SUPERFAMILY 1.75 HMM library and genome assignments server

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Paired domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   Homeodomain-like [ 46689] (19)
Family:   Paired domain [ 46748] (3)


Family statistics
Genomes (145) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,391 4,077 3
Proteins 1,390 4,071 3


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.3044Least InformativeInherited
Disease Ontology (DO)physical disorder0.0002832InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.00003355Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.00007089Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.004604Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.01197Least InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.00001012Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.00002934Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.0002339Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.0003044Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body size0.0003178Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal embryo morphology0.0006206Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.001353Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.01335Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.01347Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.01426Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.05163Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.3291Moderately InformativeInherited
Mammalian Phenotype (MP)postnatal lethality0InformativeDirect
Mammalian Phenotype (MP)abnormal jaw morphology0.0000265InformativeDirect
Mammalian Phenotype (MP)decreased body size0.0001342InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0005587InformativeDirect
Mammalian Phenotype (MP)abnormal coat appearance0.01125InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.09716InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.2574InformativeInherited
Mammalian Phenotype (MP)abnormal mouth morphology0.4229InformativeInherited
Mammalian Phenotype (MP)abnormal midbrain morphology0.0001301Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic beta cell morphology0.0002039Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.0002203Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate morphology0.0003186Highly InformativeDirect
Mammalian Phenotype (MP)pigmentation phenotype0.0005055Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thyroid gland morphology0.008113Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Least InformativeDirect
Worm Phenotype (WP)organ system development variant0.003389Moderately InformativeInherited
Worm Phenotype (WP)cell number decreased0.00000001901Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)pair rule phenotype0.0000003922Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)anatomical group0.0137Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.06292Least InformativeInherited
Fly Anatomy (FA)adult0.0659Least InformativeInherited
Fly Anatomy (FA)nervous system0.09651Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.09782Least InformativeInherited
Fly Anatomy (FA)larva0.1191Least InformativeInherited
Fly Anatomy (FA)somatic cell0.4012Least InformativeInherited
Fly Anatomy (FA)larval tagma0.002115Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.02698Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.06477Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.08009Moderately InformativeInherited
Fly Anatomy (FA)abdomen0.09777Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1673Moderately InformativeInherited
Fly Anatomy (FA)interneuron0.01344InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.04767InformativeInherited
Fly Anatomy (FA)larval abdominal segment0.0926InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.2376InformativeInherited
Fly Anatomy (FA)cuticle0.2635InformativeInherited
Fly Anatomy (FA)U neuron0.000006109Highly InformativeDirect
Fly Anatomy (FA)EL neuron0.00001144Highly InformativeDirect
Fly Anatomy (FA)larval abdominal segment A2-70.00007907Highly InformativeDirect
Fly Anatomy (FA)RP neuron0.008588Highly InformativeInherited
Fly Anatomy (FA)abdominal segment 40.06753Highly InformativeInherited
Fly Anatomy (FA)abdominal segment 80.1136Highly InformativeInherited
Fly Anatomy (FA)denticle belt1Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.03385Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.6831Least InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.1902Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.06174InformativeInherited
Zebrafish Anatomy (ZA)receptor cell (sensu Animalia)0.03715Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0.235Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.3207Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9585Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.02139Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.06079Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.4009Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.7403Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0.00004625InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.000105InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0001741InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0002682InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.0003364InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0.001384InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.004985InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.05024InformativeInherited
Xenopus ANatomical entity (XAN)anterior neural fold0.000001581Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.00001341Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.00001554Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural ridge0.00001909Highly InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0001061Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric mesenchyme0.0001116Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0001213Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode0.0002548Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.0004878Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.0006646Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0009824Highly InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0.1442Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)premetamorphosis stage0.00006647Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 187 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Homeodomain-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]