SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


ZZ domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Small proteins [ 56992] (90)
Fold:   RING/U-box [ 57849]
Superfamily:   RING/U-box [ 57850] (6)
Family:   ZZ domain [ 161211] (3)


Family statistics
Genomes (55) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 163 417 3
Proteins 163 417 3


Enzyme Commission (EC)

(
show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.07788Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.1888Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2098Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.3515Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.02222Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.02901Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.0334Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.04041Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.04312Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.0529Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.072Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.1582Moderately InformativeInherited
Phenotypic Abnormality (PA)Arrhythmia0.0006522InformativeDirect
Phenotypic Abnormality (PA)Obesity0.0006867InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the palpebral fissures0.002978InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.01793InformativeInherited
Phenotypic Abnormality (PA)Abnormal pattern of respiration0.0002643Highly InformativeDirect
Phenotypic Abnormality (PA)Syndactyly0.0002742Highly InformativeDirect
Phenotypic Abnormality (PA)Short attention span0.0002985Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperactivity0.0006021Highly InformativeDirect
Phenotypic Abnormality (PA)Autistic behavior0.0006264Highly InformativeDirect
Phenotypic Abnormality (PA)Downslanted palpebral fissures0.0006522Highly InformativeDirect
Phenotypic Abnormality (PA)Clinodactyly0.0006867Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.02734Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.034Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.002824Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.03274Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.1957Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.1979Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.3016Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.003569InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.02204InformativeInherited
Mammalian Phenotype (MP)postnatal lethality0.02548InformativeInherited
Mammalian Phenotype (MP)postnatal lethality, incomplete penetrance0.0002448Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vitelline vasculature morphology0.0003238Highly InformativeDirect
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.0003503Highly InformativeDirect
Mammalian Phenotype (MP)abnormal physical strength0.003097Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)somatic cell0.2169Least InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.0184Moderately InformativeInherited
Fly Anatomy (FA)syncytium0.003137InformativeInherited
Fly Anatomy (FA)muscle cell0.004321InformativeInherited
Fly Anatomy (FA)indirect flight muscle0.00002932Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)testis0Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0Least InformativeDirect
Plant ANatomical entity (PAN)leaf lamina0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)stalk0Least InformativeDirect
Plant ANatomical entity (PAN)branch0Least InformativeDirect
Plant ANatomical entity (PAN)phyllome apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot meristem0.000002481Highly InformativeDirect
Plant ANatomical entity (PAN)apical meristem0.00003119Highly InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000001887InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 38 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a RING/U-box domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]