SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Spectrin repeat family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   Spectrin repeat [ 46966]
Family:   Spectrin repeat [ 46967] (3)


Family statistics
Genomes (149) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,478 13,132 20
Proteins 1,113 4,555 10


Enzyme Commission (EC)

(
show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)integumentary system disease0.05599Moderately InformativeInherited
Disease Ontology (DO)vesiculobullous skin disease0.0001548Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.04411Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.04766Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.06928Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1138Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1461Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.03078Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.1242Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.1918Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.2285Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.29Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.4401Moderately InformativeInherited
Phenotypic Abnormality (PA)Epidermal thickening0.0001904InformativeDirect
Phenotypic Abnormality (PA)Abnormal myocardium morphology0.004682InformativeInherited
Phenotypic Abnormality (PA)Abnormal adipose tissue morphology0.009453InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.01748InformativeInherited
Phenotypic Abnormality (PA)Decreased cervical spine flexion due to contractures of posterior cervical muscles0.00001157Highly InformativeDirect
Phenotypic Abnormality (PA)Muscular dystrophy0.0001788Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.0002853Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the Achilles tendon0.0003756Highly InformativeDirect
Phenotypic Abnormality (PA)Lipodystrophy0.0004796Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.001079Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0007532Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.02119Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.01041Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.05879Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5002Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.001627InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1152InformativeInherited
Mammalian Phenotype (MP)abnormal somatic motor system morphology0.0000253Highly InformativeDirect
Mammalian Phenotype (MP)heart block0.000809Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.005622Highly InformativeInherited
Mammalian Phenotype (MP)abnormal physical strength0.04427Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.00312Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.004481Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.02885Least InformativeInherited
Worm Phenotype (WP)larval lethal0.1127Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.2044Least InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.00007068Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0001567Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.002097Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.002133Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.003798Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.04096Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.05706Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2406Moderately InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.00008579InformativeDirect
Worm Phenotype (WP)brood size variant0.0001149InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0001715InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0004538InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.0005126InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0008238InformativeDirect
Worm Phenotype (WP)cell component localization variant0.03864InformativeInherited
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.09624InformativeInherited
Worm Phenotype (WP)dumpy0.000001612Highly InformativeDirect
Worm Phenotype (WP)antibody staining variant0.000002532Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.000005567Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0004063Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1021Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.03113Moderately InformativeInherited
Fly Phenotype (FP)hypoactive0.0001566Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.05747Least InformativeInherited
Fly Anatomy (FA)anatomical group0.09364Least InformativeInherited
Fly Anatomy (FA)larva0.112Least InformativeInherited
Fly Anatomy (FA)nervous system0.1589Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2467Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.3Least InformativeInherited
Fly Anatomy (FA)gonad0.008149Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01001Moderately InformativeInherited
Fly Anatomy (FA)female-specific anatomical entity0.01551Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.02745Moderately InformativeInherited
Fly Anatomy (FA)digestive system0.03354Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.06553Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.4298Moderately InformativeInherited
Fly Anatomy (FA)tract0.000434InformativeDirect
Fly Anatomy (FA)midgut0.002212InformativeInherited
Fly Anatomy (FA)epithelial tube0.01001InformativeInherited
Fly Anatomy (FA)ovariole0.01095InformativeInherited
Fly Anatomy (FA)embryonic/larval digestive system0.01579InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.02384InformativeInherited
Fly Anatomy (FA)female germline cyst0.02847InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.06062InformativeInherited
Fly Anatomy (FA)germline cell0.07341InformativeInherited
Fly Anatomy (FA)fat body0.1256InformativeInherited
Fly Anatomy (FA)fat cell0.00002198Highly InformativeDirect
Fly Anatomy (FA)midgut epithelium0.00007614Highly InformativeDirect
Fly Anatomy (FA)connective0.00008031Highly InformativeDirect
Fly Anatomy (FA)neuron projection bundle of ventral nerve cord0.0004258Highly InformativeDirect
Fly Anatomy (FA)oocyte0.0006954Highly InformativeDirect
Fly Anatomy (FA)epithelial cell0.0417Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.1964Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.3733Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.5647Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7413Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.03545Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.6807Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.004786InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.01356InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.06263InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.08509InformativeInherited
Xenopus ANatomical entity (XAN)epithelial cell0.0003568Highly InformativeDirect
Xenopus ANatomical entity (XAN)bone element0.002281Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Spectrin repeat domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]