SUPERFAMILY 1.75 HMM library and genome assignments server

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Interferon regulatory factor 3 (IRF3), transactivation domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SMAD/FHA domain [ 49878]
Superfamily:   SMAD/FHA domain [ 49879] (4)
Family:   Interferon regulatory factor 3 (IRF3), transactivation domain [ 101630]


Family statistics
Genomes (45) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 83 191 2
Proteins 82 191 2


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.0001138Moderately InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of immune system physiology0Moderately InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.006507Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.09235Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1495Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.000000198Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0000136Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal B cell morphology0.007732Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.01053Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.01176Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.02209Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.03125Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.04051Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.04153Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.04496Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.06487Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.1017Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.0007174InformativeDirect
Mammalian Phenotype (MP)abnormal B cell differentiation0.000976InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell number0.001094InformativeInherited
Mammalian Phenotype (MP)decreased B cell number0.002565InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.009569InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.02071InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.4634InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to viral infection0.000000003719Highly InformativeDirect
Mammalian Phenotype (MP)decreased dendritic cell number0.000005944Highly InformativeDirect
Mammalian Phenotype (MP)decreased mature B cell number0.0004696Highly InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a SMAD/FHA domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]