SUPERFAMILY 1.75 HMM library and genome assignments server

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Pyrin domain, PYD family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DEATH domain [ 47985]
Superfamily:   DEATH domain [ 47986] (4)
Family:   Pyrin domain, PYD [ 101298] (2)


Family statistics
Genomes (33) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 64 175 2
Proteins 64 175 2


Disease Ontology (DO)

(
show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.0004569Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.02074Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.0004547InformativeDirect
Disease Ontology (DO)Crohn's disease0.00009403Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.0308Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.08298Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.09177Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.0952Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1199Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.1293Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.2791Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.4302Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.0005787Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.006847Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.01096Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.01266Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.01448Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.04787Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.06339Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.1255Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.2594Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.418Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Fever0.00002105InformativeDirect
Phenotypic Abnormality (PA)Splenomegaly0.00006629InformativeDirect
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.0003022InformativeDirect
Phenotypic Abnormality (PA)Stomatitis0.0004162InformativeDirect
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.0005052InformativeDirect
Phenotypic Abnormality (PA)Abnormal cornea morphology0.00866InformativeInherited
Phenotypic Abnormality (PA)Pain0.01171InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin physiology0.01738InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.06169InformativeInherited
Phenotypic Abnormality (PA)Leukocytosis0.0000003502Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent aphthous stomatitis0.000001229Highly InformativeDirect
Phenotypic Abnormality (PA)Keratitis0.000007347Highly InformativeDirect
Phenotypic Abnormality (PA)Conjunctivitis0.00002071Highly InformativeDirect
Phenotypic Abnormality (PA)Myalgia0.0001048Highly InformativeDirect
Phenotypic Abnormality (PA)Arthralgia0.0001503Highly InformativeDirect
Phenotypic Abnormality (PA)Photophobia0.0003384Highly InformativeDirect
Phenotypic Abnormality (PA)Inflammatory abnormality of the skin0.08347Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.09235Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0000136Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.0000364Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.00006545Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.0003259Moderately InformativeDirect
Mammalian Phenotype (MP)neoplasm0.01966Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.05716Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.4904Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.6015Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin level0.0000128InformativeDirect
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.00001965InformativeDirect
Mammalian Phenotype (MP)abnormal granulocyte morphology0.0003238InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system physiology0.0005791InformativeDirect
Mammalian Phenotype (MP)abnormal spleen morphology0.1348InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.6837InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.00000974Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neutrophil cell number0.00003833Highly InformativeDirect
Mammalian Phenotype (MP)enlarged spleen0.0002319Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interleukin-18 level0.0005232Highly InformativeDirect

Document: MP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 24 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a DEATH domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Internal database links ]