SUPERFAMILY 1.75 HMM library and genome assignments server

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Forkhead DNA-binding domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   "Winged helix" DNA-binding domain [ 46785] (84)
Family:   Forkhead DNA-binding domain [ 46832] (6)


Family statistics
Genomes (166) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,185 8,451 9
Proteins 3,182 8,441 9


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)female reproductive system disease0.02126InformativeInherited
Disease Ontology (DO)heart disease0.04882InformativeInherited
Disease Ontology (DO)premature ovarian failure0.0001336Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.0004162Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.004538Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.01783Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.06404Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.1048Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3754Least InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.00002358Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0.00003875Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00005248Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.0001686Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.001066Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.002976Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.007615Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.01886Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.02248Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.0227Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.03699Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.0663Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1356Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.2219Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.236Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.2741Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.2853Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.3755Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4545Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.6036Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.9695Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal jaw morphology0.0001461InformativeDirect
Mammalian Phenotype (MP)abnormal systemic artery morphology0.01214InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.01513InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.04206InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.06487InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas physiology0.07895InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.08382InformativeInherited
Mammalian Phenotype (MP)abnormal neuron differentiation0.08443InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland physiology0.2239InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.2279InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.2284InformativeInherited
Mammalian Phenotype (MP)abnormal ovary morphology0.231InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.237InformativeInherited
Mammalian Phenotype (MP)abnormal glial cell morphology0.2445InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.4211InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.5621InformativeInherited
Mammalian Phenotype (MP)abnormal breathing pattern0.00003678Highly InformativeDirect
Mammalian Phenotype (MP)increased liver tumor incidence0.00003742Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic beta cell morphology0.00007063Highly InformativeDirect
Mammalian Phenotype (MP)abnormal insulin secretion0.000109Highly InformativeDirect
Mammalian Phenotype (MP)hyperglycemia0.0003022Highly InformativeDirect
Mammalian Phenotype (MP)impaired lung alveolus development0.0004411Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.0007161Highly InformativeDirect
Mammalian Phenotype (MP)abnormal radial glial cell morphology0.0008725Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreas development0.0008804Highly InformativeDirect
Mammalian Phenotype (MP)abnormal anterior uvea morphology0.01738Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cornea morphology0.01772Highly InformativeInherited
Mammalian Phenotype (MP)abnormal germ layer morphology0.01856Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circulating pituitary hormone level0.02644Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.03111Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.07499Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic aorta morphology0.07703Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ovarian folliculogenesis0.1537Highly InformativeInherited
Mammalian Phenotype (MP)abnormal luteinizing hormone level0.1616Highly InformativeInherited
Mammalian Phenotype (MP)abnormal middle ear morphology0.185Highly InformativeInherited
Mammalian Phenotype (MP)abnormal follicle stimulating hormone level0.2134Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.000002863Least InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.0000000001779Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.05525Moderately InformativeInherited
Worm Phenotype (WP)vulva morphology variant0.0005867InformativeDirect
Worm Phenotype (WP)male morphology variant0.0007308InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.0005015InformativeDirect
Yeast Phenotype (YP)cell cycle progression through the G2/M phase transition0.000000008703Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)adult0.123Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1317Least InformativeInherited
Fly Anatomy (FA)larva0.518Least InformativeInherited
Fly Anatomy (FA)nervous system0.6879Least InformativeInherited
Fly Anatomy (FA)somatic cell0.8672Least InformativeInherited
Fly Anatomy (FA)digestive system0.01584Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.09364Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.1149Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.3Moderately InformativeInherited
Fly Anatomy (FA)neuron0.3331Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval digestive system0.0008994InformativeDirect
Fly Anatomy (FA)primordium0.02586InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.0805InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.09249InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.105InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.2465InformativeInherited
Fly Anatomy (FA)RP neuron0.002564Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.00002588Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.01624Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.08014Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.2556Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.8752Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9402Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system1Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.000000000001068Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.000000000006004Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.000001033Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.02511Moderately InformativeInherited
Xenopus ANatomical entity (XAN)tail region0.1617Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.1704Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.9243Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.9748Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.0000000000002016InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0000000000005018InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.00000000002284InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.0000001836InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.000004916InformativeDirect
Xenopus ANatomical entity (XAN)eye0.000008599InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.00007112InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0008211InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.002208InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.002281InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.07284InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.12InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.2242InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.633InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.7369InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0.7617InformativeInherited
Xenopus ANatomical entity (XAN)tail0.8738InformativeInherited
Xenopus ANatomical entity (XAN)endocrine system0.9163InformativeInherited
Xenopus ANatomical entity (XAN)sensorial layer of neurectoderm0.0000001667Highly InformativeDirect
Xenopus ANatomical entity (XAN)presomitic mesoderm0.000005979Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.000006117Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.00001487Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.0000191Highly InformativeDirect
Xenopus ANatomical entity (XAN)epithelial cell0.00003437Highly InformativeDirect
Xenopus ANatomical entity (XAN)periocular region0.0001172Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.0002Highly InformativeDirect
Xenopus ANatomical entity (XAN)head mesoderm0.000329Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindgut0.0007592Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural ridge0.0009196Highly InformativeDirect
Xenopus ANatomical entity (XAN)ciliated cell0.001329Highly InformativeInherited
Xenopus ANatomical entity (XAN)neural plate border0.00168Highly InformativeInherited
Xenopus ANatomical entity (XAN)tail bud0.002497Highly InformativeInherited
Xenopus ANatomical entity (XAN)foregut0.005713Highly InformativeInherited
Xenopus ANatomical entity (XAN)fin0.01842Highly InformativeInherited
Xenopus ANatomical entity (XAN)epidermis0.3781Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.000182Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)tailbud stage0.3362InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 301 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a "Winged helix" DNA-binding domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]