1wcq A:506-647 PDB entry domain

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All beta proteins [ 48724] (165)
• Fold: Galactose-binding domain-like [ 49784]
  • sandwich; 9 strands in 2 sheets; jelly-roll
• Superfamily: Galactose-binding domain-like [ 49785] (30)
• Family: Galactose-binding domain [ 49786] (2)
• Protein:
  • Sialidase, C-terminal domain [49789]
• PDB Entry Domain: 1wcq A:506-647 [ 120895]

---

InterPro annotation

• Cross references: IPR008979 SSF49785 Protein matches
• Abstract:

  Proteins containing a galactose-binding domain-like fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase [2002850], phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va [10586886], membrane-anchored ephrin for the Eph family of receptor tyrosine kinases [11780069], and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1 [10467102].

  The structure of the galactose-binding domain-like members consists of a beta-sandwich, in which the strands making up the sheets exhibit a jellyroll fold. There is a high degree of similarity in the beta-sandwich and in the loops between different family members, despite an often low level of sequence similarity.

InterPro database

---