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A middle domain of Talin 1 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   A middle domain of Talin 1 [ 109879]
Superfamily:   A middle domain of Talin 1 [ 109880]
Families:   A middle domain of Talin 1 [ 109881]


Superfamily statistics
Genomes (150) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 302 798 2
Proteins 296 791 2


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.0004602 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0003347 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000002981 Least Informative Direct
Biological Process (BP) biological regulation 0.2573 Least Informative Inherited
Biological Process (BP) tissue development 0.0002473 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.00000000002809 Moderately Informative Direct
Biological Process (BP) cell differentiation 0.000004571 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0000775 Moderately Informative Direct
Biological Process (BP) single-organism transport 0.0004197 Moderately Informative Direct
Biological Process (BP) animal organ development 0.000002779 Moderately Informative Direct
Biological Process (BP) cellular localization 0.0001846 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.005731 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.003664 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.002587 Moderately Informative Inherited
Biological Process (BP) embryo development 0.00001361 Informative Direct
Biological Process (BP) animal organ morphogenesis 0.000001759 Informative Direct
Biological Process (BP) vesicle-mediated transport 0.00001994 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0.0001968 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.00002211 Informative Direct
Biological Process (BP) cell development 0.0001151 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.0000005693 Informative Direct
Biological Process (BP) epithelium development 0.00000002278 Informative Direct
Biological Process (BP) organelle assembly 0.000007655 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.000000000465 Informative Direct
Biological Process (BP) post-embryonic development 0.001161 Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.0000000002264 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.0000000000003128 Highly Informative Direct
Biological Process (BP) biological adhesion 0.00000002102 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.0003893 Highly Informative Direct
Biological Process (BP) maintenance of location 0.00000000012 Highly Informative Direct
Biological Process (BP) striated muscle cell development 0.000000000000003734 Highly Informative Direct
Molecular Function (MF) binding 0.04733 Least Informative Inherited
Molecular Function (MF) receptor binding 0.0000001136 Informative Direct
Molecular Function (MF) cytoskeletal protein binding 0.0000006886 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0000000007015 Informative Direct
Molecular Function (MF) cell adhesion molecule binding 0.000000000002565 Highly Informative Direct
Cellular Component (CC) cell-substrate adherens junction 0.03402 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentMembrane0Least InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015224 SSF109880 Protein matches
Abstract

This domain adopts a structure consisting of five alpha helices that fold into a bundle. It contains a Vinculin binding site (VBS) composed of a hydrophobic surface spanning five turns of helix four. Activation of the VBS causes subsequent recruitment of Vinculin, which enables maturation of small integrin/talin complexes into more stable adhesions. Formation of the complex between VBS and Vinculin requires prior unfolding of this middle domain: once released from the talin hydrophobic core, the VBS helix is then available to induce the 'bundle conversion' conformational change within the vinculin head domain thereby displacing the intramolecular interaction with the vinculin tail, allowing vinculin to bind actin [PubMed15272303].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a A middle domain of Talin 1 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the A middle domain of Talin 1 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]