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Mitochondrial import receptor subunit Tom20 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Open three-helical up-and-down bundle [ 47143] (7)
Superfamily:   Mitochondrial import receptor subunit Tom20 [ 47157]
Families:   Mitochondrial import receptor subunit Tom20 [ 47158]


Superfamily statistics
Genomes (358) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 475 1,197 1
Proteins 472 1,189 1


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.00005956 Least Informative Direct
Biological Process (BP) nitrogen compound transport 0.000000001275 Moderately Informative Direct
Biological Process (BP) organic substance transport 0.000000006631 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000000008759 Moderately Informative Direct
Biological Process (BP) cellular localization 0.00000002627 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0000009673 Moderately Informative Direct
Biological Process (BP) mitochondrion organization 0.0000000000002407 Informative Direct
Biological Process (BP) protein localization to organelle 0.0000000000023 Informative Direct
Biological Process (BP) protein transport 0.00000000006675 Informative Direct
Biological Process (BP) intracellular transport 0.000000001145 Informative Direct
Biological Process (BP) mitochondrial transport 0 Highly Informative Direct
Biological Process (BP) establishment of protein localization to mitochondrion 0 Highly Informative Direct
Biological Process (BP) protein targeting 0.000000000000003734 Highly Informative Direct
Molecular Function (MF) transporter activity 0.00000003308 Moderately Informative Direct
Molecular Function (MF) P-P-bond-hydrolysis-driven transmembrane transporter activity 0.00000000002838 Informative Direct
Molecular Function (MF) amide transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) macromolecule transmembrane transporter activity 0 Highly Informative Direct
Molecular Function (MF) protein transporter activity 0 Highly Informative Direct
Cellular Component (CC) protein complex 0.00002022 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0001484 Least Informative Direct
Cellular Component (CC) membrane 0.000182 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.001623 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.002802 Least Informative Inherited
Cellular Component (CC) mitochondrial envelope 0.000000000007736 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.000000007815 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.00000004545 Moderately Informative Direct
Cellular Component (CC) mitochondrial protein complex 0.00000009849 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.00003289 Moderately Informative Direct
Cellular Component (CC) outer membrane 0.000000001819 Informative Direct
Cellular Component (CC) mitochondrial outer membrane 0.00000000000007923 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.00000000009036Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentMitochondrion outer membrane0InformativeDirect
DomainTransmembrane0Least InformativeDirect
Post-translational modificationPhosphoprotein0.00007651Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002056 SSF47157 Protein matches
Abstract Virtually all mitochondrial precursors are imported via the same mechanism [PubMed7709435]: precursors first bind to receptors on the mitochondrial surface, then insert into the translocation channel in the outer membrane. Many outer-membrane proteins participate in the early stages of import, four of which (MAS20, MAS22, MAS37 and MAS70) are components of the receptor. MAS20, which forms a subcomplex with MAS22, seems to interact with most or all mitochondrial precursors, suggesting that the protein binds directly to mitochondrial targeting sequences. The MAS37 and MAS70 components also form a subcomplex, the two subcomplexes possibly binding via their trans- membrane (TM) regions - the TM region of MAS70 promotes oligomerisation of attatched protein domains and shares sequence similarity with the TM region of MAS20 [PubMed8163528].

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Mitochondrial import receptor subunit Tom20 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Mitochondrial import receptor subunit Tom20 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]