SUPERFAMILY 1.75 HMM library and genome assignments server

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Spectrin repeat family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Spectrin repeat-like [ 46965] (16)
Superfamily:   Spectrin repeat [ 46966]
Family:   Spectrin repeat [ 46967] (3)


Family statistics
Genomes (149) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,478 13,132 20
Proteins 1,113 4,555 10


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)integumentary system disease0.05599Moderately InformativeInherited
Disease Ontology (DO)vesiculobullous skin disease0.0001548Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.0403Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.04493Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.06635Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1091Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.1395Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.03031Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.1221Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.1883Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.2195Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.2892Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.4292Moderately InformativeInherited
Phenotypic Abnormality (PA)Epidermal thickening0.0001831InformativeDirect
Phenotypic Abnormality (PA)Abnormal myocardium morphology0.005071InformativeInherited
Phenotypic Abnormality (PA)Abnormal adipose tissue morphology0.009411InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.01721InformativeInherited
Phenotypic Abnormality (PA)Decreased cervical spine flexion due to contractures of posterior cervical muscles0.0000121Highly InformativeDirect
Phenotypic Abnormality (PA)Muscular dystrophy0.0001963Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.0002463Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the Achilles tendon0.0003939Highly InformativeDirect
Phenotypic Abnormality (PA)Lipodystrophy0.0005035Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.001076Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0007546Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.02111Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.0104Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.05865Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5013Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.001637InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1152InformativeInherited
Mammalian Phenotype (MP)abnormal somatic motor system morphology0.0000253Highly InformativeDirect
Mammalian Phenotype (MP)heart block0.0008092Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.005622Highly InformativeInherited
Mammalian Phenotype (MP)abnormal physical strength0.04426Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0005489Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.003567Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.003567Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.00678Least InformativeInherited
Worm Phenotype (WP)larval lethal0.1062Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1779Least InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.00007546Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.0006723Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.004077Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.005465Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.005465Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.005489Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.005509Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.005887Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.007443Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.04078Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.2012Moderately InformativeInherited
Worm Phenotype (WP)level of protein expression variant0.00008384InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0001006InformativeDirect
Worm Phenotype (WP)brood size variant0.0001023InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.0003031InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0007911InformativeDirect
Worm Phenotype (WP)cell component localization variant0.03893InformativeInherited
Worm Phenotype (WP)drug resistant0.06456InformativeInherited
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.1151InformativeInherited
Worm Phenotype (WP)dumpy0.000001592Highly InformativeDirect
Worm Phenotype (WP)antibody staining variant0.000002388Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.000005157Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0003817Highly InformativeDirect
Worm Phenotype (WP)acetylcholinesterase inhibitor resistant0.07986Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.1071Least InformativeInherited
Fly Phenotype (FP)lethal - all die before end of P-stage0.03071Moderately InformativeInherited
Fly Phenotype (FP)hypoactive0.0001619Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.0651Least InformativeInherited
Fly Anatomy (FA)larva0.09984Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1031Least InformativeInherited
Fly Anatomy (FA)nervous system0.1815Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2763Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.3267Least InformativeInherited
Fly Anatomy (FA)gonad0.009071Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01059Moderately InformativeInherited
Fly Anatomy (FA)female organism0.01702Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.02899Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.06398Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.2825Moderately InformativeInherited
Fly Anatomy (FA)tract0.0004599InformativeDirect
Fly Anatomy (FA)epithelial tube0.01074InformativeInherited
Fly Anatomy (FA)cuboidal/columnar epithelium0.0121InformativeInherited
Fly Anatomy (FA)embryonic/larval digestive system0.01818InformativeInherited
Fly Anatomy (FA)midgut0.02042InformativeInherited
Fly Anatomy (FA)epithelial cell0.0208InformativeInherited
Fly Anatomy (FA)female germline cyst0.0306InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.05777InformativeInherited
Fly Anatomy (FA)germline cell0.07392InformativeInherited
Fly Anatomy (FA)connective0.00008828Highly InformativeDirect
Fly Anatomy (FA)neuron projection bundle of ventral nerve cord0.0004158Highly InformativeDirect
Fly Anatomy (FA)oocyte0.0007374Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.1902Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.374Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.5676Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7414Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.03617Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.6447Moderately InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.004845InformativeInherited
Xenopus ANatomical entity (XAN)epithelium0.01342InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.0626InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.08592InformativeInherited
Xenopus ANatomical entity (XAN)epithelial cell0.0003461Highly InformativeDirect
Xenopus ANatomical entity (XAN)bone element0.002325Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 13 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Spectrin repeat domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]