SUPERFAMILY 1.75 HMM library and genome assignments server

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VWC domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   FnI-like domain [ 57602]
Superfamily:   FnI-like domain [ 57603] (2)
Family:   VWC domain [ 118264]


Family statistics
Genomes (55) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 83 156 1
Proteins 83 156 1


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)connective tissue disease0.003996Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.06576Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1489Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.1862Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.196Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.2121Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.223Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2394Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.3712Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.4483Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.001612Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.004683Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.006319Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.0104Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.01137Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.01385Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.01625Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.01693Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.01737Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.01924Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.04402Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.04731Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.05685Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.2052Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.2081Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.3417Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Hernia0.00009274InformativeDirect
Phenotypic Abnormality (PA)Abnormal heart valve morphology0.0001978InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the outer ear0.0002022InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the hip joint0.0002026InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the gingiva0.0008993InformativeDirect
Phenotypic Abnormality (PA)Abnormal morphology of the great vessels0.002008InformativeInherited
Phenotypic Abnormality (PA)Abnormal palate morphology0.003287InformativeInherited
Phenotypic Abnormality (PA)Joint hypermobility0.01058InformativeInherited
Phenotypic Abnormality (PA)Joint dislocation0.02668InformativeInherited
Phenotypic Abnormality (PA)Vascular skin abnormality0.02776InformativeInherited
Phenotypic Abnormality (PA)Abnormal fundus morphology0.03664InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the dentition0.07144InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.0848InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0.1383InformativeInherited
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.2166InformativeInherited
Phenotypic Abnormality (PA)Mitral valve prolapse0.00000117Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the abdominal wall musculature0.000006138Highly InformativeDirect
Phenotypic Abnormality (PA)Ectopia lentis0.00001715Highly InformativeDirect
Phenotypic Abnormality (PA)Hernia of the abdominal wall0.00004096Highly InformativeDirect
Phenotypic Abnormality (PA)Subcutaneous nodule0.000149Highly InformativeDirect
Phenotypic Abnormality (PA)Aortic aneurysm0.0001805Highly InformativeDirect
Phenotypic Abnormality (PA)Talipes equinovarus0.0002176Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormally lax or hyperextensible skin0.0002566Highly InformativeDirect
Phenotypic Abnormality (PA)Bruising susceptibility0.0004236Highly InformativeDirect
Phenotypic Abnormality (PA)Migraine0.0005243Highly InformativeDirect
Phenotypic Abnormality (PA)Atypical scarring of skin0.004539Highly InformativeInherited
Phenotypic Abnormality (PA)Arthritis0.005471Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the skin0.01271Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the rib cage0.03468Highly InformativeInherited
Phenotypic Abnormality (PA)High palate0.4735Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.003313Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.06211Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1424Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1981Least InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.00002299Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00004235Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.0001342Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.001725Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.00327Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.01517Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.02208Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.05933Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.07112Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3111Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.4818Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.6227Moderately InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.00001325InformativeDirect
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.0009908InformativeDirect
Mammalian Phenotype (MP)abnormal mouth morphology0.004859InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.00732InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.05684InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.07979InformativeInherited
Mammalian Phenotype (MP)abnormal autopod morphology0.1864InformativeInherited
Mammalian Phenotype (MP)abnormal limb bone morphology0.4356InformativeInherited
Mammalian Phenotype (MP)abnormal long bone morphology0.5242InformativeInherited
Mammalian Phenotype (MP)microphthalmia0.000004372Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.00006558Highly InformativeDirect
Mammalian Phenotype (MP)abnormal forelimb stylopod morphology0.0002419Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.0003263Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate morphology0.001272Highly InformativeInherited
Mammalian Phenotype (MP)cleft palate0.00438Highly InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.01155Highly InformativeInherited
Mammalian Phenotype (MP)abnormal kidney size0.02756Highly InformativeInherited
Mammalian Phenotype (MP)abnormal spine curvature0.2226Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.2715Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.4728Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.7418Least InformativeInherited
Zebrafish Anatomy (ZA)skeletal system0.009509InformativeInherited
Zebrafish Anatomy (ZA)surface structure0.1614InformativeInherited
Zebrafish Anatomy (ZA)endochondral element0.00004604Highly InformativeDirect
Zebrafish Anatomy (ZA)replacement element0.0000487Highly InformativeDirect
Zebrafish Anatomy (ZA)bone element0.0001773Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.2551Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.3436Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.3537Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.03109Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.0002408InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0003879InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0006053InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0006833InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.0001082Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.3479Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)gastrula stage0.04436Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Peroxidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a FnI-like domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]