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Kazal-type serine protease inhibitors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Kazal-type serine protease inhibitors [ 100894]
Superfamily:   Kazal-type serine protease inhibitors [ 100895] (2)
Families:   Ovomucoid domain III-like [ 57468] (10)
  Serine proteinase inhibitor lekti [ 69960]


Superfamily statistics
Genomes (240) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 8,801 26,653 47
Proteins 5,025 14,424 44


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal muscle morphology0.113Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.2001Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.03707InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.08755InformativeInherited
Mammalian Phenotype (MP)decreased skeletal muscle size0.000007318Highly InformativeDirect
Mammalian Phenotype (MP)decreased quadriceps weight0.000008915Highly InformativeDirect
Mammalian Phenotype (MP)abnormal muscle weight0.00008325Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vertebrae number0.05827Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lumbar vertebrae morphology0.2675Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0Moderately InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.7079Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.7206Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00885Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.2892Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.4141Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.00005535InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.0008837InformativeDirect
Xenopus ANatomical entity (XAN)endoderm0.01296InformativeInherited
Xenopus ANatomical entity (XAN)hypochord0.000001719Highly InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00006857Highly InformativeDirect
Xenopus ANatomical entity (XAN)axial mesoderm0.0001113Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural groove0.0007342Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 22 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Kazal-type serine protease inhibitors domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 22 hidden Markov models representing the Kazal-type serine protease inhibitors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]