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Bromodomain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Bromodomain [ 47370]
Families:   Bromodomain [ 47371] (4)


Superfamily statistics
Genomes (504) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 13,754 41,549 8
Proteins 10,751 31,319 7


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.7336Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.01673Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000006826InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.4214Moderately InformativeInherited
Disease Ontology (DO)viral infectious disease0.5261InformativeInherited
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0006419Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the head0.02583Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.03655Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.04462Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1178Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1393Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5028Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6504Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.00144Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.006503Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.04007Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.04992Moderately InformativeInherited
Phenotypic Abnormality (PA)Neurodevelopmental abnormality0.06174Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.06219Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.07308Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.0902Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.1181Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1256Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.6187Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.7497Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Joint hypermobility0.0005318InformativeDirect
Phenotypic Abnormality (PA)Abnormal facial shape0.0006375InformativeDirect
Phenotypic Abnormality (PA)Abnormal hair quantity0.0007829InformativeDirect
Phenotypic Abnormality (PA)Intellectual disability0.000852InformativeDirect
Phenotypic Abnormality (PA)Abnormal testis morphology0.001446InformativeInherited
Phenotypic Abnormality (PA)Abnormal eyelid morphology0.002072InformativeInherited
Phenotypic Abnormality (PA)Congenital abnormal hair pattern0.003553InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.004095InformativeInherited
Phenotypic Abnormality (PA)Impairment in personality functioning0.008645InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.01262InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.01906InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.07334InformativeInherited
Phenotypic Abnormality (PA)Abnormal lip morphology0.09629InformativeInherited
Phenotypic Abnormality (PA)Abnormal fear/anxiety-related behavior0.000005478Highly InformativeDirect
Phenotypic Abnormality (PA)Long eyelashes0.00001496Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal lacrimal duct morphology0.0001026Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pinna0.0001357Highly InformativeDirect
Phenotypic Abnormality (PA)Cryptorchidism0.0002011Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the philtrum0.0003408Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperactivity0.0004166Highly InformativeDirect
Phenotypic Abnormality (PA)Delayed skeletal maturation0.0007172Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal dermatoglyphics0.0009978Highly InformativeDirect
Phenotypic Abnormality (PA)Spinal dysraphism0.0025Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal emotion/affect behavior0.01062Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the frontal hairline0.01886Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the knee0.3012Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.0003795Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.6473Least InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.00009958Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.02655Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.02922Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.0332Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal viscerocranium morphology0.08397InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.1999InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.0004632Highly InformativeDirect
Mammalian Phenotype (MP)small nasal bone0.0005438Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.001573Least InformativeInherited
Worm Phenotype (WP)cell development variant0.01541Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.01676Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.001264Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.005353Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.04249Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.3156Moderately InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.00002353InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.00003808InformativeDirect
Worm Phenotype (WP)sick0.000162InformativeDirect
Worm Phenotype (WP)cell number increased0.0002199InformativeDirect
Worm Phenotype (WP)drug resistant0.004949InformativeInherited
Worm Phenotype (WP)vulva development variant0.01872InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.302InformativeInherited
Worm Phenotype (WP)somatic gonad development variant0.9189InformativeInherited
Worm Phenotype (WP)organism UV hypersensitive0.000000002457Highly InformativeDirect
Worm Phenotype (WP)amphid phasmid sensillum morphology variant0.00000003774Highly InformativeDirect
Worm Phenotype (WP)amphid morphology variant0.00000008189Highly InformativeDirect
Worm Phenotype (WP)vulvaless0.000004572Highly InformativeDirect
Worm Phenotype (WP)amphid phasmid morphology variant0.000005953Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)chromosome/plasmid maintenance0.0002343InformativeDirect
Yeast Phenotype (YP)lifespan0.2361InformativeInherited
Yeast Phenotype (YP)radiation resistance0.0006273Highly InformativeDirect
Yeast Phenotype (YP)chronological lifespan0.0007173Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.0007785Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)modifier of variegation0.0002385InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.2469Least InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.0007487InformativeDirect
Zebrafish Anatomy (ZA)hematopoietic system0.003052InformativeInherited
Zebrafish Anatomy (ZA)portion of organism substance0.00179Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.00009568Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.9694Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002452Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.003093Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.05457Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.7753Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.9726Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.0000000001653InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.00000004543InformativeDirect
Enzyme Commission (EC)Protein-tyrosine kinases0.0000005091InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0005848InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.2159InformativeInherited
Enzyme Commission (EC)Adenosinetriphosphatase0.000000005314Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.000000006773Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR001487 SSF47370 Protein matches
Abstract Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [PubMed1350857]. Bromodomains can interact with acetylated lysine [PubMed9175470]. In some proteins, the classical bromodomain has diverged to such an extent that parts of the region are either missing or contain an insertion (e.g., mammalian protein HRX, Caenorhabditis elegans hypothetical protein ZK783.4, yeast protein YTA7). The bromodomain may occur as a single copy, or in duplicate.

The precise function of the domain is unclear, but it may be involved in protein-protein interactions and may play a role in assembly or activity of multi-component complexes involved in transcriptional activation [PubMed7580139].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Bromodomain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Bromodomain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]