Alpha-2,3/8-sialyltransferase CstII superfamily
SCOP classification
InterPro annotation
| Cross references | IPR009251 SSF102414 Protein matches |
| Abstract | This entry represents several alpha-2,3-sialyltransferase proteins, most of which are found in the food-borne pathogen Campylobacter jejuni. Sialyltransferases transfer a sialic acid moiety from cytidine-5'-monophospho-N-acetyl-neuraminic acid (CMP-NeuAc) to terminal positions of various key glycoconjugates, which play critical roles in cell recognition and adherence [ 14730352]. The structure of Cst-II alpha-2,3-sialyltransferase from C. jejuni consists of a 3-layer alpha/beta/alpha topology. Cst-II catalytic mechanism involves an essential histidine (general base) and two tyrosine residues (coordination of the phosphate leaving group) to carry out substrate binding and glycosyl transfer. |
InterPro database
Functional annotation
| General category | Metabolism |
| Detailed category | Other enzymes |
Function annotation of SCOP domain superfamilies
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Internal database links
The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level. Click on the 'Genome Assignments'
icon above to view the genome assignments for this superfamily.
Alignments of sequences to Alignments of sequences to 1 models
in this superfamily are available by clicking on the superfamily level 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequences may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own.
It is possible to browse and view the proteins in the genomes which have
different combinations of domains including a Alpha-2,3/8-sialyltransferase CstII domain. Click on the 'Domain Combinations' icon.
To view the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom click on the 'TaxViz' icon above. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
Undirected domain occurrence networks are available for all superfamilies. Nodes in these networks represent genomes. Connections between nodes represent the presence of domain architectures, which contain the superfamily of interest, in both genomes.
There are 1 hidden Markov models representing the Alpha-2,3/8-sialyltransferase CstII superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be viewed by clicking on the icon above.
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