SUPERFAMILY 1.73 HMM library and genome assignments server


C-terminal UvrC-binding domain of UvrB superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (258)
Fold:   Long alpha-hairpin [ 46556] (19)
  2 helices; antiparallel hairpin, left-handed twist
Superfamily:   C-terminal UvrC-binding domain of UvrB [ 46600]
Families:   C-terminal UvrC-binding domain of UvrB [ 46601]


InterPro annotation
Cross references IPR009055 SSF46600 Protein matches
Abstract

During the process of Escherichia coli nucleotide excision repair, DNA damage recognition and processing are achieved by the action of the uvrA, uvrB, and uvrC gene products [PubMed8466476]. The C-terminal domain of UvrB binds to a homologous domain in UvrC, possibly by specific hydrophobic and salt bridge interactions [PubMed10631326]. This domain forms two helices in an antiparallel hairpin fold with a left-handed twist. This interaction is important for the incision of the damaged strand [PubMed8530482].


InterPro database

Functional annotation
General category Information
Detailed category DNA replication/repair

Function annotation of SCOP domain superfamilies

Jump to [ Top of page · SCOP classification · InterPro annotation · Functional annotation ]

Internal database links

The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level. Click on the 'Genome Assignments' icon above to view the genome assignments for this superfamily.


Alignments of sequences to

Alignments of sequences to 1 models in this superfamily are available by clicking on the superfamily level 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequences may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own.


It is possible to browse and view the proteins in the genomes which have different combinations of domains including a C-terminal UvrC-binding domain of UvrB domain. Click on the 'Domain Combinations' icon.


To view the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom click on the 'TaxViz' icon above. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Undirected domain occurrence networks are available for all superfamilies. Nodes in these networks represent genomes. Connections between nodes represent the presence of domain architectures, which contain the superfamily of interest, in both genomes.

There are 1 hidden Markov models representing the C-terminal UvrC-binding domain of UvrB superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be viewed by clicking on the icon above.


Jump to [ Top of page · SCOP classification · InterPro annotation · Functional annotation · Internal database links ]