SUPERFAMILY 1.75 HMM library and genome assignments server

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SAM (sterile alpha motif) domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   SAM domain-like [ 47768] (16)
Superfamily:   SAM/Pointed domain [ 47769] (3)
Family:   SAM (sterile alpha motif) domain [ 47773] (15)


Family statistics
Genomes (106) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 598 1,395 19
Proteins 598 1,395 19


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.2857Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.002052Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.9823Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.00000000001008InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.3758Least InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.0008107InformativeDirect
Disease Ontology (DO)breast carcinoma0.003512InformativeInherited
Disease Ontology (DO)invasive ductal carcinoma0.0001509Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2378Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.879Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.0231Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.09118Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.2253Moderately InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.2297Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.3011Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4296Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.5894Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.0009545InformativeDirect
Mammalian Phenotype (MP)abnormal brain white matter morphology0.005191InformativeInherited
Mammalian Phenotype (MP)abnormal cerebral hemisphere morphology0.02521InformativeInherited
Mammalian Phenotype (MP)abnormal neuron differentiation0.0299InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.05274InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.1631InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.0006485Highly InformativeDirect
Mammalian Phenotype (MP)abnormal long term depression0.007821Highly InformativeInherited
Mammalian Phenotype (MP)vertebral transformation0.01033Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical vertebrae morphology0.01514Highly InformativeInherited
Mammalian Phenotype (MP)vertebral fusion0.019Highly InformativeInherited
Mammalian Phenotype (MP)abnormal tail morphology0.02575Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dorsal telencephalic commissure morphology0.8333Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Least InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect
Yeast Phenotype (YP)development0Moderately InformativeDirect
Yeast Phenotype (YP)vegetative growth0Moderately InformativeDirect
Yeast Phenotype (YP)sexual cycle0InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)size defective0.1084InformativeInherited
Fly Phenotype (FP)homeotic0.00004631Highly InformativeDirect
Fly Phenotype (FP)neoplasia0.0006212Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.1455Least InformativeInherited
Fly Anatomy (FA)tagma0.3141Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3392Least InformativeInherited
Fly Anatomy (FA)adult0.3474Least InformativeInherited
Fly Anatomy (FA)segment0.3477Least InformativeInherited
Fly Anatomy (FA)abdomen0.03228Moderately InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.3847Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.4332Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.5213Moderately InformativeInherited
Fly Anatomy (FA)appendage0.5331Moderately InformativeInherited
Fly Anatomy (FA)appendage segment0.01066InformativeInherited
Fly Anatomy (FA)leg0.01974InformativeInherited
Fly Anatomy (FA)male organism0.04343InformativeInherited
Fly Anatomy (FA)mesothoracic leg0.0001924Highly InformativeDirect
Fly Anatomy (FA)metatarsus0.0003165Highly InformativeDirect
Fly Anatomy (FA)adult metathoracic segment0.0008662Highly InformativeDirect
Fly Anatomy (FA)prothoracic segment0.002229Highly InformativeInherited
Fly Anatomy (FA)adult abdominal segment0.002435Highly InformativeInherited
Fly Anatomy (FA)abdominal segment 40.02454Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.0006945Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1964Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0004603InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases1InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0.000000000003738Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a SAM/Pointed domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]