SUPERFAMILY 1.75 HMM library and genome assignments server

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Retinoblastoma tumor suppressor domains family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cyclin-like [ 47953]
Superfamily:   Cyclin-like [ 47954] (3)
Family:   Retinoblastoma tumor suppressor domains [ 47969]


Family statistics
Genomes (96) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 323 915 9
Proteins 249 739 6


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)nervous system cancer0Moderately InformativeDirect
Disease Ontology (DO)retinal cell cancer0InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body composition0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal embryo morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)prenatal lethality0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal axial skeleton morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)limbs/digits/tail phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0Moderately InformativeDirect
Mammalian Phenotype (MP)neoplasm0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal head morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body size0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skin morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skin adnexa morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cartilage morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal thoracic cage morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal neuron physiology0InformativeDirect
Mammalian Phenotype (MP)abnormal prenatal body size0InformativeDirect
Mammalian Phenotype (MP)abnormal skin adnexa physiology0InformativeDirect
Mammalian Phenotype (MP)abnormal respiratory function0InformativeDirect
Mammalian Phenotype (MP)premature death0InformativeDirect
Mammalian Phenotype (MP)normal phenotype0InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal eye physiology0InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic growth/weight/body size0InformativeDirect
Mammalian Phenotype (MP)postnatal lethality0InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0InformativeDirect
Mammalian Phenotype (MP)postnatal growth retardation0InformativeDirect
Mammalian Phenotype (MP)decreased total tissue mass0InformativeDirect
Mammalian Phenotype (MP)increased malignant tumor incidence0InformativeDirect
Mammalian Phenotype (MP)decreased neuron number0InformativeDirect
Mammalian Phenotype (MP)abnormal limb bone morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal mouth morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal bone ossification0InformativeDirect
Mammalian Phenotype (MP)abnormal long bone morphology0InformativeDirect
Mammalian Phenotype (MP)decreased body size0InformativeDirect
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0InformativeDirect
Mammalian Phenotype (MP)abnormal retinal ganglion cell morphology0Highly InformativeDirect
Mammalian Phenotype (MP)decreased fetal size0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0Highly InformativeDirect
Mammalian Phenotype (MP)postnatal lethality, incomplete penetrance0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuron apoptosis0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal forelimb stylopod morphology0Highly InformativeDirect
Mammalian Phenotype (MP)decreased length of long bones0Highly InformativeDirect
Mammalian Phenotype (MP)distended abdomen0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal bipolar cell morphology0Highly InformativeDirect
Mammalian Phenotype (MP)neonatal lethality, incomplete penetrance0Highly InformativeDirect
Mammalian Phenotype (MP)neonatal lethality, complete penetrance0Highly InformativeDirect
Mammalian Phenotype (MP)increased liver tumor incidence0Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0Highly InformativeDirect
Mammalian Phenotype (MP)decreased retinal photoreceptor cell number0Highly InformativeDirect

Document: MP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cyclin-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Internal database links ]