SUPERFAMILY 1.75 HMM library and genome assignments server

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Cell cycle transcription factor e2f-dp family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   "Winged helix" DNA-binding domain [ 46785] (84)
Family:   Cell cycle transcription factor e2f-dp [ 46847] (2)


Family statistics
Genomes (193) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 512 1,368 2
Proteins 512 1,367 2


Mouse Phenotype (MP)

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show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.002267Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.004601Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.008804Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.01197Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01591Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1583Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3247Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.00086Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.001853Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.003468Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.009834Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.01409Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.0163Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.02053Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.02319Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.04485Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.07075Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1072Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.4931Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.7857Moderately InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.0001396InformativeDirect
Mammalian Phenotype (MP)abnormal testis morphology0.0001582InformativeDirect
Mammalian Phenotype (MP)abnormal T cell differentiation0.0004724InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0005584InformativeDirect
Mammalian Phenotype (MP)abnormal prenatal body size0.000621InformativeDirect
Mammalian Phenotype (MP)premature death0.0008126InformativeDirect
Mammalian Phenotype (MP)decreased cell proliferation0.0009489InformativeDirect
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.00221InformativeInherited
Mammalian Phenotype (MP)abnormal placenta morphology0.002724InformativeInherited
Mammalian Phenotype (MP)decreased neuron number0.005577InformativeInherited
Mammalian Phenotype (MP)lethality throughout fetal growth and development0.02994InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.2632InformativeInherited
Mammalian Phenotype (MP)abnormal retinal bipolar cell morphology0.000006931Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal ganglion cell morphology0.00004767Highly InformativeDirect
Mammalian Phenotype (MP)lethality throughout fetal growth and development, complete penetrance0.0001686Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell cycle0.0002129Highly InformativeDirect
Mammalian Phenotype (MP)abnormal trophoblast layer morphology0.0002497Highly InformativeDirect
Mammalian Phenotype (MP)embryonic lethality during organogenesis, complete penetrance0.0004043Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00718Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.01807Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.00133Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.00305Moderately InformativeInherited
Worm Phenotype (WP)vulva development variant0.000003807InformativeDirect
Worm Phenotype (WP)cell fate specification variant0.00001536InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.00001589InformativeDirect
Worm Phenotype (WP)multivulva0.0000007235Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect
Fly Phenotype (FP)wild-type0InformativeDirect
Fly Phenotype (FP)partially lethal0Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 301 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a "Winged helix" DNA-binding domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]