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Hypoxia-inducible factor Hif2a, C-terminal domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   Profilin-like [ 55769] (10)
Superfamily:   PYP-like sensor domain (PAS domain) [ 55785] (7)
Family:   Hypoxia-inducible factor Hif2a, C-terminal domain [ 103184]


Family statistics
Genomes (68) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 248 918 1
Proteins 248 918 1


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)female reproductive system disease0.002265InformativeInherited
Disease Ontology (DO)endometriosis0.0008472Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1333Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.0241Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.03402Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.04041Moderately InformativeInherited
Phenotypic Abnormality (PA)Obesity0.0006867InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating hormone level0.0006954InformativeDirect
Phenotypic Abnormality (PA)Abnormal glucose homeostasis0.002301InformativeInherited
Phenotypic Abnormality (PA)Glucose intolerance0.000644Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.002295Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.007042Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1375Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.347Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.3656Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3789Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.0004581Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.001805Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.004345Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.03582Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.05025Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.07187Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.12Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1988Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.215Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2413Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.4979Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa physiology0.0002751InformativeDirect
Mammalian Phenotype (MP)abnormal angiogenesis0.00286InformativeInherited
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.003364InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.003763InformativeInherited
Mammalian Phenotype (MP)abnormal heartbeat0.01612InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.05633InformativeInherited
Mammalian Phenotype (MP)abnormal spleen morphology0.06998InformativeInherited
Mammalian Phenotype (MP)abnormal heart size0.09169InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.1188InformativeInherited
Mammalian Phenotype (MP)abnormal erythrocyte morphology0.145InformativeInherited
Mammalian Phenotype (MP)decreased heart rate0.00005904Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pulmonary alveolus morphology0.0002759Highly InformativeDirect
Mammalian Phenotype (MP)enlarged brain ventricles0.0006522Highly InformativeDirect
Mammalian Phenotype (MP)hyperglycemia0.0006719Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart weight0.0009237Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.001908Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sleep behavior0.002079Highly InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.003287Highly InformativeInherited
Mammalian Phenotype (MP)abnormal associative learning0.2436Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.1071InformativeInherited
Fly Phenotype (FP)locomotor rhythm defective0.00004286Highly InformativeDirect
Fly Phenotype (FP)semi-sterile0.0001031Highly InformativeDirect
Fly Phenotype (FP)sleep defective0.0001619Highly InformativeDirect
Fly Phenotype (FP)decreased fecundity0.0006391Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)adult heart0.0009363InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.2366Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.2948Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.3631Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.408Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.5044Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system0.6912Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.8235Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.01443Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.01799Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.101Moderately InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.001272InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.002695InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.0141InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.02644InformativeInherited
Xenopus ANatomical entity (XAN)trunk musculature0.00001543Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric tubule0.0003564Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a PYP-like sensor domain (PAS domain) domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]