SUPERFAMILY 1.75 HMM library and genome assignments server

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Pointed domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   SAM domain-like [ 47768] (16)
Superfamily:   SAM/Pointed domain [ 47769] (3)
Family:   Pointed domain [ 47770] (6)


Family statistics
Genomes (104) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 557 1,660 9
Proteins 557 1,660 9


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.01337Least InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.006497Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.0148Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.04166Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6476Least InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular development0.00006746Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel morphology0.0005413Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.000687Moderately InformativeDirect
Mammalian Phenotype (MP)decreased hematopoietic cell number0.001555Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.002529Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.04407Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.09169Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.1037Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2315Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.3016Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.3287Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.4059Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.5788Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.5923Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.6772Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.00004354InformativeDirect
Mammalian Phenotype (MP)abnormal blood vessel physiology0.0001119InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0004274InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.001196InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.02307InformativeInherited
Mammalian Phenotype (MP)lethality throughout fetal growth and development0.05114InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.5048InformativeInherited
Mammalian Phenotype (MP)decreased thymocyte number0.0001096Highly InformativeDirect
Mammalian Phenotype (MP)lethality throughout fetal growth and development, complete penetrance0.0008751Highly InformativeDirect
Mammalian Phenotype (MP)abnormal platelet morphology0.00417Highly InformativeInherited
Mammalian Phenotype (MP)decreased myeloid cell number0.04446Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)decreased cell number0.0008727InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)acellular anatomical structure0.008898Moderately InformativeInherited
Fly Anatomy (FA)egg0.003075InformativeInherited
Fly Anatomy (FA)dorsal appendage0.0002044Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0006474InformativeDirect
Xenopus ANatomical entity (XAN)ventral blood island0Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0Highly InformativeDirect
Xenopus ANatomical entity (XAN)periocular region0.0000001701Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.00002589Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a SAM/Pointed domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Internal database links ]