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1ro7 C: PDB entry domain
SCOP classification
InterPro annotation
| Cross references | IPR009251 SSF102414 Protein matches |
| Abstract | This entry represents several alpha-2,3-sialyltransferase proteins, most of which are found in the food-borne pathogen Campylobacter jejuni. Sialyltransferases transfer a sialic acid moiety from cytidine-5'-monophospho-N-acetyl-neuraminic acid (CMP-NeuAc) to terminal positions of various key glycoconjugates, which play critical roles in cell recognition and adherence [ 14730352]. The structure of Cst-II alpha-2,3-sialyltransferase from C. jejuni consists of a 3-layer alpha/beta/alpha topology. Cst-II catalytic mechanism involves an essential histidine (general base) and two tyrosine residues (coordination of the phosphate leaving group) to carry out substrate binding and glycosyl transfer. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
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Internal database links
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