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Transducin (alpha subunit), insertion domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Transducin (alpha subunit), insertion domain [ 47894]
Superfamily:   Transducin (alpha subunit), insertion domain [ 47895]
Families:   Transducin (alpha subunit), insertion domain [ 47896]


Superfamily statistics
Genomes (449) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,875 11,171 25
Proteins 3,834 11,072 25


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.04728Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.06816Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.07994Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.16Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.02376Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.04017Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.08228Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1074Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.206Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.2277Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.2699Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.001276InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.001456InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.001896InformativeInherited
Mammalian Phenotype (MP)impaired muscle contractility0.002476InformativeInherited
Mammalian Phenotype (MP)abnormal touch/ nociception0.007432InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.01041InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.01739InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.04134InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.07547InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.1388InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.1725InformativeInherited
Mammalian Phenotype (MP)decreased systemic arterial blood pressure0.00000123Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.000003414Highly InformativeDirect
Mammalian Phenotype (MP)abnormal rib morphology0.0002584Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vascular smooth muscle physiology0.0009334Highly InformativeDirect
Mammalian Phenotype (MP)abnormal joint morphology0.001567Highly InformativeInherited
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.001662Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lumbar vertebrae morphology0.002363Highly InformativeInherited
Mammalian Phenotype (MP)abnormal eye electrophysiology0.003983Highly InformativeInherited
Mammalian Phenotype (MP)abnormal mineral level0.02983Highly InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-2 secretion0.09379Highly InformativeInherited
Mammalian Phenotype (MP)abnormal tumor necrosis factor secretion0.1565Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.2824Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.00000000000006794Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000000000002915Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.000000001549Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.04054Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.3776Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.4631Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.4636Least InformativeInherited
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)movement variant0Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.000000000000001777Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.000000000000005323Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.000000000000005323Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.000000000000005765Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.000000000000005765Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.000000000000007977Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.00000106Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.1498Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.158Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.2399Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.244Moderately InformativeInherited
Worm Phenotype (WP)drug response variant1Moderately InformativeInherited
Worm Phenotype (WP)body posture variant0InformativeDirect
Worm Phenotype (WP)male mating variant0InformativeDirect
Worm Phenotype (WP)foraging behavior variant0InformativeDirect
Worm Phenotype (WP)localized movement variant0InformativeDirect
Worm Phenotype (WP)body bend variant0InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.00000000000009343InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.00000000001648InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.0000002026InformativeDirect
Worm Phenotype (WP)electrophysiology variant0.00003315InformativeDirect
Worm Phenotype (WP)directionality variant0.00007362InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.00066InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.001792InformativeInherited
Worm Phenotype (WP)protein modification variant0.01388InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.06048InformativeInherited
Worm Phenotype (WP)small1InformativeInherited
Worm Phenotype (WP)locomotion reduced1InformativeInherited
Worm Phenotype (WP)amphid phasmid morphology variant0Highly InformativeDirect
Worm Phenotype (WP)male mating defective0Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0Highly InformativeDirect
Worm Phenotype (WP)fat0.0000000000178Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.0000000001712Highly InformativeDirect
Worm Phenotype (WP)foraging hyperactive0.0000000003329Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.000000001587Highly InformativeDirect
Worm Phenotype (WP)pausing variant0.0000001563Highly InformativeDirect
Worm Phenotype (WP)short0.00002428Highly InformativeDirect
Worm Phenotype (WP)neuron physiology variant0.00004509Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.0001429Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.0002182Highly InformativeDirect
Worm Phenotype (WP)path curvature variant0.0002627Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.473Highly InformativeInherited
Worm Phenotype (WP)forward point velocity variant0.8556Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)wild-type0.0004693InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)nervous system0.1042Least InformativeInherited
Fly Anatomy (FA)somatic cell0.1795Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2001Least InformativeInherited
Fly Anatomy (FA)adult0.5232Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.09308Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2082Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.4158Moderately InformativeInherited
Fly Anatomy (FA)chemosensory system0.0001168InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.005869Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2401Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.00008991Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.09654Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.0000000000005635InformativeDirect
Xenopus ANatomical entity (XAN)urinary system0.000002788InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.00001275InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.00003878InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.01847InformativeInherited
Xenopus ANatomical entity (XAN)neuron0.001346Highly InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone0.04289Highly InformativeInherited
Xenopus ANatomical entity (XAN)olfactory system0.13Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)root system0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence meristem0Moderately InformativeDirect
Plant ANatomical entity (PAN)cotyledon0Moderately InformativeDirect
Plant ANatomical entity (PAN)pollen0Moderately InformativeDirect
Plant ANatomical entity (PAN)rosette leaf0.0000023InformativeDirect
Plant ANatomical entity (PAN)fruit0.00001333InformativeDirect
Plant ANatomical entity (PAN)shoot axis stele0.000000000666Highly InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR011025 SSF47895 Protein matches
Abstract

Guanine nucleotide binding proteins (G proteins) are membrane-associated, heterotrimeric proteins composed of three subunits: alpha , beta and gamma [PubMed15119945]. G proteins act as signal transducers, relaying a signal from a ligand-activated GPCR (G protein-coupled receptor) to an enzyme or ion channel effector. The activated GPCR promotes the exchange of GDP for GTP on the G protein alpha subunit, allowing the trimeric G protein to be released from the receptor and to dissociate into active (GTP-bound) alpha subunit and beta/gamma dimer, both of which activate distinct downstream effectors. There are several isoforms of each subunit, which together can makeup hundreds of combinations of G proteins, each one linking a specific receptor to a certain effector.

The heterotrimeric G protein alpha subunit is composed of two domains: a GTP-binding domain and a helical insertion domain. The GTP-binding domain is homologous to Ras-like small GTPases, and includes switch regions I and II, which change conformation during activation. The helical insertion domain is inserted into the GTP-binding domain before switch region I, and is unique to heterotrimeric G proteins. This helical insertion domain functions to sequester the guanine nucleotide at the interface with the GTP-binding domain and must be displaced to enable nucleotide dissociation [PubMed12517447]. This entry represents the G protein alpha subunit helical insertion domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transducin (alpha subunit), insertion domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Transducin (alpha subunit), insertion domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]