SUPERFAMILY 1.75 HMM library and genome assignments server

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Calponin-homology domain, CH-domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Family:   Calponin-homology domain, CH-domain [ 47577] (9)


Family statistics
Genomes (493) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,680 17,766 21
Proteins 5,657 17,716 21


Human Phenotype (HP)

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show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.04669Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.06723Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.08148Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.113Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2744Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.02136Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.03693Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.03907Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.0707Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.1361Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.1954Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.4903Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating protein level0.00797InformativeInherited
Phenotypic Abnormality (PA)Abnormal adipose tissue morphology0.01758InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.04439InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.08591InformativeInherited
Phenotypic Abnormality (PA)Decreased cervical spine flexion due to contractures of posterior cervical muscles0.00002651Highly InformativeDirect
Phenotypic Abnormality (PA)Lipodystrophy0.0001725Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.0004404Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature of the lower limbs0.0004814Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.0008683Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the Achilles tendon0.0008767Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the sternum0.002068Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1109Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.4773Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5262Least InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.02384Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.1319Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.2229Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.2306Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.541Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.5468Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.6846Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.7805Moderately InformativeInherited
Mammalian Phenotype (MP)decreased B cell number0.03688InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.08735InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.286InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.3092InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.6128InformativeInherited
Mammalian Phenotype (MP)abnormal cell adhesion0.0008151Highly InformativeDirect
Mammalian Phenotype (MP)increased immature B cell number0.002976Highly InformativeInherited
Mammalian Phenotype (MP)abnormal transitional stage B cell morphology0.005007Highly InformativeInherited
Mammalian Phenotype (MP)gastrointestinal ulcer0.007192Highly InformativeInherited
Mammalian Phenotype (MP)decreased immature B cell number0.1193Highly InformativeInherited
Mammalian Phenotype (MP)abnormal intestinal mucosa morphology0.9208Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0000003909Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0008992Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.0008992Least InformativeDirect
Worm Phenotype (WP)cell development variant0.1271Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.005725Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.01428Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.01791Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.2355Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.519Moderately InformativeInherited
Worm Phenotype (WP)brood size variant0.000005586InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0002919InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0003771InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.00269InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.00565InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.04522InformativeInherited
Worm Phenotype (WP)cell component localization variant0.06512InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.6229InformativeInherited
Worm Phenotype (WP)cleavage furrow defective early emb0.00000756Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0003452Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.0004943Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0008494Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0.04673Least InformativeInherited
Fly Anatomy (FA)adult0.05818Least InformativeInherited
Fly Anatomy (FA)somatic cell0.06668Least InformativeInherited
Fly Anatomy (FA)segment0.1214Least InformativeInherited
Fly Anatomy (FA)nervous system0.1698Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2305Least InformativeInherited
Fly Anatomy (FA)larva0.4824Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.008156Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.08815Moderately InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.1326Moderately InformativeInherited
Fly Anatomy (FA)larval tagma0.4782Moderately InformativeInherited
Fly Anatomy (FA)abdomen0.5942Moderately InformativeInherited
Fly Anatomy (FA)syncytium0.003532InformativeInherited
Fly Anatomy (FA)muscle cell0.0072InformativeInherited
Fly Anatomy (FA)larval abdominal segment0.06797InformativeInherited
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.08025InformativeInherited
Fly Anatomy (FA)nerve0.1079InformativeInherited
Fly Anatomy (FA)indirect flight muscle0.0002675Highly InformativeDirect
Fly Anatomy (FA)abdominal segmental nerve0.0007282Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.000000000000004898Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]