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Zebrafish Anatomy (ZA): compound organ
(show info)
Phenotype Ontology
Like Gene Ontology (GO), phenotypy ontology classifies and organizes gene-mutant/null phenotypic information from the very general at the top to more specific terms in the directed acyclic graph (DAG) by viewing an individual term as a node and its relations to parental terms (allowing for multiple parents) as directed edges. To navigate this hierarchy, we display all parental phenotypic terms to the current phenotypic term of interest ordered by their shortest distances to the current term. Also, only direct children phenotypic terms of the current phenotypic term are listed. Phenotype ontologies we have incorporated are as follows:
- Disease Ontology (DO) Ontology (DO) DO semantically integrates disease and medical vocabularies through extensive cross mapping of DO terms to MeSH, ICD, NCI thesaurus, SNOMED and OMIM.
- Human Phenotype (HP) Ontology (HP) HP captures phenotypic abnormalities that are described in OMIM, along with the corresponding disease-causing genes. It includes three complementary biological concepts: Mode_of_Inheritance (MI), ONset_and_clinical_course (ON), and Phenotypic_Abnormality (PA).
- Mouse Phenotype (MP) Ontology (MP) MP describes phenotypes of the mouse after a specific gene is genetically disrupted. Using it, Mouse Genome Informatics (MGI) provides high-coverate gene-level phenotypes for the mouse.
- Worm Phenotype (WP) Ontology (WP) WP classifies and organizes phenotype descriptions for C. elegans and other nematodes. Using it, WormBase provides primary resource for phenotype annotations for C. elegans.
- Yeast Phenotype (YP) Ontology (YP) Based on YP which is the major contributor to the Ascomycete phenotype ontology, Saccharomyces Genome Database (SGD) provides single mutant phenotypes for every gene in the yeast genome.
- Fly Phenotype (FP) Ontology (FP) FP refers to FlyBase controlled vocabulary. Specifically, a structured controlled vocabulary is used for the annotation of alleles (for their mutagen etc) in FlyBase.
- Fly Anatomy (FA) Ontology (FA) FA is a structured controlled vocabulary of the anatomy of Drosophila melanogaster, used for the description of phenotypes and where a gene is expressed.
- Zebrafish Anatomy (ZA) Ontology (ZA) ZA displays anatomical terms of the zebrafish using standard anatomical nomenclature, together with affected genes.
- Xenopus Anatomy (XA) Ontology (XA) XA represents the lineage of tissues and the timing of development for frogs (Xenopus laevis and Xenopus tropicalis). It is used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes.
- Arabidopsis Plant Ontology (AP) Ontology (AP) As a major contributor to Plant Ontology which describes plant anatomical and morphological structures (AN) and growth and developmental stages (DE), the Arabidopsis Information Resource (TAIR) provides arabidopsis plant ontology annotations for the model higher plant Arabidopsis thaliana.
- Enzyme Commission (EC) Ontology (EC) Each enzyme is allocated a four-digit EC number, the first three digits of which define the reaction catalysed and the fourth of which is a unique identifier (serial number). Each enzyme is also assigned a systematic name that uniquely defines the reaction catalysed.
- DrugBank ATC (DB) Ontology (DB) In the Anatomical Therapeutic Chemical (ATC) classification system, drugs are classified in groups at five different levels according to the organ or system (1st level, anatomical main group) on which they act and their therapeutic (2nd level, therapeutic subgroup), pharmacological (3rd level, pharmacological subgroup) and chemical properties (4th level, chemical subgroup; 5th level, chemical substance). Only drugs in DrugBank are considered.
- UniProtKB KeyWords (KW) Ontology (KW) Keywords in UniProtKB are controlled vocabulary, providing a summary of the entry content and are used to index UniProtKB/Swiss-Prot entries based on 10 categories (the category "Technical term" being excluded here). Each keyword is attributed manually to UniProtKB/Swiss-Prot entries and automatically to UniProtKB/TrEMBL entries (according to specific annotation rules).
- UniProtKB UniPathway (UP) Ontology (UP) UP is a fully manually curated resource for the representation and annotation of metabolic pathways, being used as controlled vocabulary for pathway annotation in UniProtKB.
Structural Domain Phenotype Ontology and its Annotations
Structural Classification of Proteins (SCOP) classifies evolutionary-related domains into Superfamily level and Family level. Using the phenotype ontologies above, we have generated the domain-centric phenotype annotations, and further identified those phenotype terms which are the most informative to annotate SCOP domains. Promisingly, domain-centric phenotypic annotations can serve as an alternative starting point to explore genotype-phenotype relationships. We provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Structural Domain Disease Ontology (DO) Ontology (SDDO) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DO.txt, and the corresponding ontology:SDDO.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Human Phenotype (HP) Ontology (SDHP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2HP.txt, and the corresponding ontology:SDHP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Mouse Phenotype (MP) Ontology (SDMP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2MP.txt, and the corresponding ontology:SDMP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Worm Phenotype (WP) Ontology (SDWP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2WP.txt, and the corresponding ontology:SDWP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Yeast Phenotype (YP) Ontology (SDYP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2YP.txt, and the corresponding ontology:SDYP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Phenotype (FP) Ontology (SDFP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FP.txt, and the corresponding ontology:SDFP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Fly Anatomy (FA) Ontology (SDFA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2FA.txt, and the corresponding ontology:SDFA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Zebrafish Anatomy (ZA) Ontology (SDZA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2ZA.txt, and the corresponding ontology:SDZA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Xenopus Anatomy (XA) Ontology (SDXA) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2XA.txt, and the corresponding ontology:SDXA.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Arabidopsis Plant Ontology (AP) Ontology (SDAP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2AP.txt, and the corresponding ontology:SDAP.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain Enzyme Commission (EC) Ontology (SDEC) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2EC.txt, and the corresponding ontology:SDEC.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain DrugBank ATC (DB) Ontology (SDDB) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2DB.txt, and the corresponding ontology:SDDB.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB KeyWords (KW) Ontology (SDKW) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2KW.txt, and the corresponding ontology:SDKW.txt) and mysql tables (Domain2PO.sql.gz).
- Structural Domain UniProtKB UniPathway (UP) Ontology (SDUP) and its Annotations: For details, please visit Document: PO annotation for SCOP domains, wherein Data Availability contains parsable flat files (the annotation:Domain2UP.txt, and the corresponding ontology:SDUP.txt) and mysql tables (Domain2PO.sql.gz).
Supra-domain Phenotype Ontology and its Annotations
Although domain-centric annotations hold great promise in describing phenotypic nature of independent domains, most domains themselves may not just work alone. In multi-domain proteins, they may be combined together to form distinct domain architectures. The recombination of the existing domains is considered as one of major driving forces for phenotypic diversificaation. As an extension, we have also generated supra-domain phenotype ontology and its annotations. Compared to domain-centric phenotype ontology and annotations (SCOP domains at the Superfamily level and Family level), this version focuses on supra-domains and individual SCOP domains ONLY at the Superfamily level. Besides, in terms of individual superfamilies, their annotations from the domain-centric version may be different from those from supra-domains version. Depending on your focus, the former should be used for the consideration of both the Superfamily level and Family level, otherwise the latter should be used if you are interested in domain combinations. Also, we provide several relevant files for the download, including the annotation and the corresponding ontology for each phenotype ontology.
- Supra-domain Domain Disease Ontology (DO) Ontology (SPDO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DO.txt, and the corresponding ontology:SPDO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Human Phenotype (HP) Ontology (SPHO) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2HP.txt, and the corresponding ontology:SPHO.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Mouse Phenotype (MP) Ontology (SPMP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2MP.txt, and the corresponding ontology:SPMP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Worm Phenotype (WP) Ontology (SPWP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2WP.txt, and the corresponding ontology:SPWP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Yeast Phenotype (YP) Ontology (SPYP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2YP.txt, and the corresponding ontology:SPYP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Phenotype (FP) Ontology (SPFP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FP.txt, and the corresponding ontology:SPFP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Fly Anatomy (FA) Ontology (SPFA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2FA.txt, and the corresponding ontology:SPFA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Zebrafish Anatomy (ZA) Ontology (SPZA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2ZA.txt, and the corresponding ontology:SPZA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Xenopus Anatomy (XA) Ontology (SPXA) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2XA.txt, and the corresponding ontology:SPXA.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Arabidopsis Plant Ontology (AP) Ontology (SPAP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2AP.txt, and the corresponding ontology:SPAP.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain Enzyme Commission (EC) Ontology (SPEC) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2EC.txt, and the corresponding ontology:SPEC.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain DrugBank ATC (DB) Ontology (SPDB) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2DB.txt, and the corresponding ontology:SPDB.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB KeyWords (KW) Ontology (SPKW) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2KW.txt, and the corresponding ontology:SPKW.txt) and mysql tables (SP2PO.sql.gz).
- Supra-domain Domain UniProtKB UniPathway (UP) Ontology (SPUP) and its Annotations: For details, please visit Document: PO annotation for Supra-domains, wherein Data Availability contains parsable flat files (the annotation:SP2UP.txt, and the corresponding ontology:SPUP.txt) and mysql tables (SP2PO.sql.gz).
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Root: ZA Hierarchy (zebrafish anatomy from ZFIN zebrafish anatomy ontology)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Superfamily(show details)
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Family(show details)
Family domains annotated to this ZA term (Not in SDZA)
Highlighted in gray are those with FDR_all>0.001
SCOP term | FDR (all) | Annotation (direct or inherited) |
SRF-like | 0 | DIRECT |
Elongation factors | 0 | DIRECT |
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | DIRECT |
Platelet-derived growth factor-like | 0 | DIRECT |
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | DIRECT |
Actin/HSP70 | 0 | DIRECT |
Mammalian PLC | 0 | DIRECT |
F-box domain | 0 | DIRECT |
Formin homology 2 domain (FH2 domain) | 0 | DIRECT |
Cdc48 domain 2-like | 0 | DIRECT |
Ephrin receptor ligand binding domain | 0 | DIRECT |
Hydantoinase (dihydropyrimidinase) | 0 | DIRECT |
Sec7 domain | 0 | DIRECT |
SNARE fusion complex | 0 | DIRECT |
L domain | 0 | DIRECT |
Aquaporin-like | 0 | DIRECT |
Biotinyl/lipoyl-carrier proteins and domains | 0 | DIRECT |
CalX-beta domain | 0 | DIRECT |
Histone lysine methyltransferases | 0 | DIRECT |
P4 origin-binding domain-like | 0 | DIRECT |
Ephrin ectodomain | 0 | DIRECT |
Cytoplasmic domain of inward rectifier potassium channel | 0 | DIRECT |
V set domains (antibody variable domain-like) | 0 | DIRECT |
Adenylyl and guanylyl cyclase catalytic domain | 0 | DIRECT |
Small Kunitz-type inhibitors & BPTI-like toxins | 0 | DIRECT |
Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | DIRECT |
Cap-Gly domain | 0 | DIRECT |
C5 cytosine-specific DNA methylase, DCM | 0 | DIRECT |
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | DIRECT |
Histone deacetylase, HDAC | 0 | DIRECT |
Tubulin, GTPase domain | 0 | DIRECT |
Noncollagenous (NC1) domain of collagen IV | 0 | DIRECT |
Pyridoxal-dependent decarboxylase | 0 | DIRECT |
CCCH zinc finger | 0 | DIRECT |
Hairy Orange domain | 0 | DIRECT |
Tubulin, C-terminal domain | 0 | DIRECT |
CCHHC domain | 0 | DIRECT |
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | DIRECT |
Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | DIRECT |
LCCL domain | 0 | DIRECT |
Connexin43 | 0 | DIRECT |
Phoshoinositide 3-kinase (PI3K) helical domain | 0 | DIRECT |
Anticodon-binding domain of Class II aaRS | 0 | DIRECT |
Regulator of chromosome condensation RCC1 | 0 | DIRECT |
Reprolysin-like | 0 | DIRECT |
Doublecortin (DC) | 0 | DIRECT |
Extracellular domain of cell surface receptors | 0 | DIRECT |
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
Hormone receptor domain | 0 | DIRECT |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
Nuclear receptor coactivator interlocking domain | 0 | DIRECT |
Chromo domain | 0 | DIRECT |
Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | DIRECT |
Glycerophosphoryl diester phosphodiesterase | 0 | DIRECT |
Moesin tail domain | 0 | DIRECT |
Erythroid transcription factor GATA-1 | 0 | DIRECT |
VWC domain | 0 | DIRECT |
Tetramerization domain of potassium channels | 0 | DIRECT |
Long-chain cytokines | 0 | DIRECT |
Caspase catalytic domain | 0 | DIRECT |
Cell cycle transcription factor e2f-dp | 0 | DIRECT |
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0 | DIRECT |
ALDH-like | 0 | DIRECT |
PP2C-like | 0 | DIRECT |
Notch domain | 0 | DIRECT |
Ras GEF | 0 | DIRECT |
Pentraxin (pentaxin) | 0 | DIRECT |
Cdc48 N-terminal domain-like | 0 | DIRECT |
FHA domain | 0 | DIRECT |
Rel/Dorsal transcription factors, DNA-binding domain | 0 | DIRECT |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0 | DIRECT |
Ovomucoid domain III-like | 0 | DIRECT |
Single strand DNA-binding domain, SSB | 0 | DIRECT |
Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
BRK domain-like | 0 | DIRECT |
SWIRM domain | 0 | DIRECT |
Protein kinases, catalytic subunit | 0.0028 | INHERITED FROM: dorsal longitudinal anastomotic vessel |
Nuclear receptor ligand-binding domain | 0.02302 | INHERITED FROM: gonad || ovarian follicle stage IV || hypophysis |
Nuclear receptor | 0.02773 | INHERITED FROM: gonad || ovarian follicle stage IV || hypophysis |
Homeodomain | 0.03337 | INHERITED FROM: endocrine pancreas || diencephalon || preoptic area || dorsal telencephalon || forebrain |
WD40-repeat | 0.07015 | INHERITED FROM: photoreceptor outer segment layer || retinal cone cell |
SH2 domain | 0.1032 | INHERITED FROM: thymus |
Motor proteins | 0.1206 | INHERITED FROM: renal corpuscle || photoreceptor outer segment layer || pronephric podocyte |
Fibronectin type III | 0.1278 | INHERITED FROM: glomerular layer || synencephalon |
Tetratricopeptide repeat (TPR) | 0.1818 | INHERITED FROM: retinal rod cell |
HMG-box | 0.1818 | INHERITED FROM: ceratobranchial 5 bone |
Zf-UBP | 0.231 | INHERITED FROM: chondrocranium cartilage || Meckel's cartilage || ethmoid cartilage |
Transforming growth factor (TGF)-beta | 0.2527 | INHERITED FROM: spermatogenic cyst || pineal complex |
I set domains | 0.2674 | INHERITED FROM: synencephalon |
POU-specific domain | 0.2791 | INHERITED FROM: diencephalon || forebrain |
Phenylalanine metabolism regulatory domain | 0.4071 | INHERITED FROM: ventral wall of dorsal aorta || dorsal aorta || artery |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.4071 | INHERITED FROM: ventral wall of dorsal aorta || dorsal aorta || artery |
Multidrug efflux transporter AcrB transmembrane domain | 0.4071 | INHERITED FROM: retinal ganglion cell layer || hyosymplectic cartilage |
Group II chaperonin (CCT, TRIC), intermediate domain | 0.4071 | INHERITED FROM: solid compound organ || liver |
PDZ domain | 0.4155 | INHERITED FROM: central canal |
Classic zinc finger, C2H2 | 0.4326 | INHERITED FROM: ventral thalamus || thalamus |
Cytochrome P450 | 0.4818 | INHERITED FROM: hypophysis |
Fibroblast growth factors (FGF) | 0.4893 | INHERITED FROM: intramembranous bone |
Tropomyosin | 0.4893 | INHERITED FROM: sinus venosus |
T-box | 0.5322 | INHERITED FROM: pronephros || atrioventricular canal |
LIM domain | 0.5618 | INHERITED FROM: cardiac ventricle |
Group II chaperonin (CCT, TRIC), apical domain | 0.6242 | INHERITED FROM: solid compound organ |
Calcium ATPase, transmembrane domain M | 0.6242 | INHERITED FROM: atrium |
Group II chaperonin (CCT, TRIC), ATPase domain | 0.7027 | INHERITED FROM: solid compound organ || liver |
Cadherin | 0.7168 | INHERITED FROM: cranial nerve II || optic tectum || diencephalic white matter |
Retrovirus zinc finger-like domains | 0.7815 | INHERITED FROM: gill || pharyngeal arch 3-7 |
Ubiquitin carboxyl-terminal hydrolase, UCH | 0.7947 | INHERITED FROM: skeletal element || cartilage element || cranial cartilage || ethmoid cartilage || pharyngeal arch cartilage |
Carbonic anhydrase | 0.8865 | INHERITED FROM: swim bladder |
HLH, helix-loop-helix DNA-binding domain | 0.944 | INHERITED FROM: Kolmer-Agduhr neuron |
SCOP term | FDR (all) | Annotation (direct or inherited) |
SRF-like | 0 | Direct |
Elongation factors | 0 | Direct |
Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit | 0 | Direct |
Platelet-derived growth factor-like | 0 | Direct |
Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A | 0 | Direct |
Actin/HSP70 | 0 | Direct |
Mammalian PLC | 0 | Direct |
F-box domain | 0 | Direct |
Formin homology 2 domain (FH2 domain) | 0 | Direct |
Cdc48 domain 2-like | 0 | Direct |
Ephrin receptor ligand binding domain | 0 | Direct |
Hydantoinase (dihydropyrimidinase) | 0 | Direct |
Sec7 domain | 0 | Direct |
SNARE fusion complex | 0 | Direct |
L domain | 0 | Direct |
Aquaporin-like | 0 | Direct |
Biotinyl/lipoyl-carrier proteins and domains | 0 | Direct |
CalX-beta domain | 0 | Direct |
Histone lysine methyltransferases | 0 | Direct |
P4 origin-binding domain-like | 0 | Direct |
Ephrin ectodomain | 0 | Direct |
Cytoplasmic domain of inward rectifier potassium channel | 0 | Direct |
V set domains (antibody variable domain-like) | 0 | Direct |
Adenylyl and guanylyl cyclase catalytic domain | 0 | Direct |
Small Kunitz-type inhibitors & BPTI-like toxins | 0 | Direct |
Lipovitellin-phosvitin complex; beta-sheet shell regions | 0 | Direct |
Cap-Gly domain | 0 | Direct |
C5 cytosine-specific DNA methylase, DCM | 0 | Direct |
Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta | 0 | Direct |
Histone deacetylase, HDAC | 0 | Direct |
Tubulin, GTPase domain | 0 | Direct |
Noncollagenous (NC1) domain of collagen IV | 0 | Direct |
Pyridoxal-dependent decarboxylase | 0 | Direct |
CCCH zinc finger | 0 | Direct |
Hairy Orange domain | 0 | Direct |
Tubulin, C-terminal domain | 0 | Direct |
CCHHC domain | 0 | Direct |
NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain | 0 | Direct |
Phoshoinositide 3-kinase (PI3K), catalytic domain | 0 | Direct |
LCCL domain | 0 | Direct |
Connexin43 | 0 | Direct |
Phoshoinositide 3-kinase (PI3K) helical domain | 0 | Direct |
Anticodon-binding domain of Class II aaRS | 0 | Direct |
Regulator of chromosome condensation RCC1 | 0 | Direct |
Reprolysin-like | 0 | Direct |
Doublecortin (DC) | 0 | Direct |
Extracellular domain of cell surface receptors | 0 | Direct |
Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
Hormone receptor domain | 0 | Direct |
Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
Nuclear receptor coactivator interlocking domain | 0 | Direct |
Chromo domain | 0 | Direct |
Hydantoinase (dihydropyrimidinase), catalytic domain | 0 | Direct |
Glycerophosphoryl diester phosphodiesterase | 0 | Direct |
Moesin tail domain | 0 | Direct |
Erythroid transcription factor GATA-1 | 0 | Direct |
VWC domain | 0 | Direct |
Tetramerization domain of potassium channels | 0 | Direct |
Long-chain cytokines | 0 | Direct |
Caspase catalytic domain | 0 | Direct |
Cell cycle transcription factor e2f-dp | 0 | Direct |
Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain | 0 | Direct |
ALDH-like | 0 | Direct |
PP2C-like | 0 | Direct |
Notch domain | 0 | Direct |
Ras GEF | 0 | Direct |
Pentraxin (pentaxin) | 0 | Direct |
Cdc48 N-terminal domain-like | 0 | Direct |
FHA domain | 0 | Direct |
Rel/Dorsal transcription factors, DNA-binding domain | 0 | Direct |
EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
Class I aminoacyl-tRNA synthetases (RS), catalytic domain | 0 | Direct |
Ovomucoid domain III-like | 0 | Direct |
Single strand DNA-binding domain, SSB | 0 | Direct |
Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
BRK domain-like | 0 | Direct |
SWIRM domain | 0 | Direct |
Protein kinases, catalytic subunit | 0.0028 | Inherited |
Nuclear receptor ligand-binding domain | 0.02302 | Inherited |
Nuclear receptor | 0.02773 | Inherited |
Homeodomain | 0.03337 | Inherited |
WD40-repeat | 0.07015 | Inherited |
SH2 domain | 0.1032 | Inherited |
Motor proteins | 0.1206 | Inherited |
Fibronectin type III | 0.1278 | Inherited |
Tetratricopeptide repeat (TPR) | 0.1818 | Inherited |
HMG-box | 0.1818 | Inherited |
Zf-UBP | 0.231 | Inherited |
Transforming growth factor (TGF)-beta | 0.2527 | Inherited |
I set domains | 0.2674 | Inherited |
POU-specific domain | 0.2791 | Inherited |
Phenylalanine metabolism regulatory domain | 0.4071 | Inherited |
Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.4071 | Inherited |
Multidrug efflux transporter AcrB transmembrane domain | 0.4071 | Inherited |
Group II chaperonin (CCT, TRIC), intermediate domain | 0.4071 | Inherited |
PDZ domain | 0.4155 | Inherited |
Classic zinc finger, C2H2 | 0.4326 | Inherited |
Cytochrome P450 | 0.4818 | Inherited |
Fibroblast growth factors (FGF) | 0.4893 | Inherited |
Tropomyosin | 0.4893 | Inherited |
T-box | 0.5322 | Inherited |
LIM domain | 0.5618 | Inherited |
Group II chaperonin (CCT, TRIC), apical domain | 0.6242 | Inherited |
Calcium ATPase, transmembrane domain M | 0.6242 | Inherited |
Group II chaperonin (CCT, TRIC), ATPase domain | 0.7027 | Inherited |
Cadherin | 0.7168 | Inherited |
Retrovirus zinc finger-like domains | 0.7815 | Inherited |
Ubiquitin carboxyl-terminal hydrolase, UCH | 0.7947 | Inherited |
Carbonic anhydrase | 0.8865 | Inherited |
HLH, helix-loop-helix DNA-binding domain | 0.944 | Inherited |
Plot distribution on phylogenetic tree for Superfamily and/or Family domains annotated by this phenotype term
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Trees by TreeVector
A presence/absence matrix is generated using protein domain
architecture data for all genomes in SUPERFAMILY. The PAUP
software is used to produce a single, large tree topology using
heuristic parsimony methods. Genome combinations, or specific clades, can be displayed as
if individual trees had been produced. However, this data is extracted from the single
large tree. This produces a higher quality topology than if the trees had been produced
on their own, and allows the trees to be displayed instantly.
Jump to [ Top · Phenotype Hierarchy · Superfamily · Family · Supra-domain ]
Supra-domain (including individual superfamily)
(show details)
Supra-domains annotated to this ZA term (Not in SPZA)
Highlighted in gray are those with FDR>0.001
(show details)
Supra-domains annotated to this ZA term (Not in SPZA)
Highlighted in gray are those with FDR>0.001
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55550,55550 55550 - SH2 domain 55550 - SH2 domain | 0 | DIRECT |
52374,47323 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | DIRECT |
48425,50729 48425 - Sec7 domain 50729 - PH domain-like | 0 | DIRECT |
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | DIRECT |
52058,49265 52058 - L domain-like 49265 - Fibronectin type III | 0 | DIRECT |
54160,54160 54160 - Chromo domain-like 54160 - Chromo domain-like | 0 | DIRECT |
56968,48431 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions 48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | DIRECT |
89837,89837 89837 - Doublecortin (DC) 89837 - Doublecortin (DC) | 0 | DIRECT |
81324,81324 81324 - Voltage-gated potassium channels 81324 - Voltage-gated potassium channels | 0 | DIRECT |
46966,47473 46966 - Spectrin repeat 47473 - EF-hand | 0 | DIRECT |
56112,56112 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like | 0 | DIRECT |
103575,81296 103575 - Plexin repeat 81296 - E set domains | 0 | DIRECT |
50729,47473 50729 - PH domain-like 47473 - EF-hand | 0 | DIRECT |
47986,52129 47986 - DEATH domain 52129 - Caspase-like | 0 | DIRECT |
63380,52343 63380 - Riboflavin synthase domain-like 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | DIRECT |
111418,81321 111418 - Hormone receptor domain 81321 - Family A G protein-coupled receptor-like | 0 | DIRECT |
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like | 0 | DIRECT |
90193,90193 90193 - Notch domain 90193 - Notch domain | 0 | DIRECT |
47473,51695 47473 - EF-hand 51695 - PLC-like phosphodiesterases | 0 | DIRECT |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 0 | DIRECT |
57362,57362 57362 - BPTI-like 57362 - BPTI-like | 0 | DIRECT |
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain | 0 | DIRECT |
57196,63825 57196 - EGF/Laminin 63825 - YWTD domain | 0 | DIRECT |
141072,141072 141072 - CalX-like 141072 - CalX-like | 0 | DIRECT |
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
57184,57603 57184 - Growth factor receptor domain 57603 - FnI-like domain | 0 | DIRECT |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49417,81296 49417 - p53-like transcription factors 81296 - E set domains | 0 | DIRECT |
54001,143791 54001 - Cysteine proteinases 143791 - DUSP-like | 0 | DIRECT |
50978,50998 50978 - WD40 repeat-like 50998 - Quinoprotein alcohol dehydrogenase-like | 0 | DIRECT |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | DIRECT |
49265,49899 49265 - Fibronectin type III 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | DIRECT |
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
81324,81296 81324 - Voltage-gated potassium channels 81296 - E set domains | 0 | DIRECT |
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57603,57603 57603 - FnI-like domain 57603 - FnI-like domain | 0 | DIRECT |
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins | 0 | DIRECT |
51556,51338 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases | 0 | DIRECT |
52799,49562 52799 - (Phosphotyrosine protein) phosphatases II 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | DIRECT |
48097,56112 48097 - Regulator of G-protein signaling, RGS 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
49899,57196 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin | 0 | DIRECT |
57196,90193 57196 - EGF/Laminin 90193 - Notch domain | 0 | DIRECT |
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like | 0 | DIRECT |
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like | 0 | DIRECT |
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger | 0 | DIRECT |
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
56112,47769 56112 - Protein kinase-like (PK-like) 47769 - SAM/Pointed domain | 0 | DIRECT |
48371,48371 48371 - ARM repeat 48371 - ARM repeat | 0 | DIRECT |
54160,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.06102 | INHERITED FROM: synencephalon |
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.1753 | INHERITED FROM: heart || Kolmer-Agduhr neuron || cardiac ventricle || VeLD |
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0.1879 | INHERITED FROM: blood vasculature || blood vessel |
90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0.278 | INHERITED FROM: midbrain hindbrain boundary |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.3204 | INHERITED FROM: blood vasculature |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.3875 | INHERITED FROM: synencephalon || brain nucleus |
55021,56534 55021 - ACT-like 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.4052 | INHERITED FROM: artery || ventral wall of dorsal aorta || dorsal aorta |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0.4218 | INHERITED FROM: head kidney |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.4808 | INHERITED FROM: ventral thalamus || thalamus |
49562,48350 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48350 - GTPase activation domain, GAP | 0.4883 | INHERITED FROM: hindbrain |
69179,69179 69179 - Integrin domains 69179 - Integrin domains | 0.6271 | INHERITED FROM: bone element |
69318,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains | 0.6271 | INHERITED FROM: bone element |
48452,48452 48452 - TPR-like 48452 - TPR-like | 0.6614 | INHERITED FROM: pronephros |
54897,52743 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like | 0.7023 | INHERITED FROM: optic tectum |
50156,50156 50156 - PDZ domain-like 50156 - PDZ domain-like | 0.706 | INHERITED FROM: eye photoreceptor cell || retinal outer nuclear layer |
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like | 0.7613 | INHERITED FROM: optic tectum || cranial nerve II || retinal ganglion cell layer || diencephalic white matter |
Supra-domain (Duplex) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
55550,55550 55550 - SH2 domain 55550 - SH2 domain | 0 | Direct |
52374,47323 52374 - Nucleotidylyl transferase 47323 - Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases | 0 | Direct |
48425,50729 48425 - Sec7 domain 50729 - PH domain-like | 0 | Direct |
52058,57184 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | Direct |
52058,49265 52058 - L domain-like 49265 - Fibronectin type III | 0 | Direct |
54160,54160 54160 - Chromo domain-like 54160 - Chromo domain-like | 0 | Direct |
56968,48431 56968 - Lipovitellin-phosvitin complex; beta-sheet shell regions 48431 - Lipovitellin-phosvitin complex, superhelical domain | 0 | Direct |
89837,89837 89837 - Doublecortin (DC) 89837 - Doublecortin (DC) | 0 | Direct |
81324,81324 81324 - Voltage-gated potassium channels 81324 - Voltage-gated potassium channels | 0 | Direct |
46966,47473 46966 - Spectrin repeat 47473 - EF-hand | 0 | Direct |
56112,56112 56112 - Protein kinase-like (PK-like) 56112 - Protein kinase-like (PK-like) | 0 | Direct |
47459,158457 47459 - HLH, helix-loop-helix DNA-binding domain 158457 - Orange domain-like | 0 | Direct |
103575,81296 103575 - Plexin repeat 81296 - E set domains | 0 | Direct |
50729,47473 50729 - PH domain-like 47473 - EF-hand | 0 | Direct |
47986,52129 47986 - DEATH domain 52129 - Caspase-like | 0 | Direct |
63380,52343 63380 - Riboflavin synthase domain-like 52343 - Ferredoxin reductase-like, C-terminal NADP-linked domain | 0 | Direct |
111418,81321 111418 - Hormone receptor domain 81321 - Family A G protein-coupled receptor-like | 0 | Direct |
57184,52058 57184 - Growth factor receptor domain 52058 - L domain-like | 0 | Direct |
90193,90193 90193 - Notch domain 90193 - Notch domain | 0 | Direct |
47473,51695 47473 - EF-hand 51695 - PLC-like phosphodiesterases | 0 | Direct |
50044,55550 50044 - SH3-domain 55550 - SH2 domain | 0 | Direct |
57362,57362 57362 - BPTI-like 57362 - BPTI-like | 0 | Direct |
46785,46785 46785 - "Winged helix" DNA-binding domain 46785 - "Winged helix" DNA-binding domain | 0 | Direct |
57196,63825 57196 - EGF/Laminin 63825 - YWTD domain | 0 | Direct |
141072,141072 141072 - CalX-like 141072 - CalX-like | 0 | Direct |
55550,56112 55550 - SH2 domain 56112 - Protein kinase-like (PK-like) | 0 | Direct |
57196,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
53067,100920 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
57184,57603 57184 - Growth factor receptor domain 57603 - FnI-like domain | 0 | Direct |
48371,56112 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | Direct |
49417,81296 49417 - p53-like transcription factors 81296 - E set domains | 0 | Direct |
54001,143791 54001 - Cysteine proteinases 143791 - DUSP-like | 0 | Direct |
50978,50998 50978 - WD40 repeat-like 50998 - Quinoprotein alcohol dehydrogenase-like | 0 | Direct |
49562,48371 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat | 0 | Direct |
49265,49899 49265 - Fibronectin type III 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54791,54791 54791 - Eukaryotic type KH-domain (KH-domain type I) 54791 - Eukaryotic type KH-domain (KH-domain type I) | 0 | Direct |
50447,50465 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
81324,81296 81324 - Voltage-gated potassium channels 81296 - E set domains | 0 | Direct |
54585,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57603,57603 57603 - FnI-like domain 57603 - FnI-like domain | 0 | Direct |
52540,50447 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins | 0 | Direct |
51556,51338 51556 - Metallo-dependent hydrolases 51338 - Composite domain of metallo-dependent hydrolases | 0 | Direct |
52799,49562 52799 - (Phosphotyrosine protein) phosphatases II 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) | 0 | Direct |
48097,56112 48097 - Regulator of G-protein signaling, RGS 56112 - Protein kinase-like (PK-like) | 0 | Direct |
49899,57196 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin | 0 | Direct |
57196,90193 57196 - EGF/Laminin 90193 - Notch domain | 0 | Direct |
50692,54585 50692 - ADC-like 54585 - Cdc48 domain 2-like | 0 | Direct |
52490,55307 52490 - Tubulin nucleotide-binding domain-like 55307 - Tubulin C-terminal domain-like | 0 | Direct |
57903,57903 57903 - FYVE/PHD zinc finger 57903 - FYVE/PHD zinc finger | 0 | Direct |
50729,56112 50729 - PH domain-like 56112 - Protein kinase-like (PK-like) | 0 | Direct |
56112,47769 56112 - Protein kinase-like (PK-like) 47769 - SAM/Pointed domain | 0 | Direct |
48371,48371 48371 - ARM repeat 48371 - ARM repeat | 0 | Direct |
54160,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.06102 | Inherited |
57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.1753 | Inherited |
57184,57184 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0.1879 | Inherited |
90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0.278 | Inherited |
57196,57196 57196 - EGF/Laminin 57196 - EGF/Laminin | 0.3204 | Inherited |
48726,49265 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.3875 | Inherited |
55021,56534 55021 - ACT-like 56534 - Aromatic aminoacid monoxygenases, catalytic and oligomerization domains | 0.4052 | Inherited |
49265,49265 49265 - Fibronectin type III 49265 - Fibronectin type III | 0.4218 | Inherited |
57667,57667 57667 - beta-beta-alpha zinc fingers 57667 - beta-beta-alpha zinc fingers | 0.4808 | Inherited |
49562,48350 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48350 - GTPase activation domain, GAP | 0.4883 | Inherited |
69179,69179 69179 - Integrin domains 69179 - Integrin domains | 0.6271 | Inherited |
69318,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains | 0.6271 | Inherited |
48452,48452 48452 - TPR-like 48452 - TPR-like | 0.6614 | Inherited |
54897,52743 54897 - Protease propeptides/inhibitors 52743 - Subtilisin-like | 0.7023 | Inherited |
50156,50156 50156 - PDZ domain-like 50156 - PDZ domain-like | 0.706 | Inherited |
49313,49313 49313 - Cadherin-like 49313 - Cadherin-like | 0.7613 | Inherited |
(show details)
Supra-domains annotated to this ZA term (Not in SPZA)
Highlighted in gray are those with FDR>0.001
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,47473,51695 50729 - PH domain-like 47473 - EF-hand 51695 - PLC-like phosphodiesterases | 0 | DIRECT |
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | DIRECT |
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | DIRECT |
57196,57184,57196 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0 | DIRECT |
90257,90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0 | DIRECT |
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain | 0 | DIRECT |
57184,57184,57196 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0 | DIRECT |
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | DIRECT |
57196,49899,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | DIRECT |
54160,52540,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57196,57196,90193 57196 - EGF/Laminin 57196 - EGF/Laminin 90193 - Notch domain | 0 | DIRECT |
90193,90193,90193 90193 - Notch domain 90193 - Notch domain 90193 - Notch domain | 0 | DIRECT |
54160,54160,52540 54160 - Chromo domain-like 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
57196,57184,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0 | DIRECT |
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like | 0 | DIRECT |
49899,57196,57196 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin 57196 - EGF/Laminin | 0 | DIRECT |
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | DIRECT |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | DIRECT |
57184,52058,49265 57184 - Growth factor receptor domain 52058 - L domain-like 49265 - Fibronectin type III | 0 | DIRECT |
103575,81296,81296 103575 - Plexin repeat 81296 - E set domains 81296 - E set domains | 0 | DIRECT |
46966,46966,47473 46966 - Spectrin repeat 46966 - Spectrin repeat 47473 - EF-hand | 0 | DIRECT |
57196,90193,90193 57196 - EGF/Laminin 90193 - Notch domain 90193 - Notch domain | 0 | DIRECT |
52058,49265,49265 52058 - L domain-like 49265 - Fibronectin type III 49265 - Fibronectin type III | 0 | DIRECT |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.09047 | INHERITED FROM: synencephalon |
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.4813 | INHERITED FROM: cardiac ventricle |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.565 | INHERITED FROM: synencephalon || brain nucleus |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 0.6127 | INHERITED FROM: optic tectum || cranial nerve II || retinal ganglion cell layer || diencephalic white matter |
69318,69179,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains 69179 - Integrin domains | 0.6271 | INHERITED FROM: bone element |
69179,69179,69179 69179 - Integrin domains 69179 - Integrin domains 69179 - Integrin domains | 0.6271 | INHERITED FROM: bone element |
Supra-domain (Triple) in N- to C-terminal order |
FDR (all) |
Annotation (direct or inherited) |
50729,47473,51695 50729 - PH domain-like 47473 - EF-hand 51695 - PLC-like phosphodiesterases | 0 | Direct |
57184,52058,57184 57184 - Growth factor receptor domain 52058 - L domain-like 57184 - Growth factor receptor domain | 0 | Direct |
52540,50447,50465 52540 - P-loop containing nucleoside triphosphate hydrolases 50447 - Translation proteins 50465 - EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain | 0 | Direct |
57196,57184,57196 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0 | Direct |
90257,90257,90257 90257 - Myosin rod fragments 90257 - Myosin rod fragments 90257 - Myosin rod fragments | 0 | Direct |
57603,57603,57603 57603 - FnI-like domain 57603 - FnI-like domain 57603 - FnI-like domain | 0 | Direct |
57184,57184,57196 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain 57196 - EGF/Laminin | 0 | Direct |
53067,53067,100920 53067 - Actin-like ATPase domain 53067 - Actin-like ATPase domain 100920 - Heat shock protein 70kD (HSP70), peptide-binding domain | 0 | Direct |
57196,49899,49899 57196 - EGF/Laminin 49899 - Concanavalin A-like lectins/glucanases 49899 - Concanavalin A-like lectins/glucanases | 0 | Direct |
54160,52540,52540 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
54585,52540,52540 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57196,57196,90193 57196 - EGF/Laminin 57196 - EGF/Laminin 90193 - Notch domain | 0 | Direct |
90193,90193,90193 90193 - Notch domain 90193 - Notch domain 90193 - Notch domain | 0 | Direct |
54160,54160,52540 54160 - Chromo domain-like 54160 - Chromo domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
57196,57184,57184 57196 - EGF/Laminin 57184 - Growth factor receptor domain 57184 - Growth factor receptor domain | 0 | Direct |
52058,57184,52058 52058 - L domain-like 57184 - Growth factor receptor domain 52058 - L domain-like | 0 | Direct |
49899,57196,57196 49899 - Concanavalin A-like lectins/glucanases 57196 - EGF/Laminin 57196 - EGF/Laminin | 0 | Direct |
50692,54585,52540 50692 - ADC-like 54585 - Cdc48 domain 2-like 52540 - P-loop containing nucleoside triphosphate hydrolases | 0 | Direct |
49562,48371,56112 49562 - C2 domain (Calcium/lipid-binding domain, CaLB) 48371 - ARM repeat 56112 - Protein kinase-like (PK-like) | 0 | Direct |
57184,52058,49265 57184 - Growth factor receptor domain 52058 - L domain-like 49265 - Fibronectin type III | 0 | Direct |
103575,81296,81296 103575 - Plexin repeat 81296 - E set domains 81296 - E set domains | 0 | Direct |
46966,46966,47473 46966 - Spectrin repeat 46966 - Spectrin repeat 47473 - EF-hand | 0 | Direct |
57196,90193,90193 57196 - EGF/Laminin 90193 - Notch domain 90193 - Notch domain | 0 | Direct |
52058,49265,49265 52058 - L domain-like 49265 - Fibronectin type III 49265 - Fibronectin type III | 0 | Direct |
48726,48726,48726 48726 - Immunoglobulin 48726 - Immunoglobulin 48726 - Immunoglobulin | 0.09047 | Inherited |
57716,57716,57716 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) 57716 - Glucocorticoid receptor-like (DNA-binding domain) | 0.4813 | Inherited |
48726,48726,49265 48726 - Immunoglobulin 48726 - Immunoglobulin 49265 - Fibronectin type III | 0.565 | Inherited |
49313,49313,49313 49313 - Cadherin-like 49313 - Cadherin-like 49313 - Cadherin-like | 0.6127 | Inherited |
69318,69179,69179 69318 - Integrin alpha N-terminal domain 69179 - Integrin domains 69179 - Integrin domains | 0.6271 | Inherited |
69179,69179,69179 69179 - Integrin domains 69179 - Integrin domains 69179 - Integrin domains | 0.6271 | Inherited |
Plot distribution on phylogenetic tree for Supra-domains (Single/Individual) annotated by this phenotype term
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A presence/absence matrix is generated using protein domains and supradomains
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