Eukaryotic DNA topoisomerase I, dispensable insert domain superfamily
SCOP classification
InterPro annotation
| Cross references | IPR009054 SSF46596 Protein matches |
| Abstract | Topoisomerase strand cleavage involves nucleophilic attack by a catalytic tyrosine residue, resulting in the enzyme being covalently attached to one end of the broken DNA strand. Eukaryotic DNA topoisomerase I is a multi-domain protein. The dispensable insert domain is the linker region that connects the central core of the enzyme to the C-terminal domain; it assumes a coiled-coil configuration and protrudes away from the remainder of the enzyme [ 9488652].
More information about this protein can be found at Protein of the Month: DNA Topoisomerase. |
InterPro database
Functional annotation
| General category | Information |
| Detailed category | DNA replication/repair |
Function annotation of SCOP domain superfamilies
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Internal database links
The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level. Click on the 'Genome Assignments'
icon above to view the genome assignments for this superfamily.
Alignments of sequences to Alignments of sequences to 1 models
in this superfamily are available by clicking on the superfamily level 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequences may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own.
It is possible to browse and view the proteins in the genomes which have
different combinations of domains including a Eukaryotic DNA topoisomerase I, dispensable insert domain domain. Click on the 'Domain Combinations' icon.
To view the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom click on the 'TaxViz' icon above. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
Undirected domain occurrence networks are available for all superfamilies. Nodes in these networks represent genomes. Connections between nodes represent the presence of domain architectures, which contain the superfamily of interest, in both genomes.
There are 1 hidden Markov models representing the Eukaryotic DNA topoisomerase I, dispensable insert domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be viewed by clicking on the icon above.
Jump to [ Top of page · SCOP classification · InterPro annotation · Functional annotation · Internal database links ]
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