SUPERFAMILY 1.75 HMM library and genome assignments server

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EF-hand modules in multidomain proteins family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   EF Hand-like [ 47472] (4)
Superfamily:   EF-hand [ 47473] (11)
Family:   EF-hand modules in multidomain proteins [ 47547] (8)


Family statistics
Genomes (126) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,482 4,580 13
Proteins 1,146 3,379 12


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.0000000664Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)myopathy1InformativeInherited
Disease Ontology (DO)muscular dystrophy0.0000636Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1343Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2515Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.01558Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.1838Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.3571Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.03992InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.04618InformativeInherited
Mammalian Phenotype (MP)increased interleukin-2 secretion0.00009074Highly InformativeDirect
Mammalian Phenotype (MP)abnormal somatic motor system morphology0.0005282Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spine curvature0.002411Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.001469Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.0052Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.0052Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.02137Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.00002734Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0.0003987Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.06041Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.00000001529InformativeDirect
Worm Phenotype (WP)cell stress response variant0.0000611InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)peripheral nervous system0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.0000000000001065Least InformativeDirect
Enzyme Commission (EC)Transferases0.3945Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.0000006826Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.00001532Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000000000001548InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 174 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a EF-hand domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]