SUPERFAMILY 1.73 HMM library and genome assignments server


C-terminal effector domain of the bipartite response regulators superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (258)
Fold:   DNA/RNA-binding 3-helical bundle [ 46688] (14)
  core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down
Superfamily:   C-terminal effector domain of the bipartite response regulators [ 46894] (3)
Families:   PhoB-like [ 46895] (5)
  contains 4-stranded meander beta-sheet in the N-terminal extension
  GerE-like (LuxR/UhpA family of transcriptional regulators) [ 46900] (5)
  contains additional, fourth helix in the C-terminal extension
  Spo0A [ 46903]
  elaborated with additional helices


Superfamily statistics
Genomes (860) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 12,759 17,940 13
Proteins 12,745 17,927 13


Functional annotation
General category Regulation
Detailed category DNA-binding

Function annotation of SCOP domain superfamilies

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a C-terminal effector domain of the bipartite response regulators domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 13 hidden Markov models representing the C-terminal effector domain of the bipartite response regulators superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]