SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Pointed domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   SAM domain-like [ 47768] (16)
Superfamily:   SAM/Pointed domain [ 47769] (3)
Family:   Pointed domain [ 47770] (6)


Family statistics
Genomes (104) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 557 1,660 9
Proteins 557 1,660 9


Disease Ontology (DO)

(
show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.01337Least InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.006507Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.01483Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.04172Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6476Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular development0.00006739Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.0005412Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.0006902Moderately InformativeDirect
Mammalian Phenotype (MP)decreased hematopoietic cell number0.001562Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.002529Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.044Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.09202Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.104Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2311Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.3016Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.3281Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.4064Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.5787Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.5916Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.6777Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.00004348InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel physiology0.0001118InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0004275InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.001195InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.02305InformativeInherited
Mammalian Phenotype (MP)lethality throughout fetal growth and development0.05116InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.5055InformativeInherited
Mammalian Phenotype (MP)decreased thymocyte number0.0001096Highly InformativeDirect
Mammalian Phenotype (MP)lethality throughout fetal growth and development, complete penetrance0.0008751Highly InformativeDirect
Mammalian Phenotype (MP)abnormal platelet morphology0.004172Highly InformativeInherited
Mammalian Phenotype (MP)decreased myeloid cell number0.04435Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell number defective0.0003969InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.008177Moderately InformativeInherited
Fly Anatomy (FA)egg0.002764InformativeInherited
Fly Anatomy (FA)dorsal appendage0.0001888Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0006583InformativeDirect
Xenopus ANatomical entity (XAN)ventral blood island0Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0Highly InformativeDirect
Xenopus ANatomical entity (XAN)periocular region0.0000001756Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.00002609Highly InformativeDirect
Xenopus ANatomical entity (XAN)lateral plate mesoderm0.0007672Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a SAM/Pointed domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Internal database links ]