SUPERFAMILY 1.75 HMM library and genome assignments server

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Second domain of FERM family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl-CoA binding protein-like [ 47026] (2)
Superfamily:   Second domain of FERM [ 47031]
Family:   Second domain of FERM [ 47032] (8)


Family statistics
Genomes (155) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,365 7,897 21
Proteins 2,364 7,894 21


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000009819Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000000000003089Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.8764Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.03515Moderately InformativeInherited
Disease Ontology (DO)meningioma0.00008657InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8491Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.8609Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.2521Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.7391Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.06615InformativeInherited
Phenotypic Abnormality (PA)Internal hemorrhage0.2626InformativeInherited
Phenotypic Abnormality (PA)Cerebral hemorrhage0.000554Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.1151Least InformativeInherited
Worm Phenotype (WP)cell development variant0.2613Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.8305Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.007478Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.02488Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.000005573InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00005088InformativeDirect
Worm Phenotype (WP)cell component localization variant0.00007343InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00008416InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.00009913InformativeDirect
Worm Phenotype (WP)cell migration variant0.0007827InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.0000003591Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.00002479Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anatomical group0.007347Least InformativeInherited
Fly Anatomy (FA)nervous system0.009923Least InformativeInherited
Fly Anatomy (FA)adult head0.0000823Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.006607Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.05129Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.08898Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.0979Moderately InformativeInherited
Fly Anatomy (FA)adult external head0.03773InformativeInherited
Fly Anatomy (FA)chaeta0.06768InformativeInherited
Fly Anatomy (FA)nerve0.1067InformativeInherited
Fly Anatomy (FA)embryonic/larval optic stalk0.00002381Highly InformativeDirect
Fly Anatomy (FA)head bristle0.0003682Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.004288Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.008552Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2718Least InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve1Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.00003752Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.02325Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.00000008624Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.08611Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.00000000000002439InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.00000214InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Second domain of FERM domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]