SUPERFAMILY 1.75 HMM library and genome assignments server

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EF-hand superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   EF Hand-like [ 47472] (4)
Superfamily:   EF-hand [ 47473] (11)
Families:   Calbindin D9K [ 47474]
  S100 proteins [ 47478]
  Polcalcin [ 89048] (3)
  Osteonectin [ 47489]
  Parvalbumin [ 47492] (2)
  Calmodulin-like [ 47502] (23)
  Eps15 homology domain (EH domain) [ 47543] (3)
  Cbp40 (plasmodial specific CaII-binding protein LAV1-2) [ 81758]
  Penta-EF-hand proteins [ 63550] (6)
  EF-hand modules in multidomain proteins [ 47547] (8)
  p25-alpha [ 140538] (2)


Superfamily statistics
Genomes (1,144) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 70,336 206,497 217
Proteins 62,203 182,476 215


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.00000996Least InformativeDirect
Enzyme Commission (EC)Isomerases0.8525Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.0001396Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.9116Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.1217Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0.0000000521InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.00004132InformativeDirect
Enzyme Commission (EC)With a oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor0.000000003307Highly InformativeDirect
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.05916Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.2424Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.3731Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.7852Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.786Least InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.02815Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.4149Moderately InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.9251Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.000005263InformativeDirect
Worm Phenotype (WP)defecation variant0.003189InformativeInherited
Worm Phenotype (WP)pericellular component morphology variant0.1333InformativeInherited
Worm Phenotype (WP)cell stress response variant0.1933InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.8714InformativeInherited
Worm Phenotype (WP)gonad sheath contractions variant0.00000000221Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.0000002576Highly InformativeDirect
Worm Phenotype (WP)osmotic stress response variant0.00000107Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.000002018Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.0001692Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0.9097Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.9224Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.1064Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.07113InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.834InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)pollen tube cell0.0000004698InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.6588InformativeInherited
Plant ANatomical entity (PAN)parenchyma cell0.002369Highly InformativeInherited
Plant ANatomical entity (PAN)mesophyll1Highly InformativeInherited
Plant structure DEvelopment stage (PDE)pollen development stage0.000000111Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0000000000000598Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.0000004994Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.002722Moderately InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0.9769Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect
Enzyme Commission (EC)Acting on NADH or NADPH0.000000000000008949InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.00000006596InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.0000002784InformativeDirect
Enzyme Commission (EC)Omega peptidases0.02259InformativeInherited
Enzyme Commission (EC)Acting on a peroxide as acceptor0.1233InformativeInherited
Enzyme Commission (EC)Serine endopeptidases1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect
Enzyme Commission (EC)With a quinone or similar compound as acceptor0.00000002349Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0.0000004984Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.0000243Highly InformativeDirect
Enzyme Commission (EC)Diphosphotransferases0.005541Highly InformativeInherited
Enzyme Commission (EC)With a quinone or similar compound as acceptor0.4012Highly InformativeInherited
Enzyme Commission (EC)Transketolases and transaldolases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 174 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a EF-hand domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 174 hidden Markov models representing the EF-hand superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]