SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


p53 tetramerization domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   p53 tetramerization domain [ 47718]
Superfamily:   p53 tetramerization domain [ 47719]
Families:   p53 tetramerization domain [ 47720]


Superfamily statistics
Genomes (76) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 306 985 6
Proteins 306 985 6


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system disease0Least InformativeDirect
Disease Ontology (DO)disease of mental health0Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0Moderately InformativeDirect
Disease Ontology (DO)genetic disease0Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)autosomal dominant disease0InformativeDirect
Disease Ontology (DO)lymphoblastic leukemia0InformativeDirect
Disease Ontology (DO)connective tissue cancer0InformativeDirect
Disease Ontology (DO)respiratory system cancer0InformativeDirect
Disease Ontology (DO)viral infectious disease0InformativeDirect
Disease Ontology (DO)cell type benign neoplasm0InformativeDirect
Disease Ontology (DO)substance dependence0InformativeDirect
Disease Ontology (DO)endocrine gland cancer0InformativeDirect
Disease Ontology (DO)head and neck carcinoma0InformativeDirect
Disease Ontology (DO)carcinoma0InformativeDirect
Disease Ontology (DO)liver carcinoma0InformativeDirect
Disease Ontology (DO)melanoma0Highly InformativeDirect
Disease Ontology (DO)progressive multifocal leukoencephalopathy0Highly InformativeDirect
Disease Ontology (DO)head and neck squamous cell carcinoma0Highly InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0Highly InformativeDirect
Disease Ontology (DO)hereditary breast ovarian cancer syndrome0Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)prenatal lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body composition0Moderately InformativeDirect
Mammalian Phenotype (MP)neoplasm0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)decreased total tissue mass0InformativeDirect
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0InformativeDirect
Mammalian Phenotype (MP)premature death0InformativeDirect
Mammalian Phenotype (MP)abnormal voluntary movement0InformativeDirect
Mammalian Phenotype (MP)decreased body size0InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0InformativeDirect
Mammalian Phenotype (MP)abnormal cartilage morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology0InformativeDirect
Mammalian Phenotype (MP)increased carcinoma incidence0InformativeDirect
Mammalian Phenotype (MP)increased gland tumor incidence0InformativeDirect
Mammalian Phenotype (MP)abnormal intestine morphology0InformativeDirect
Mammalian Phenotype (MP)hemorrhage0InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0InformativeDirect
Mammalian Phenotype (MP)abnormal embryo development0InformativeDirect
Mammalian Phenotype (MP)abnormal head morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0InformativeDirect
Mammalian Phenotype (MP)increased leukemia incidence0Highly InformativeDirect
Mammalian Phenotype (MP)paralysis0Highly InformativeDirect
Mammalian Phenotype (MP)increased adenoma incidence0Highly InformativeDirect
Mammalian Phenotype (MP)increased alimentary system tumor incidence0Highly InformativeDirect
Mammalian Phenotype (MP)increased T cell derived lymphoma incidence0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cell nucleus morphology0Highly InformativeDirect
Mammalian Phenotype (MP)altered metastatic potential0Highly InformativeDirect
Mammalian Phenotype (MP)increased adenocarcinoma incidence0Highly InformativeDirect
Mammalian Phenotype (MP)decreased sensitivity to induced cell death0Highly InformativeDirect
Mammalian Phenotype (MP)increased respiratory system tumor incidence0Highly InformativeDirect
Mammalian Phenotype (MP)decreased apoptosis0Highly InformativeDirect
Mammalian Phenotype (MP)weight loss0Highly InformativeDirect
Mammalian Phenotype (MP)premature aging0Highly InformativeDirect

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

InterPro annotation
Cross references IPR010991 SSF47719 Protein matches
Abstract

The p53 protein is a tetrameric transcription factor that plays a central role in the prevention of neoplastic transformation [PubMed7878469]. Oligomerization appears to be essential for the tumour suppressing activity of p53. p53 can be divided into different functional domains: an N-terminal transactivation domain, a proline-rich domain, a DNA-binding domain , a tetramerisation domain and a C-terminal regulatory region. The tetramerisation domain of human p53 extends from residues 325 to 356, and has a 4-helical bundle fold. The tetramerisation domain is essential for DNA binding, protein-protein interactions, post-translational modifications, and p53 degradation [PubMed11420672].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a p53 tetramerization domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the p53 tetramerization domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]