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1nnb A: PDB entry domain

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   Sialidases [ 50939] (2)
Family:   Sialidases (neuraminidases) [ 50940] (9)
Protein:   Influenza neuraminidase [50943]
   
PDB Entry Domain:   1nnb A: [ 27584]
  SUPERFAMILY domain annotation for 1nnba
  PDB structure summary for 1nnb


InterPro annotation
Cross references IPR011040 SSF50939 Protein matches
Abstract

Neuraminidases (sialidases) hydrolyse the non-reducing, terminal sialic acid linkage in various natural substrates, such as glycoproteins, glycolipids, gangliosides, and polysaccharides [PubMed12374200]. In mammals, neuraminidases occur in the lysosome, the cytosol, and associated with the plasma membrane. Neuraminidases have also been implicated in the pathogenesis of many diseases. For example, in viruses neuraminidases enable the transport of the virus through mucin, the eruption of the virus from the infected host cell, and the prevention of self-aggregation of virus particles through the destruction of the host cell receptor recognised by the virus [PubMed14561719]. Eukaryotic, bacterial and viral neuraminidases share highly conserved regions of beta-sheet motifs. Bacterial neuraminidases often possess domains in addition to the catalytic neuraminidase domain, for instance the neuraminidase from Micromonospora viridifaciens contains three domains, of which the catalytic domain described here is the N-terminal domain [PubMed8591030]. Similarly, leech neuraminidase is a multidomain protein, where the catalytic domain is the C-terminal domain [PubMed9878409]. In several paramyxoviruses, neuraminidase forms part of the multi-functional haemagglutinin-neuraminidase glycoprotein found on the viral envelope [PubMed14729348].


InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 39 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Sialidases domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Internal database links ]