SUPERFAMILY 1.75 HMM library and genome assignments server

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Second domain of FERM family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl-CoA binding protein-like [ 47026] (2)
Superfamily:   Second domain of FERM [ 47031]
Family:   Second domain of FERM [ 47032] (8)


Family statistics
Genomes (155) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,365 7,897 21
Proteins 2,364 7,894 21


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000009819Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000000000003089Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.8764Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.03515Moderately InformativeInherited
Disease Ontology (DO)meningioma0.00008657InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8451Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.8535Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.2449Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.7305Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebral vasculature0.06473InformativeInherited
Phenotypic Abnormality (PA)Internal hemorrhage0.2624InformativeInherited
Phenotypic Abnormality (PA)Cerebral hemorrhage0.0005253Highly InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.09242Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.125Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.125Least InformativeInherited
Worm Phenotype (WP)cell development variant0.2657Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.3657Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.7881Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.007226Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.02573Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.04204Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.242Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.00000285InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00004482InformativeDirect
Worm Phenotype (WP)cell component localization variant0.00007414InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00007772InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.00009519InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.0000003393Highly InformativeDirect
Worm Phenotype (WP)protein expression reduced0.00002412Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)anatomical group0.008097Least InformativeInherited
Fly Anatomy (FA)nervous system0.01309Least InformativeInherited
Fly Anatomy (FA)adult0.01686Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.006956Moderately InformativeInherited
Fly Anatomy (FA)head0.05013Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.06077Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.08555Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.1179Moderately InformativeInherited
Fly Anatomy (FA)adult external head0.05017InformativeInherited
Fly Anatomy (FA)chaeta0.07444InformativeInherited
Fly Anatomy (FA)nerve0.1069InformativeInherited
Fly Anatomy (FA)adult head sensillum0.1745InformativeInherited
Fly Anatomy (FA)embryonic/larval optic stalk0.00002622Highly InformativeDirect
Fly Anatomy (FA)head bristle0.0003558Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.006836Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.008467Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2699Least InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.00237InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve0.006898Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.00003875Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.02337Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.00000008626Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.07835Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.00000000000002508InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000002125InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Second domain of FERM domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]