SUPERFAMILY 1.75 HMM library and genome assignments server

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VWC domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   FnI-like domain [ 57602]
Superfamily:   FnI-like domain [ 57603] (2)
Family:   VWC domain [ 118264]


Family statistics
Genomes (55) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 83 156 1
Proteins 83 156 1


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)connective tissue disease0.003996Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.06318Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1427Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.1821Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1936Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.2037Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2195Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.234Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.363Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.4361Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.001534Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.004591Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.01011Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.01061Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.0136Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.01546Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.01658Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.01658Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.03655Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.04545Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.04555Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.2006Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.2041Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.2914Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.3313Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Hernia0.00008979InformativeDirect
Phenotypic Abnormality (PA)Abnormal heart valve morphology0.0001604InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the outer ear0.0001826InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the gingiva0.0008827InformativeDirect
Phenotypic Abnormality (PA)Abnormal morphology of the great vessels0.001863InformativeInherited
Phenotypic Abnormality (PA)Abnormal palate morphology0.00309InformativeInherited
Phenotypic Abnormality (PA)Joint hypermobility0.009885InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.02924InformativeInherited
Phenotypic Abnormality (PA)Abnormal fundus morphology0.03604InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the dentition0.07156InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.08303InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.1363InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.2162InformativeInherited
Phenotypic Abnormality (PA)Mitral valve prolapse0.000001037Highly InformativeDirect
Phenotypic Abnormality (PA)Ectopia lentis0.00002107Highly InformativeDirect
Phenotypic Abnormality (PA)Hernia of the abdominal wall0.0000399Highly InformativeDirect
Phenotypic Abnormality (PA)Subcutaneous nodule0.0001467Highly InformativeDirect
Phenotypic Abnormality (PA)Aortic aneurysm0.0001702Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormally lax or hyperextensible skin0.0002551Highly InformativeDirect
Phenotypic Abnormality (PA)Bruising susceptibility0.0004402Highly InformativeDirect
Phenotypic Abnormality (PA)Migraine0.0004562Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of refraction0.0009718Highly InformativeDirect
Phenotypic Abnormality (PA)Atypical scarring of skin0.004701Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the skin0.0133Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the rib cage0.0353Highly InformativeInherited
Phenotypic Abnormality (PA)High palate0.4622Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.003302Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.06199Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1425Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1982Least InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.00002302Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00004242Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.0001343Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.001726Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.003272Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.01518Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.02206Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.05933Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.07092Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3106Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.4826Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.6228Moderately InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.00001327InformativeDirect
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.000991InformativeDirect
Mammalian Phenotype (MP)abnormal mouth morphology0.00486InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.007315InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.05717InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.07917InformativeInherited
Mammalian Phenotype (MP)abnormal autopod morphology0.1864InformativeInherited
Mammalian Phenotype (MP)abnormal limb bone morphology0.4356InformativeInherited
Mammalian Phenotype (MP)abnormal long bone morphology0.5241InformativeInherited
Mammalian Phenotype (MP)microphthalmia0.000004377Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.00006444Highly InformativeDirect
Mammalian Phenotype (MP)abnormal forelimb stylopod morphology0.0002418Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.0003263Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate morphology0.001272Highly InformativeInherited
Mammalian Phenotype (MP)cleft palate0.004379Highly InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.01154Highly InformativeInherited
Mammalian Phenotype (MP)abnormal kidney size0.02774Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spine curvature0.2225Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.3474Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.5679Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.5826Least InformativeInherited
Zebrafish Anatomy (ZA)skeletal system0.00427InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.09675InformativeInherited
Zebrafish Anatomy (ZA)endochondral element0.00002182Highly InformativeDirect
Zebrafish Anatomy (ZA)replacement element0.0000231Highly InformativeDirect
Zebrafish Anatomy (ZA)bone element0.00008019Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.2532Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.3414Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.3899Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.03112Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neural tube0.0001026InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0002291InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0003884InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.000616InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0006879InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.3453Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)gastrula stage0.04463Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Peroxidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a FnI-like domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]