SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Forkhead DNA-binding domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   "Winged helix" DNA-binding domain [ 46785] (84)
Family:   Forkhead DNA-binding domain [ 46832] (6)


Family statistics
Genomes (166) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,185 8,451 9
Proteins 3,182 8,441 9


Disease Ontology (DO)

(
show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)female reproductive system disease0.02126InformativeInherited
Disease Ontology (DO)heart disease0.04882InformativeInherited
Disease Ontology (DO)premature ovarian failure0.0001336Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.0004174Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.004515Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.01785Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.06413Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1048Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3751Least InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.00002358Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0.00003882Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00005258Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.0001687Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.001067Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.002976Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.00761Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.019Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.02251Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.02271Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.03699Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.06625Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1355Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.2214Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.2354Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.2739Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.2852Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.3749Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4557Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6036Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.9695Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal jaw morphology0.0001462InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.01213InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.01513InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.04225InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.06483InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas physiology0.07892InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.08381InformativeInherited
Mammalian Phenotype (MP)abnormal neuron differentiation0.08439InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland physiology0.2238InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.2284InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.2285InformativeInherited
Mammalian Phenotype (MP)abnormal ovary morphology0.231InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2369InformativeInherited
Mammalian Phenotype (MP)abnormal glial cell morphology0.2445InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.4211InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.5621InformativeInherited
Mammalian Phenotype (MP)abnormal breathing pattern0.00003685Highly InformativeDirect
Mammalian Phenotype (MP)increased liver tumor incidence0.00003748Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic beta cell morphology0.00007067Highly InformativeDirect
Mammalian Phenotype (MP)abnormal insulin secretion0.000109Highly InformativeDirect
Mammalian Phenotype (MP)hyperglycemia0.0003021Highly InformativeDirect
Mammalian Phenotype (MP)impaired lung alveolus development0.000441Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.0007168Highly InformativeDirect
Mammalian Phenotype (MP)abnormal radial glial cell morphology0.0008722Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreas development0.0008799Highly InformativeDirect
Mammalian Phenotype (MP)abnormal anterior uvea morphology0.01738Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cornea morphology0.01771Highly InformativeInherited
Mammalian Phenotype (MP)abnormal germ layer morphology0.01856Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circulating pituitary hormone level0.02643Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.03125Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.07496Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic aorta morphology0.07701Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ovarian folliculogenesis0.1536Highly InformativeInherited
Mammalian Phenotype (MP)abnormal luteinizing hormone level0.1616Highly InformativeInherited
Mammalian Phenotype (MP)abnormal middle ear morphology0.1849Highly InformativeInherited
Mammalian Phenotype (MP)abnormal follicle stimulating hormone level0.2133Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)body region morphology variant0.00415Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.00415Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.004173Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.004197Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.004556Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.05805Moderately InformativeInherited
Worm Phenotype (WP)vulva morphology variant0.0005412InformativeDirect
Worm Phenotype (WP)male morphology variant0.000694InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.0005015InformativeDirect
Yeast Phenotype (YP)cell cycle progression through the G2/M phase transition0.000000008703Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)adult0.1497Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1497Least InformativeInherited
Fly Anatomy (FA)larva0.4979Least InformativeInherited
Fly Anatomy (FA)nervous system0.7367Least InformativeInherited
Fly Anatomy (FA)somatic cell0.8876Least InformativeInherited
Fly Anatomy (FA)ganglion0.1133Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.2956Moderately InformativeInherited
Fly Anatomy (FA)neuron0.3505Moderately InformativeInherited
Fly Anatomy (FA)primordium0.02652InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.09686InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.1088InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.1404InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.2376InformativeInherited
Fly Anatomy (FA)RP neuron0.002641Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.00002618Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.01633Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.07865Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.2475Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.8767Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9417Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system1Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.0000000000007741Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.000000000001074Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0000005399Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.02545Moderately InformativeInherited
Xenopus ANatomical entity (XAN)tail region0.1563Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.1733Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.9241Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.9757Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.0000000000001956InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0000000000004952InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.00000000002025InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.000000196InformativeDirect
Xenopus ANatomical entity (XAN)eye0.000004385InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.000004626InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.00007139InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.0001841InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0007422InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.002098InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.002173InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.07277InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.119InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.2257InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.6295InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.7397InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0.7656InformativeInherited
Xenopus ANatomical entity (XAN)tail0.8681InformativeInherited
Xenopus ANatomical entity (XAN)endocrine system0.9144InformativeInherited
Xenopus ANatomical entity (XAN)presomitic mesoderm0.000006325Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.000006362Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.00001477Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.00001942Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelial cell0.00003355Highly InformativeDirect
Xenopus ANatomical entity (XAN)periocular region0.0001123Highly InformativeDirect
Xenopus ANatomical entity (XAN)head mesoderm0.0003392Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindgut0.0007785Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural ridge0.0008991Highly InformativeDirect
Xenopus ANatomical entity (XAN)ciliated cell0.001365Highly InformativeInherited
Xenopus ANatomical entity (XAN)neural plate border0.001647Highly InformativeInherited
Xenopus ANatomical entity (XAN)tail bud0.002946Highly InformativeInherited
Xenopus ANatomical entity (XAN)foregut0.005209Highly InformativeInherited
Xenopus ANatomical entity (XAN)fin0.01736Highly InformativeInherited
Xenopus ANatomical entity (XAN)epidermis0.3959Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0001717Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)tailbud stage0.3362InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 301 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a "Winged helix" DNA-binding domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]