SUPERFAMILY 1.75 HMM library and genome assignments server

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Bromodomain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Bromodomain [ 47370]
Family:   Bromodomain [ 47371] (4)


Family statistics
Genomes (415) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,306 4,151 8
Proteins 1,180 3,724 7


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.6062Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.005645Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000001965InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.4203Moderately InformativeInherited
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0004982Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.02351Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.03509Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1009Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1091Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.3881Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.4265Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.4535Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.6042Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.0009378Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.003431Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.01407Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.02169Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skull size0.02643Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.02739Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.0378Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.05431Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.06047Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.06749Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.1061Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1125Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.1354Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.1516Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.2496Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.3276Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.4527Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.6938Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Joint hypermobility0.0004006InformativeDirect
Phenotypic Abnormality (PA)Intellectual disability0.0004106InformativeDirect
Phenotypic Abnormality (PA)Abnormal hair quantity0.000416InformativeDirect
Phenotypic Abnormality (PA)Abnormal facial shape0.0004191InformativeDirect
Phenotypic Abnormality (PA)Microcephaly0.0004749InformativeDirect
Phenotypic Abnormality (PA)Abnormal conjugate eye movement0.001001InformativeInherited
Phenotypic Abnormality (PA)Obesity0.002182InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.002381InformativeInherited
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.002788InformativeInherited
Phenotypic Abnormality (PA)Impairment in personality functioning0.004594InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.008945InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.01161InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palm0.02395InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb joint0.05916InformativeInherited
Phenotypic Abnormality (PA)Abnormal lip morphology0.07457InformativeInherited
Phenotypic Abnormality (PA)Abnormal aggressive, impulsive or violent behavior0.000009708Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal lacrimal duct morphology0.0000554Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pinna0.00006329Highly InformativeDirect
Phenotypic Abnormality (PA)Spina bifida occulta0.0001028Highly InformativeDirect
Phenotypic Abnormality (PA)Cryptorchidism0.0001118Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the philtrum0.0001745Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperactivity0.0002532Highly InformativeDirect
Phenotypic Abnormality (PA)Delayed skeletal maturation0.0004505Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal dermatoglyphics0.0005706Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal eyelash morphology0.009495Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hairline0.1857Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the knee0.289Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.0003016Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.6508Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.02285Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.02913Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.06625Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.1195Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.164InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.5215InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.0003452Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.02926Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0000001497Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.3916Moderately InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.0000255InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.00008987InformativeDirect
Worm Phenotype (WP)sick0.0002929InformativeDirect
Worm Phenotype (WP)cell number increased0.0003882InformativeDirect
Worm Phenotype (WP)organism stress response variant0.0009374InformativeDirect
Worm Phenotype (WP)drug resistant0.008031InformativeInherited
Worm Phenotype (WP)vulva development variant0.0157InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.2964InformativeInherited
Worm Phenotype (WP)gonad development variant0.5845InformativeInherited
Worm Phenotype (WP)multivulva0.000001054Highly InformativeDirect
Worm Phenotype (WP)amphid phasmid morphology variant0.00001278Highly InformativeDirect
Worm Phenotype (WP)organism UV response variant0.00001575Highly InformativeDirect
Worm Phenotype (WP)intestinal development variant0.0009544Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)development0.002858Moderately InformativeInherited
Yeast Phenotype (YP)chromosome/plasmid maintenance0.0001938InformativeDirect
Yeast Phenotype (YP)lifespan0.2146InformativeInherited
Yeast Phenotype (YP)radiation resistance0.0005092Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.0006442Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)modifier of variegation0.000164InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.2202Least InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.0005536InformativeDirect
Zebrafish Anatomy (ZA)hematopoietic system0.002727InformativeInherited
Zebrafish Anatomy (ZA)blood cell0.0000288Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.0001078Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.000000000000073Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.9234Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.002137Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.8949Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002634InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.06582InformativeInherited
Enzyme Commission (EC)In phosphorus-containing anhydrides0.1841InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.5869InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000003957Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.000000007549Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Bromodomain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]