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Bromodomain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Bromodomain [ 47370]
Families:   Bromodomain [ 47371] (4)


Superfamily statistics
Genomes (504) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 13,754 41,549 8
Proteins 10,751 31,319 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.7336Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.01673Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000006826InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.4214Moderately InformativeInherited
Disease Ontology (DO)viral infectious disease0.5261InformativeInherited
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0006419Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the head0.02873Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.0395Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.04646Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.125Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1447Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5041Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6464Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.001637Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.00734Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.04158Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.0501Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.06245Moderately InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0.0625Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.07621Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.09681Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.1102Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.1119Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1242Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.7646Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Joint hypermobility0.0006223InformativeDirect
Phenotypic Abnormality (PA)Abnormal hair quantity0.0008288InformativeDirect
Phenotypic Abnormality (PA)Abnormal facial shape0.0008326InformativeDirect
Phenotypic Abnormality (PA)Intellectual disability0.0008861InformativeDirect
Phenotypic Abnormality (PA)Abnormal testis morphology0.001555InformativeInherited
Phenotypic Abnormality (PA)Abnormal eyelid morphology0.002407InformativeInherited
Phenotypic Abnormality (PA)Congenital abnormal hair pattern0.004218InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.004826InformativeInherited
Phenotypic Abnormality (PA)Impairment in personality functioning0.008763InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.0742InformativeInherited
Phenotypic Abnormality (PA)Abnormal lip morphology0.1013InformativeInherited
Phenotypic Abnormality (PA)Long eyelashes0.000000705Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal fear/anxiety-related behavior0.000006453Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal aggressive, impulsive or violent behavior0.00002107Highly InformativeDirect
Phenotypic Abnormality (PA)Low anterior hairline0.00007533Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal lacrimal duct morphology0.00009927Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal patella morphology0.0001541Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pinna0.0001698Highly InformativeDirect
Phenotypic Abnormality (PA)Thick eyebrow0.0002039Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the philtrum0.000428Highly InformativeDirect
Phenotypic Abnormality (PA)Delayed skeletal maturation0.0007776Highly InformativeDirect
Phenotypic Abnormality (PA)Spinal dysraphism0.002631Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.000379Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.6471Least InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.00009938Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.02655Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.02928Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.03318Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal viscerocranium morphology0.08399InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.2InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.000463Highly InformativeDirect
Mammalian Phenotype (MP)small nasal bone0.0005436Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.000005343Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.000256Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.001802Least InformativeInherited
Worm Phenotype (WP)cell development variant0.01516Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.03969Least InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.004946Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.0474Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.05978Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.2057Moderately InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.00003264InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.00004385InformativeDirect
Worm Phenotype (WP)anesthetic response variant0.00007732InformativeDirect
Worm Phenotype (WP)sick0.0001719InformativeDirect
Worm Phenotype (WP)cell number increased0.0002525InformativeDirect
Worm Phenotype (WP)drug resistant0.005559InformativeInherited
Worm Phenotype (WP)vulva development variant0.02359InformativeInherited
Worm Phenotype (WP)chemical resistant0.04041InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.317InformativeInherited
Worm Phenotype (WP)somatic gonad development variant0.9166InformativeInherited
Worm Phenotype (WP)organism UV hypersensitive0.000000003446Highly InformativeDirect
Worm Phenotype (WP)vulvaless0.00000495Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance0.0002343InformativeDirect
Yeast Phenotype (YP)lifespan0.2361InformativeInherited
Yeast Phenotype (YP)radiation resistance0.0006273Highly InformativeDirect
Yeast Phenotype (YP)chronological lifespan0.0007173Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.0007785Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)modifier of variegation0.0002322InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)hematopoietic system0.0003919InformativeDirect
Zebrafish Anatomy (ZA)blood0.00004496Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.0000946Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.9085Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.001914Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.002075Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.06214Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.7537Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000000288InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.0000003601InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0004375InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.215InformativeInherited
Enzyme Commission (EC)Adenosinetriphosphatase0.000000004016Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.000000004754Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR001487 SSF47370 Protein matches
Abstract Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [PubMed1350857]. Bromodomains can interact with acetylated lysine [PubMed9175470]. In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). The bromodomain may occur as a single copy, or in duplicate.

The precise function of the domain is unclear, but it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation [PubMed7580139].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bromodomain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Bromodomain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]