SUPERFAMILY 1.75 HMM library and genome assignments server

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HMG-box family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HMG-box [ 47094]
Superfamily:   HMG-box [ 47095]
Family:   HMG-box [ 47096] (9)


Family statistics
Genomes (385) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,324 12,875 25
Proteins 3,462 10,657 24


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.000000007154Least InformativeDirect
Enzyme Commission (EC)Methyltransferases0.0000000003989Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cell type cancer0.8859Moderately InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.08297Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.08668Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.1064Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1202Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1362Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.4265Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.01613Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.03155Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.06991Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.07193Moderately InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental delay0.1688Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.282Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.844Moderately InformativeInherited
Phenotypic Abnormality (PA)Global developmental delay0.0006638InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.0008521InformativeDirect
Phenotypic Abnormality (PA)Abnormal vertebral morphology0.1326InformativeInherited
Phenotypic Abnormality (PA)Hernia0.1446InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.1645InformativeInherited
Phenotypic Abnormality (PA)Abnormality of reproductive system physiology0.4575InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the diaphragm0.0003776Highly InformativeDirect
Phenotypic Abnormality (PA)Dilatation of the renal pelvis0.0005829Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the sense of smell0.0008853Highly InformativeDirect
Phenotypic Abnormality (PA)Hypogonadism0.1282Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal form of the vertebral bodies0.6118Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.008432Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.01855Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.08942Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3749Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.6142Least InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.0004597Moderately InformativeDirect
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.005219Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.008452Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.05229Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1052Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.1677Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.1926Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.3Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.3085Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.3194Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.7674Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.004443InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.01372InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.02585InformativeInherited
Mammalian Phenotype (MP)abnormal testis morphology0.02774InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.04738InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton development0.2475InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.2629InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.0000859Highly InformativeDirect
Mammalian Phenotype (MP)distended abdomen0.0004395Highly InformativeDirect
Mammalian Phenotype (MP)persistent truncus arteriosis0.0009252Highly InformativeDirect
Mammalian Phenotype (MP)abnormal autonomic nervous system morphology0.001372Highly InformativeInherited
Mammalian Phenotype (MP)abnormal optic nerve morphology0.001677Highly InformativeInherited
Mammalian Phenotype (MP)abnormal limb development0.002386Highly InformativeInherited
Mammalian Phenotype (MP)abnormal seminiferous tubule morphology0.2126Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.002362Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.005047Least InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.00008513Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.0003915Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.001403Moderately InformativeInherited
Worm Phenotype (WP)vulva morphology variant0.00001959InformativeDirect
Worm Phenotype (WP)epithelial system development variant0.04395InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.07957InformativeInherited
Worm Phenotype (WP)gonad arm morphology variant0.000002817Highly InformativeDirect
Worm Phenotype (WP)maintenance of gene silencing variant0.00001905Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003299Highly InformativeDirect
Worm Phenotype (WP)lineage variant0.005352Highly InformativeInherited
Worm Phenotype (WP)amphid phasmid morphology variant0.3435Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)cell cycle progression0.0009667InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.04438Least InformativeInherited
Fly Anatomy (FA)adult0.04762Least InformativeInherited
Fly Anatomy (FA)segment0.08529Least InformativeInherited
Fly Anatomy (FA)tagma0.1102Least InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.0004189Moderately InformativeDirect
Fly Anatomy (FA)appendage0.001168Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.005852Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.4782Moderately InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.001159Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.04062Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.4708Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.5655Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.07661Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.2834Moderately InformativeInherited
Zebrafish Anatomy (ZA)head0.6369Moderately InformativeInherited
Zebrafish Anatomy (ZA)embryonic structure0.09214InformativeInherited
Zebrafish Anatomy (ZA)skeletal system0.1419InformativeInherited
Zebrafish Anatomy (ZA)pharyngeal arch0.3408InformativeInherited
Zebrafish Anatomy (ZA)digestive system0.3474InformativeInherited
Zebrafish Anatomy (ZA)pharynx0.06791Highly InformativeInherited
Zebrafish Anatomy (ZA)endochondral element0.0759Highly InformativeInherited
Zebrafish Anatomy (ZA)replacement element0.07859Highly InformativeInherited
Zebrafish Anatomy (ZA)gill0.08017Highly InformativeInherited
Zebrafish Anatomy (ZA)bone element0.1601Highly InformativeInherited
Zebrafish Anatomy (ZA)ectoderm0.2244Highly InformativeInherited
Zebrafish Anatomy (ZA)cranial ganglion0.7215Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.004882Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.005132Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.01103Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.07107Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.07174Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.4932Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.5979Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.00006544Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0001003Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.0002017Moderately InformativeDirect
Xenopus ANatomical entity (XAN)brain0.004558Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.08614Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.2109Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.3343Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0.000005492InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.00001526InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0.000284InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0004576InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0007258InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.03673InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.05215InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.0752InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.15InformativeInherited
Xenopus ANatomical entity (XAN)neural plate border0.0000000398Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0000006133Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.000003118Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.00001082Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain-hindbrain boundary0.00009883Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.0002004Highly InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0005273Highly InformativeDirect
Xenopus ANatomical entity (XAN)splanchnocranium0.00088Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode0.001294Highly InformativeInherited
Xenopus ANatomical entity (XAN)optic vesicle0.01218Highly InformativeInherited
Xenopus ANatomical entity (XAN)blastopore lip0.1152Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant ovule0.0008035Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.0008264Least InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.00000001064Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 28 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a HMG-box domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]