SUPERFAMILY 1.75 HMM library and genome assignments server

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ets domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
Superfamily:   "Winged helix" DNA-binding domain [ 46785] (84)
Family:   ets domain [ 46859] (8)


Family statistics
Genomes (145) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,075 5,776 14
Proteins 2,075 5,768 14


Human Phenotype (HP)

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show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.005075Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.00859Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02586Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.05149Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.09588Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.3085Least InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.001195Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.001846Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.004537Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.007118Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.01378Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.01763Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.084Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.08859Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.1163Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.1955Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2251Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.349Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.3787Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.6666Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.7848Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.0001085InformativeDirect
Mammalian Phenotype (MP)abnormal B cell differentiation0.01598InformativeInherited
Mammalian Phenotype (MP)lethality throughout fetal growth and development0.01905InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.06707InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.4036InformativeInherited
Mammalian Phenotype (MP)lethality throughout fetal growth and development, complete penetrance0.00003601Highly InformativeDirect
Mammalian Phenotype (MP)decreased thymocyte number0.000625Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hematopoietic stem cell morphology0.0007516Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B cell apoptosis0.003958Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)organ system development variant0.0003747Moderately InformativeDirect
Worm Phenotype (WP)nervous system development variant0.00002125Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)epithelium0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.1517Least InformativeInherited
Zebrafish Anatomy (ZA)motile cell0.01013InformativeInherited
Zebrafish Anatomy (ZA)immune system0.01609InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.01952InformativeInherited
Zebrafish Anatomy (ZA)granulocyte0.0003675Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0.09245Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.1465Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system0.1875Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.000000001257Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.00000004908Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.00001503Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.5528Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pharyngeal region0.00000000003886InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.000000002073InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.000001043InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00001619InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.00006905InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0003059InformativeDirect
Xenopus ANatomical entity (XAN)urinary system0.0003845InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0004945InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0.002089InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.002772InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.006294InformativeInherited
Xenopus ANatomical entity (XAN)ventral blood island0.000000000006236Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.0000000007022Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0000001159Highly InformativeDirect
Xenopus ANatomical entity (XAN)periocular region0.00006901Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 301 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a "Winged helix" DNA-binding domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]