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Protozoan pheromone proteins superfamily
SCOP classification
Superfamily statistics
Functional annotation
| General category | Other |
| Detailed category | Unknown function |
Function annotation of SCOP domain superfamilies
InterPro annotation
| Cross references | IPR009064 SSF47014 Protein matches |
| Abstract | Protozoan pheromones are cell-type specific protein signals. Representatives of this family of proteins include Er-1, Er-2, Er-10, Er11 and Er22 from the ciliated protozoan Euplotes raikovi, which are constitutively secreted and bound back in an autocrine fashion with a positive effect on mitotic cell growth. The mitogenic activity induced by the Er pheromone autocrine signalling can be inhibited by cAMP [ 12681291]. The NMR structure reveals a closed up-and-down bundle of three helices with a left-handed twist [7833812]. In some cases, these pheromones can compete with each other in binding to their cell-surface receptors.
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InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]
Internal database links
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Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 5 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a Protozoan pheromone proteins domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 5 hidden Markov models representing the Protozoan pheromone proteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]
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