SUPERFAMILY 1.75 HMM library and genome assignments server

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Plexin repeat family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Trefoil/Plexin domain-like [ 57491] (3)
Superfamily:   Plexin repeat [ 103575]
Family:   Plexin repeat [ 103576] (3)


Family statistics
Genomes (40) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 117 304 5
Proteins 117 304 5


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)hypersensitivity reaction type II disease0.09929Moderately InformativeInherited
Disease Ontology (DO)integumentary system disease0.2637Moderately InformativeInherited
Disease Ontology (DO)bullous skin disease0.0003564InformativeDirect
Disease Ontology (DO)autoimmune disease of skin and connective tissue0.000394InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.01044Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.08895Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.1765InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the thyroid gland0.0007331Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0002693Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.01648Least InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.0001599Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0.0007153Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.00573Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4208Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.4811Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell migration0.000009303InformativeDirect
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.0001231InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.001339InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.01356InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.03215InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.03235InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.04217InformativeInherited
Mammalian Phenotype (MP)abnormal brain white matter morphology0.04846InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.08671InformativeInherited
Mammalian Phenotype (MP)abnormal cerebral hemisphere morphology0.09395InformativeInherited
Mammalian Phenotype (MP)abnormal limbic system morphology0.1225InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule epithelium morphology0.000003002Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.00002826Highly InformativeDirect
Mammalian Phenotype (MP)ectopic neuron0.0002249Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuronal migration0.000558Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to kidney reperfusion injury0.00101Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cerebellar layer morphology0.5225Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.008581Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.001011Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.001545Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.001545Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.001551Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.001558Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.001655Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.000000072InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.00002339InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.0356InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.000000005185Highly InformativeDirect
Worm Phenotype (WP)male ray morphology variant0.000000005802Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.000003748Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)segment0.047Least InformativeInherited
Fly Anatomy (FA)anatomical group0.07945Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1002Least InformativeInherited
Fly Anatomy (FA)tagma0.1767Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)abdomen0.0002945Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.0003378Moderately InformativeDirect
Fly Anatomy (FA)larval tagma0.006798Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.008488Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.02072Moderately InformativeInherited
Fly Anatomy (FA)larval abdominal segment0.000003084InformativeDirect
Fly Anatomy (FA)ventral nerve cord0.00001606InformativeDirect
Fly Anatomy (FA)nerve0.0003452InformativeDirect
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.0008906InformativeDirect
Fly Anatomy (FA)embryonic/larval digestive system0.02925InformativeInherited
Fly Anatomy (FA)tract0.1248InformativeInherited
Fly Anatomy (FA)fascicle0.00000006957Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval salivary gland0.0002572Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.4343Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.5682Least InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.06641Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.4474Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.017InformativeInherited
Zebrafish Anatomy (ZA)ectoderm0.001227Highly InformativeInherited
Zebrafish Anatomy (ZA)motor neuron0.002185Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.5922Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.6025Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7425Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.0001544Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.002693Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.01674Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.1826Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.8438Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.00007212InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.1424InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.7901InformativeInherited
Xenopus ANatomical entity (XAN)periocular region0.00003472Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.0001164Highly InformativeDirect
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.0005386Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.1222Highly InformativeInherited
Xenopus ANatomical entity (XAN)neurogenic placode1Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Plexin repeat domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]