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ACP-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Acyl carrier protein-like [ 47335] (3)
Superfamily:   ACP-like [ 47336] (3)
Families:   Acyl-carrier protein (ACP) [ 47337] (6)
  Peptidyl carrier domain [ 47342]
  apo-D-alanyl carrier protein [ 63535]


Superfamily statistics
Genomes (3,027) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 32,761 235,148 17
Proteins 22,023 162,731 17


Functional annotation
General category Other
Detailed category Unknown function

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Ligases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.3969Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.6299Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1608Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Ligases forming aminoacyl-tRNA and related compoun0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.00001226Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.0001655Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0006292Moderately InformativeDirect
Enzyme Commission (EC)Forming carbon-nitrogen bonds1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.2262Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00186Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.191Moderately InformativeInherited
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s2.368e-16InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.00000000000006478InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00000000004563InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.0000002007InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.0000002175InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00005191InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0001778InformativeDirect
Enzyme Commission (EC)Acid--D-amino-acid ligases (peptide synthases)0.01316InformativeInherited
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0Highly InformativeDirect
Enzyme Commission (EC)L-aminoadipate-semialdehyde dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)Formyltetrahydrofolate dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valin0Highly InformativeDirect
Enzyme Commission (EC)Phenylalanine racemase (ATP-hydrolyzing)0.000000000000279Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.000000000001391Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.00000005831Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details) Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.005115Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.06613Least InformativeInherited
Worm Phenotype (WP)cell development variant0.08154Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.1686Least InformativeInherited
Worm Phenotype (WP)germ cell differentiation variant0.001615Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.003821Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant0.008492Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.02458Moderately InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.000503InformativeDirect
Worm Phenotype (WP)RNA expression variant0.009508InformativeInherited
Worm Phenotype (WP)organism starvation response variant0.000000392Highly InformativeDirect
Worm Phenotype (WP)oocyte number decreased0.00003136Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tracheal system0InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)limb0InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect
Xenopus DEvelopment stage (XDE)climax stage0Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)NF stage 660InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.0103Least InformativeInherited
Enzyme Commission (EC)Lyases0.9595Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.1337Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.2215Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0.3693Moderately InformativeInherited
Enzyme Commission (EC)Ligases0.5283Moderately InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases0.00000005655InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.000002253InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000006235InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0.0001535InformativeDirect
Enzyme Commission (EC)Acid--amino-acid ligases (peptide synthases)0.0003751InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.0007454InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0487InformativeInherited
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.000000000000001017Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0.0000000000003371Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase system0.0000000000005052Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.000000001153Highly InformativeDirect
Enzyme Commission (EC)2-methylbutanoate polyketide synthase0.00000001421Highly InformativeDirect
Enzyme Commission (EC)Acting on amino acids and derivatives0.00000002096Highly InformativeDirect
Enzyme Commission (EC)Lovastatin nonaketide synthase0.00000004391Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0.0000002554Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.0000004874Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.0000191Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR009081 SSF47336 Protein matches
Abstract

Acyl carrier protein (ACP) is an essential cofactor in the synthesis of fatty acids by the fatty acid synthetases systems in bacteria and plants. In addition to fatty acid synthesis, ACP is also involved in many other reactions that require acyl transfer steps, such as the synthesis of polyketide antibiotics, biotin precursor, membrane-derived oligosaccharides, and activation of toxins, and functions as an essential cofactor in lipoylation of pyruvate and alpha-ketoglutarate dehydrogenase complexes [PubMed12057197]. The core structure of ACP consists of a four-helical bundle, where helix three is shorter than the others.

Several other proteins share structural homology with ACP, such as the bacterial apo-D-alanyl carrier protein, which facilitates the incorporation of D-alanine into lipoteichoic acid by a ligase, necessary for the growth and development of Gram-positive organisms [PubMed11434765]; and the thioester domain of the bacterial peptide carrier protein found within large modular non-ribosomal peptide synthetases, which are responsible for the synthesis of a variety of microbial bioactive peptides [PubMed10801488].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 30 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a ACP-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 30 hidden Markov models representing the ACP-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]