|
|
Methylated DNA-protein cysteine methyltransferase, C-terminal domain superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Metabolism |
| Detailed category | Transferases |
Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR014048 SSF46767 Protein matches |
| Abstract | Synonym(s): 6-O-methylguanine-DNA methyltransferase, O-6-methylguanine-DNA-alkyltransferase
This entry represents the DNA binding region of 6-O-methylguanine-DNA methyltransferases. The repair of DNA containing O6-alkylated
guanine is carried out by DNA-[protein]-cysteine S-methyltransferase . The major mutagenic and carcinogenic effect of methylating agents in DNA is the formation of O6-alkylguanine. The
alkyl group at the O-6 position is transferred to a cysteine residue in the
enzyme [ 3052269]. This is a suicide reaction since the enzyme is irreversibly inactivated
and the methylated protein accumulates as a dead-end product. Most, but not
all of the methyltransferases are also able to repair O-4-methylthymine. DNA-[protein]-cysteine S-methyltransferases are widely distributed and are found in various prokaryotic and eukaryotic sources [1579490]. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
|
Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
|
Alignments of sequences to 3 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
|
|
Browse and view proteins in genomes which have
different domain combinations including a Methylated DNA-protein cysteine methyltransferase, C-terminal domain domain.
|
Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
|
|
Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
|
There are 3 hidden Markov models representing the Methylated DNA-protein cysteine methyltransferase, C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
|
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
|
0
