SUPERFAMILY 1.75 HMM library and genome assignments server

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Cell cycle transcription factor e2f-dp family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   "Winged helix" DNA-binding domain [ 46785] (84)
Family:   Cell cycle transcription factor e2f-dp [ 46847] (2)


Family statistics
Genomes (193) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 512 1,368 2
Proteins 512 1,367 2


Mouse Phenotype (MP)

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show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.002268Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.004604Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.008807Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.01194Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01587Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1583Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3246Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.0008603Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.001853Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.003469Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.009788Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01409Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.0163Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.02041Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.02313Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.04483Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.07077Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1072Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.4931Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.7854Moderately InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.0001396InformativeDirect
Mammalian Phenotype (MP)abnormal testis morphology0.0001583InformativeDirect
Mammalian Phenotype (MP)abnormal T cell differentiation0.0004726InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0005609InformativeDirect
Mammalian Phenotype (MP)abnormal prenatal body size0.0006213InformativeDirect
Mammalian Phenotype (MP)premature death0.0008121InformativeDirect
Mammalian Phenotype (MP)decreased cell proliferation0.0009488InformativeDirect
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.002209InformativeInherited
Mammalian Phenotype (MP)abnormal placenta morphology0.002723InformativeInherited
Mammalian Phenotype (MP)decreased neuron number0.005575InformativeInherited
Mammalian Phenotype (MP)lethality throughout fetal growth and development0.02993InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.2627InformativeInherited
Mammalian Phenotype (MP)abnormal retinal bipolar cell morphology0.000006928Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal ganglion cell morphology0.00004768Highly InformativeDirect
Mammalian Phenotype (MP)lethality throughout fetal growth and development, complete penetrance0.0001686Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell cycle0.0002126Highly InformativeDirect
Mammalian Phenotype (MP)abnormal trophoblast layer morphology0.0002496Highly InformativeDirect
Mammalian Phenotype (MP)embryonic lethality during organogenesis, complete penetrance0.0004044Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.007349Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.02268Least InformativeInherited
Worm Phenotype (WP)movement variant0.001109Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.001238Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.006572Moderately InformativeInherited
Worm Phenotype (WP)directionality variant0.000001932InformativeDirect
Worm Phenotype (WP)vulva development variant0.000003155InformativeDirect
Worm Phenotype (WP)cell fate specification variant0.000013InformativeDirect
Worm Phenotype (WP)multivulva0.0000005417Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)wild-type0InformativeDirect
Fly Phenotype (FP)partially lethal0Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 301 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a "Winged helix" DNA-binding domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]