A DNA-binding domain in eukaryotic transcription factors family

SCOP classification

• Root: SCOP hierarchy in SUPERFAMILY [ 0] (11)
• Class: All alpha proteins [ 46456] (284)
• Fold: A DNA-binding domain in eukaryotic transcription factors [ 47453]
• Superfamily: A DNA-binding domain in eukaryotic transcription factors [ 47454]
• Family: A DNA-binding domain in eukaryotic transcription factors [ 47455] (2)

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Family statistics

	Genomes (7)	Uniprot 2018_03 genome	PDB chains (SCOP 1.75)
Domains	17	33	1
Proteins	17	33	1

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Disease Ontology (DO)

Highlighted in gray are those with FDR_all>0.001

	DO term	FDR (all)	IC level	SDDO level	Annotation (direct or inherited)
Disease Ontology (DO)	immune system cancer	0.0001342	0.89	--	DIRECT
Disease Ontology (DO)	cancer	0.2552	0.2555	--	INHERITED FROM: immune system cancer || hematologic cancer
Disease Ontology (DO)	disease of cellular proliferation	0.2756	0.2322	--	INHERITED FROM: immune system cancer || hematologic cancer
Disease Ontology (DO)	organ system cancer	0.02649	0.4879	Least Informative	INHERITED FROM: hematologic cancer || immune system cancer
Disease Ontology (DO)	hematologic cancer	0.0001274	0.89	Moderately Informative	DIRECT

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Human Phenotype (HP)

Highlighted in gray are those with FDR_all>0.001

	HP term	FDR (all)	IC level	SDHP level	Annotation (direct or inherited)
Mode of Inheritance (MI)	Autosomal dominant inheritance	0	0.516	Least Informative	DIRECT

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Mouse Phenotype (MP)

Highlighted in gray are those with FDR_all>0.001

	MP term	FDR (all)	IC level	SDMP level	Annotation (direct or inherited)
Mammalian Phenotype (MP)	abnormal erythrocyte physiology	0.0002501	2.603	--	DIRECT
Mammalian Phenotype (MP)	thrombocytopenia	0.0002981	2.302	--	DIRECT
Mammalian Phenotype (MP)	abnormal platelet cell number	0.002053	2.302	--	INHERITED FROM: thrombocytopenia
Mammalian Phenotype (MP)	abnormal bone marrow hematopoietic cell morphology	0.002669	2.126	--	INHERITED FROM: abnormal megakaryocyte morphology
Mammalian Phenotype (MP)	abnormal liver size	0.008124	1.758	--	INHERITED FROM: small liver
Mammalian Phenotype (MP)	abnormal megakaryocyte progenitor cell morphology	0.01041	2.126	--	INHERITED FROM: abnormal megakaryocyte morphology
Mammalian Phenotype (MP)	abnormal myeloid cell number	0.01463	1.758	--	INHERITED FROM: thrombocytopenia
Mammalian Phenotype (MP)	abnormal hematopoietic cell morphology	0.06138	0.7167	--	INHERITED FROM: abnormal megakaryocyte morphology || thrombocytopenia
Mammalian Phenotype (MP)	abnormal hematopoietic system physiology	0.08705	0.8789	--	INHERITED FROM: abnormal erythrocyte physiology
Mammalian Phenotype (MP)	abnormal liver morphology	0.09013	1.156	--	INHERITED FROM: small liver
Mammalian Phenotype (MP)	abnormal hepatobiliary system morphology	0.113	1.098	--	INHERITED FROM: small liver
Mammalian Phenotype (MP)	abnormal hematopoietic system morphology/development	0.4403	0.6686	--	INHERITED FROM: abnormal megakaryocyte morphology || thrombocytopenia
Mammalian Phenotype (MP)	abnormal hematopoietic cell number	0.5855	0.8473	--	INHERITED FROM: thrombocytopenia
Mammalian Phenotype (MP)	abnormal blood cell physiology	0.7518	0.8789	--	INHERITED FROM: abnormal erythrocyte physiology
Mammalian Phenotype (MP)	hematopoietic system phenotype	0.08702	0.5945	Least Informative	INHERITED FROM: abnormal erythrocyte physiology || abnormal megakaryocyte morphology || thrombocytopenia
Mammalian Phenotype (MP)	abnormal myeloid cell morphology	0.007044	0.9904	Moderately Informative	INHERITED FROM: thrombocytopenia || abnormal megakaryocyte morphology
Mammalian Phenotype (MP)	decreased hematopoietic cell number	0.04594	1.072	Moderately Informative	INHERITED FROM: thrombocytopenia
Mammalian Phenotype (MP)	liver/biliary system phenotype	0.1503	1.012	Moderately Informative	INHERITED FROM: small liver
Mammalian Phenotype (MP)	abnormal blood cell morphology	0.1666	0.9129	Moderately Informative	INHERITED FROM: thrombocytopenia
Mammalian Phenotype (MP)	abnormal bone marrow cell morphology/development	0.05118	1.7	Informative	INHERITED FROM: abnormal megakaryocyte morphology
Mammalian Phenotype (MP)	small liver	0.0004898	2.001	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal megakaryocyte morphology	0.0005791	2.126	Highly Informative	DIRECT
Mammalian Phenotype (MP)	abnormal platelet morphology	0.01621	2.126	Highly Informative	INHERITED FROM: thrombocytopenia
Mammalian Phenotype (MP)	decreased myeloid cell number	0.01706	1.904	Highly Informative	INHERITED FROM: thrombocytopenia

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Worm Phenotype (WP)

Highlighted in gray are those with FDR_all>0.001

	WP term	FDR (all)	IC level	SDWP level	Annotation (direct or inherited)
Worm Phenotype (WP)	embryonic lethal	0	0.046	--	DIRECT
Worm Phenotype (WP)	lethal	0	0.00521	--	DIRECT
Worm Phenotype (WP)	development variant	0	0.001482	--	DIRECT
Worm Phenotype (WP)	organism development variant	0	0.00297	--	DIRECT
Worm Phenotype (WP)	embryonic development variant	0	0.04518	--	DIRECT
Worm Phenotype (WP)	physiology variant	1	0	--	INHERITED FROM: lethal || development variant || embryonic development variant || embryonic lethal || organism development variant

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Fly Phenotype (FP)

Highlighted in gray are those with FDR_all>0.001

	FP term	FDR (all)	IC level	SDFP level	Annotation (direct or inherited)
Fly Phenotype (FP)	phenotype	0	0.06546	--	DIRECT
Fly Phenotype (FP)	visible	0	1.239	Moderately Informative	DIRECT

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Fly Anatomy (FA)

Highlighted in gray are those with FDR_all>0.001

	FA term	FDR (all)	IC level	SDFA level	Annotation (direct or inherited)
Fly Anatomy (FA)	organism	0	0.06695	--	DIRECT
Fly Anatomy (FA)	thorax	0	0.912	--	DIRECT
Fly Anatomy (FA)	thoracic segment	0	0.912	--	DIRECT
Fly Anatomy (FA)	mesothoracic segment	0	0.9578	--	DIRECT
Fly Anatomy (FA)	adult tagma	0	0.6649	--	DIRECT
Fly Anatomy (FA)	adult segment	0	0.821	--	DIRECT
Fly Anatomy (FA)	adult thorax	0	0.942	--	DIRECT
Fly Anatomy (FA)	adult thoracic segment	0	0.942	--	DIRECT
Fly Anatomy (FA)	wing	0	1.243	--	DIRECT
Fly Anatomy (FA)	organ system	0	0.1823	--	DIRECT
Fly Anatomy (FA)	integumentary system	0	0.8094	--	DIRECT
Fly Anatomy (FA)	adult integumentary system	0	0.9578	--	DIRECT
Fly Anatomy (FA)	organism subdivision	0	0.5027	--	DIRECT
Fly Anatomy (FA)	region of integument	0	0.884	--	DIRECT
Fly Anatomy (FA)	tagmatic subdivision of integument	0	0.9742	--	DIRECT
Fly Anatomy (FA)	multicellular structure	0	0.008955	--	DIRECT
Fly Anatomy (FA)	anatomical structure	1	0	--	INHERITED FROM: adult external thorax || organism || mesothoracic segment || adult mesothoracic segment || adult || segment || thoracic segment || wing || tagmatic subdivision of integument || adult thorax || appendage || region of integument || adult tagma || adult segment || tagma || organ system subdivision || thorax || adult integumentary system || adult thoracic segment || organ system || organism subdivision || integumentary system || multicellular structure
Fly Anatomy (FA)	material anatomical entity	1	0	--	INHERITED FROM: adult thoracic segment || organ system || organism subdivision || integumentary system || multicellular structure || thorax || adult integumentary system || adult tagma || adult segment || tagma || organ system subdivision || adult thorax || appendage || region of integument || tagmatic subdivision of integument || segment || thoracic segment || wing || adult mesothoracic segment || adult || adult external thorax || organism || mesothoracic segment
Fly Anatomy (FA)	anterior-posterior subdivision of organism	1	0.5027	--	INHERITED FROM: mesothoracic segment || adult external thorax || adult thorax || tagma || adult segment || adult tagma || adult mesothoracic segment || wing || thorax || thoracic segment || segment || adult thoracic segment
Fly Anatomy (FA)	tagma	0	0.5027	Least Informative	DIRECT
Fly Anatomy (FA)	segment	0	0.6568	Least Informative	DIRECT
Fly Anatomy (FA)	adult	0	0.4496	Least Informative	DIRECT
Fly Anatomy (FA)	organ system subdivision	0	0.4301	Least Informative	DIRECT
Fly Anatomy (FA)	adult mesothoracic segment	0	0.9912	Moderately Informative	DIRECT
Fly Anatomy (FA)	adult external thorax	0	1.009	Moderately Informative	DIRECT
Fly Anatomy (FA)	appendage	0	1.047	Moderately Informative	DIRECT

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Xenopus Anatomy (XA)

Highlighted in gray are those with FDR_all>0.001

	XA term	FDR (all)	IC level	SDXA level	Annotation (direct or inherited)
Xenopus ANatomical entity (XAN)	anatomical structure	0	0	--	DIRECT
Xenopus DEvelopment stage (XDE)	NF stage	0	0.01895	--	DIRECT

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