SUPERFAMILY 1.75 HMM library and genome assignments server

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C-terminal UvrC-binding domain of UvrB superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Long alpha-hairpin [ 46556] (20)
Superfamily:   C-terminal UvrC-binding domain of UvrB [ 46600]
Families:   C-terminal UvrC-binding domain of UvrB [ 46601]


Superfamily statistics
Genomes (2,609) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,733 48,439 7
Proteins 5,727 48,428 7


Functional annotation
General category Information
Detailed category DNA replication/repair

Document:
Function annotation of SCOP domain superfamilies

InterPro annotation
Cross references IPR009055 SSF46600 Protein matches
Abstract

During the process of Escherichia coli nucleotide excision repair, DNA damage recognition and processing are achieved by the action of the uvrA, uvrB, and uvrC gene products [PubMed8466476]. The C-terminal domain of UvrB binds to a homologous domain in UvrC, possibly by specific hydrophobic and salt bridge interactions [PubMed10631326]. This domain forms two helices in an antiparallel hairpin fold with a left-handed twist. This interaction is important for the incision of the damaged strand [PubMed8530482].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-terminal UvrC-binding domain of UvrB domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the C-terminal UvrC-binding domain of UvrB superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]