SUPERFAMILY 1.75 HMM library and genome assignments server

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Plexin repeat family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   Trefoil/Plexin domain-like [ 57491] (3)
Superfamily:   Plexin repeat [ 103575]
Family:   Plexin repeat [ 103576] (3)


Family statistics
Genomes (40) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 117 304 5
Proteins 117 304 5


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)hypersensitivity reaction type II disease0.09929Moderately InformativeInherited
Disease Ontology (DO)integumentary system disease0.2637Moderately InformativeInherited
Disease Ontology (DO)bullous skin disease0.0003564InformativeDirect
Disease Ontology (DO)autoimmune disease of skin and connective tissue0.000394InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.01124Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.09024Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.1764InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the thyroid gland0.0007107Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0005163Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.02398Least InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.0002352Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0.0007154Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.002305Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4209Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.481Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell migration0.0000093InformativeDirect
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.0001522InformativeDirect
Mammalian Phenotype (MP)abnormal metencephalon morphology0.001606InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.005004InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.0116InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.03238InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.05733InformativeInherited
Mammalian Phenotype (MP)abnormal cerebral hemisphere morphology0.09399InformativeInherited
Mammalian Phenotype (MP)abnormal limbic system morphology0.1225InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule epithelium morphology0.0000001486Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.00002827Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to kidney reperfusion injury0.0001187Highly InformativeDirect
Mammalian Phenotype (MP)ectopic neuron0.0002252Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuronal migration0.0005583Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cerebellar layer morphology0.5226Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.008362Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.001104Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.00000007746InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0000002897InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.000003703InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.000000005228Highly InformativeDirect
Worm Phenotype (WP)male ray morphology variant0.000000006532Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0000000382Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)segment0.04279Least InformativeInherited
Fly Anatomy (FA)anatomical group0.07317Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.0907Least InformativeInherited
Fly Anatomy (FA)tagma0.1543Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)abdomen0.0002677Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.0003158Moderately InformativeDirect
Fly Anatomy (FA)larval segment0.001785Moderately InformativeInherited
Fly Anatomy (FA)larval tagma0.005951Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.008745Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.02119Moderately InformativeInherited
Fly Anatomy (FA)digestive system0.04913Moderately InformativeInherited
Fly Anatomy (FA)larval abdominal segment0.000003118InformativeDirect
Fly Anatomy (FA)ventral nerve cord0.00001677InformativeDirect
Fly Anatomy (FA)nerve0.0003484InformativeDirect
Fly Anatomy (FA)embryonic/larval digestive system0.02615InformativeInherited
Fly Anatomy (FA)tract0.1235InformativeInherited
Fly Anatomy (FA)fascicle0.00000006344Highly InformativeDirect
Fly Anatomy (FA)salivary gland0.0006077Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.4303Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.5755Least InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.07059Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.4492Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.01855InformativeInherited
Zebrafish Anatomy (ZA)ectoderm0.001398Highly InformativeInherited
Zebrafish Anatomy (ZA)motor neuron0.002356Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.5352Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.5928Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.7486Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.0001823Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.005826Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.01673Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.1834Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.8011Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.00007244InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.1469InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.7439InformativeInherited
Xenopus ANatomical entity (XAN)periocular region0.00003624Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.0001131Highly InformativeDirect
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.0005211Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.1215Highly InformativeInherited
Xenopus ANatomical entity (XAN)neurogenic placode1Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Plexin repeat domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]