SUPERFAMILY 1.75 HMM library and genome assignments server

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Interferon regulatory factor 3 (IRF3), transactivation domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SMAD/FHA domain [ 49878]
Superfamily:   SMAD/FHA domain [ 49879] (4)
Family:   Interferon regulatory factor 3 (IRF3), transactivation domain [ 101630]


Family statistics
Genomes (45) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 83 191 2
Proteins 82 191 2


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.0001138Moderately InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of immune system physiology0Moderately InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.006497Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.09228Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1493Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.0000001983Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.00001352Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal B cell morphology0.007686Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.01049Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.01172Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.02202Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.03125Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.0404Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.0414Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.04485Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.06475Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.1017Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.0007179InformativeDirect
Mammalian Phenotype (MP)abnormal B cell differentiation0.0009763InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell number0.001081InformativeInherited
Mammalian Phenotype (MP)decreased B cell number0.002543InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.009516InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.02063InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.4635InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to viral infection0.000000003721Highly InformativeDirect
Mammalian Phenotype (MP)decreased dendritic cell number0.000005945Highly InformativeDirect
Mammalian Phenotype (MP)decreased mature B cell number0.0004627Highly InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a SMAD/FHA domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]