direct |
| Metallo-dependent hydrolases | 0 | Direct |
| POZ domain | 0 | Direct |
| Carbonic anhydrase | 0 | Direct |
| GLA-domain | 0 | Direct |
| F-box domain | 0 | Direct |
| Class II aaRS ABD-related | 0 | Direct |
| Kringle-like | 0 | Direct |
| STAT | 0 | Direct |
| Formate/glycerate dehydrogenase catalytic domain-like | 0 | Direct |
| FAD/NAD(P)-binding domain | 0 | Direct |
| CCCH zinc finger | 0 | Direct |
| PLP-dependent transferases | 0 | Direct |
| SH2 domain | 0 | Direct |
| CalX-like | 0 | Direct |
| Heme-dependent peroxidases | 0 | Direct |
| ADC-like | 0 | Direct |
| Cdc48 domain 2-like | 0 | Direct |
| Galactose-binding domain-like | 0 | Direct |
| Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
| SOCS box-like | 0 | Direct |
| Immunoglobulin | 0.03223 | Inherited |
| Homeodomain-like | 0.04067 | Inherited |
| EGF/Laminin | 0.05085 | Inherited |
| Glucocorticoid receptor-like (DNA-binding domain) | 0.05791 | Inherited |
| Cystine-knot cytokines | 0.1008 | Inherited |
| WD40 repeat-like | 0.1015 | Inherited |
| Ankyrin repeat | 0.3398 | Inherited |
| FnI-like domain | 0.3442 | Inherited |
| C-type lectin-like | 0.3442 | Inherited |
| Nucleotide-diphospho-sugar transferases | 0.369 | Inherited |
| Protein kinase-like (PK-like) | 0.3935 | Inherited |
| DBL homology domain (DH-domain) | 0.4242 | Inherited |
| Fibronectin type III | 0.4252 | Inherited |
| Snake toxin-like | 0.5234 | Inherited |
| Kelch motif | 0.5234 | Inherited |
| Cysteine proteinases | 0.5242 | Inherited |
| lambda repressor-like DNA-binding domains | 0.5601 | Inherited |
| Cytokine | 0.5601 | Inherited |
| PDZ domain-like | 0.5682 | Inherited |
| Cadherin-like | 0.6062 | Inherited |
| p53-like transcription factors | 0.6092 | Inherited |
| Protease propeptides/inhibitors | 0.6401 | Inherited |
| GroEL-intermediate domain like | 0.6401 | Inherited |
| beta-beta-alpha zinc fingers | 0.6401 | Inherited |
| Multidrug efflux transporter AcrB transmembrane domain | 0.6401 | Inherited |
| HLH, helix-loop-helix DNA-binding domain | 0.6554 | Inherited |
| NAD(P)-binding Rossmann-fold domains | 0.6578 | Inherited |
| Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7328 | Inherited |
| Retrovirus zinc finger-like domains | 0.7328 | Inherited |
| ACT-like | 0.7328 | Inherited |
| Cytochrome P450 | 0.7709 | Inherited |
| HMG-box | 0.7795 | Inherited |
| IP3 receptor type 1 binding core, domain 2 | 0.7829 | Inherited |
| Serine protease inhibitors | 0.7829 | Inherited |
| WW domain | 0.7997 | Inherited |
| GroEL equatorial domain-like | 0.8609 | Inherited |
| GroEL apical domain-like | 0.8899 | Inherited |
| MIR domain | 0.9738 | Inherited |
(show details)
Supra-domains annotated to this ZA term (Not in SPZA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0 | DIRECT |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | DIRECT |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | DIRECT |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0 | DIRECT |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | DIRECT |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | DIRECT |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
141072,141072
141072 - CalX-like
141072 - CalX-like | 0 | DIRECT |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
49785,57184
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | DIRECT |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
46966,47473
46966 - Spectrin repeat
47473 - EF-hand | 0 | DIRECT |
82109,82109
82109 - MIR domain
82109 - MIR domain | 0 | DIRECT |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0 | DIRECT |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | DIRECT |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | DIRECT |
100909,49899
100909 - IP3 receptor type 1 binding core, domain 2
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | DIRECT |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | DIRECT |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | DIRECT |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | DIRECT |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0 | DIRECT |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0 | DIRECT |
90257,57997
90257 - Myosin rod fragments
57997 - Tropomyosin | 0 | DIRECT |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 0 | DIRECT |
89837,89837
89837 - Doublecortin (DC)
89837 - Doublecortin (DC) | 0 | DIRECT |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | DIRECT |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | DIRECT |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0 | DIRECT |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0 | DIRECT |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | DIRECT |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | DIRECT |
49785,49899
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
103575,81296
103575 - Plexin repeat
81296 - E set domains | 0 | DIRECT |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | DIRECT |
54001,143791
54001 - Cysteine proteinases
143791 - DUSP-like | 0 | DIRECT |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | DIRECT |
49854,49785
49854 - Spermadhesin, CUB domain
49785 - Galactose-binding domain-like | 0 | DIRECT |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
49854,57196
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin | 0 | DIRECT |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | DIRECT |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | DIRECT |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | DIRECT |
111418,81321
111418 - Hormone receptor domain
81321 - Family A G protein-coupled receptor-like | 0 | DIRECT |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0 | DIRECT |
49265,49899
49265 - Fibronectin type III
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
49562,48350
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | DIRECT |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | DIRECT |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0 | DIRECT |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | DIRECT |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0 | DIRECT |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0 | DIRECT |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0 | DIRECT |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
52058,49265
52058 - L domain-like
49265 - Fibronectin type III | 0 | DIRECT |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | DIRECT |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0 | DIRECT |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0 | DIRECT |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | DIRECT |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57196,49854
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | DIRECT |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | DIRECT |
57184,57603
57184 - Growth factor receptor domain
57603 - FnI-like domain | 0 | DIRECT |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0 | DIRECT |
81296,81296
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | DIRECT |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | DIRECT |
54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | DIRECT |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0 | DIRECT |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
48097,56112
48097 - Regulator of G-protein signaling, RGS
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0 | DIRECT |
81324,81324
81324 - Voltage-gated potassium channels
81324 - Voltage-gated potassium channels | 0 | DIRECT |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0 | DIRECT |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | DIRECT |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | DIRECT |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | DIRECT |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
82199,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers | 0 | DIRECT |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | DIRECT |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.03286 | INHERITED FROM: white matter || synencephalon || medial longitudinal fasciculus |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.07009 | INHERITED FROM: lymph vessel || vasculature || lymphatic system || lateral line ganglion || blood vasculature || posterior lateral line ganglion |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.147 | INHERITED FROM: VeLD || Kolmer-Agduhr neuron || heart || cardiac ventricle |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.2426 | INHERITED FROM: white matter || synencephalon || brain nucleus || brainstem || medial longitudinal fasciculus |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.4553 | INHERITED FROM: blood vessel endothelium || blood vessel endothelial cell || vascular endothelium |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.4589 | INHERITED FROM: head kidney |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.6401 | INHERITED FROM: striated muscle cell || myotome || trunk musculature || skeletal muscle cell || liver and biliary system || liver || muscle cell || skeletal muscle || musculature system |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6401 | INHERITED FROM: striated muscle cell || myotome || trunk musculature || skeletal muscle cell || liver and biliary system || liver || muscle cell || skeletal muscle || musculature system |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.6578 | INHERITED FROM: white matter || cranial nerve || diencephalic white matter || cranial nerve II || optic tectum || retinal ganglion cell layer || nerve |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0.6855 | INHERITED FROM: myotome || trunk musculature |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7328 | INHERITED FROM: axial blood vessel || ventral wall of dorsal aorta || artery || dorsal aorta |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.7417 | INHERITED FROM: pronephros || renal system |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.7446 | INHERITED FROM: ventral thalamus || thalamus |
82109,100909
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0.7829 | INHERITED FROM: striated muscle cell || skeletal muscle cell || muscle cell || skeletal muscle |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 1 | INHERITED FROM: eye photoreceptor cell || retinal outer nuclear layer |
| Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
52540,50447
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins | 0 | Direct |
46785,46785
46785 - "Winged helix" DNA-binding domain
46785 - "Winged helix" DNA-binding domain | 0 | Direct |
90193,90193
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
55550,50044
55550 - SH2 domain
50044 - SH3-domain | 0 | Direct |
53067,53067
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain | 0 | Direct |
69318,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains | 0 | Direct |
52283,51735
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51735 - NAD(P)-binding Rossmann-fold domains | 0 | Direct |
55486,50923
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
57903,57903
57903 - FYVE/PHD zinc finger
57903 - FYVE/PHD zinc finger | 0 | Direct |
57184,52058
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
141072,141072
141072 - CalX-like
141072 - CalX-like | 0 | Direct |
82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
49785,57184
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | Direct |
56436,56436
56436 - C-type lectin-like
56436 - C-type lectin-like | 0 | Direct |
47655,49417
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
46966,47473
46966 - Spectrin repeat
47473 - EF-hand | 0 | Direct |
82109,82109
82109 - MIR domain
82109 - MIR domain | 0 | Direct |
52058,52058
52058 - L domain-like
52058 - L domain-like | 0 | Direct |
52743,49785
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
50729,47473
50729 - PH domain-like
47473 - EF-hand | 0 | Direct |
57362,57362
57362 - BPTI-like
57362 - BPTI-like | 0 | Direct |
100909,49899
100909 - IP3 receptor type 1 binding core, domain 2
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | Direct |
49417,81296
49417 - p53-like transcription factors
81296 - E set domains | 0 | Direct |
52058,57184
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
82153,82153
82153 - FAS1 domain
82153 - FAS1 domain | 0 | Direct |
57440,57440
57440 - Kringle-like
57440 - Kringle-like | 0 | Direct |
54585,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57196,90193
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
50044,55550
50044 - SH3-domain
55550 - SH2 domain | 0 | Direct |
69179,69179
69179 - Integrin domains
69179 - Integrin domains | 0 | Direct |
90257,57997
90257 - Myosin rod fragments
57997 - Tropomyosin | 0 | Direct |
49265,48726
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
57850,57850
57850 - RING/U-box
57850 - RING/U-box | 0 | Direct |
89837,89837
89837 - Doublecortin (DC)
89837 - Doublecortin (DC) | 0 | Direct |
49899,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin | 0 | Direct |
54897,52743
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like | 0 | Direct |
57603,57603
57603 - FnI-like domain
57603 - FnI-like domain | 0 | Direct |
81324,81296
81324 - Voltage-gated potassium channels
81296 - E set domains | 0 | Direct |
57196,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54160,54160
54160 - Chromo domain-like
54160 - Chromo domain-like | 0 | Direct |
57184,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
47090,55486
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain | 0 | Direct |
49785,49899
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
103575,81296
103575 - Plexin repeat
81296 - E set domains | 0 | Direct |
103575,48726
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | Direct |
54001,143791
54001 - Cysteine proteinases
143791 - DUSP-like | 0 | Direct |
49562,48371
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat | 0 | Direct |
49854,49785
49854 - Spermadhesin, CUB domain
49785 - Galactose-binding domain-like | 0 | Direct |
63380,52343
63380 - Riboflavin synthase domain-like
52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
49854,57196
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin | 0 | Direct |
55550,55550
55550 - SH2 domain
55550 - SH2 domain | 0 | Direct |
101912,103575
101912 - Sema domain
103575 - Plexin repeat | 0 | Direct |
48425,50729
48425 - Sec7 domain
50729 - PH domain-like | 0 | Direct |
111418,81321
111418 - Hormone receptor domain
81321 - Family A G protein-coupled receptor-like | 0 | Direct |
52833,47616
52833 - Thioredoxin-like
47616 - GST C-terminal domain-like | 0 | Direct |
49265,49899
49265 - Fibronectin type III
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
49562,48350
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48350 - GTPase activation domain, GAP | 0 | Direct |
48092,47655
48092 - Transcription factor STAT-4 N-domain
47655 - STAT | 0 | Direct |
50044,50044
50044 - SH3-domain
50044 - SH3-domain | 0 | Direct |
47986,52129
47986 - DEATH domain
52129 - Caspase-like | 0 | Direct |
49785,49785
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | Direct |
50978,50998
50978 - WD40 repeat-like
50998 - Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
63825,57196
63825 - YWTD domain
57196 - EGF/Laminin | 0 | Direct |
48371,56112
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
50447,50465
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
63712,90112
63712 - Nicotinic receptor ligand binding domain-like
90112 - Neurotransmitter-gated ion-channel transmembrane pore | 0 | Direct |
49562,49562
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
47454,57959
47454 - A DNA-binding domain in eukaryotic transcription factors
57959 - Leucine zipper domain | 0 | Direct |
50044,52540
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
52058,49265
52058 - L domain-like
49265 - Fibronectin type III | 0 | Direct |
50729,56112
50729 - PH domain-like
56112 - Protein kinase-like (PK-like) | 0 | Direct |
54236,47031
54236 - Ubiquitin-like
47031 - Second domain of FERM | 0 | Direct |
57196,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
47459,158457
47459 - HLH, helix-loop-helix DNA-binding domain
158457 - Orange domain-like | 0 | Direct |
57716,48508
57716 - Glucocorticoid receptor-like (DNA-binding domain)
48508 - Nuclear receptor ligand-binding domain | 0 | Direct |
75399,75399
75399 - Plakin repeat
75399 - Plakin repeat | 0 | Direct |
49417,55550
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
53067,100920
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
55550,56112
55550 - SH2 domain
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57196,49854
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | Direct |
50692,54585
50692 - ADC-like
54585 - Cdc48 domain 2-like | 0 | Direct |
57586,57586
57586 - TNF receptor-like
57586 - TNF receptor-like | 0 | Direct |
57184,57603
57184 - Growth factor receptor domain
57603 - FnI-like domain | 0 | Direct |
90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0 | Direct |
81296,81296
81296 - E set domains
81296 - E set domains | 0 | Direct |
52490,55307
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like | 0 | Direct |
54160,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
47413,46689
47413 - lambda repressor-like DNA-binding domains
46689 - Homeodomain-like | 0 | Direct |
54791,54791
54791 - Eukaryotic type KH-domain (KH-domain type I)
54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
54236,54236
54236 - Ubiquitin-like
54236 - Ubiquitin-like | 0 | Direct |
52777,52777
52777 - CoA-dependent acyltransferases
52777 - CoA-dependent acyltransferases | 0 | Direct |
56112,56112
56112 - Protein kinase-like (PK-like)
56112 - Protein kinase-like (PK-like) | 0 | Direct |
57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
48097,56112
48097 - Regulator of G-protein signaling, RGS
56112 - Protein kinase-like (PK-like) | 0 | Direct |
48371,48371
48371 - ARM repeat
48371 - ARM repeat | 0 | Direct |
81324,81324
81324 - Voltage-gated potassium channels
81324 - Voltage-gated potassium channels | 0 | Direct |
52799,49562
52799 - (Phosphotyrosine protein) phosphatases II
49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
56968,48431
56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions
48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
47954,47954
47954 - Cyclin-like
47954 - Cyclin-like | 0 | Direct |
57903,47370
57903 - FYVE/PHD zinc finger
47370 - Bromodomain | 0 | Direct |
57196,63825
57196 - EGF/Laminin
63825 - YWTD domain | 0 | Direct |
51556,51338
51556 - Metallo-dependent hydrolases
51338 - Composite domain of metallo-dependent hydrolases | 0 | Direct |
52374,47323
52374 - Nucleotidylyl transferase
47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
50156,50044
50156 - PDZ domain-like
50044 - SH3-domain | 0 | Direct |
47473,51695
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
82199,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers | 0 | Direct |
57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
51905,54373
51905 - FAD/NAD(P)-binding domain
54373 - FAD-linked reductases, C-terminal domain | 0 | Direct |
48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.03286 | Inherited |
57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin | 0.07009 | Inherited |
57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.147 | Inherited |
48726,49265
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.2426 | Inherited |
48065,50729
48065 - DBL homology domain (DH-domain)
50729 - PH domain-like | 0.4553 | Inherited |
49265,49265
49265 - Fibronectin type III
49265 - Fibronectin type III | 0.4589 | Inherited |
48592,54849
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like | 0.6401 | Inherited |
54849,52029
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6401 | Inherited |
49313,49313
49313 - Cadherin-like
49313 - Cadherin-like | 0.6578 | Inherited |
53300,53300
53300 - vWA-like
53300 - vWA-like | 0.6855 | Inherited |
55021,56534
55021 - ACT-like
56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.7328 | Inherited |
48452,48452
48452 - TPR-like
48452 - TPR-like | 0.7417 | Inherited |
57667,57667
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0.7446 | Inherited |
82109,100909
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0.7829 | Inherited |
50156,50156
50156 - PDZ domain-like
50156 - PDZ domain-like | 1 | Inherited |
(show details)
Supra-domains annotated to this ZA term (Not in SPZA)
Highlighted in gray are those with FDR>0.001
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | DIRECT |
49854,49785,49785
49854 - Spermadhesin, CUB domain
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | DIRECT |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | DIRECT |
57196,90193,90193
57196 - EGF/Laminin
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | DIRECT |
52743,49785,57184
52743 - Subtilisin-like
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | DIRECT |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | DIRECT |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0 | DIRECT |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | DIRECT |
90193,90193,90193
90193 - Notch domain
90193 - Notch domain
90193 - Notch domain | 0 | DIRECT |
49854,57196,49854
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | DIRECT |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0 | DIRECT |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
82109,100909,49899
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
82109,82109,100909
82109 - MIR domain
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | DIRECT |
46966,46966,47473
46966 - Spectrin repeat
46966 - Spectrin repeat
47473 - EF-hand | 0 | DIRECT |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | DIRECT |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
90257,90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0 | DIRECT |
52058,49265,49265
52058 - L domain-like
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | DIRECT |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49785,49785,49899
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | DIRECT |
103575,81296,81296
103575 - Plexin repeat
81296 - E set domains
81296 - E set domains | 0 | DIRECT |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | DIRECT |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
57184,52058,49265
57184 - Growth factor receptor domain
52058 - L domain-like
49265 - Fibronectin type III | 0 | DIRECT |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0 | DIRECT |
75399,75399,75399
75399 - Plakin repeat
75399 - Plakin repeat
75399 - Plakin repeat | 0 | DIRECT |
57196,63825,57196
57196 - EGF/Laminin
63825 - YWTD domain
57196 - EGF/Laminin | 0 | DIRECT |
55753,55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | DIRECT |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | DIRECT |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0 | DIRECT |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
82199,57667,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0 | DIRECT |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | DIRECT |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | DIRECT |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | DIRECT |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | DIRECT |
49899,57196,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | DIRECT |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | DIRECT |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.06502 | INHERITED FROM: white matter || synencephalon || medial longitudinal fasciculus |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.3198 | INHERITED FROM: skeletal muscle cell || white matter || synencephalon || brain nucleus || brainstem || medial longitudinal fasciculus |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.3957 | INHERITED FROM: cardiac ventricle |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6401 | INHERITED FROM: striated muscle cell || myotome || trunk musculature || skeletal muscle cell || liver and biliary system || liver || muscle cell || skeletal muscle || musculature system |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.6861 | INHERITED FROM: macula || white matter || cranial nerve || diencephalic white matter || cranial nerve II || optic tectum || retinal ganglion cell layer || nerve |
| Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
101912,103575,48726
101912 - Sema domain
103575 - Plexin repeat
48726 - Immunoglobulin | 0 | Direct |
49854,49785,49785
49854 - Spermadhesin, CUB domain
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like | 0 | Direct |
54585,52540,52540
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57184,52058,57184
57184 - Growth factor receptor domain
52058 - L domain-like
57184 - Growth factor receptor domain | 0 | Direct |
52058,57184,52058
52058 - L domain-like
57184 - Growth factor receptor domain
52058 - L domain-like | 0 | Direct |
47090,55486,50923
47090 - PGBD-like
55486 - Metalloproteases ("zincins"), catalytic domain
50923 - Hemopexin-like domain | 0 | Direct |
57196,90193,90193
57196 - EGF/Laminin
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
57184,57196,57196
57184 - Growth factor receptor domain
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
81296,81296,81296
81296 - E set domains
81296 - E set domains
81296 - E set domains | 0 | Direct |
57196,57196,90193
57196 - EGF/Laminin
57196 - EGF/Laminin
90193 - Notch domain | 0 | Direct |
52743,49785,57184
52743 - Subtilisin-like
49785 - Galactose-binding domain-like
57184 - Growth factor receptor domain | 0 | Direct |
57196,57196,57184
57196 - EGF/Laminin
57196 - EGF/Laminin
57184 - Growth factor receptor domain | 0 | Direct |
48726,49265,49265
48726 - Immunoglobulin
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
57850,57850,57850
57850 - RING/U-box
57850 - RING/U-box
57850 - RING/U-box | 0 | Direct |
49899,49899,49899
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54160,54160,52540
54160 - Chromo domain-like
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57424,57424,57424
57424 - LDL receptor-like module
57424 - LDL receptor-like module
57424 - LDL receptor-like module | 0 | Direct |
90193,90193,90193
90193 - Notch domain
90193 - Notch domain
90193 - Notch domain | 0 | Direct |
49854,57196,49854
49854 - Spermadhesin, CUB domain
57196 - EGF/Laminin
49854 - Spermadhesin, CUB domain | 0 | Direct |
54160,52540,52540
54160 - Chromo domain-like
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
69318,69179,69179
69318 - Integrin alpha N-terminal domain
69179 - Integrin domains
69179 - Integrin domains | 0 | Direct |
57184,57184,57196
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
82109,100909,49899
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
82109,82109,100909
82109 - MIR domain
82109 - MIR domain
100909 - IP3 receptor type 1 binding core, domain 2 | 0 | Direct |
46966,46966,47473
46966 - Spectrin repeat
46966 - Spectrin repeat
47473 - EF-hand | 0 | Direct |
82895,82895,82895
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat
82895 - TSP-1 type 1 repeat | 0 | Direct |
50692,54585,52540
50692 - ADC-like
54585 - Cdc48 domain 2-like
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
90257,90257,90257
90257 - Myosin rod fragments
90257 - Myosin rod fragments
90257 - Myosin rod fragments | 0 | Direct |
52058,49265,49265
52058 - L domain-like
49265 - Fibronectin type III
49265 - Fibronectin type III | 0 | Direct |
49562,48371,56112
49562 - C2 domain (Calcium/lipid-binding domain, CaLB)
48371 - ARM repeat
56112 - Protein kinase-like (PK-like) | 0 | Direct |
49785,49785,49899
49785 - Galactose-binding domain-like
49785 - Galactose-binding domain-like
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
57196,57184,57184
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
47655,49417,55550
47655 - STAT
49417 - p53-like transcription factors
55550 - SH2 domain | 0 | Direct |
103575,81296,81296
103575 - Plexin repeat
81296 - E set domains
81296 - E set domains | 0 | Direct |
54897,52743,49785
54897 - Protease propeptides/inhibitors
52743 - Subtilisin-like
49785 - Galactose-binding domain-like | 0 | Direct |
57196,57196,57196
57196 - EGF/Laminin
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
52540,50447,50465
52540 - P-loop containing nucleoside triphosphate hydrolases
50447 - Translation proteins
50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
57184,52058,49265
57184 - Growth factor receptor domain
52058 - L domain-like
49265 - Fibronectin type III | 0 | Direct |
57603,57603,57603
57603 - FnI-like domain
57603 - FnI-like domain
57603 - FnI-like domain | 0 | Direct |
75399,75399,75399
75399 - Plakin repeat
75399 - Plakin repeat
75399 - Plakin repeat | 0 | Direct |
57196,63825,57196
57196 - EGF/Laminin
63825 - YWTD domain
57196 - EGF/Laminin | 0 | Direct |
55753,55753,55753
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins
55753 - Actin depolymerizing proteins | 0 | Direct |
57196,49899,49899
57196 - EGF/Laminin
49899 - Concanavalin A-like lectins/glucanases
49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
52540,52540,52540
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57184,57184,57184
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain
57184 - Growth factor receptor domain | 0 | Direct |
69179,69179,69179
69179 - Integrin domains
69179 - Integrin domains
69179 - Integrin domains | 0 | Direct |
50156,50044,52540
50156 - PDZ domain-like
50044 - SH3-domain
52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
82199,57667,57667
82199 - SET domain
57667 - beta-beta-alpha zinc fingers
57667 - beta-beta-alpha zinc fingers | 0 | Direct |
53067,53067,100920
53067 - Actin-like ATPase domain
53067 - Actin-like ATPase domain
100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
48092,47655,49417
48092 - Transcription factor STAT-4 N-domain
47655 - STAT
49417 - p53-like transcription factors | 0 | Direct |
54236,47031,50729
54236 - Ubiquitin-like
47031 - Second domain of FERM
50729 - PH domain-like | 0 | Direct |
57196,57184,57196
57196 - EGF/Laminin
57184 - Growth factor receptor domain
57196 - EGF/Laminin | 0 | Direct |
48726,49265,48726
48726 - Immunoglobulin
49265 - Fibronectin type III
48726 - Immunoglobulin | 0 | Direct |
49899,57196,57196
49899 - Concanavalin A-like lectins/glucanases
57196 - EGF/Laminin
57196 - EGF/Laminin | 0 | Direct |
50729,47473,51695
50729 - PH domain-like
47473 - EF-hand
51695 - PLC-like phosphodiesterases | 0 | Direct |
48726,48726,48726
48726 - Immunoglobulin
48726 - Immunoglobulin
48726 - Immunoglobulin | 0.06502 | Inherited |
48726,48726,49265
48726 - Immunoglobulin
48726 - Immunoglobulin
49265 - Fibronectin type III | 0.3198 | Inherited |
57716,57716,57716
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.3957 | Inherited |
48592,54849,52029
48592 - GroEL equatorial domain-like
54849 - GroEL-intermediate domain like
52029 - GroEL apical domain-like | 0.6401 | Inherited |
49313,49313,49313
49313 - Cadherin-like
49313 - Cadherin-like
49313 - Cadherin-like | 0.6861 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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