SUPERFAMILY 1.75 HMM library and genome assignments server

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Calponin-homology domain, CH-domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Family:   Calponin-homology domain, CH-domain [ 47577] (9)


Family statistics
Genomes (493) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,680 17,766 21
Proteins 5,657 17,716 21


Human Phenotype (HP)

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show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.05021Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.07083Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.08534Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1191Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.02196Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.03812Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.04159Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.06642Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.1961Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.4911Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.01486InformativeInherited
Phenotypic Abnormality (PA)Abnormal adipose tissue morphology0.01764InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.08357InformativeInherited
Phenotypic Abnormality (PA)Decreased cervical spine flexion due to contractures of posterior cervical muscles0.00002532Highly InformativeDirect
Phenotypic Abnormality (PA)Lipodystrophy0.0001637Highly InformativeDirect
Phenotypic Abnormality (PA)Scapular winging0.0003314Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.0004388Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature of the lower limbs0.0005218Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the Achilles tendon0.0008386Highly InformativeDirect
Phenotypic Abnormality (PA)Heart block0.0009955Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the sternum0.002264Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1111Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.4769Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5268Least InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.02384Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.1326Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.2237Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.2313Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.5414Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.5474Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.6836Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.7803Moderately InformativeInherited
Mammalian Phenotype (MP)decreased B cell number0.03721InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.08728InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.2853InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.3093InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.6137InformativeInherited
Mammalian Phenotype (MP)abnormal cell adhesion0.0008154Highly InformativeDirect
Mammalian Phenotype (MP)increased immature B cell number0.002977Highly InformativeInherited
Mammalian Phenotype (MP)abnormal transitional stage B cell morphology0.005007Highly InformativeInherited
Mammalian Phenotype (MP)gastrointestinal ulcer0.007196Highly InformativeInherited
Mammalian Phenotype (MP)decreased immature B cell number0.1186Highly InformativeInherited
Mammalian Phenotype (MP)abnormal intestinal mucosa morphology0.9208Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0007016Least InformativeDirect
Worm Phenotype (WP)cell development variant0.1233Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.005464Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.006487Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.01246Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.2298Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.4273Moderately InformativeInherited
Worm Phenotype (WP)brood size variant0.000006972InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0004076InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0005779InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.002613InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.005952InformativeInherited
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.01796InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.04458InformativeInherited
Worm Phenotype (WP)cell component localization variant0.06443InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.6293InformativeInherited
Worm Phenotype (WP)actin organization biogenesis variant0.000006313Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective early emb0.000007926Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0004382Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0009154Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0.09367Least InformativeInherited
Fly Anatomy (FA)adult0.1134Least InformativeInherited
Fly Anatomy (FA)segment0.1202Least InformativeInherited
Fly Anatomy (FA)somatic cell0.128Least InformativeInherited
Fly Anatomy (FA)nervous system0.3157Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3274Least InformativeInherited
Fly Anatomy (FA)larva0.6815Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.01212Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.08898Moderately InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.1665Moderately InformativeInherited
Fly Anatomy (FA)larval segment0.2982Moderately InformativeInherited
Fly Anatomy (FA)larval tagma0.5127Moderately InformativeInherited
Fly Anatomy (FA)abdomen0.5927Moderately InformativeInherited
Fly Anatomy (FA)syncytium0.004059InformativeInherited
Fly Anatomy (FA)muscle cell0.008124InformativeInherited
Fly Anatomy (FA)larval abdominal segment0.08048InformativeInherited
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.08508InformativeInherited
Fly Anatomy (FA)nerve0.1067InformativeInherited
Fly Anatomy (FA)flight muscle0.0007025Highly InformativeDirect
Fly Anatomy (FA)abdominal segmental nerve0.0008909Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.000000000000004716Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

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Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]