SUPERFAMILY 1.75 HMM library and genome assignments server

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Sema domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   Sema domain [ 101912]
Family:   Sema domain [ 101913] (3)


Family statistics
Genomes (135) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,823 7,646 3
Proteins 2,789 7,610 3


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the face0.2646Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.2962Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.01221Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.01689Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.02534Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.05719InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the thyroid gland0.0001682Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the sense of smell0.0004746Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0001393Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.1237Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.002318Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.004709Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.02793Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.2873Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4243Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.00001606InformativeDirect
Mammalian Phenotype (MP)abnormal cell migration0.00008697InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.001166InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.007206InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.02504InformativeInherited
Mammalian Phenotype (MP)abnormal brain white matter morphology0.0277InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.04167InformativeInherited
Mammalian Phenotype (MP)abnormal limbic system morphology0.07479InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.1034InformativeInherited
Mammalian Phenotype (MP)abnormal cerebral hemisphere morphology0.1149InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.1313InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.3128InformativeInherited
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.000003273Highly InformativeDirect
Mammalian Phenotype (MP)abnormal renal tubule epithelium morphology0.00002008Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to kidney reperfusion injury0.0001084Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuronal migration0.0002319Highly InformativeDirect
Mammalian Phenotype (MP)ectopic neuron0.0005832Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urinary system development0.05536Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cerebellar layer morphology0.5671Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.001944Least InformativeInherited
Worm Phenotype (WP)adult body morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0002053Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0InformativeDirect
Worm Phenotype (WP)male morphology variant0InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.00000005121InformativeDirect
Worm Phenotype (WP)male ray morphology variant0Highly InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.0000000008817Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.000000004934Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)abdomen0Moderately InformativeDirect
Fly Anatomy (FA)larval tagma0Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0Moderately InformativeDirect
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)ganglion0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0Moderately InformativeDirect
Fly Anatomy (FA)ventral nerve cord0InformativeDirect
Fly Anatomy (FA)larval abdominal segment0InformativeDirect
Fly Anatomy (FA)nerve0InformativeDirect
Fly Anatomy (FA)embryonic/larval peripheral nervous system0InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval system0.002944InformativeInherited
Fly Anatomy (FA)tract0.1897InformativeInherited
Fly Anatomy (FA)intersegmental nerve0Highly InformativeDirect
Fly Anatomy (FA)abdominal segmental nerve0Highly InformativeDirect
Fly Anatomy (FA)fascicle0.0000006936Highly InformativeDirect
Fly Anatomy (FA)connective0.00002104Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.00004515Highly InformativeDirect
Fly Anatomy (FA)neuron projection bundle of ventral nerve cord0.0007266Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.2834Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.4308Least InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.04131Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.3205Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.01111InformativeInherited
Zebrafish Anatomy (ZA)ectoderm0.0007745Highly InformativeDirect
Zebrafish Anatomy (ZA)motor neuron0.001399Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.1036Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.3947Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4209Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.5382Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.000001975Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.0001452Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.0003914Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.006175Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.3148Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.000004032InformativeDirect
Xenopus ANatomical entity (XAN)eye0.0009423InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.05445InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.6029InformativeInherited
Xenopus ANatomical entity (XAN)cranial neural crest0.000002956Highly InformativeDirect
Xenopus ANatomical entity (XAN)periocular region0.000005473Highly InformativeDirect
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.0001682Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0002044Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.0008517Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode1Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Sema domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]