SUPERFAMILY 1.75 HMM library and genome assignments server

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Serum paraoxonase/arylesterase 1, PON1 family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   Calcium-dependent phosphotriesterase [ 63829] (3)
Family:   Serum paraoxonase/arylesterase 1, PON1 [ 101895]


Family statistics
Genomes (75) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 197 457 1
Proteins 195 456 1


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0Least InformativeDirect
Disease Ontology (DO)artery disease0Moderately InformativeDirect
Disease Ontology (DO)neurodegenerative disease0Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0Moderately InformativeDirect
Disease Ontology (DO)heart disease0InformativeDirect
Disease Ontology (DO)coronary artery disease0InformativeDirect
Disease Ontology (DO)celiac disease0Highly InformativeDirect
Disease Ontology (DO)lateral sclerosis0Highly InformativeDirect
Disease Ontology (DO)amyotrophic lateral sclerosis0Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Behavioral abnormality0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the respiratory system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of central motor function0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal muscle tone0Moderately InformativeDirect
Phenotypic Abnormality (PA)Pain0InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness0InformativeDirect
Phenotypic Abnormality (PA)Functional respiratory abnormality0InformativeDirect
Phenotypic Abnormality (PA)Fatigue0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle size0InformativeDirect
Phenotypic Abnormality (PA)Impairment in personality functioning0InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0InformativeDirect
Phenotypic Abnormality (PA)Nausea and vomiting0InformativeDirect
Phenotypic Abnormality (PA)Hypertonia0InformativeDirect
Phenotypic Abnormality (PA)Skeletal muscle atrophy0Highly InformativeDirect
Phenotypic Abnormality (PA)Agitation0Highly InformativeDirect
Phenotypic Abnormality (PA)Depressivity0Highly InformativeDirect
Phenotypic Abnormality (PA)Paralysis0Highly InformativeDirect
Phenotypic Abnormality (PA)Respiratory insufficiency0Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal larynx physiology0Highly InformativeDirect
Phenotypic Abnormality (PA)Emotional lability0Highly InformativeDirect
Phenotypic Abnormality (PA)Dyspnea0Highly InformativeDirect
Phenotypic Abnormality (PA)Anxiety0Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized muscle weakness0Highly InformativeDirect
Phenotypic Abnormality (PA)Spasticity0Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of salivation0Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness of swallowing muscles0Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigable weakness of respiratory muscles0Highly InformativeDirect
Phenotypic Abnormality (PA)Motor neuron atrophy0Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Least InformativeDirect

Document: WP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Calcium-dependent phosphotriesterase domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Enzyme Commission (EC) · Internal database links ]