SUPERFAMILY 1.75 HMM library and genome assignments server

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Interferons/interleukin-10 (IL-10) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   4-helical cytokines [ 47265]
Superfamily:   4-helical cytokines [ 47266] (3)
Family:   Interferons/interleukin-10 (IL-10) [ 47305] (8)

Family statistics
Genomes (60) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 677 1,824 26
Proteins 677 1,822 24

Disease Ontology (DO)

show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)connective tissue disease0.0004092Moderately InformativeDirect
Disease Ontology (DO)integumentary system disease0.000989Moderately InformativeDirect
Disease Ontology (DO)lower respiratory tract disease0.001198Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.008915Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.02522Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.04817Moderately InformativeInherited
Disease Ontology (DO)interstitial lung disease0.0002485InformativeDirect
Disease Ontology (DO)arthropathy0.0004782InformativeDirect
Disease Ontology (DO)liver disease0.0008238InformativeDirect
Disease Ontology (DO)periodontal disease0.001168InformativeInherited
Disease Ontology (DO)glomerulonephritis0.3683InformativeInherited
Disease Ontology (DO)myopathy1InformativeInherited
Disease Ontology (DO)sarcoidosis0.000008345Highly InformativeDirect
Disease Ontology (DO)hepatitis0.0001237Highly InformativeDirect
Disease Ontology (DO)tuberculosis0.0001313Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.0109Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.0122Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5008Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.0001087Moderately InformativeDirect
Mammalian Phenotype (MP)neoplasm0.009034Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.01368Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.02693Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.03241Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.1397Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.2296Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.5307Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.000009918InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.00004252InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system physiology0.002263InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.006909InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.1126InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-10 secretion0.000004603Highly InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to induced colitis0.00004558Highly InformativeDirect
Mammalian Phenotype (MP)abnormal large intestine morphology0.0004914Highly InformativeDirect
Mammalian Phenotype (MP)lung inflammation0.0007012Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.2222Highly InformativeInherited

Document: MP annotation of SCOP domains

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Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 58 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a 4-helical cytokines domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Internal database links ]